Searching for up to 100 curated homologs for 353168 FitnessBrowser__Btheta:353168 (456 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.22.5.3 / Q9KDT3 Neurotransmitter:sodium symporter of 455 aas, MhsT from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
46% identity, 98% coverage of query (363 bits)
6yu6B / Q9KDT3 Crystal structure of mhst in complex with l-leucine (see paper)
47% identity, 97% coverage of query (363 bits)
6yu7A Crystal structure of mhst in complex with l-tyrosine
47% identity, 97% coverage of query (363 bits)
6yu4A Crystal structure of mhst in complex with l-4f-phenylalanine
47% identity, 97% coverage of query (363 bits)
6yu5A Crystal structure of mhst in complex with l-valine
47% identity, 97% coverage of query (362 bits)
6yu3A Crystal structure of mhst in complex with l-phenylalanine
47% identity, 97% coverage of query (362 bits)
6yu2A Crystal structure of mhst in complex with l-isoleucine
47% identity, 97% coverage of query (362 bits)
4us3A Crystal structure of the bacterial nss member mhst in an occluded inward-facing state
47% identity, 97% coverage of query (362 bits)
4us4A Crystal structure of the bacterial nss member mhst in an occluded inward-facing state (lipidic cubic phase form)
47% identity, 96% coverage of query (355 bits)
TC 2.A.22.5.1 / Q58715 Hypothetical Na+-dependent permease from Methanococcus jannaschii (see paper)
36% identity, 76% coverage of query (202 bits)
TC 2.A.22.5.2 / Q8RHM5 The 11 TMS Na+-dependent tyrosine transporter, Tyt1 from Fusobacterium nucleatum subsp. nucleatum (see paper)
35% identity, 76% coverage of query (194 bits)
Build an alignment for 353168 and 11 homologs with ≥ 30% identity
Or download the sequences
TC 2.A.22.4.1 / O50649 High affinity tryptophan:Na+ symporter, TnaT, of 501 aas and 12 TMSs (Androutsellis-Theotokis et al., 2003). The Km for Tryptophan is 145 nM; tryptamine and serotonin weakly inhibited with Ki values of 200 and 440 μM, respectively. An evolutionarily conserved role of adjacent transmembrane segments 7 and 8 has been proposed from Symbiobacterium thermophilum (see 2 papers)
tnaT / BAD39427.1 sodium-and chloride-dependent transporter, TnaT from Symbiobacterium thermophilum IAM 14863 (see paper)
29% identity, 96% coverage of query (191 bits)
TC 2.A.22.4.3 / Q8NRL8 Transporter, component of The methionine/alanine uptake porter, MetPS (Trotschel et al., 2008) (MetP is the transporter; MetS is an essential auxiliary subunit) from Corynebacterium glutamicum
34% identity, 89% coverage of query (182 bits)
3gwwA Leucine transporter leut in complex with s-fluoxetine
31% identity, 97% coverage of query (182 bits)
2q6hA / O67854 Crystal structure analysis of leut complexed with l-leucine, sodium, and clomipramine (see paper)
31% identity, 98% coverage of query (180 bits)
3uslA Crystal structure of leut bound to l-selenomethionine in space group c2 from lipid bicelles
31% identity, 97% coverage of query (180 bits)
3usgA Crystal structure of leut bound to l-leucine in space group c2 from lipid bicelles
31% identity, 97% coverage of query (180 bits)
3f3aA Crystal structure of leut bound to l-tryptophan and sodium
31% identity, 97% coverage of query (179 bits)
2qeiA Crystal structure analysis of leut complexed with l-alanine, sodium, and clomipramine
31% identity, 97% coverage of query (179 bits)
2q72A Crystal structure analysis of leut complexed with l-leucine, sodium, and imipramine
31% identity, 97% coverage of query (179 bits)
3gwuA Leucine transporter leut in complex with sertraline
31% identity, 97% coverage of query (179 bits)
3f4jA Crystal structure of leut bound to glycine and sodium
31% identity, 97% coverage of query (179 bits)
3f3dA Crystal structure of leut bound to l-methionine and sodium
31% identity, 97% coverage of query (179 bits)
3f3cA Crystal structure of leut bound to 4-fluoro-l-phenylalanine and sodium
31% identity, 97% coverage of query (179 bits)
3gwvA Leucine transporter leut in complex with r-fluoxetine
31% identity, 97% coverage of query (179 bits)
2qb4A Crystal structure analysis of leut complexed with l-leucine, sodium and desipramine
31% identity, 97% coverage of query (179 bits)
3uspA Crystal structure of leut in heptyl-beta-d-selenoglucoside
31% identity, 97% coverage of query (179 bits)
TC 2.A.22.4.2 / O67854 The amino acid (leucine):2 Na+ symporter, LeuTAa (Yamashita et al., 2005). LeuT possesses two ion binding sites, NA1 and NA2, both highly specific for Na+ but with differing mechanisms of binding (Noskov and Roux, 2008). X-ray structures have been determined for LeuT in substrate-free outward-open and apo inward-open states from Aquifex aeolicus (see paper)
30% identity, 98% coverage of query (178 bits)
3mpnA F177r1 mutant of leut
31% identity, 97% coverage of query (176 bits)
4mm9A Crystal structure of leubat (delta13 mutant) in complex with fluvoxamine
31% identity, 97% coverage of query (175 bits)
4mm4A Crystal structure of leubat (delta13 mutant) in complex with paroxetine
31% identity, 97% coverage of query (175 bits)
4mm7A Crystal structure of leubat (delta13 mutant) in complex with desvenlafaxine
31% identity, 97% coverage of query (174 bits)
4mm4B Crystal structure of leubat (delta13 mutant) in complex with paroxetine
31% identity, 97% coverage of query (174 bits)
4mm6A Crystal structure of leubat (delta13 mutant) in complex with (s)- duloxetine
31% identity, 97% coverage of query (174 bits)
4mmeA Crystal structure of leubat (delta6 mutant) in complex with mazindol
31% identity, 97% coverage of query (171 bits)
6xwmA Mechanism of substrate release in neurotransmitter:sodium symporters: the structure of leut in an inward-facing occluded conformation
31% identity, 95% coverage of query (170 bits)
8de4A Native serotonin transporter in complex with 15b8 fab in the presence of methamphetamine
30% identity, 80% coverage of query (147 bits)
8de3A Native serotonin transporter in complex with 15b8 fab antibody in the presence of cocaine
30% identity, 80% coverage of query (147 bits)
7txtS Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and nacl
28% identity, 80% coverage of query (145 bits)
7lwdA Cryo-em structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15b8 fab
28% identity, 80% coverage of query (145 bits)
6vrlA Cryo-em structure of the wild-type human serotonin transporter complexed with i-paroxetine and 8b6 fab
28% identity, 80% coverage of query (145 bits)
6vrkA Cryo-em structure of the wild-type human serotonin transporter complexed with br-paroxetine and 8b6 fab
28% identity, 80% coverage of query (145 bits)
6awnA / P31645 X-ray structure of the s439t human serotonin transporter complexed with paroxetine at the central site (see paper)
29% identity, 80% coverage of query (144 bits)
SC6A4_HUMAN / P31645 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Homo sapiens (Human) (see 20 papers)
TC 2.A.22.1.1 / P31645 Serotonin (5-hydroxytryptamine; 5 HT):Na+:Cl- symporter, SERT-A from Homo sapiens (Human) (see 16 papers)
SLC6A4 / GB|AAW80933.1 sodium-dependent serotonin transporter from Homo sapiens
29% identity, 80% coverage of query (144 bits)
6dzvA Wild type human serotonin transporter in complex with 15b8 fab bound to ibogaine in occluded conformation
29% identity, 80% coverage of query (144 bits)
7li9A 5-ht bound serotonin transporter reconstituted in lipid nanodisc in kcl
29% identity, 80% coverage of query (144 bits)
SC6A4_RAT / P31652 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Rattus norvegicus (Rat) (see 13 papers)
30% identity, 73% coverage of query (143 bits)
5i74A X-ray structure of the ts3 human serotonin transporter complexed with br-citalopram at the central site
28% identity, 80% coverage of query (143 bits)
5i71A X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site
28% identity, 80% coverage of query (143 bits)
6awpA X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site
28% identity, 80% coverage of query (142 bits)
6awoA X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site
28% identity, 80% coverage of query (142 bits)
5i6xA X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site
28% identity, 80% coverage of query (142 bits)
SC6A4_CAVPO / O35899 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Cavia porcellus (Guinea pig) (see paper)
29% identity, 73% coverage of query (141 bits)
SC6A4_BOVIN / Q9XT49 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Bos taurus (Bovine) (see paper)
29% identity, 80% coverage of query (141 bits)
SC6A4_MOUSE / Q60857 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Mus musculus (Mouse) (see 10 papers)
30% identity, 73% coverage of query (140 bits)
SC6A4_MACMU / Q9MYX0 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Macaca mulatta (Rhesus macaque) (see paper)
29% identity, 73% coverage of query (140 bits)
4xp9C / Q7K4Y6 X-ray structure of drosophila dopamine transporter bound to psychostimulant d-amphetamine (see paper)
27% identity, 99% coverage of query (139 bits)
4xpaA X-ray structure of drosophila dopamine transporter bound to 3, 4dichlorophenethylamine
27% identity, 99% coverage of query (139 bits)
4xp6A X-ray structure of drosophila dopamine transporter bound to psychostimulant methamphetamine
27% identity, 99% coverage of query (139 bits)
4xp5A X-ray structure of drosophila dopamine transporter bound to cocaine analogue-rti55
27% identity, 99% coverage of query (139 bits)
4xp4A X-ray structure of drosophila dopamine transporter in complex with cocaine
27% identity, 99% coverage of query (139 bits)
4xp1A X-ray structure of drosophila dopamine transporter bound to neurotransmitter dopamine
27% identity, 99% coverage of query (139 bits)
4xnxA X-ray structure of drosophila dopamine transporter in complex with reboxetine
27% identity, 99% coverage of query (139 bits)
7wlwA X-ray structure of thermostabilized drosophila dopamine transporter with gaba transporter1-like substitutions in the binding site, in complex with skf89976a
28% identity, 82% coverage of query (138 bits)
7wgtA X-ray structure of thermostabilized drosophila dopamine transporter with gaba transporter1-like substitutions in the binding site, in complex with no711.
28% identity, 82% coverage of query (138 bits)
6m38A X-ray structure of a drosophila dopamine transporter with subsiteb mutations (d121g/s426m) in s-duloxetine bound form
27% identity, 99% coverage of query (138 bits)
4xpfA X-ray structure of drosophila dopamine transporter with subsiteb mutations (d121g/s426m) bound to rti-55
28% identity, 99% coverage of query (138 bits)
6m47A X-ray structure of a drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in tramadol bound form
28% identity, 77% coverage of query (137 bits)
6m3zA X-ray structure of a drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in milnacipran bound form
28% identity, 77% coverage of query (137 bits)
6m0zA X-ray structure of drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in l-norepinephrine bound form
28% identity, 77% coverage of query (137 bits)
SC6A1_HUMAN / P30531 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Homo sapiens (Human) (see 2 papers)
TC 2.A.22.3.2 / P30531 γ-aminobutyric acid (GABA):Na+:Cl- symporter, GAT-1 (Stoichiometry, GABA:Na+ = 1:2 where both Na+ binding sites, Na1 and Na2, have been identified. Na2 but not Na1 can accommodate Li+ (Zhou et al., 2006)). Cai et al. 2005 have reported that N-glycosylation increases the stability, trafficking and GABA-uptake of GABA transporter 1. Glutamine 291 is essential for Cl- binding (Ben-Yona et al., 2011). Four human isoforms have been identified, GAT-1, GAT-2, GAT-3, and GAT-4, all about 70% identical to each other (Borden et al., 1992). GAT-2 transports γ-aminobutyric acid and β-alanine (Christiansen et al, 2007) It also concentratively takes up β-alanine and α-fluoro-β-alanine (Liu et al., 1999). GAT1 is capable of intracellular Na+-, Cl-- and GABA-induced outward currents (reverse GABA transport; GABA efflux) from Homo sapiens (Human) (see 3 papers)
27% identity, 85% coverage of query (136 bits)
4xnuA X-ray structure of drosophila dopamine transporter in complex with nisoxetine
29% identity, 82% coverage of query (136 bits)
4m48A X-ray structure of dopamine transporter elucidates antidepressant mechanism
29% identity, 82% coverage of query (136 bits)
S6A13_HUMAN / Q9NSD5 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13 from Homo sapiens (Human) (see 3 papers)
TC 2.A.22.3.10 / Q9NSD5 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) from Homo sapiens (see 5 papers)
27% identity, 86% coverage of query (135 bits)
SC6A1_RAT / P23978 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Rattus norvegicus (Rat) (see 4 papers)
SC6A1_MOUSE / P31648 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Mus musculus (Mouse) (see 4 papers)
27% identity, 85% coverage of query (135 bits)
S6A13_MOUSE / P31649 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 13 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.22.3.8 / P31649 Mouse GABA, β-alanine, fluoro-β-alanine and taurine transporter-3 (GAT3) (Liu et al. 1999). Orthologous to rat and human GAT2; 72% identical to GAT4 (2.A.22.3.7) (takes up GABA with high affinity into presynaptic terminals). Also takes up the carnitine precursor, gamma-butyrobetaine from Mus musculus (see 3 papers)
27% identity, 86% coverage of query (135 bits)
4xpgA X-ray structure of drosophila dopamine transporter with subsiteb mutations (d121g/s426m) bound to beta-cft or win35428
29% identity, 82% coverage of query (135 bits)
S6A13_RAT / P31646 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13 from Rattus norvegicus (Rat) (see 2 papers)
27% identity, 86% coverage of query (134 bits)
INE_DROME / Q9VR07 Sodium- and chloride-dependent GABA transporter ine; Protein inebriated; Protein receptor oscillation A from Drosophila melanogaster (Fruit fly) (see 6 papers)
TC 2.A.22.3.12 / Q9VR07 Sodium- and chloride-dependent GABA transporter, Ine (Protein inebriated) (Protein receptor oscillation A) from Drosophila melanogaster (see 10 papers)
26% identity, 89% coverage of query (133 bits)
7sk2A / P30531 Human wildtype gaba reuptake transporter 1 in complex with tiagabine, inward-open conformation (see paper)
27% identity, 84% coverage of query (132 bits)
SC6A1_MUSCO / P48057 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Mus cookii (Cook's mouse) (see paper)
27% identity, 85% coverage of query (132 bits)
8gnkA Cryoem structure of cytosol-facing, substrate-bound ratgat1
27% identity, 84% coverage of query (132 bits)
7y7wA Cryo-em structure of human gaba transporter gat1 bound with gaba in nacl solution in an inward-occluded state at 2.4 angstrom
27% identity, 84% coverage of query (132 bits)
7y7yA Cryo-em structure of human gaba transporter gat1 bound with nipecotic acid in nacl solution in an inward-occluded state at 2.4 angstrom
27% identity, 83% coverage of query (132 bits)
S6A12_MOUSE / P31651 Sodium- and chloride-dependent betaine transporter; BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 12 from Mus musculus (Mouse) (see paper)
28% identity, 88% coverage of query (130 bits)
TC 2.A.22.2.9 / B2ZXL8 The densovirus type-2 (BmDNV-2) receptor; putative amino acid transporter, the densonucleosis refractoriness, Nsd-2 protein, of 625 aas and 11-12 TMSs (Abe et al. 2000). Deletion of the nsd2 gene, encoding this transporter in the midgut membrane, causes resistance to this parvo-like virus as well as bidensovirus from Bombyx mori (see paper)
29% identity, 74% coverage of query (127 bits)
S6A12_HUMAN / P48065 Sodium- and chloride-dependent betaine transporter; BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12 from Homo sapiens (Human) (see paper)
TC 2.A.22.3.1 / P48065 Betaine/GABA:Na+ symporter, BGT1. (Substrates include: betaine, GABA, diaminobutyrate, β-alanine, proline, quinidine, dimethylglycine, glycine, and sarcosine with decreasing affinity in that order) from Homo sapiens (Human) (see 5 papers)
26% identity, 85% coverage of query (127 bits)
NTDO_CAEEL / Q03614 Sodium-dependent dopamine transporter; DA transporter; DAT from Caenorhabditis elegans (see 3 papers)
TC 2.A.22.1.4 / Q03614 Antidepressant- and cocaine-sensitive dopamine transporter, T23G5.5 (Km for dopamine, 1.2 µM; dependent on extracellular Na+ and Cl-; blocked by cocaine and D-amphetamine) (Jayanthi et al. 1998) from Caenorhabditis elegans (see 3 papers)
28% identity, 77% coverage of query (127 bits)
SC6A4_DROME / P51905 Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; Cocaine-sensitive serotonin transporter; dSERT1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
TC 2.A.22.1.9 / P51905 The sodium-dependent serotonin transporter of 622 aas and 12 TMSs, SERT or SerT from Drosophila melanogaster
27% identity, 77% coverage of query (126 bits)
SC6A5_MOUSE / Q761V0 Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5 from Mus musculus (Mouse) (see paper)
TC 2.A.22.2.6 / Q761V0 Glycine:Na+ transporter, GlyT2b (glycine/3Na+/1Cl- symporter, SLC6A5) (see paper)
27% identity, 77% coverage of query (124 bits)
SC6A7_RAT / P28573 Sodium-dependent proline transporter; Solute carrier family 6 member 7 from Rattus norvegicus (Rat) (see paper)
TC 2.A.22.2.1 / P28573 Proline:Na+ symporter from Rattus norvegicus (Rat) (see paper)
Slc6a7 / RF|NP_446448.2 sodium-dependent proline transporter from Rattus norvegicus
29% identity, 79% coverage of query (123 bits)
TC 2.A.22.2.8 / Q6VS78 Cation-dependent nutrient amino acid transporter, AAT1 (L-phe > cys > his > ala > ser > met > ile > tyr > D-phe > thr > gly) from Aedes aegypti (Yellowfever mosquito)
26% identity, 73% coverage of query (122 bits)
SC6A2_HUMAN / P23975 Sodium-dependent noradrenaline transporter; Norepinephrine transporter; NET; Solute carrier family 6 member 2 from Homo sapiens (Human) (see 5 papers)
TC 2.A.22.1.2 / P23975 Noradrenaline (norepinephrine):Na+ symporter (NET1, NAT1, SLC6?A2) (also transports 1-methyl-4-tetrahydropyridinium and amphetamines; it is a target of cocaine and amphetamines as well as of therapetics for depression, obsessive-compulsive disorders, and post-traumatic stress disorder. This homooligomeric transporter binds one substrate molecule per transporter subunit (Schwartz et al., 2005; Schlessinger et al., 2011; Andersen et al., 2011). Extracellular loop 3 contributes to substrate and inhibitor selectivity (Lynagh et al. 2013). The highly conserved MELAL and GQXXRXG motifs, located in the second transmembrane domain and the first intracellular loop of hNET, respectively, are determinants of NET cell surface expression, and substrate and inhibitor binding (Sucic and Bryan-Lluka 2007). Based on modeling, the high affinity substrate binding site (S1) of the human norepinephrine transporter has been predicted and then verified by mutational studies from Homo sapiens (Human) (see 5 papers)
SLC6A2 / RF|NP_001034.1 sodium-dependent noradrenaline transporter from Homo sapiens
26% identity, 88% coverage of query (120 bits)
SC6A6_MOUSE / O35316 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Mus musculus (Mouse) (see 4 papers)
26% identity, 84% coverage of query (119 bits)
SC6A7_HUMAN / Q99884 Sodium-dependent proline transporter; Solute carrier family 6 member 7 from Homo sapiens (Human) (see paper)
TC 2.A.22.2.11 / Q99884 Sodium-dependent proline transporter (Solute carrier family 6 member 7) from Homo sapiens (see 3 papers)
28% identity, 79% coverage of query (119 bits)
SC6A3_HUMAN / Q01959 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Homo sapiens (Human) (see 10 papers)
TC 2.A.22.1.3 / Q01959 Dopamine:Na+ symporter, DAT (also takes up amphetamines in symport with Na+ which promotes intracellular Na+-dependent dopamine efflux (Khoshbouei et al., 2003)). It is inhibited by cocaine, amphetamines, neurotoxins, antidepressants and ethanol (Chen et al., 2004)]. Zn2+ potentiates uncoupled Cl- conductance from Homo sapiens (Human) (see 16 papers)
SLC6A3 / GB|ABO77644.1 sodium-dependent dopamine transporter from Homo sapiens (see paper)
26% identity, 88% coverage of query (118 bits)
S6A11_HUMAN / P48066 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11 from Homo sapiens (Human) (see paper)
TC 2.A.22.3.9 / P48066 Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11). Expression of GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, and a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people as well. Thus, impaired GABA clearance within the amygdala contributes to alcohol addiction from Homo sapiens (see 2 papers)
28% identity, 86% coverage of query (118 bits)
S6A11_MOUSE / P31650 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Sodium- and chloride-dependent GABA transporter 4; GAT-4; Solute carrier family 6 member 11 from Mus musculus (Mouse) (see 2 papers)
TC 2.A.22.3.7 / Q8BWA7 The GABA transporter, GAT4 (single mutations render this transporter C1- independent) from Mus musculus (see 2 papers)
29% identity, 86% coverage of query (117 bits)
SC6A6_HUMAN / P31641 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Homo sapiens (Human) (see 5 papers)
TC 2.A.22.3.3 / P31641 The taurine:Na+ symporter, TauT or SLC6A6 (also transports β-alanine and γ-aminobutyric acid (GABA); Tomi et al., 2008; Anderson et al., 2009). Biallelic mutation of TauT is linked to early retinal degeneration (Preising et al. 2019). Oral taurine administration of retinal degeneration and cardiomyopathy reverses the phenotype from Homo sapiens (Human) (see 4 papers)
26% identity, 84% coverage of query (117 bits)
SC6A6_CANLF / Q00589 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Canis lupus familiaris (Dog) (Canis familiaris) (see 2 papers)
26% identity, 84% coverage of query (117 bits)
Or start over
Lawrence Berkeley National Laboratory