Sites on a Tree

 

Searching for up to 100 curated homologs for 353229 FitnessBrowser__Btheta:353229 (738 a.a.)

Found high-coverage hits (≥70%) to 13 curated proteins.

Removed hits that are identical to the query, leaving 11

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2zq0A Crystal structure of susb complexed with acarbose
    98% identity, 97% coverage of query (1468 bits)

3wfaA Catalytic role of the calcium ion in gh97 inverting glycoside hydrolase
    98% identity, 97% coverage of query (1462 bits)

2jkpA Structure of a family 97 alpha-glucosidase from bacteroides thetaiotaomicron in complex with castanospermine
    97% identity, 96% coverage of query (1435 bits)

2jkeA Structure of a family 97 alpha-glucosidase from bacteroides thetaiotaomicron in complex with deoxynojirimycin
    97% identity, 96% coverage of query (1435 bits)

AEW20125.1 α-glucosidase (SusB;Aglu;BFO_2272) (EC 3.2.1.20) (see protein)
    71% identity, 98% coverage of query (1107 bits)

5hq4A / A0A0Y0DFX2 A glycoside hydrolase family 97 enzyme from pseudoalteromonas sp. Strain k8 (see paper)
    40% identity, 95% coverage of query (505 bits)

5hqaA A glycoside hydrolase family 97 enzyme in complex with acarbose from pseudoalteromonas sp. Strain k8
    40% identity, 95% coverage of query (505 bits)

Build an alignment

Build an alignment for 353229 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

AGAL_BACTN / Q8A6L0 Retaining alpha-galactosidase; BtGH97b; Melibiase; EC 3.2.1.22 from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) (see 2 papers)
AAO76978.1 α-galactosidase (BtGH97b;BT1871;BT_1871) (EC 3.2.1.22) (see protein)
    27% identity, 98% coverage of query (221 bits)

5e1qB / Q8A6L0 Mutant (d415g) gh97 alpha-galactosidase in complex with gal-lac (see paper)
    27% identity, 95% coverage of query (212 bits)

AAO77727.1 α-mannan α-galactosidase (BT2620) (EC 3.2.1.22) (see protein)
    24% identity, 98% coverage of query (169 bits)

5xfmA / Q8A1K0 Crystal structure of beta-arabinopyranosidase (see paper)
    23% identity, 94% coverage of query (131 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory