Searching for up to 100 curated homologs for 353437 FitnessBrowser__Btheta:353437 (313 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
MDH_FLAFR / Q25QU7 Malate dehydrogenase; EC 1.1.1.37 from Flavobacterium frigidimaris (see 2 papers)
72% identity, 98% coverage of query (462 bits)
MDH_THET7 / A0A0S3QTC6 Malate dehydrogenase; MDH; EC 1.1.1.37 from Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6) (see paper)
49% identity, 99% coverage of query (305 bits)
MDH_CHLTE / P80039 Malate dehydrogenase; EC 1.1.1.37 from Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum) (see paper)
49% identity, 95% coverage of query (293 bits)
1guzA / P0C890,P80039 Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases (see paper)
48% identity, 95% coverage of query (292 bits)
7f8dA / A0A143T1U9 Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) g218y mutant (see paper)
47% identity, 96% coverage of query (290 bits)
4pltB / A0A075B5H0 Crystal structure of ancestral apicomplexan malate dehydrogenase with oxamate. (see paper)
47% identity, 96% coverage of query (290 bits)
7byaA Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and adenosine 5'- diphosphoribose (apr)
47% identity, 96% coverage of query (290 bits)
7by9A Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and nicotinamide adenine dinucleotide (NAD)
47% identity, 96% coverage of query (290 bits)
4plyA Crystal structure of ancestral apicomplexan malate dehydrogenase with malate.
47% identity, 96% coverage of query (290 bits)
MDH_PROVB / P0C890 Malate dehydrogenase; EC 1.1.1.37 from Prosthecochloris vibrioformis (Chlorobium vibrioforme) (see paper)
47% identity, 95% coverage of query (289 bits)
1uxgA / P80040 Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface. (see paper)
49% identity, 98% coverage of query (287 bits)
MDH_CHLAA / P80040 Malate dehydrogenase; EC 1.1.1.37 from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see 3 papers)
49% identity, 98% coverage of query (286 bits)
1gv0A / P80039 Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases (see paper)
48% identity, 95% coverage of query (279 bits)
P49814 Malate dehydrogenase; Vegetative protein 69; VEG69; EC 1.1.1.37 from Bacillus subtilis (strain 168)
45% identity, 96% coverage of query (278 bits)
mdh / Q84FY8 malate dehydrogenase subunit (EC 1.1.1.37) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see paper)
Q84FY8 malate dehydrogenase (EC 1.1.1.37) from Methylorubrum extorquens (see paper)
42% identity, 99% coverage of query (271 bits)
4rosA / A9W386 Crystal structure of methylobacterium extorquens malate dehydrogenase complexed with oxaloacetate and adenosine-5-diphosphoribose
42% identity, 99% coverage of query (271 bits)
5ujkA Malate dehydrogenase from methylobacterium extorquens, complexed with NAD
42% identity, 99% coverage of query (271 bits)
3gvhA / Q2YLR9 Crystal structure of lactate/malate dehydrogenase from brucella melitensis
41% identity, 96% coverage of query (269 bits)
4plfB / A0A075B5G8 Crystal structure of ancestral apicomplexan lactate dehydrogenase with lactate. (see paper)
40% identity, 99% coverage of query (257 bits)
U80676 / P93052 acyl-CoA reductase (NADH) from Botryococcus braunii (see 2 papers)
41% identity, 95% coverage of query (257 bits)
4plcA Crystal structure of ancestral apicomplexan lactate dehydrogenase with malate.
40% identity, 99% coverage of query (257 bits)
3gviA Crystal structure of lactate/malate dehydrogenase from brucella melitensis in complex with adp
40% identity, 96% coverage of query (252 bits)
2hjrB / Q5CYZ3 Crystal structure of cryptosporidium parvum malate dehydrogenase (see paper)
43% identity, 98% coverage of query (251 bits)
MDH_PYRIL / A1RS58 Malate dehydrogenase; EC 1.1.1.37 from Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) (see paper)
37% identity, 97% coverage of query (249 bits)
A3MWU9 malate dehydrogenase (EC 1.1.1.37) from Pyrobaculum calidifontis (see paper)
37% identity, 95% coverage of query (246 bits)
MDH_AERPE / Q9YEA1 Malate dehydrogenase; EC 1.1.1.299 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
41% identity, 95% coverage of query (245 bits)
6vdjA Crystal structure of ancestral apicomplexan lactate dehydrogenase with sulfate and nadh4.
41% identity, 98% coverage of query (241 bits)
Q7Z0X7 L-lactate dehydrogenase (EC 1.1.1.27) from Babesia bovis (see paper)
CH_024078 L-lactate dehydrogenase; EC 1.1.1.27 from Babesia bovis T2Bo (see paper)
39% identity, 97% coverage of query (238 bits)
Q27797 L-lactate dehydrogenase (EC 1.1.1.27) from Toxoplasma gondii (see paper)
39% identity, 99% coverage of query (231 bits)
1sowA T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxalate
39% identity, 97% coverage of query (230 bits)
3czmB / Q27797 T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxq
39% identity, 97% coverage of query (229 bits)
Q8I8U5 L-lactate dehydrogenase (EC 1.1.1.27) from Eimeria acervulina (see paper)
39% identity, 99% coverage of query (227 bits)
2fn7A / Q5CYZ2 Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (lactic acid) and cofactor (b- nicotinamide adenine dinucleotide)
41% identity, 97% coverage of query (221 bits)
4nd2A Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor analog (3-acetylpyridine adenine dinucleotide)
41% identity, 97% coverage of query (221 bits)
Q9GT92 L-lactate dehydrogenase (EC 1.1.1.27) from Cryptosporidium parvum (see 2 papers)
42% identity, 90% coverage of query (220 bits)
6ct6B / U6M598 Crystal structure of lactate dehydrogenase from eimeria maxima with nadh and oxamate
40% identity, 95% coverage of query (218 bits)
Q8I8U3 L-lactate dehydrogenase (EC 1.1.1.27) from Eimeria maxima (see paper)
39% identity, 95% coverage of query (216 bits)
4b7uA Plasmodium falciparum l-lactate dehydrogenase complexed with bicine
37% identity, 93% coverage of query (208 bits)
LDH lactate dehydrogenase; EC 1.1.1.27 from Plasmodium falciparum (see paper)
LDH / GB|ABA46354.1 lactate dehydrogenase; EC 1.1.1.27 from Plasmodium falciparum (see paper)
37% identity, 93% coverage of query (207 bits)
3zh2A Structure of plasmodium falciparum lactate dehydrogenase in complex with a DNA aptamer
37% identity, 93% coverage of query (207 bits)
2a94A Structure of plasmodium falciparum lactate dehydrogenase complexed to apadh.
37% identity, 93% coverage of query (207 bits)
1t2dA Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and oxalate
37% identity, 93% coverage of query (207 bits)
1t26A Plasmodium falciparum lactate dehydrogenase complexed with nadh and 4- hydroxy-1,2,5-thiadiazole-3-carboxylic acid
37% identity, 93% coverage of query (207 bits)
1t25A Plasmodium falciparum lactate dehydrogenase complexed with nadh and 3- hydroxyisoxazole-4-carboxylic acid
37% identity, 93% coverage of query (207 bits)
1t24A Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid
37% identity, 93% coverage of query (207 bits)
Q8I8U4 L-lactate dehydrogenase (EC 1.1.1.27) from Eimeria tenella (see paper)
39% identity, 97% coverage of query (206 bits)
1xivA Plasmodium falciparum lactate dehydrogenase complexed with 2-({4- chloro-[hydroxy(methoxy)methyl]cyclohexyl}amino)ethane-1,1,2-triol
38% identity, 93% coverage of query (205 bits)
LDH_PLABA / Q7SI97 L-lactate dehydrogenase; EC 1.1.1.27 from Plasmodium berghei (strain Anka) (see paper)
36% identity, 93% coverage of query (204 bits)
4b7uB Plasmodium falciparum l-lactate dehydrogenase complexed with bicine
38% identity, 93% coverage of query (204 bits)
1u5cA Plasmodium falciparum lactate dehydrogenase complexed with 3,7- dihydroxynaphthalene-2-carboxylic acid and NAD+
38% identity, 93% coverage of query (204 bits)
1u4oA Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedicarboxylic acid
37% identity, 93% coverage of query (204 bits)
1oc4A Lactate dehydrogenase from plasmodium berghei
36% identity, 93% coverage of query (204 bits)
1u4sA Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedisulphonic acid
37% identity, 93% coverage of query (204 bits)
1u5aA Plasmodium falciparum lactate dehydrogenase complexed with 3,5- dihydroxy-2-naphthoic acid
37% identity, 93% coverage of query (203 bits)
1cetA Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.
38% identity, 93% coverage of query (202 bits)
P90613 L-lactate dehydrogenase (EC 1.1.1.27) from Toxoplasma gondii (see 2 papers)
38% identity, 99% coverage of query (199 bits)
3om9A / P90613 T. Gondii bradyzoite-specific ldh (ldh1) in complex with NAD and oxq
38% identity, 99% coverage of query (199 bits)
2a92C / Q4PRK9 Crystal structure of lactate dehydrogenase from plasmodium vivax: complex with nadh (see paper)
36% identity, 93% coverage of query (199 bits)
LDHA_PIG / P00339 L-lactate dehydrogenase A chain; LDH-A; LDH muscle subunit; LDH-M; EC 1.1.1.27 from Sus scrofa (Pig) (see paper)
P00339 L-lactate dehydrogenase (EC 1.1.1.27) from Sus scrofa (see paper)
37% identity, 98% coverage of query (199 bits)
LDHA_MOUSE / P06151 L-lactate dehydrogenase A chain; LDH-A; LDH muscle subunit; LDH-M; EC 1.1.1.27 from Mus musculus (Mouse) (see paper)
36% identity, 98% coverage of query (199 bits)
LDH6A_HUMAN / Q6ZMR3 L-lactate dehydrogenase A-like 6A; LDHA-like protein 6A; EC 1.1.1.27 from Homo sapiens (Human) (see paper)
34% identity, 98% coverage of query (199 bits)
1pzgA T.Gondii ldh1 complexed with apad and sulfate at 1.6 angstroms
38% identity, 99% coverage of query (199 bits)
1pzfA T.Gondii ldh1 ternary complex with apad+ and oxalate
38% identity, 99% coverage of query (199 bits)
B7XH73 L-lactate dehydrogenase (EC 1.1.1.27) from Equus caballus (see paper)
36% identity, 98% coverage of query (198 bits)
LDHA_RABIT / P13491 L-lactate dehydrogenase A chain; LDH-A; LDH muscle subunit; LDH-M; EC 1.1.1.27 from Oryctolagus cuniculus (Rabbit) (see paper)
P13491 L-lactate dehydrogenase (EC 1.1.1.27) from Oryctolagus cuniculus (see 2 papers)
35% identity, 98% coverage of query (197 bits)
5nqqC Rabbit muscle l-lactate dehydrogenase in complex with nadh and oxaloacetate
35% identity, 98% coverage of query (197 bits)
6p6uC Crystal structure of monoclinic rabbit muscle lactate dehydrogenase with four tetramers as the asymmetric unit
35% identity, 98% coverage of query (197 bits)
6sbvA X-ray structure of human ldh-a with an allosteric inhibitor (compound 7)
35% identity, 98% coverage of query (197 bits)
5w8jA Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 29
35% identity, 98% coverage of query (197 bits)
5w8iA Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 23 and zinc
35% identity, 98% coverage of query (197 bits)
LDHA_HUMAN / P00338 L-lactate dehydrogenase A chain; LDH-A; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59; EC 1.1.1.27 from Homo sapiens (Human) (see 5 papers)
P00338 L-lactate dehydrogenase (EC 1.1.1.27) from Homo sapiens (see 3 papers)
35% identity, 98% coverage of query (196 bits)
4qsmA / P00338 Crystal structure of human muscle l-lactate dehydrogenase in complex with inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3- sulfamoylquinolin-4-yl]amino}benzoic acid (see paper)
35% identity, 98% coverage of query (196 bits)
Ldha / P04642 lactate dehydrogenase subunit (EC 1.1.1.27) from Rattus norvegicus (see 3 papers)
35% identity, 98% coverage of query (196 bits)
5kkcA L-lactate dehydrogenase from rabbit muscle with the inhibitor 6dhnad
35% identity, 98% coverage of query (196 bits)
8fw6A Human lactate dehydrogenase a in complex with inhibitor chk-336
35% identity, 98% coverage of query (196 bits)
6q13A Crystal structure of ldha in complex with compound ncgc00420737-09 at 2.00 a resolution
35% identity, 98% coverage of query (196 bits)
6q0dA Crystal structure of ldha in complex with compound ncgc00384414-01 at 2.05 a resolution
35% identity, 98% coverage of query (196 bits)
6bb3A Lactate dehydrogenase in complex with inhibitor 3-((2-chlorophenyl) thio)-6-(6-((4-fluorophenyl)amino)pyridin-2-yl)-4-hydroxy-6- (thiophen-3-yl)-5,6-dihydro-2h-pyran-2-one
35% identity, 98% coverage of query (196 bits)
6badA Lactate dehydrogenase in complex with inhibitor (r)-3-((2- chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6- (thiophen-3-yl)-5,6-dihydro-2h-pyran-2-one
35% identity, 98% coverage of query (196 bits)
5zjfA Ldha-ma
35% identity, 98% coverage of query (196 bits)
5w8lA Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 59 and nadh
35% identity, 98% coverage of query (196 bits)
5w8hA Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 11
35% identity, 98% coverage of query (196 bits)
5ixyA Lactate dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{s})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4- oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one
35% identity, 98% coverage of query (196 bits)
4zvvA Lactate dehydrogenase a in complex with a trisubstituted piperidine-2, 4-dione inhibitor gne-140
35% identity, 98% coverage of query (196 bits)
4r68A Lactate dehydrogenase in complex with inhibitor compound 31
35% identity, 98% coverage of query (196 bits)
4qo8A Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound 104
35% identity, 98% coverage of query (196 bits)
4qo7A Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound 7
35% identity, 98% coverage of query (196 bits)
4oknB Crystal structure of human muscle l-lactate dehydrogenase, ternary complex with nadh and oxalate
35% identity, 98% coverage of query (196 bits)
4oknA Crystal structure of human muscle l-lactate dehydrogenase, ternary complex with nadh and oxalate
35% identity, 98% coverage of query (196 bits)
4m49A Lactate dehydrogenase a in complex with a substituted pyrazine inhibitor compound 18
35% identity, 98% coverage of query (196 bits)
1i10A Human muscle l-lactate dehydrogenase m chain, ternary complex with nadh and oxamate
35% identity, 98% coverage of query (196 bits)
4qt0A Crystal structure of human muscle l-lactate dehydrogenase in complex with inhibitor 1, 3-{[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl) quinolin-4-yl]amino}benzoic acid
35% identity, 98% coverage of query (196 bits)
4ajnA Rat ldha in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino)ethyl)phenyl)methyl) propanedioic acid
35% identity, 98% coverage of query (196 bits)
7m2nA Crystal structure of human lactate dehydrogenase a with inhibitor compound 15
35% identity, 98% coverage of query (196 bits)
6bb2D Lactate dehydrogenase in complex with inhibitor (s)-5-((2- chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)- 2,3-dihydro-[2,2'-bipyridin]-6(1h)-one
35% identity, 98% coverage of query (196 bits)
6sbuA X-ray structure of human ldha with an allosteric inhibitor (compound 3)
35% identity, 98% coverage of query (196 bits)
4al4A Rat ldha in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)3-oxo-propyl)carbamoylamino)ethoxy) phenyl) methylpropanedioic acid
35% identity, 98% coverage of query (196 bits)
4ajoA Rat ldha in complex with 2-((4-(4-((3-((2-methyl-1,3-benzothiazol-6yl) amino)-3-oxo-propyl)amino)-4-oxo-butyl)phenyl)methyl)propanedioic acid
35% identity, 98% coverage of query (196 bits)
4aj4A Rat ldha in complex with 4-((2-allylsulfanyl-1,3-benzothizol-6-yl) amino)-4-oxo-butanoic acid
35% identity, 98% coverage of query (196 bits)
4ajlA Rat ldha in complex with 3-(ethylcarbamoylamino)-n-(2-methyl-1,3- benzothiazol-6-yl)propanamide
35% identity, 98% coverage of query (196 bits)
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Lawrence Berkeley National Laboratory