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Searching for up to 100 curated homologs for 353501 FitnessBrowser__Btheta:353501 (353 a.a.)

Found high-coverage hits (≥70%) to 35 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q8U0A8 3-dehydroquinate synthase (EC 4.2.3.4) from Pyrococcus furiosus (see paper)
    36% identity, 88% coverage of query (170 bits)

aroB / CAA05722.1 3-dehydroquinate synthetase from Neisseria gonorrhoeae (see paper)
    36% identity, 92% coverage of query (168 bits)

Q9KNV2 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    36% identity, 81% coverage of query (165 bits)

3okfA / Q9KNV2 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase (arob) from vibrio cholerae
    36% identity, 81% coverage of query (162 bits)

Q6GGU4 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Staphylococcus aureus (strain MRSA252)
    34% identity, 89% coverage of query (162 bits)

Q3M4V2 3-dehydroquinate synthase (EC 4.2.3.4) from Trichormus variabilis (see paper)
    33% identity, 93% coverage of query (160 bits)

AROB_HELPY / P56081 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
    35% identity, 93% coverage of query (158 bits)

P9WPX9 3-dehydroquinate synthase (EC 4.2.3.4) from Mycobacterium tuberculosis (see 3 papers)
    37% identity, 77% coverage of query (157 bits)

P9WPX9 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    37% identity, 77% coverage of query (157 bits)

1xagA / Q6GGU4 Crystal structure of staphlyococcus aureus 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD+ and carbaphosphonate (see paper)
    33% identity, 89% coverage of query (156 bits)

DHQS_SOLLC / Q8RU74 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
    36% identity, 81% coverage of query (154 bits)

Q5NFS1 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
    35% identity, 93% coverage of query (153 bits)

3qbeA / P9WPX9 Crystal structure of the 3-dehydroquinate synthase (arob) from mycobacterium tuberculosis
    36% identity, 77% coverage of query (149 bits)

5hvnA / Q5NFS1 3.0 angstrom crystal structure of 3-dehydroquinate synthase (arob) from francisella tularensis in complex with NAD.
    34% identity, 93% coverage of query (144 bits)

DHQS_ACTCC / U3KRF2 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Actinidia chinensis var. chinensis (Chinese soft-hair kiwi) (see paper)
    35% identity, 80% coverage of query (144 bits)

3zokA / U3KRF2 Structure of 3-dehydroquinate synthase from actinidia chinensis in complex with NAD (see paper)
    35% identity, 80% coverage of query (144 bits)

1dqsA Crystal structure of dehydroquinate synthase (dhqs) complexed with carbaphosphonate, NAD+ and zn2+
    33% identity, 87% coverage of query (141 bits)

1nr5A / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD and carbaphosphonate (see paper)
    32% identity, 87% coverage of query (138 bits)

1nr5B / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD and carbaphosphonate (see paper)
    32% identity, 87% coverage of query (138 bits)

1nvbB / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and carbaphosphonate (see paper)
    32% identity, 87% coverage of query (138 bits)

6hqvA / G0S061 Pentafunctional arom complex from chaetomium thermophilum (see paper)
    31% identity, 87% coverage of query (138 bits)

3qbdA 3-dehydroquinate synthase (arob) from mycobacterium tuberculosis in complex with NAD
    35% identity, 77% coverage of query (138 bits)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans (see paper)
aromA pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans (see 4 papers)
    34% identity, 72% coverage of query (137 bits)

5eksA / V5V8R5 Structure of 3-dehydroquinate synthase from acinetobacter baumannii in complex with NAD
    34% identity, 81% coverage of query (133 bits)

6llaB Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+ and NAD (see paper)
    34% identity, 89% coverage of query (133 bits)

1nrxA / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and NAD (see paper)
    34% identity, 72% coverage of query (132 bits)

ARO1 / P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    30% identity, 92% coverage of query (132 bits)

1nrxB / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and NAD (see paper)
    34% identity, 72% coverage of query (132 bits)

6lk2A Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+, NAD and chlorogenic acid
    34% identity, 89% coverage of query (132 bits)

1nvaA Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and adp
    33% identity, 72% coverage of query (129 bits)

Build an alignment

Build an alignment for 353501 and 30 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

4p53A / H2K887 Vala (2-epi-5-epi-valiolone synthase) from streptomyces hygroscopicus subsp. Jinggangensis 5008 with NAD+ and zn2+ bound (see paper)
    28% identity, 80% coverage of query (126 bits)

valA / H2K887 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) (see 3 papers)
VALA_STRHJ / H2K887 2-epi-5-epi-valiolone synthase; EEVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.152 from Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) (see 2 papers)
H2K887 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces hygroscopicus (see paper)
valA / AAW88569.1 ValA from Streptomyces hygroscopicus subsp. jinggangensis (see paper)
valA / ABA41506.1 2-epi-5-epi-valiolone synthase from Streptomyces hygroscopicus subsp. jinggangensis (see paper)
    27% identity, 80% coverage of query (123 bits)

Amir_2000 / C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101) (see paper)
EVS_ACTMD / C6WFL3 2-epi-valiolone synthase; EVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.155 from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101) (see paper)
C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) from Actinosynnema mirum (see paper)
    30% identity, 82% coverage of query (121 bits)

EVS_STIAD / Q08VU0 2-epi-valiolone synthase; EVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.155 from Stigmatella aurantiaca (strain DW4/3-1) (see paper)
Q08VU0 2-epi-valiolone synthase (EC 4.2.3.155) from Stigmatella aurantiaca (see paper)
    31% identity, 75% coverage of query (121 bits)

EEVS_STIAD / E3FKM2 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Stigmatella aurantiaca (strain DW4/3-1) (see paper)
    30% identity, 76% coverage of query (115 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory