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Searching for up to 100 curated homologs for 354080 FitnessBrowser__Btheta:354080 (292 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q57VZ2 uridine phosphorylase (EC 2.4.2.3) from Trypanosoma brucei (see paper)
    30% identity, 90% coverage of query (134 bits)

3bjeA / Q57VZ2 Crystal structure of trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity (see paper)
    30% identity, 89% coverage of query (134 bits)

Build an alignment

Build an alignment for 354080 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

TK1479 / Q5JJC1 uridine phosphorylase (EC 2.4.2.2) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
UDP_THEKO / Q5JJC1 Uridine phosphorylase; UPase; UrdPase; EC 2.4.2.3 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    29% identity, 93% coverage of query (102 bits)

Q9YA34 uridine phosphorylase (EC 2.4.2.3) from Aeropyrum pernix (see 2 papers)
    30% identity, 89% coverage of query (94.7 bits)

Q5XA29 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) from Streptococcus pyogenes (see paper)
    29% identity, 87% coverage of query (90.5 bits)

3qpbC / Q5XA29 Crystal structure of streptococcus pyogenes uridine phosphorylase reveals a subclass of the np-i superfamily (see paper)
    29% identity, 87% coverage of query (90.1 bits)

4daeA / O34925 Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 6-chloroguanosine (see paper)
    27% identity, 92% coverage of query (79.7 bits)

4da0A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 2'-deoxyguanosine
    27% identity, 92% coverage of query (79.7 bits)

4darA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with tubercidin
    27% identity, 92% coverage of query (79.7 bits)

4dabA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with hypoxanthine
    27% identity, 92% coverage of query (79.7 bits)

4da8A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 8-bromoguanosine
    27% identity, 92% coverage of query (79.7 bits)

4da7A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with aciclovir
    27% identity, 92% coverage of query (79.7 bits)

4da6A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with ganciclovir
    27% identity, 92% coverage of query (79.7 bits)

4d9hA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with adenosine
    27% identity, 92% coverage of query (79.7 bits)

4d8vA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis at ph 4.2
    27% identity, 92% coverage of query (79.7 bits)

O34925 purine-nucleoside phosphorylase (EC 2.4.2.1) from Bacillus subtilis (see paper)
    27% identity, 93% coverage of query (79.3 bits)

4danA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 2-fluoroadenosine
    28% identity, 88% coverage of query (79.3 bits)

P77835 purine-nucleoside phosphorylase (EC 2.4.2.1) from Geobacillus stearothermophilus (see paper)
punB / BAA13510.1 purine nucleoside phosphorylase from Geobacillus stearothermophilus (see paper)
    26% identity, 93% coverage of query (78.2 bits)

1jdsA 5'-deoxy-5'-methylthioadenosine phosphorylase complex with phosphate (space group p21)
    24% identity, 91% coverage of query (70.9 bits)

1jdvA Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with adenosine and sulfate ion
    24% identity, 91% coverage of query (70.9 bits)

1jdzA Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase with formycin b and sulfate ion
    24% identity, 91% coverage of query (70.9 bits)

Sama_0412 Uridine phosphorylase (EC 2.4.2.3) from Shewanella amazonensis SB2B
    27% identity, 87% coverage of query (70.5 bits)

4yjkA Crystal structure of c212s mutant of shewanella oneidensis mr-1 uridine phosphorylase
    27% identity, 87% coverage of query (70.5 bits)

6k8pA / A0A410UCT3 Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete phytophthora capsici. (see paper)
    26% identity, 91% coverage of query (70.1 bits)

A0A410UCT3 uridine phosphorylase (EC 2.4.2.3) from Phytophthora capsici (see paper)
    26% identity, 91% coverage of query (70.1 bits)

4r2wD / Q8E9X9 X-ray structure of uridine phosphorylase from shewanella oneidensis mr-1 in complex with uridine at 1.6 a resolution (see paper)
    27% identity, 87% coverage of query (69.7 bits)

6k5kA Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete phytophthora capsici.
    27% identity, 88% coverage of query (69.7 bits)

6k5hA Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete phytophthora capsici.
    27% identity, 88% coverage of query (69.7 bits)

SO4133 Uridine phosphorylase (EC 2.4.2.3) from Shewanella oneidensis MR-1
C7EWM3 uridine phosphorylase (EC 2.4.2.3) from Shewanella oneidensis (see 4 papers)
    27% identity, 87% coverage of query (69.3 bits)

Shewana3_3680 Uridine phosphorylase (EC 2.4.2.3) from Shewanella sp. ANA-3
    27% identity, 87% coverage of query (69.3 bits)

4r2wF X-ray structure of uridine phosphorylase from shewanella oneidensis mr-1 in complex with uridine at 1.6 a resolution
    27% identity, 87% coverage of query (69.3 bits)

Q9K4U1 uridine phosphorylase (EC 2.4.2.3) from Vibrio cholerae (see 2 papers)
5efoB / Q9K4U1 X-ray structure uridine phosphorylase from vibrio cholerae in complex with cytidine and cytosine at 1.63a.
udp / CAB94933.1 uridine phosphorylase from Vibrio cholerae (see paper)
    28% identity, 88% coverage of query (68.9 bits)

udp / CAB94934.1 uridine phosphorylase from Yersinia pseudotuberculosis (see paper)
    27% identity, 87% coverage of query (68.9 bits)

4oglA X-ray structure uridine phosphorylase from vibrio cholerae in complex with thymine at 1.25 a resolution
    28% identity, 88% coverage of query (68.9 bits)

6rcaA X-ray structure uridine phosphorylase from vibrio cholerae in complex with 2.2'-anhydrouridine at 1.34 a
    28% identity, 88% coverage of query (68.9 bits)

5efoE X-ray structure uridine phosphorylase from vibrio cholerae in complex with cytidine and cytosine at 1.63a.
    28% identity, 88% coverage of query (68.9 bits)

5c80A X-ray structure uridine phosphorylase from vibrio cholerae in complex with uridine at 2.24 a resolution
    28% identity, 88% coverage of query (68.9 bits)

4k6oA X-ray structure uridine phosphorylase from vibrio cholerae in complex with 6-methyluracil at 1.17 a resolution
    28% identity, 88% coverage of query (68.9 bits)

4u2kD X-ray structure uridine phosphorylase from vibrio cholerae in complex with anticancer compound at 2.13 a resolution
    28% identity, 88% coverage of query (68.6 bits)

Udp / b3831 uridine phosphorylase (EC 2.4.2.2; EC 2.4.2.3) from Escherichia coli K-12 substr. MG1655 (see 82 papers)
udp / P12758 uridine phosphorylase (EC 2.4.2.2) from Escherichia coli (strain K12) (see 80 papers)
UDP_ECOLI / P12758 Uridine phosphorylase; UPase; UrdPase; EC 2.4.2.3 from Escherichia coli (strain K12) (see 3 papers)
udp uridine phosphorylase; EC 2.4.2.3 from Escherichia coli K12 (see 9 papers)
    28% identity, 87% coverage of query (67.8 bits)

1rxsB E. Coli uridine phosphorylase: 2'-deoxyuridine phosphate complex
    28% identity, 87% coverage of query (67.8 bits)

1u1eA Structure of e. Coli uridine phosphorylase complexed to 5(phenylseleno)acyclouridine (psau)
    28% identity, 87% coverage of query (67.8 bits)

1u1dA Structure of e. Coli uridine phosphorylase complexed to 5- (phenylthio)acyclouridine (ptau)
    28% identity, 87% coverage of query (67.8 bits)

1u1cA Structure of e. Coli uridine phosphorylase complexed to 5- benzylacyclouridine (bau)
    28% identity, 87% coverage of query (67.8 bits)

1jdtA Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with mta and sulfate ion
    24% identity, 91% coverage of query (67.8 bits)

1rxcA E. Coli uridine phosphorylase: 5-fluorouracil ribose-1-phosphate complex
    28% identity, 87% coverage of query (67.8 bits)

1tgyA Structure of e. Coli uridine phosphorylase complexed with uracil and ribose 1-phosphate
    28% identity, 87% coverage of query (67.8 bits)

1rxcJ E. Coli uridine phosphorylase: 5-fluorouracil ribose-1-phosphate complex
    28% identity, 87% coverage of query (67.8 bits)

1rxcB E. Coli uridine phosphorylase: 5-fluorouracil ribose-1-phosphate complex
    28% identity, 87% coverage of query (67.8 bits)

BWI76_RS01295 Uridine phosphorylase (EC 2.4.2.3) from Klebsiella michiganensis M5al
    28% identity, 87% coverage of query (67.4 bits)

3uawA / Q5EEL8 Crystal structure of adenosine phosphorylase from bacillus cereus complexed with adenosine (see paper)
    25% identity, 93% coverage of query (67.4 bits)

P0A1F6 uridine phosphorylase (EC 2.4.2.3) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
2hn9A / P0A1F6 Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with thymine and phosphate ion at 2.12a resolution
    27% identity, 87% coverage of query (67.4 bits)

deoD purine nucleoside phosphorylase; EC 2.4.2.1 from Bacillus anthracis (see paper)
    25% identity, 93% coverage of query (67.4 bits)

1rxsa E. Coli uridine phosphorylase: 2'-deoxyuridine phosphate complex
    28% identity, 87% coverage of query (67.4 bits)

2hwuA Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with uridine and phosphate ion at 2.91a resolution
    27% identity, 87% coverage of query (67.4 bits)

1u1gA Structure of e. Coli uridine phosphorylase complexed to 5-(m- (benzyloxy)benzyl)barbituric acid (bbba)
    27% identity, 93% coverage of query (67.4 bits)

1zl2B Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with 2,2'-anhydrouridine and phosphate ion at 1.85a resolution
    27% identity, 87% coverage of query (67.0 bits)

1y1rB Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with inhibitor and phosphate ion at 2.11a resolution
    27% identity, 87% coverage of query (67.0 bits)

3uaxA Crystal structure of adenosine phosphorylase from bacillus cereus complexed with inosine
    24% identity, 93% coverage of query (67.0 bits)

1je1A 5'-deoxy-5'-methylthioadenosine phosphorylase complex with guanosine and sulfate
    23% identity, 91% coverage of query (67.0 bits)

1jdvC / P50389 Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with adenosine and sulfate ion (see paper)
    24% identity, 93% coverage of query (66.6 bits)

PNPH_SACS2 / P50389 Purine nucleoside phosphorylase; PNP; 5'-methylthioadenosine phosphorylase I; MTA phosphorylase I; MTAPI; EC 2.4.2.1; EC 2.4.2.28 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
P50389 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Saccharolobus solfataricus (see 4 papers)
    24% identity, 93% coverage of query (66.6 bits)

3kvvA Trapping of an oxocarbenium ion intermediate in up crystals
    28% identity, 86% coverage of query (66.6 bits)

1u1fA Structure of e. Coli uridine phosphorylase complexed to 5-(m- (benzyloxy)benzyl)acyclouridine (bbau)
    28% identity, 86% coverage of query (66.6 bits)

4u2kB X-ray structure uridine phosphorylase from vibrio cholerae in complex with anticancer compound at 2.13 a resolution
    27% identity, 86% coverage of query (66.6 bits)

3pnsB Crystal structure of uridine phosphorylase complexed with uracil from vibrio cholerae o1 biovar el tor
    27% identity, 86% coverage of query (66.2 bits)

1vhwA Crystal structure of purine nucleoside phosphorylase with adenosine
    23% identity, 93% coverage of query (66.2 bits)

1y1qC Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with uridine-5p-monophosphate and sulfate ion at 2.35a resolution
    27% identity, 86% coverage of query (65.9 bits)

Q72IR2 purine-nucleoside phosphorylase (EC 2.4.2.1) from Thermus thermophilus (see 2 papers)
    25% identity, 87% coverage of query (65.5 bits)

1odiA / Q5SID9 Purine nucleoside phosphorylase from thermus thermophilus (see paper)
    25% identity, 87% coverage of query (65.5 bits)

1odjA Purine nucleoside phosphorylase from thermus thermophilus
    25% identity, 87% coverage of query (65.5 bits)

3of3A / Q9KPM0 Crystal structure of pnp with an inhibitor dadme_immh from vibrio cholerae
    23% identity, 93% coverage of query (64.7 bits)

6k8pB Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete phytophthora capsici.
    26% identity, 87% coverage of query (64.7 bits)

1pr5A Escherichia coli purine nucleoside phosphorylase complexed with 7- deazaadenosine and phosphate/sulfate
    24% identity, 92% coverage of query (64.7 bits)

1ovgA M64v pnp +mepdr
    24% identity, 93% coverage of query (62.8 bits)

1ov6A M64v pnp + allo
    24% identity, 93% coverage of query (62.8 bits)

1oumA M64v pnp +talo
    24% identity, 93% coverage of query (62.8 bits)

Pup / b4384 purine nucleoside phosphorylase (EC 2.4.2.15; EC 2.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
deoD / P0ABP8 purine nucleoside phosphorylase (EC 2.4.2.15; EC 2.4.2.1) from Escherichia coli (strain K12) (see 30 papers)
DEOD_ECOLI / P0ABP8 Purine nucleoside phosphorylase DeoD-type; PNP; EC 2.4.2.1 from Escherichia coli (strain K12) (see 5 papers)
deoD / RF|NP_418801 purine nucleoside phosphorylase deoD-type; EC 2.4.2.1 from Escherichia coli K12 (see 13 papers)
    24% identity, 93% coverage of query (62.0 bits)

5iu6A Crystal structure of e.Coli purine nucleoside phosphorylase with 7- deazahypoxanthine
    24% identity, 93% coverage of query (62.0 bits)

5i3cA Crystal structure of e.Coli purine nucleoside phosphorylase with acycloguanosine
    24% identity, 93% coverage of query (62.0 bits)

3ut6A Crystal structure of e. Coli pnp complexed with po4 and formycin a
    24% identity, 93% coverage of query (62.0 bits)

1pw7A Crystal structure of e. Coli purine nucleoside phosphorylase complexed with 9-beta-d-arabinofuranosyladenine and sulfate/phosphate
    24% identity, 93% coverage of query (62.0 bits)

1pr0A Escherichia coli purine nucleoside phosphorylase complexed with inosine and phosphate/sulfate
    24% identity, 93% coverage of query (62.0 bits)

1pkeA Crystal structure of e. Coli purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine and sulfate/phosphate
    24% identity, 93% coverage of query (62.0 bits)

1pk9A Crystal structure of e. Coli purine nucleoside phosphorylase complexed with 2-fluoroadenosine and sulfate/phosphate
    24% identity, 93% coverage of query (62.0 bits)

1pk7A Crystal structure of e. Coli purine nucleoside phosphorylase complexed with adenosine and sulfate/phosphate
    24% identity, 93% coverage of query (62.0 bits)

1otyA Native pnp +allo
    24% identity, 93% coverage of query (62.0 bits)

1k9sD Purine nucleoside phosphorylase from e. Coli in complex with formycin a derivative and phosphate
    24% identity, 93% coverage of query (62.0 bits)

1k9sA Purine nucleoside phosphorylase from e. Coli in complex with formycin a derivative and phosphate
    24% identity, 93% coverage of query (62.0 bits)

1a69A Purine nucleoside phosphorylase in complex with formycin b and sulphate (phosphate)
    24% identity, 93% coverage of query (62.0 bits)

1pr6A Escherichia coli purine nucleoside phosphorylase complexed with 9- beta-d-xylofuranosyladenine and phosphate/sulfate
    24% identity, 92% coverage of query (62.0 bits)

P0ABP9 Purine nucleoside phosphorylase DeoD-type; PNP; EC 2.4.2.1 from Escherichia coli O157:H7
    24% identity, 93% coverage of query (62.0 bits)

3occF / B1JL34 Crystal structure of pnp with dadmeimmh from yersinia pseudotuberculosis
    23% identity, 93% coverage of query (60.8 bits)

1pr4A Escherichia coli purine nucleoside phosphorylase complexed with 9- beta-d-ribofuranosyl-6-methylthiopurine and phosphate/sulfate
    24% identity, 93% coverage of query (60.8 bits)

DEOD_SALTY / Q8ZJV7 Purine nucleoside phosphorylase DeoD-type; PNP; EC 2.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    23% identity, 93% coverage of query (57.8 bits)

A0A518Y5Z2 purine-nucleoside phosphorylase (EC 2.4.2.1) from Helicobacter pylori (see paper)
    25% identity, 87% coverage of query (55.8 bits)

2iscD / A2E7Y6 Crystal structure of purine nucleoside phosphorylase from trichomonas vaginalis with dadme-imm-a (see paper)
    26% identity, 90% coverage of query (55.8 bits)

2i4tA Crystal structure of purine nucleoside phosphorylase from trichomonas vaginalis with imm-a
    25% identity, 90% coverage of query (55.5 bits)

5mx4C Crystal structure of h. Pylori purine nucleoside phosphorylase from clinical isolate hppnp-1
    25% identity, 87% coverage of query (55.1 bits)

P56463 purine-nucleoside phosphorylase (EC 2.4.2.1) from Helicobacter pylori (see paper)
6f4wA / P56463 Crystal structure of h. Pylori purine nucleoside phosphorylase in complex with formycin a (see paper)
    24% identity, 87% coverage of query (54.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory