Searching for up to 100 curated homologs for 3606703 FitnessBrowser__Dino:3606703 (97 a.a.)
Found high-coverage hits (≥70%) to 14 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PHS_DROME / O76454 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Drosophila melanogaster (Fruit fly) (see paper)
58% identity, 100% coverage of query (125 bits)
PHS_MOUSE / P61458 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Mus musculus (Mouse) (see paper)
56% identity, 99% coverage of query (109 bits)
1f93A / P61459 Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator dcoh (see paper)
55% identity, 99% coverage of query (108 bits)
PCBD1 / P61457 Pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96) from Homo sapiens (see paper)
PHS_HUMAN / P61457 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Homo sapiens (Human) (see 5 papers)
PHS_RAT / P61459 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Rattus norvegicus (Rat) (see 7 papers)
55% identity, 99% coverage of query (108 bits)
PHS_CHICK / O73930 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; cDcoH; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Gallus gallus (Chicken) (see paper)
55% identity, 99% coverage of query (107 bits)
1dcpA Dcoh, a bifunctional protein-binding transcriptional coactivator, complexed with biopterin
55% identity, 98% coverage of query (107 bits)
PHS2_MOUSE / Q9CZL5 Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor; EC 4.2.1.96 from Mus musculus (Mouse) (see paper)
50% identity, 99% coverage of query (100 bits)
PCBD2 / Q9H0N5 Pterin-4-alpha-carbinolamine dehydratase 2 (EC 4.2.1.96) from Homo sapiens (see 3 papers)
PHS2_HUMAN / Q9H0N5 Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor; EC 4.2.1.96 from Homo sapiens (Human) (see paper)
Q9H0N5 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Homo sapiens (see paper)
47% identity, 97% coverage of query (94.7 bits)
Q2Q449 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Toxoplasma gondii (see paper)
53% identity, 78% coverage of query (88.2 bits)
2v6tB / Q2Q449 Crystal structure of a complex of pterin-4a-carbinolamine dehydratase from toxoplasma gondii with 7,8-dihydrobiopterin (see paper)
53% identity, 78% coverage of query (87.8 bits)
PHS_SCHPO / O42658 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Overlapping meiotic transcript 2; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
omt2 / RF|NP_594610.1 4-alpha-hydroxytetrahydrobiopterin dehydratase (predicted); EC 4.2.1.96 from Schizosaccharomyces pombe (see 2 papers)
44% identity, 96% coverage of query (85.9 bits)
PDL2_ARATH / Q6QJ72 Pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial; 4-alpha-hydroxy-tetrahydropterin dehydratase; PCD/DCoH-like protein 2; EC 4.2.1.96 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
34% identity, 79% coverage of query (45.8 bits)
Build an alignment for 3606703 and 12 homologs with ≥ 30% identity
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PHS_YEAST / P38744 Putative pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 87% coverage of query (45.4 bits)
Q02I31 Putative pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Pseudomonas aeruginosa (strain UCBPP-PA14)
33% identity, 90% coverage of query (42.7 bits)
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Lawrence Berkeley National Laboratory