Searching for up to 100 curated homologs for 3607252 FitnessBrowser__Dino:3607252 (729 a.a.)
Found high-coverage hits (≥70%) to 45 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.3.27.1 / Q9JZI0 Functionally uncharacterized P-type ATPase family 27 (FUPA27) (multiple proteins from α-, β- and γ- proteobacteria; 817-851aas) from Neisseria meningitidis serogroup B (see paper)
36% identity, 95% coverage of query (387 bits)
TC 3.A.3.27.5 / Q9I3G8 Cu+ export ATPase, CopA2; provides copper for cytochrome oxidase assembly from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
37% identity, 98% coverage of query (368 bits)
TC 3.A.3.5.34 / Q9HX93 Cu+ export ATPase, CopA1, required to maintain cytoplasmic copper levels from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
37% identity, 95% coverage of query (362 bits)
TC 3.A.3.27.3 / A6Q500 Functionally uncharacterized from Nitratiruptor sp. (strain SB155-2) (see paper)
31% identity, 96% coverage of query (350 bits)
TC 3.A.3.27.2 / B0STR2 Functionally uncharacterized P-type ATPase family 27 (FUPA27), Lbi2 ( from Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris) (see paper)
30% identity, 97% coverage of query (335 bits)
COPA_ENTHA / P32113 Probable copper-importing P-type ATPase A; EC 7.2.2.8 from Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R) (see 4 papers)
30% identity, 94% coverage of query (331 bits)
COPA_STAA8 / Q2FV64 Copper-exporting P-type ATPase; Copper-exporting P-type ATPase A; Cu(+)-exporting ATPase; Cu(I)-translocating P-type ATPase; EC 7.2.2.8 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
30% identity, 95% coverage of query (329 bits)
TC 3.A.3.5.1 / P32113 Cu2+-ATPase (uptake) from Enterococcus hirae (see 5 papers)
30% identity, 94% coverage of query (328 bits)
TC 3.A.3.5.19 / Q7A3E6 The Cu2+, Fe3+, Pb2+ resistance efflux pump, CopA (induced by copper and to a lesser extent by Fe3+ and Pb2+) from Staphylococcus aureus (strain N315) (see paper)
30% identity, 95% coverage of query (327 bits)
TC 3.A.3.5.31 / B1MHH7 Mycobacterial copper transporter, MctB from Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)
36% identity, 95% coverage of query (315 bits)
CTPA_MYCTU / P9WPU1 Copper-exporting P-type ATPase; Copper-exporting P-type ATPase A; EC 7.2.2.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
35% identity, 95% coverage of query (313 bits)
copA copper-exporting ATPase; EC 3.6.3.n1 from Bacillus subtilis (see 7 papers)
32% identity, 96% coverage of query (312 bits)
COPA_BACSU / O32220 Copper-exporting P-type ATPase; Protein CopA; Copper-exporting P-type ATPase A; Cu(+)-exporting ATPase; EC 7.2.2.8 from Bacillus subtilis (strain 168) (see 3 papers)
O32220 P-type Cu+ transporter (EC 7.2.2.8) from Bacillus subtilis (see 2 papers)
TC 3.A.3.5.18 / O32220 The copper resistance ATPase, CopA (Ettema et al., 2006; from Bacillus subtilis (see 7 papers)
32% identity, 96% coverage of query (312 bits)
Build an alignment for 3607252 and 13 homologs with ≥ 30% identity
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TC 3.A.3.27.6 / Q6MK07 Functionally uncharacterized P-type ATPase family 29 (FUPA29) (1 protein from a δ-proteobacterium, 798 aas) from Bdellovibrio bacteriovorus (see paper)
29% identity, 94% coverage of query (301 bits)
TC 3.A.3.27.4 / Q5GCB0 The Cu2+ - ATPase, CtpA. Required for assembly of periplasmic and membrane embedded copper-dependent oxidases, but not for copper tolerance (Hassani, et al. 2010). Possibly CtpA delivers Cu2+ directly to the enzymes in the membrane rather than catalyzing transmembrane transport: similar to (3.A.3.27.1) from Rhodocyclus gelatinosus (see paper)
35% identity, 95% coverage of query (300 bits)
CTPV_MYCTU / P9WPS3 Probable copper-exporting P-type ATPase V; Cu(+)-exporting ATPase; EC 7.2.2.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
35% identity, 79% coverage of query (299 bits)
Q9WYF3 P-type Cu+ transporter (EC 7.2.2.8) from Thermotoga maritima (see paper)
TC 3.A.3.5.33 / Q9WYF3 Ca2+ from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
29% identity, 95% coverage of query (298 bits)
TC 3.A.3.5.15 / Q3MNJ6 The transferable, plasmid-localized, copper sensitivity (uptake) ATPase, TcrA (811aas) (46% identical to 3.A.3.5.1) (Hasman, 2005) from Enterococcus faecium (Streptococcus faecium) (see 2 papers)
29% identity, 95% coverage of query (292 bits)
4bbjA / Q5ZWR1 Copper-transporting pib-atpase in complex with beryllium fluoride representing the e2p state (see paper)
35% identity, 79% coverage of query (292 bits)
COPA_LEGPH / Q5ZWR1 Copper-exporting P-type ATPase; Copper-exporting P-type ATPase A; Copper-transporting PIB-type ATPase; Cu(+) transport ATPase; Cu(+)-ATPase LpCopA; LpCopA; EC 7.2.2.8 from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) (see 2 papers)
Q5ZWR1 P-type Cu+ transporter (EC 7.2.2.8) from Legionella pneumophila subsp. pneumophila (see 2 papers)
35% identity, 79% coverage of query (291 bits)
4bevA Atpase crystal structure with bound phosphate analogue
35% identity, 79% coverage of query (291 bits)
3rfuA Crystal structure of a copper-transporting pib-type atpase
35% identity, 79% coverage of query (291 bits)
TC 3.A.3.5.30 / Q5X2N1 Copper (Cu+) exporting P-ATPase, CopA (3-D structure known to 3.2 from Legionella pneumophila (strain Paris) (see paper)
35% identity, 79% coverage of query (290 bits)
TC 3.A.3.5.20 / Q8ZRG7 The gold (Au2+) resistance ATPase, GolT (regulated by GolS in response to Au2+; it may function with a cytoplasmic metal binding protein, GolB from Salmonella typhimurium (see paper)
31% identity, 95% coverage of query (281 bits)
PAA1 / Q9SZC9 copper-transporting ATPase (EC 7.2.2.9) from Arabidopsis thaliana (see 3 papers)
HMA6_ARATH / Q9SZC9 Copper-transporting ATPase PAA1, chloroplastic; Protein HEAVY METAL ATPASE 6; Protein glucose insensitive root 1; EC 7.2.2.8 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9SZC9 P-type Cu2+ transporter (EC 7.2.2.9) from Arabidopsis thaliana (see 2 papers)
TC 3.A.3.5.11 / Q9SZC9 Chloroplast envelope Cu+-uptake ATPase, PAA1 or HMA1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
PAA1 / RF|NP_974675.1 putative copper-transporting ATPase PAA1 from Arabidopsis thaliana
30% identity, 95% coverage of query (277 bits)
HMA5_ORYSJ / A3AWA4 Copper-transporting ATPase HMA5; Protein HEAVY METAL ATPASE 5; OsHMA5; EC 7.2.2.8 from Oryza sativa subsp. japonica (Rice) (see paper)
31% identity, 79% coverage of query (276 bits)
SILP_SALTM / Q9ZHC7 Silver exporting P-type ATPase; EC 7.2.2.15 from Salmonella typhimurium (see paper)
TC 3.A.3.5.4 / Q9ZHC7 Ag+-ATPase (efflux) from Salmonella typhimurium (see paper)
32% identity, 79% coverage of query (275 bits)
COPA_ARCFU / O29777 Probable copper-exporting P-type ATPase; Copper-exporting P-type ATPase A; Cu(+)-exporting ATPase; EC 7.2.2.8 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 4 papers)
O29777 P-type Cu+ transporter (EC 7.2.2.8) from Archaeoglobus fulgidus (see 13 papers)
TC 3.A.3.5.7 / O29777 CopA aka PaeS aka AF0473, component of Cu+-Ag+-ATPase (efflux), CopA of 804 aas. Exhibits maximal activity at 75˚C (Cattoni et al., 2007). The 3-D structure of the ATP-binding domain has been solved (2HC8_A) (functions with the Cu+ chaperone, CopZ; 130aas) (González-Guerrero and Argüello, 2008). This protein has both N- and C- terminal metal binding domains (MBDs). The N-MBD exhibits a conserved ferredoxin-like fold, binds metals to CXXC, and regulates turnover. The C-MBD interacts with the ATP-binding (ATPB) domain and the actuator (A) domain (Agarwal et al., 2010). Cysteine is a non-essential activator of CopA, interacting with the cytoplasmic side of the enzyme in the E1 form from Archaeoglobus fulgidus (see 7 papers)
31% identity, 94% coverage of query (273 bits)
7si6A / A0A6I8R0A5 Structure of atp7b in state 1 (see paper)
28% identity, 92% coverage of query (271 bits)
COPB_ARCFU / O30085 Copper-exporting P-type ATPase B; EC 7.2.2.9 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 3 papers)
O30085 P-type Cu2+ transporter (EC 7.2.2.9) from Archaeoglobus fulgidus (see 2 papers)
TC 3.A.3.5.10 / O30085 Cu+ (Km 0.3 μM), Ag+ transporting ATPase, CopB from Archaeoglobus fulgidus (see 3 papers)
32% identity, 84% coverage of query (270 bits)
YbaR / b0484 Cu+ exporting P-type ATPase (EC 7.2.2.8) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
copA / Q59385 Cu+ exporting P-type ATPase (EC 7.2.2.8) from Escherichia coli (strain K12) (see 16 papers)
COPA_ECOLI / Q59385 Copper-exporting P-type ATPase; Copper-exporting P-type ATPase A; Cu(+)-exporting ATPase; Soluble copper chaperone CopA(Z); EC 7.2.2.8 from Escherichia coli (strain K12) (see 9 papers)
Q59385 P-type Cu+ transporter (EC 7.2.2.8) from Escherichia coli (see paper)
TC 3.A.3.5.5 / Q59385 Cu+, Ag+-ATPase (efflux) from Escherichia coli (see 8 papers)
30% identity, 95% coverage of query (266 bits)
ATP7A_HUMAN / Q04656 Copper-transporting ATPase 1; Copper pump 1; Menkes disease-associated protein; EC 7.2.2.8 from Homo sapiens (Human) (see 28 papers)
Q04656 P-type Cu+ transporter (EC 7.2.2.8); P-type Cu2+ transporter (EC 7.2.2.9) from Homo sapiens (see 23 papers)
27% identity, 92% coverage of query (266 bits)
Q9S7J8 Copper-transporting ATPase RAN1; Protein HEAVY METAL ATPASE 7; Protein RESPONSIVE TO ANTAGONIST 1; EC 7.2.2.8 from Arabidopsis thaliana (Mouse-ear cress)
31% identity, 78% coverage of query (262 bits)
8ioyA / P35670 Structure of atp7b c983s/c985s/d1027a mutant with amp-pnp (see paper)
28% identity, 92% coverage of query (257 bits)
ATP7B_HUMAN / P35670 Copper-transporting ATPase 2; Copper pump 2; Wilson disease-associated protein; EC 7.2.2.8 from Homo sapiens (Human) (see 90 papers)
P35670 P-type Cu+ transporter (EC 7.2.2.8); P-type Cu2+ transporter (EC 7.2.2.9) from Homo sapiens (see 34 papers)
TC 3.A.3.5.3 / P35670 Cu+-, Ag+-ATPase (efflux from the cytosol into the secretory pathway) (Barnes et al., 2005); ATP7B (Wilson's disease protein, α-chain) (continuously expressed in Purkinje neurons). It delivers Cu+ to the ferroxidase, ceruloplasmin, in liver. May also transport Fe2+ from Homo sapiens (Human) (see 58 papers)
28% identity, 92% coverage of query (256 bits)
7r0hA / O29777 Structural basis of ion uptake in copper-transporting p1b-type atpases (see paper)
32% identity, 79% coverage of query (252 bits)
ATU2_YEAST / P38995 Copper-transporting ATPase; Cu(2+)-ATPase; EC 7.2.2.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 11 papers)
P38995 P-type Cu2+ transporter (EC 7.2.2.9) from Saccharomyces cerevisiae (see paper)
TC 3.A.3.5.17 / P38995 Golgi Cu2+ ATPase, Ccc2, retrieves Cu2+ from the metallochaperone Atx1 and transports it to the lumen of Golgi vesicles from Saccharomyces cerevisiae (Baker's yeast) (see 4 papers)
CCC2 / AAC37425.1 Cu++-transporting P-type ATPase from Saccharomyces cerevisiae (see paper)
28% identity, 78% coverage of query (233 bits)
ATU1_YEAST / P38360 P-type cation-transporting ATPase; Cadmium resistance protein 2; Cadmium-translocating P-type ATPase; Cd(2+)-exporting ATPase; EC 7.2.2.21 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
29% identity, 76% coverage of query (221 bits)
CTPC_MYCTU / P9WPT5 Manganese-exporting P-type ATPase; Cation-transporting P-type ATPase CtpC; Metal-transporting ATPase Mta72; EC 7.2.2.22 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
P9WPT5 P-type Mn2+ transporter (EC 7.2.2.22) from Mycobacterium tuberculosis (see paper)
TC 3.A.3.32.2 / P0A503 Probable heavy metal cation-transporting P-type ATPase, FUPA32.2 (718aas) from Mycobacterium bovis (see paper)
31% identity, 77% coverage of query (219 bits)
ZNTA_SHISS / Q3YW59 Zinc/cadmium/lead-transporting P-type ATPase; Zn(2+)/Cd(2+)/Pb(2+) export ATPase; EC 7.2.2.-; EC 7.2.2.12; EC 7.2.2.21 from Shigella sonnei (strain Ss046) (see paper)
Q3YW59 P-type Zn2+ transporter (EC 7.2.2.12) from Shigella sonnei (see paper)
29% identity, 98% coverage of query (208 bits)
YhhO / b3469 Zn2+/Cd2+/Pb2+ exporting P-type ATPase (EC 7.2.2.12) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
zntA / P37617 Zn2+/Cd2+/Pb2+ exporting P-type ATPase (EC 7.2.2.12; EC 7.2.2.21) from Escherichia coli (strain K12) (see 30 papers)
ZNTA_ECOLI / P37617 Zinc/cadmium/lead-transporting P-type ATPase; Pb(II)/Cd(II)/Zn(II)-translocating ATPase; Zn(2+)/Cd(2+)/Pb(2+) export ATPase; EC 7.2.2.-; EC 7.2.2.12; EC 7.2.2.21 from Escherichia coli (strain K12) (see 8 papers)
TC 3.A.3.6.2 / P37617 Zn2+-, Cd2+-, Co2+-, Hg2+-, Ni2+-, Cu2+, Pb2+-ATPase (efflux) from Escherichia coli (see 8 papers)
29% identity, 98% coverage of query (204 bits)
4umvA / Q3YW59 Crystal structure of a zinc-transporting pib-type atpase in the e2p state (see paper)
32% identity, 70% coverage of query (197 bits)
4umwA Crystal structure of a zinc-transporting pib-type atpase in e2.Pi state
32% identity, 70% coverage of query (193 bits)
HMA3B_ARATH / P0CW78 Cadmium/zinc-transporting ATPase HMA3; Cadmium/zinc-transporting ATPase 4; Protein HEAVY METAL ATPASE 3; EC 7.2.2.12; EC 7.2.2.21 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
P0CW78 Cd2+-exporting ATPase (EC 7.2.2.21) from Arabidopsis thaliana (see paper)
TC 3.A.3.6.20 / P0CW78 Cadmium/zinc-transporting ATPase 4, HMA3 from Arabidopsis thaliana (see 2 papers)
29% identity, 70% coverage of query (191 bits)
HMA3_ORYSJ / Q8H384 Cadmium/zinc-transporting ATPase HMA3; Protein HEAVY METAL ATPASE 3; OsHMA3; EC 7.2.2.12; EC 7.2.2.21 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
Q8H384 ABC-type Cd2+ transporter (EC 7.2.2.2) from Oryza sativa (see paper)
TC 3.A.3.6.17 / Q8H384 Cd2+-selective export ATPase, HMA3 (expressed in root cell tonoplasts wherein Cd2+ is sequestered (Ueno et al., 2010)). HMA3 may play a role in Cd2+ accumulation in rice from Oryza sativa subsp. japonica (see 2 papers)
28% identity, 89% coverage of query (145 bits)
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