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Searching for up to 100 curated homologs for 3607686 Dshi_1095 aldehyde dehydrogenase (RefSeq) (506 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

adh / A1B4L2 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Paracoccus denitrificans (strain Pd 1222) (see paper)
ALDH_PARDP / A1B4L2 Aldehyde dehydrogenase; Acetaldehyde dehydrogenase; EC 1.2.1.3 from Paracoccus denitrificans (strain Pd 1222) (see paper)
    77% identity, 97% coverage of query (813 bits)

aldA / AAC13641.1 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (see paper)
    75% identity, 98% coverage of query (790 bits)

aldB / AAC13644.1 NAD-dependent chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (see paper)
    71% identity, 100% coverage of query (763 bits)

HP15_3144 Aldehyde dehydrogenase (EC 1.2.1.3) from Marinobacter adhaerens HP15
    70% identity, 99% coverage of query (739 bits)

adh3 / Q768S6 NAD+-dependent secondary alcohol dehydrogenase III monomer from Gordonia sp. (strain TY-5) (see paper)
    69% identity, 98% coverage of query (734 bits)

ALD1_ACISP / Q9FDS1 Long-chain-aldehyde dehydrogenase; Aldehyde dehydrogenase 1; EC 1.2.1.48 from Acinetobacter sp. (see paper)
    70% identity, 97% coverage of query (733 bits)

YiaX / b3588 aldehyde dehydrogenase B (EC 1.2.1.4) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
aldB / P37685 aldehyde dehydrogenase B (EC 1.2.1.4) from Escherichia coli (strain K12) (see 7 papers)
ALDB_ECOLI / P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see 2 papers)
aldB / GB|AAC76612.2 aldehyde dehydrogenase B; EC 1.2.1.- from Escherichia coli K12 (see 5 papers)
aldB / AAC36939.1 aldehyde dehydrogenase B from Escherichia coli (see paper)
    68% identity, 97% coverage of query (726 bits)

Q4F895 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Rhodococcus erythropolis (see paper)
    70% identity, 98% coverage of query (719 bits)

thcA / AAC77472.1 ThcA from Rhodococcus erythropolis (see 3 papers)
    69% identity, 98% coverage of query (709 bits)

BWI76_RS21985 acetaldehyde dehydrogenase (EC 1.2.1.3) from Klebsiella michiganensis M5al
    67% identity, 97% coverage of query (704 bits)

ald / Q8NLZ0 acetaldehyde dehydrogenase (EC 1.2.1.3; EC 1.2.1.46) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
    69% identity, 97% coverage of query (704 bits)

Psest_2276 Aldehyde dehydrogenase (EC 1.2.1.3) from Pseudomonas stutzeri RCH2
    68% identity, 98% coverage of query (703 bits)

ACLDH_PSEAI / Q9ZAA1 Acetaldehyde dehydrogenase; EC 1.2.1.- from Pseudomonas aeruginosa (see paper)
    68% identity, 98% coverage of query (702 bits)

pedI / B1N7J6 phenylacetaldehyde dehydrogenase (EC 1.2.1.39) from Pseudomonas putida (see paper)
    67% identity, 98% coverage of query (697 bits)

Q8KZT4 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Cytophaga sp. (see paper)
    65% identity, 99% coverage of query (696 bits)

FLUDE_STREN / F8JX40 Fluoroacetaldehyde dehydrogenase; EC 1.2.1.69 from Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) (Streptomyces cattleya) (see paper)
    67% identity, 98% coverage of query (685 bits)

Q402C7 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Sphingomonas sp. (see paper)
phnN / BAE19973.1 aldehyde dehydrogenase from Sphingomonas sp. 14DN-61 (see paper)
    44% identity, 97% coverage of query (408 bits)

ALDH4_BACSU / O34660 Putative aldehyde dehydrogenase DhaS; EC 1.2.1.3 from Bacillus subtilis (strain 168) (see paper)
    43% identity, 98% coverage of query (395 bits)

pnpD / C6FI42 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Pseudomonas putida (see paper)
    42% identity, 94% coverage of query (380 bits)

Q9FRX7 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Oryza sativa (see paper)
    46% identity, 93% coverage of query (379 bits)

pdcG / D2STN3 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Pseudomonas sp. 1-7 (see paper)
    43% identity, 94% coverage of query (377 bits)

pnpE / C1I208 maleylacetate reductase (EC 1.3.1.32) from Pseudomonas sp. (strain WBC-3) (see paper)
C1I208 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Pseudomonas sp. WBC-3 (see paper)
    42% identity, 96% coverage of query (377 bits)

AL2B4_ARATH / Q9SU63 Aldehyde dehydrogenase family 2 member B4, mitochondrial; ALDH2a; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    43% identity, 94% coverage of query (377 bits)

4go4A / C1I208 Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
    43% identity, 94% coverage of query (377 bits)

4o6rA / B4EJX1 Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
    43% identity, 95% coverage of query (375 bits)

AL2B7_ARATH / Q8S528 Aldehyde dehydrogenase family 2 member B7, mitochondrial; ALDH2b; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    43% identity, 99% coverage of query (374 bits)

F8TW85 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Sphingomonas sp. (see paper)
    42% identity, 96% coverage of query (370 bits)

praB / C4TP02 2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85) from Paenibacillus sp. JJ-1b (see paper)
praB / BAH79100.1 2-hydroxymuconate-6-semialdehyde dehydrogenase from Paenibacillus sp. JJ-1b (see paper)
    41% identity, 94% coverage of query (370 bits)

Q9LRI6 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Oryza sativa (see paper)
    44% identity, 94% coverage of query (368 bits)

ALDH2 / P05091 mitochondrial aldehyde dehydrogenase subunit (EC 1.2.1.3; EC 1.2.1.39) from Homo sapiens (see 14 papers)
ALDH2_HUMAN / P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 2 papers)
P05091 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens (see 13 papers)
    43% identity, 94% coverage of query (366 bits)

BALDH_ANTMA / C7A2A0 Benzaldehyde dehydrogenase, mitochondrial; 2-phenylacetaldehyde dehydrogenase; Acetaldehyde dehydrogenase; EC 1.2.1.28; EC 1.2.1.39; EC 1.2.1.3 from Antirrhinum majus (Garden snapdragon) (see paper)
    42% identity, 98% coverage of query (366 bits)

5l13A Structure of aldh2 in complex with 2p3
    43% identity, 94% coverage of query (366 bits)

4kwgA Crystal structure analysis of aldh2+aldib13
    43% identity, 94% coverage of query (366 bits)

4kwfA Crystal structure analysis of aldh2+aldib33
    43% identity, 94% coverage of query (366 bits)

3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one
    43% identity, 94% coverage of query (366 bits)

3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1
    43% identity, 94% coverage of query (366 bits)

2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase
    43% identity, 94% coverage of query (366 bits)

1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+
    43% identity, 94% coverage of query (366 bits)

1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+
    43% identity, 94% coverage of query (366 bits)

4fr8C / P05091 Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
    43% identity, 94% coverage of query (365 bits)

4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin
    43% identity, 94% coverage of query (365 bits)

P11884 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Rattus norvegicus (see 4 papers)
    42% identity, 94% coverage of query (364 bits)

P47738 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see 4 papers)
    42% identity, 94% coverage of query (363 bits)

2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+
    43% identity, 92% coverage of query (363 bits)

1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+
    43% identity, 94% coverage of query (362 bits)

ALDH_DAVTA / P40108 Aldehyde dehydrogenase; ALDDH; ALDH; Allergen Cla h 3; Allergen Cla h III; Allergen Cla h 10; EC 1.2.1.3 from Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum) (see paper)
    41% identity, 97% coverage of query (360 bits)

P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine)
    42% identity, 94% coverage of query (360 bits)

7mjcA / P30837 Crystal structure analysis of aldh1b1
    42% identity, 94% coverage of query (359 bits)

P30837 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens (see 2 papers)
    42% identity, 94% coverage of query (359 bits)

AL2C4_ARATH / Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    42% identity, 94% coverage of query (359 bits)

7radA Crystal structure analysis of aldh1b1
    42% identity, 94% coverage of query (359 bits)

7mjdA Crystal structure analysis of aldh1b1
    42% identity, 94% coverage of query (359 bits)

O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    43% identity, 93% coverage of query (359 bits)

Q9CZS1 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see 2 papers)
    41% identity, 94% coverage of query (358 bits)

5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
    40% identity, 94% coverage of query (358 bits)

5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
    40% identity, 94% coverage of query (358 bits)

6aljA / O94788 Aldh1a2 liganded with NAD and compound win18,446 (see paper)
    42% identity, 94% coverage of query (357 bits)

ALDH1A2 / O94788 retinal dehydrogenase 2 (EC 1.2.1.36) from Homo sapiens (see 4 papers)
AL1A2_HUMAN / O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 3 papers)
O94788 retinal dehydrogenase (EC 1.2.1.36) from Homo sapiens (see 6 papers)
    42% identity, 94% coverage of query (357 bits)

orf19.6306 trimethylaminobutyraldehyde dehydrogenase from Candida albicans (see paper)
    40% identity, 94% coverage of query (357 bits)

ALDH1_ARTAN / C5I9X1 Aldehyde dehydrogenase 1; Artemisinic aldehyde oxidase; Artemisinate synthase; Dihydroartemisinic aldehyde oxidase; EC 1.2.1.- from Artemisia annua (Sweet wormwood) (see 3 papers)
    43% identity, 93% coverage of query (357 bits)

6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121)
    42% identity, 94% coverage of query (357 bits)

6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118)
    42% identity, 94% coverage of query (357 bits)

ALDH1 / A0A2I7G3B0 trans-chrysanthemal dehydrogenase from Tanacetum cinerariifolium (see paper)
ALDH1_TANCI / A0A2I7G3B0 Aldehyde dehydrogenase 1; TcALDH1; Trans-chrysanthemic acid synthase; EC 1.2.1.5; EC 1.2.1.- from Tanacetum cinerariifolium (Dalmatian daisy) (Chrysanthemum cinerariifolium) (see paper)
    43% identity, 93% coverage of query (355 bits)

AL1A2_RAT / Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
Q63639 retinal dehydrogenase (EC 1.2.1.36) from Rattus norvegicus (see 4 papers)
    41% identity, 94% coverage of query (350 bits)

4pxlA / Q8S532 Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
    42% identity, 94% coverage of query (349 bits)

AL9A1_GADMC / P56533 4-trimethylaminobutyraldehyde dehydrogenase; TMABA-DH; TMABADH; Aldehyde dehydrogenase family 9 member A1; Betaine aldehyde dehydrogenase; BADH; EC 1.2.1.47; EC 1.2.1.3 from Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias) (see paper)
1bpwA / P56533 Betaine aldehyde dehydrogenase from cod liver (see paper)
    40% identity, 94% coverage of query (342 bits)

4pz2B / W8SZG1 Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
    44% identity, 94% coverage of query (342 bits)

4neaA / A0A0H2X0S3 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
    39% identity, 96% coverage of query (339 bits)

BADH1_ORYSJ / O24174 Betaine aldehyde dehydrogenase 1; OsBADH1; EC 1.2.1.8 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
O24174 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Oryza sativa Japonica Group (see paper)
    40% identity, 97% coverage of query (333 bits)

BADH_SPIOL / P17202 Aminoaldehyde dehydrogenase BADH; 4-trimethylammoniobutyraldehyde dehydrogenase BADH; Aminobutyraldehyde dehydrogenase BADH; Betaine aldehyde dehydrogenase; SoBADH; EC 1.2.1.-; EC 1.2.1.47; EC 1.2.1.19; EC 1.2.1.8 from Spinacia oleracea (Spinach) (see 5 papers)
P17202 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Spinacia oleracea (see 3 papers)
    40% identity, 96% coverage of query (332 bits)

2d4eC / Q5SJP9 Crystal structure of the hpcc from thermus thermophilus hb8
    39% identity, 96% coverage of query (330 bits)

4v37A / P17202 Crystal structure of betaine aldehyde dehydrogenase from spinach showing a thiohemiacetal with 3-aminopropionaldehyde
    40% identity, 96% coverage of query (328 bits)

7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound
    38% identity, 94% coverage of query (328 bits)

7a6qA / P47895 Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
    38% identity, 94% coverage of query (328 bits)

5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid
    38% identity, 94% coverage of query (328 bits)

ALDH1A3 / P47895 retinal dehydrogenase 3 (EC 1.2.1.36) from Homo sapiens (see 3 papers)
AL1A3_HUMAN / P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 9 papers)
P47895 retinal dehydrogenase (EC 1.2.1.36); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Homo sapiens (see 6 papers)
    38% identity, 94% coverage of query (328 bits)

7qk9A Crystal structure of the aldh1a3-atp complex
    38% identity, 94% coverage of query (328 bits)

4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens
    36% identity, 94% coverage of query (328 bits)

4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens
    36% identity, 94% coverage of query (328 bits)

4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens
    36% identity, 94% coverage of query (328 bits)

6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor
    38% identity, 94% coverage of query (327 bits)

5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d
    36% identity, 94% coverage of query (326 bits)

5kj5B / Q83V33 Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
    36% identity, 94% coverage of query (326 bits)

BETB_PSEAE / Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
Q9HTJ1 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Pseudomonas aeruginosa (see 5 papers)
    39% identity, 94% coverage of query (325 bits)

4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens
    36% identity, 94% coverage of query (325 bits)

4cazA / Q9HTJ1 Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
    39% identity, 94% coverage of query (325 bits)

2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct.
    39% identity, 94% coverage of query (325 bits)

2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa
    39% identity, 94% coverage of query (325 bits)

5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa
    39% identity, 94% coverage of query (325 bits)

5iuvA / Q88BC5 Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
    39% identity, 94% coverage of query (325 bits)

6tryA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with mf13 inhibitor compound
    38% identity, 94% coverage of query (324 bits)

6te5B Crystal structure of human aldehyde dehydrogenase 1a3 in complex with lq43 inhibitor compound
    38% identity, 94% coverage of query (324 bits)

6wsbA / Q3JLL8 Crystal structure of a betaine aldehyde dehydrogenase from burkholderia pseudomallei bound to cofactor NAD (see paper)
    39% identity, 95% coverage of query (323 bits)

5teiA Structure of human aldh1a1 with inhibitor cm039
    39% identity, 96% coverage of query (323 bits)

4x4lA Structure of human aldh1a1 with inhibitor cm037
    39% identity, 96% coverage of query (323 bits)

7jwwA Crystal structure of human aldh1a1 bound to compound (r)-28
    39% identity, 96% coverage of query (323 bits)

7jwvA Crystal structure of human aldh1a1 bound to compound (r)-28
    39% identity, 96% coverage of query (323 bits)

7jwuA Crystal structure of human aldh1a1 bound to compound (r)-28
    39% identity, 96% coverage of query (323 bits)

7jwtA Crystal structure of human aldh1a1 bound to compound (r)-28
    39% identity, 96% coverage of query (323 bits)

7jwsA Crystal structure of human aldh1a1 bound to compound (r)-28
    39% identity, 96% coverage of query (323 bits)

Build an alignment

Build an alignment for 3607686 and 100 homologs with ≥ 30% identity

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory