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Searching for up to 100 curated homologs for 3607862 FitnessBrowser__Dino:3607862 (372 a.a.)

Found high-coverage hits (≥70%) to 52 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5yaqB Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with scyllo-inosose
    42% identity, 96% coverage of query (258 bits)

5ya8A Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with myo-inositol
    42% identity, 96% coverage of query (258 bits)

K7ZP76 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Paracoccus laeviglucosivorans (see paper)
lgdA / BAM68195.1 scyllo-inositol dehydrogenase with L-glucose dehydrogenase activity from Paracoccus laeviglucosivorans (see 2 papers)
    42% identity, 96% coverage of query (257 bits)

6ktkC / K7ZP76 Crystal structure of scyllo-inositol dehydrogenase r178a mutant, complexed with nadh and l-glucono-1,5-lactone, from paracoccus laeviglucosivorans (see paper)
    42% identity, 96% coverage of query (254 bits)

6a3iA Levoglucosan dehydrogenase, complex with nadh and levoglucosan
    40% identity, 98% coverage of query (244 bits)

6a3jC / F0M433 Levoglucosan dehydrogenase, complex with nadh and l-sorbose (see paper)
    40% identity, 98% coverage of query (241 bits)

Asphe3_10730 / F0M433 levoglucosan dehydrogenase monomer (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (see 2 papers)
LGDH_PSEPM / F0M433 Levoglucosan dehydrogenase; LGDH; 1,6-anhydro-beta-D-glucose dehydrogenase; PpLGDH; EC 1.1.1.425 from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (Arthrobacter phenanthrenivorans) (see paper)
F0M433 levoglucosan dehydrogenase (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (see paper)
    39% identity, 99% coverage of query (240 bits)

Q5KYQ3 inositol 2-dehydrogenase (EC 1.1.1.18) from Geobacillus kaustophilus (see paper)
    32% identity, 98% coverage of query (193 bits)

Build an alignment

Build an alignment for 3607862 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Echvi_3375 predicted 3-ketohexose reductase from Echinicola vietnamensis KMM 6221, DSM 17526
    26% identity, 97% coverage of query (126 bits)

6jw7A / Q6L737 The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin a (see paper)
    28% identity, 99% coverage of query (101 bits)

6jw8A The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin b
    28% identity, 99% coverage of query (101 bits)

6jw6A The crystal structure of kand2 in complex with NAD
    28% identity, 99% coverage of query (101 bits)

CCNA_01702 predicted 3-ketohexose reductase from Caulobacter crescentus NA1000
    28% identity, 87% coverage of query (90.1 bits)

Echvi_1844 predicted 3-ketohexose reductase from Echinicola vietnamensis KMM 6221, DSM 17526
    26% identity, 76% coverage of query (87.4 bits)

iolX / P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (strain 168) (see paper)
IOLX_BACSU / P40332 scyllo-inositol 2-dehydrogenase (NAD(+)); EC 1.1.1.370 from Bacillus subtilis (strain 168) (see paper)
P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (see 2 papers)
    28% identity, 75% coverage of query (85.5 bits)

iolG / Q9WYP5 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
IOLG_THEMA / Q9WYP5 Myo-inositol 2-dehydrogenase; EC 1.1.1.18 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9WYP5 D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Thermotoga maritima (see paper)
    26% identity, 98% coverage of query (84.3 bits)

apsD / B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium radiobacter (strain K84 / ATCC BAA-868) (see paper)
APSD_RHIR8 / B9JK80 D-apiose dehydrogenase; EC 1.1.1.420 from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter) (see paper)
B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium tumefaciens (see paper)
    25% identity, 99% coverage of query (84.0 bits)

SM_b20330 glucoside 3-dehydrogenase; active on raffinose or trehalose (thuB) (EC 1.1.99.13) from Sinorhizobium meliloti 1021
    27% identity, 95% coverage of query (82.4 bits)

5uhwA / B9JK80 Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+ and magnesium
    25% identity, 98% coverage of query (81.6 bits)

5uiaA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, r-2,3-dihydroxyisovalerate and magnesium
    25% identity, 98% coverage of query (81.6 bits)

5ui9A Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, 2 -hydroxy-2-hydroxymethyl propanoic acid and magnesium
    25% identity, 98% coverage of query (81.6 bits)

5uhzA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, d-apionate and magnesium
    25% identity, 98% coverage of query (81.6 bits)

4n54A / A0A0J9X1Y7 Crystal structure of scyllo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD(h) and scyllo-inositol
    29% identity, 75% coverage of query (79.3 bits)

E1U888 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    29% identity, 75% coverage of query (79.3 bits)

Q9EZV8 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium fredii (see paper)
    27% identity, 97% coverage of query (75.9 bits)

iolW / O32223 scyllo-inositol dehydrogenase (NADP+) (EC 1.1.1.371) from Bacillus subtilis (strain 168) (see paper)
IOLW_BACSU / O32223 scyllo-inositol 2-dehydrogenase (NADP(+)) IolW; NADP(+)-dependent scyllo-inositol dehydrogenase 1; NADP(+)-dependent SI dehydrogenase 1; EC 1.1.1.371 from Bacillus subtilis (strain 168) (see 3 papers)
O32223 scyllo-inositol 2-dehydrogenase (NADP+) (EC 1.1.1.371) from Bacillus subtilis (see 2 papers)
    25% identity, 96% coverage of query (75.5 bits)

ntdC / O07564 glucose-6-phosphate 3-dehydrogenase (EC 1.1.1.361) from Bacillus subtilis (strain 168) (see 4 papers)
NTDC_BACSU / O07564 Glucose-6-phosphate 3-dehydrogenase; EC 1.1.1.361 from Bacillus subtilis (strain 168) (see 3 papers)
O07564 glucose-6-phosphate 3-dehydrogenase (EC 1.1.1.361) from Bacillus subtilis (see 2 papers)
    23% identity, 93% coverage of query (75.1 bits)

3dtyA / Q880Y1 Crystal structure of an oxidoreductase from pseudomonas syringae
    26% identity, 73% coverage of query (73.9 bits)

6o15A / P39353 Crystal structure of a putative oxidoreductase yjhc from escherichia coli in complex with NAD(h) (see paper)
    28% identity, 73% coverage of query (73.2 bits)

SM_b20899 Inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti 1021
MI2D_RHIME / O68965 Inositol 2-dehydrogenase; Myo-inositol 2-dehydrogenase; MI-dehydrogenase; EC 1.1.1.18 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
O68965 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti (see paper)
    28% identity, 78% coverage of query (67.0 bits)

5a03C / Q9A8X3 Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose (see paper)
    24% identity, 77% coverage of query (66.2 bits)

5a06A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with sorbitol
    24% identity, 77% coverage of query (66.2 bits)

5a05A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with maltotriose
    24% identity, 77% coverage of query (65.9 bits)

5a04A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glucose
    24% identity, 77% coverage of query (65.9 bits)

5a03E Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose
    24% identity, 77% coverage of query (65.9 bits)

5a02A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glycerol
    24% identity, 77% coverage of query (65.9 bits)

1zh8A / Q9WYE8 Crystal structure of oxidoreductase (tm0312) from thermotoga maritima at 2.50 a resolution
    24% identity, 71% coverage of query (63.2 bits)

3q2kC / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    23% identity, 71% coverage of query (61.2 bits)

3q2kK / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    23% identity, 71% coverage of query (61.2 bits)

gnnA / Q6QHI6 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Acidithiobacillus ferrooxidans (see 12 papers)
7bvjA / B7JA34 Udp-n-acetylglucosamine 3-dehydrogenase gnna from acidithiobacillus ferrooxidans (p21) (see paper)
    25% identity, 95% coverage of query (57.0 bits)

3q2iA / Q7NQL0 Crystal structure of the wlba dehydrognase from chromobactrium violaceum in complex with nadh and udp-glcnaca at 1.50 a resolution (see paper)
    22% identity, 92% coverage of query (55.5 bits)

4l8vA / P26935 Crystal structure of a12k/d35s mutant myo-inositol dehydrogenase from bacillus subtilis with bound cofactor NADP (see paper)
    23% identity, 99% coverage of query (53.5 bits)

Q7NQL0 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (EC 1.1.1.335) from Chromobacterium violaceum (see paper)
    22% identity, 71% coverage of query (52.0 bits)

iolG / P26935 inositol 2-dehydrogenase monomer (EC 1.1.1.18; EC 1.1.1.369) from Bacillus subtilis (strain 168) (see 5 papers)
IOLG_BACSU / P26935 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; MI 2-dehydrogenase/DCI 3-dehydrogenase; EC 1.1.1.18; EC 1.1.1.369 from Bacillus subtilis (strain 168) (see 3 papers)
P26935 inositol 2-dehydrogenase (EC 1.1.1.18); D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Bacillus subtilis (see 7 papers)
    23% identity, 99% coverage of query (52.0 bits)

3nt5A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor and product inosose
    23% identity, 99% coverage of query (52.0 bits)

3nt4A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor nadh and inositol
    23% identity, 99% coverage of query (52.0 bits)

3nt2B Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    23% identity, 99% coverage of query (52.0 bits)

3nt2A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    23% identity, 99% coverage of query (52.0 bits)

8qc2A Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ and sulfoquinovose (sq)
    25% identity, 85% coverage of query (49.7 bits)

8qc8B Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
    25% identity, 85% coverage of query (49.3 bits)

8qc8D Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
    25% identity, 76% coverage of query (47.8 bits)

8qc6A / A0A1C9WRL0 Crystal structure of NAD-dependent glycoside hydrolase from arthrobacter sp. U41 in complex with NAD+ and sulfoquinovose (sq) (see paper)
    24% identity, 85% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory