Searching for up to 100 curated homologs for 3608254 FitnessBrowser__Dino:3608254 (298 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.15.9 / Q92LL4 PUTATIVE IRON TRANSPORT ATP-BINDING ABC TRANSPORTER PROTEIN aka SitB, component of Manganese (Mn2+) and Iron (Fe2+) porter, SitABCD from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
75% identity, 94% coverage of query (429 bits)
TC 3.A.1.15.7 / Q9XCS1 SitB aka STM2862, component of Manganese (Mn2+) (Km=0.1 μM) and iron (Fe2+) (5 μM) porter (inhibited by Cd2+ > Co2+ > Ni2+, Cu2+) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella from Salmonella typhimurium (see 2 papers)
71% identity, 88% coverage of query (381 bits)
TC 3.A.1.15.4 / Q56953 YfeB aka YPO2440 aka Y1896, component of Iron and manganese porter from Yersinia pestis (see 4 papers)
67% identity, 89% coverage of query (366 bits)
sitB / SP|Q6J5N9 iron/manganese ABC transporter, ATP-binding protein from Escherichia coli (see paper)
67% identity, 90% coverage of query (362 bits)
TC 3.A.1.15.1 / Q55281 MntA aka SLL1599, component of Manganese (Mn2+) porter (see 2 papers)
62% identity, 78% coverage of query (297 bits)
TC 3.A.1.15.8 / P96117 TroB, component of Manganese (Mn2+), zinc (Zn2+) and possibly iron (Fe2+) uptake porter, TroABCD from Treponema pallidum (see 2 papers)
44% identity, 83% coverage of query (216 bits)
MNTB_BACSU / O34338 Manganese transport system ATP-binding protein MntB from Bacillus subtilis (strain 168) (see paper)
45% identity, 78% coverage of query (215 bits)
Q832Z4 ABC-type Mn2+ transporter (subunit 3/3) (EC 7.2.2.5) from Enterococcus faecalis (see paper)
41% identity, 82% coverage of query (199 bits)
TC 3.A.1.15.14 / Q97PG9 Manganese ABC transporter, ATP-binding protein, component of High affinity Mn2+ uptake complex, PsaABC from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
41% identity, 83% coverage of query (189 bits)
Q6NK67 ABC-type Mn2+ transporter (subunit 3/3) (EC 7.2.2.5) from Corynebacterium diphtheriae (see paper)
41% identity, 80% coverage of query (188 bits)
TC 3.A.1.15.12 / O84071 Probable metal transport system ATP-binding protein CT_068, component of Metal ion (probably iron) uptake permease , YtgABC-RD. The third gene in the ytg from Chlamydia trachomatis (strain D/UW-3/Cx)
36% identity, 80% coverage of query (174 bits)
MTSC_STRGN / P42360 Manganese import ATP-binding protein ScaC; ORF1; EC 7.2.2.5 from Streptococcus gordonii (see paper)
TC 3.A.1.15.2 / P42360 YSC1 aka ScaC, component of Manganese (Mn2+) and zinc (Zn2+) porter from Streptococcus gordonii challis (see paper)
39% identity, 79% coverage of query (171 bits)
TC 3.A.1.15.6 / Q9RNI9 MtsB aka SPY0454 aka SPYM3_0319 aka SPS1538, component of Iron (Fe2+)/Zinc (Zn2+)/Copper (Cu2+) porter from Streptococcus pyogenes (see paper)
34% identity, 81% coverage of query (150 bits)
TC 3.A.1.15.13 / B2IWT0 ABC transporter related, component of The ZnuA18/ZnuA08/ZnuB/ZnuC zinc (Zn2+) uptake system from Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
38% identity, 78% coverage of query (144 bits)
TC 3.A.1.15.10 / A1IQK5 MntA (C), component of The Mn2+/Zn2+ transporter MntABC (KB of Mn2+ and Zn2+ is 0.1μM which bind with equal affinity to the same site from Neisseria meningitidis serogroup A (see paper)
37% identity, 76% coverage of query (144 bits)
TC 3.A.1.15.15 / G0LRW9 ABC transporter ATP-binding protein, component of High affinity Mn2+ uptake complex, MntABC from Staphylococcus aureus subsp. aureus LGA251
35% identity, 73% coverage of query (143 bits)
TC 3.A.1.14.7 / Q9X665 FhuC aka FhuA, component of Iron (Fe3+)-hydroxamate porter (transports Fe3+-ferrichrome and Fe3+-ferrioxamine B with FhuD1, and these compounds plus aerobactin and coprogen with FhuD2) (see 2 papers)
36% identity, 78% coverage of query (135 bits)
FecE / b4287 ferric citrate ABC transporter ATP binding subunit (EC 7.2.2.18) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
FecE / P15031 ferric citrate ABC transporter ATP binding subunit (EC 7.2.2.18) from Escherichia coli (strain K12) (see 2 papers)
FECE_ECOLI / P15031 Fe(3+) dicitrate transport ATP-binding protein FecE; Iron(III) dicitrate transport ATP-binding protein FecE; EC 7.2.2.18 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.14.1 / P15031 Fe(3+) dicitrate transport ATP-binding protein FecE, component of Iron (Fe3+) or ferric-dicitrate porter from Escherichia coli (strain K12) (see 4 papers)
fecE / GB|AAC77243.1 iron(III) dicitrate transport ATP-binding protein FecE from Escherichia coli K12 (see 6 papers)
33% identity, 78% coverage of query (123 bits)
TC 3.A.1.14.8 / Q8GRB0 PvuE, component of The iron-vibrioferrin uptake porter from Vibrio parahaemolyticus (see paper)
31% identity, 80% coverage of query (122 bits)
TC 3.A.1.14.14 / Q9A197 Putative ferrichrome ABC transporter aka SiuA aka Spy0386, component of The Fe3+ /Fe3+ferrichrome/Fe3+heme uptake porter; SiuABDG (FTSABCD) from Streptococcus pyogenes serotype M1 (see 2 papers)
33% identity, 72% coverage of query (122 bits)
MOLC_HAEIN / Q57399 Molybdate import ATP-binding protein MolC; EC 7.3.2.5 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 7 papers)
Q57399 ABC-type molybdate transporter (EC 7.3.2.5) from Haemophilus influenzae (see paper)
TC 3.A.1.14.11 / Q57399 Uncharacterized ABC transporter ATP-binding protein HI_1470, component of The molybdate/tungstate ABC transporter, MolABC from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
31% identity, 71% coverage of query (121 bits)
BTUDA_HALSA / Q9HQ18 Cobalamin import ATP-binding protein BtuD; Vitamin B12-transporting ATPase; EC 7.6.2.8 from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
38% identity, 74% coverage of query (119 bits)
fhuC / GI|2832798 ferrichrome transport ATP-binding protein FhuC from Bacillus subtilis (see paper)
35% identity, 72% coverage of query (117 bits)
FPUD_BACAN / Q81V82 Petrobactin import ATP-binding protein FpuD; EC 7.2.2.- from Bacillus anthracis (see paper)
33% identity, 71% coverage of query (116 bits)
TC 3.A.1.14.12 / Q9L177 DesC, component of Desferrioxamine B uptake porter, DesABC from Streptomyces coelicolor (see paper)
35% identity, 78% coverage of query (115 bits)
FhuC / b0151 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FhuC / P07821 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli (strain K12) (see paper)
FHUC_ECOLI / P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.14.3 / P07821 FhuC aka B0151, component of Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter from Escherichia coli (see 6 papers)
fhuC / GB|BAB96727.2 ferrichrome transport ATP-binding protein FhuC; EC 3.6.3.34 from Escherichia coli K12 (see 8 papers)
31% identity, 78% coverage of query (114 bits)
TC 3.A.1.14.6 / Q9RCF3 ViuC, component of The iron-vibriobactin/enterobactin uptake porter from Vibrio cholerae (see 2 papers)
30% identity, 78% coverage of query (112 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
33% identity, 77% coverage of query (112 bits)
ABC1_MYCTU / O65934 ABC transporter ATP-binding/permease protein Rv1747; EC 7.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
34% identity, 70% coverage of query (101 bits)
Build an alignment for 3608254 and 29 homologs with ≥ 30% identity
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6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
29% identity, 79% coverage of query (97.4 bits)
8bmpA Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp
32% identity, 76% coverage of query (95.5 bits)
5xu1B / Q8DQF8 Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
30% identity, 71% coverage of query (95.5 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
31% identity, 79% coverage of query (95.1 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
31% identity, 79% coverage of query (95.1 bits)
5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
33% identity, 77% coverage of query (95.1 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
31% identity, 79% coverage of query (94.7 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
33% identity, 74% coverage of query (94.0 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
33% identity, 74% coverage of query (94.0 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
33% identity, 74% coverage of query (94.0 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
30% identity, 79% coverage of query (93.6 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
28% identity, 74% coverage of query (93.2 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 73% coverage of query (92.8 bits)
8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
32% identity, 73% coverage of query (92.0 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
31% identity, 70% coverage of query (88.6 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
30% identity, 70% coverage of query (87.4 bits)
7y1nA / Q63563 Structure of sur2b in complex with mg-atp, mg-adp, and repaglinide in the partially occluded state (see paper)
31% identity, 70% coverage of query (87.0 bits)
7vltA Structure of sur2b in complex with mg-atp/adp and levcromakalim
31% identity, 70% coverage of query (87.0 bits)
7vlsA Structure of sur2b in complex with mgatp/adp and p1075
31% identity, 70% coverage of query (87.0 bits)
7vlrA Structure of sur2b in complex with mg-atp/adp
31% identity, 70% coverage of query (87.0 bits)
7w4oB The structure of katp h175k mutant in pre-open state
28% identity, 83% coverage of query (87.0 bits)
7y1lA Structure of sur2b in complex with mg-atp and repaglinide in the inward-facing conformation
31% identity, 70% coverage of query (86.7 bits)
7y1jA / Q63563 Structure of sur2a in complex with mg-atp and repaglinide in the inward-facing conformation. (see paper)
31% identity, 70% coverage of query (86.7 bits)
7mitE / Q63563 Vascular katp channel: kir6.1 sur2b propeller-like conformation 1 (see paper)
30% identity, 70% coverage of query (86.3 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
25% identity, 79% coverage of query (86.3 bits)
4fi3C / P06611 Structure of vitamin b12 transporter btucd-f in a nucleotide-bound state (see paper)
30% identity, 77% coverage of query (86.3 bits)
5ywdB Structure of pancreatic atp-sensitive potassium channel bound with mg- adp (focused refinement of sur1 abc transporter module at 4.22a)
28% identity, 83% coverage of query (85.9 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
28% identity, 71% coverage of query (85.9 bits)
7witA Structure of sur1 in complex with mitiglinide
29% identity, 83% coverage of query (85.1 bits)
6jb1B / A0A1U7R319 Structure of pancreatic atp-sensitive potassium channel bound with repaglinide and atpgammas at 3.3a resolution (see paper)
29% identity, 83% coverage of query (85.1 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
32% identity, 82% coverage of query (84.3 bits)
5yw7B Structure of pancreatic atp-sensitive potassium channel bound with glibenclamide and atpgammas (focused refinement on sur1 abc transporter module at 4.4a)
29% identity, 83% coverage of query (84.3 bits)
5ykfB / A0A1U7R319 Structure of pancreatic atp-sensitive potassium channel bound with glibenclamide and atpgammas (3d class1 at 4.33a) (see paper)
29% identity, 83% coverage of query (84.3 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
30% identity, 72% coverage of query (84.0 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 73% coverage of query (84.0 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
28% identity, 73% coverage of query (84.0 bits)
2olkA Abc protein artp in complex with adp-beta-s
28% identity, 73% coverage of query (84.0 bits)
2oljA Abc protein artp in complex with adp/mg2+
28% identity, 73% coverage of query (84.0 bits)
MRP1_RAT / Q8CG09 Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter; EC 7.6.2.2; EC 7.6.2.3 from Rattus norvegicus (Rat) (see 3 papers)
29% identity, 85% coverage of query (83.6 bits)
1l7vC Bacterial abc transporter involved in b12 uptake
30% identity, 73% coverage of query (83.6 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
26% identity, 70% coverage of query (82.0 bits)
8hprD Lpqy-sugabc in state 4
30% identity, 75% coverage of query (82.0 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
27% identity, 76% coverage of query (82.0 bits)
8hprC Lpqy-sugabc in state 4
30% identity, 75% coverage of query (81.6 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
30% identity, 76% coverage of query (81.6 bits)
ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
28% identity, 73% coverage of query (81.3 bits)
P59852 Lactococcin-G-processing and transport ATP-binding protein LagD; EC 3.4.22.-; EC 7.-.-.- from Lactococcus lactis subsp. lactis (Streptococcus lactis)
27% identity, 74% coverage of query (80.9 bits)
7u1sE / Q09427 Cryo-em structure of the pancreatic atp-sensitive potassium channel bound to atp and repaglinide with sur1-out conformation (see paper)
29% identity, 76% coverage of query (80.9 bits)
7m33C The structure of bacillus subtilis bmrcd in the inward-facing conformation bound to hoechst-33342 and atp
30% identity, 70% coverage of query (80.5 bits)
MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
32% identity, 72% coverage of query (80.5 bits)
7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
32% identity, 72% coverage of query (80.5 bits)
6uy0A Cryo-em structure of wild-type bovine multidrug resistance protein 1 (mrp1) under active turnover conditions
30% identity, 72% coverage of query (80.5 bits)
8fhkC / O07550 Heterodimeric abc transporter bmrcd in the occluded conformation bound to atp: bmrcd_oc-atp (see paper)
30% identity, 70% coverage of query (80.1 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
30% identity, 76% coverage of query (80.1 bits)
7bcwA Structure of msba in salipro with adp vanadate
32% identity, 72% coverage of query (80.1 bits)
8dmmA Structure of the vanadate-trapped msba bound to kdl
32% identity, 72% coverage of query (80.1 bits)
6bppA E. Coli msba in complex with lps and inhibitor g092
32% identity, 72% coverage of query (80.1 bits)
6bplA E. Coli msba in complex with lps and inhibitor g907
32% identity, 72% coverage of query (80.1 bits)
8t1pC Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
30% identity, 70% coverage of query (80.1 bits)
7mewA E. Coli msba in complex with g247
32% identity, 72% coverage of query (80.1 bits)
7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
32% identity, 72% coverage of query (79.7 bits)
3nh9A Nucleotide binding domain of human abcb6 (atp bound structure)
29% identity, 74% coverage of query (79.7 bits)
ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
29% identity, 73% coverage of query (79.7 bits)
7selA E. Coli msba in complex with lps and inhibitor g7090 (compound 3)
31% identity, 72% coverage of query (79.3 bits)
7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
26% identity, 71% coverage of query (79.3 bits)
MRP2_HUMAN / Q92887 ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2; EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3 from Homo sapiens (Human) (see 14 papers)
Q92887 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 12 papers)
28% identity, 79% coverage of query (79.0 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
26% identity, 76% coverage of query (78.6 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
30% identity, 75% coverage of query (78.6 bits)
6bhuA / Q8HXQ5 Cryo-em structure of atp-bound, outward-facing bovine multidrug resistance protein 1 (mrp1) (see paper)
31% identity, 71% coverage of query (78.2 bits)
8f4bA / Q8HXQ5 Bovine multidrug resistance protein 1 (mrp1) bound to cyclic peptide inhibitor 1 (cpi1) (see paper)
31% identity, 71% coverage of query (78.2 bits)
5ujaA Cryo-em structure of bovine multidrug resistance protein 1 (mrp1) bound to leukotriene c4
31% identity, 71% coverage of query (77.8 bits)
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Lawrence Berkeley National Laboratory