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Searching for up to 100 curated homologs for 3608583 Dshi_1977 Extracellular ligand-binding receptor (RefSeq) (420 a.a.)

Found high-coverage hits (≥70%) to 17 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.4.2 / Q55387 NatB aka SLR0559, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
    31% identity, 89% coverage of query (126 bits)

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Build an alignment for 3608583 and 1 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.4.6 / Q8YVY4 NatB, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
    29% identity, 88% coverage of query (119 bits)

BRAC_PSEAE / P21175 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein; LIVAT-BP; Leu/Ile/Val/Thr/Ala-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
TC 3.A.1.4.8 / P21175 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    26% identity, 86% coverage of query (84.0 bits)

LIVB3_RHIJ3 / Q1MDE9 Leu/Ile/Val-binding protein BraC3 from Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium leguminosarum bv. viciae) (see paper)
    28% identity, 72% coverage of query (82.4 bits)

Pf6N2E2_2921 ABC transporter for L-leucine/L-phenylalanine/D-alanine, substrate-binding component LivK from Pseudomonas fluorescens FW300-N2E2
    24% identity, 90% coverage of query (75.5 bits)

TC 3.A.1.4.3 / Q9L3M3 BraC, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
braC / CAB75553.1 periplasmic binding protein from Rhizobium leguminosarum bv. viciae (see 2 papers)
    24% identity, 84% coverage of query (71.6 bits)

BASB_HALS3 / B0R6I5 Chemotactic signal transduction system substrate-binding protein BasB; Amino acid binding protein from Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) (see paper)
    27% identity, 84% coverage of query (68.9 bits)

HSERO_RS00870 L-proline ABC transporter, substrate-binding component from Herbaspirillum seropedicae SmR1
    24% identity, 80% coverage of query (66.6 bits)

AZOBR_RS08260 L-proline and D-alanine ABC transporter, substrate-binding component from Azospirillum brasilense Sp245
    25% identity, 84% coverage of query (63.2 bits)

3td9A / Q9X0L9 Crystal structure of a leucine binding protein livk (tm1135) from thermotoga maritima msb8 at 1.90 a resolution
    24% identity, 87% coverage of query (60.8 bits)

Ac3H11_2396 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, substrate-binding component from Acidovorax sp. GW101-3H11
    23% identity, 88% coverage of query (58.5 bits)

TC 3.A.1.4.10 / Q8DQI1 ABC transporter substrate-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    24% identity, 79% coverage of query (50.4 bits)

HrbC / b3458 L-leucine/L-phenylalanine ABC transporter periplasmic binding protein (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 17 papers)
livK / P04816 L-leucine/L-phenylalanine ABC transporter periplasmic binding protein (EC 7.4.2.2) from Escherichia coli (strain K12) (see 16 papers)
TC 3.A.1.4.1 / P04816 Livk aka B3458, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 9 papers)
livK leucine-specific-binding protein LivK from Escherichia coli K12 (see 9 papers)
    22% identity, 71% coverage of query (49.7 bits)

4gnrA / J9PBT7 1.0 angstrom resolution crystal structure of the branched-chain amino acid transporter substrate binding protein livj from streptococcus pneumoniae str. Canada mdr_19a in complex with isoleucine
    24% identity, 71% coverage of query (49.7 bits)

4q6wA / Q7VS30 Crystal structure of periplasmic binding protein type 1 from bordetella pertussis tohama i complexed with 3-hydroxy benzoic acid
    24% identity, 74% coverage of query (45.4 bits)

4rv5A The crystal structure of a solute-binding protein from anabaena variabilis atcc 29413 in complex with pyruvic acid
    21% identity, 72% coverage of query (44.3 bits)

4obbA The crystal structure of a solute-binding protein from anabaena variabilis atcc 29413 in complex with (3s)-3-methyl-2-oxopentanoic acid.
    21% identity, 72% coverage of query (44.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory