Sites on a Tree

 

Searching for up to 100 curated homologs for 3608627 FitnessBrowser__Dino:3608627 (543 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AAV49510.1 phosphoglucomutase from Acidithiobacillus ferrooxidans (see paper)
    61% identity, 99% coverage of query (667 bits)

PGM / Q9SCY0 phosphoglucomutase (α-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see 2 papers)
PGMP_ARATH / Q9SCY0 Phosphoglucomutase, chloroplastic; PGM; Glucose phosphomutase; Protein REDUCED GRAVITROPIC 2; EC 5.4.2.2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SCY0 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
    53% identity, 99% coverage of query (592 bits)

P93805 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Zea mays (see paper)
    53% identity, 99% coverage of query (579 bits)

PGMC1_MAIZE / P93804 Phosphoglucomutase, cytoplasmic 1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Zea mays (Maize) (see paper)
P93804 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Zea mays (see paper)
    53% identity, 99% coverage of query (578 bits)

Q9SGC1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
    51% identity, 99% coverage of query (572 bits)

6snoA / P36871 Crystal structures of human pgm1 isoform 2 (see paper)
    52% identity, 100% coverage of query (570 bits)

O49299 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
    52% identity, 99% coverage of query (564 bits)

PGM1_RABIT / P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
    51% identity, 99% coverage of query (562 bits)

3pmgA Structure of rabbit muscle phosphoglucomutase at 2.4 angstroms resolution. Use of freezing point depressant and reduced temperature to enhance diffractivity
    51% identity, 99% coverage of query (562 bits)

1c4gA Phosphoglucomutase vanadate based transition state analog complex
    51% identity, 99% coverage of query (562 bits)

1c47A Binding driven structural changes in crystaline phosphoglucomutase associated with chemical reaction
    51% identity, 99% coverage of query (562 bits)

PGM1_RAT / P38652 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Rattus norvegicus (Rat) (see paper)
    51% identity, 99% coverage of query (560 bits)

PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
    51% identity, 99% coverage of query (559 bits)

6snqA Crystal structures of human pgm1 isoform 2
    51% identity, 100% coverage of query (558 bits)

5jn5A Crystal structure of the d263y missense variant of human pgm1
    50% identity, 99% coverage of query (546 bits)

A0A2H5BEG8 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Ganoderma lucidum (see paper)
    49% identity, 99% coverage of query (542 bits)

PGM_SCHPO / O74374 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    51% identity, 99% coverage of query (526 bits)

A8N8Z1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Coprinopsis cinerea (see paper)
    48% identity, 100% coverage of query (524 bits)

6y8yA / A0A6P3VN15 Structure of baltic herring (clupea harengus) phosphoglucomutase 5 (pgm5) with bound glucose-1-phosphate (see paper)
    49% identity, 100% coverage of query (521 bits)

PGM5_MOUSE / Q8BZF8 Phosphoglucomutase-like protein 5 from Mus musculus (Mouse) (see paper)
    48% identity, 100% coverage of query (517 bits)

7p5oB / Q4WY53 Crystal structure of aspergillus fumigatus phosphoglucomutase in complex with the reaction intermediate
    46% identity, 100% coverage of query (516 bits)

PGM5_HUMAN / Q15124 Phosphoglucomutase-like protein 5; Aciculin; Phosphoglucomutase-related protein; PGM-RP from Homo sapiens (Human) (see 2 papers)
    48% identity, 100% coverage of query (516 bits)

Q670S5 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Trypanosoma cruzi (see paper)
    48% identity, 99% coverage of query (515 bits)

PGM_EMENI / Q9P931 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
pgmB phosphoglucomutase; EC 5.4.2.2 from Emericella nidulans (see paper)
    46% identity, 100% coverage of query (514 bits)

PGM5_RAT / D3ZVR9 Phosphoglucomutase-like protein 5 from Rattus norvegicus (Rat) (see paper)
    48% identity, 100% coverage of query (510 bits)

PGM_DROME / Q9VUY9 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Drosophila melanogaster (Fruit fly) (see paper)
    46% identity, 99% coverage of query (508 bits)

1kfqA / P47244 Crystal structure of exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutse) from paramecium. Open form (see paper)
    48% identity, 99% coverage of query (505 bits)

PGM1_PARTE / P47244 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; Parafusin; Pf; pp63; EC 5.4.2.2 from Paramecium tetraurelia (see paper)
    48% identity, 99% coverage of query (505 bits)

1kfiA Crystal structure of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase) from paramecium
    48% identity, 99% coverage of query (505 bits)

Q4QCF1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Leishmania major (see paper)
    47% identity, 99% coverage of query (498 bits)

7s0wB / P36871 Crystal structure of the t337m variant of human pgm-1 (see paper)
    48% identity, 95% coverage of query (491 bits)

7pjcB / A0A1D8PSA9 The structure of candida albicans phosphoglucomutase with isothiazolone modification on cys359
    44% identity, 99% coverage of query (491 bits)

PGM2 / P37012 phosphoglucomutase-2 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
PGM2_YEAST / P37012 Phosphoglucomutase 2; PGM 2; D-glucose-1,6-diphosphate:D-glucose-1-phosphate phosphotransferase; Glucose phosphomutase 2; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 10 papers)
    45% identity, 99% coverage of query (485 bits)

4qg5A / Q4QCF1 Crystal structure of phosphoglucomutase from leishmania major at 3.5 angstrom resolution
    47% identity, 95% coverage of query (479 bits)

PGM1 / P33401 phosphoglucomutase-1 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
PGM1_YEAST / P33401 Phosphoglucomutase 1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
    45% identity, 99% coverage of query (474 bits)

PGM_ENTH1 / O15820 Phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see paper)
    44% identity, 99% coverage of query (462 bits)

C6L2E2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Toxoplasma gondii (see paper)
    42% identity, 98% coverage of query (443 bits)

Build an alignment

Build an alignment for 3608627 and 37 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

celB / AAA21561.1 phosphoglucomutase from Komagataeibacter xylinus (see paper)
    27% identity, 94% coverage of query (103 bits)

2fuvA / Q8ZQW9 Phosphoglucomutase from salmonella typhimurium.
    28% identity, 93% coverage of query (100 bits)

A0A0H3NJ17 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
Q8ZQW9 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    28% identity, 93% coverage of query (100 bits)

P74027 glucose-1,6-bisphosphate synthase from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    25% identity, 83% coverage of query (94.7 bits)

Blu / b0688 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
pgm / P36938 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli (strain K12) (see 11 papers)
PGM_ECOLI / P36938 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Escherichia coli (strain K12) (see 2 papers)
pgm / GB|ABB65241.1 phosphoglucomutase; EC 5.4.2.2 from Escherichia coli K12 (see 6 papers)
    28% identity, 93% coverage of query (87.8 bits)

PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
    26% identity, 74% coverage of query (71.6 bits)

pgmA / I6Y2G3 phosphoglucomutase (EC 5.4.2.2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
I6Y2G3 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Mycobacterium tuberculosis (see paper)
    27% identity, 92% coverage of query (70.1 bits)

pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
    23% identity, 80% coverage of query (69.7 bits)

PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    25% identity, 90% coverage of query (66.2 bits)

pgmA / CAB96418.1 phosphoglucomutase from Streptococcus thermophilus (see paper)
    25% identity, 70% coverage of query (59.7 bits)

Q980S1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Saccharolobus solfataricus (see paper)
    23% identity, 81% coverage of query (58.5 bits)

ST0242 / Q976E4 hexose-6-phosphate mutase/isomerase (EC 5.3.1.8; EC 5.3.1.9; EC 5.4.2.10; EC 5.4.2.13) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see paper)
PGMUT_SULTO / Q976E4 Phosphoglucosamine/phosphogalactosamine mutase; PGlcNM; EC 5.4.2.10; EC 5.4.2.13 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q976E4 phosphogalactosamine mutase (EC 5.4.2.13) from Sulfurisphaera tokodaii (see paper)
    22% identity, 74% coverage of query (57.0 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory