Sites on a Tree

 

Searching for up to 100 curated homologs for 3609639 Dshi_3022 PfkB domain protein (RefSeq) (333 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3uboA / Q92T17 The crystal structure of adenosine kinase from sinorhizobium meliloti
    47% identity, 97% coverage of query (279 bits)

4k8pA / Q2KDX6 Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 2-ethylbenzyl alcohol
    43% identity, 98% coverage of query (260 bits)

4lc4A Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with guanosine
    43% identity, 98% coverage of query (260 bits)

4kbeA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with benzoguanamine
    43% identity, 98% coverage of query (260 bits)

4kanA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 2-(2,5-dimethyl-1,3-thiazol-4-yl)acetic acid
    43% identity, 98% coverage of query (260 bits)

4kalA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with quinoline-3-carboxylic acid
    43% identity, 98% coverage of query (260 bits)

4kahA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 4-bromo-1h-pyrazole
    43% identity, 98% coverage of query (260 bits)

4kadA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with n1-(2.3-dihydro-1h-inden-5-yl)acetam
    43% identity, 98% coverage of query (260 bits)

4k9iA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with norharmane
    43% identity, 98% coverage of query (260 bits)

4k9cA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with n-(hydroxymethyl)benzamide and 4-methyl-3,4- dihydro-2h-1,4-benzoxazine-7-carboxylic acid
    43% identity, 98% coverage of query (260 bits)

4k93A Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with n-(hydroxymethyl)benzamide
    43% identity, 98% coverage of query (260 bits)

4k8tA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with ethyl 3,4-diaminobenzoate
    43% identity, 98% coverage of query (260 bits)

4k8cA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with adp
    43% identity, 98% coverage of query (260 bits)

4jkuA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with quinaldic acid, nysgrc target 14306
    43% identity, 98% coverage of query (260 bits)

4lbxA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with cytidine
    43% identity, 98% coverage of query (260 bits)

4k8kA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 1-(4-methoxyphenyl)-1-cyclopropane and 2- aminoperimidine
    43% identity, 98% coverage of query (260 bits)

1liiA Structure of t. Gondii adenosine kinase bound to adenosine 2 and amp- pcp
    31% identity, 93% coverage of query (108 bits)

1lijA Structure of t. Gondii adenosine kinase bound to prodrug 2 7- iodotubercidin and amp-pcp
    32% identity, 93% coverage of query (106 bits)

1dgmA Crystal structure of adenosine kinase from toxoplasma gondii
    32% identity, 93% coverage of query (105 bits)

2a9yA / Q9TVW2 Crystal structure of t. Gondii adenosine kinase complexed with n6- dimethyladenosine (see paper)
    31% identity, 93% coverage of query (102 bits)

2aa0A Crystal structure of t. Gondii adenosine kinase complexed with 6- methylmercaptopurine riboside
    31% identity, 93% coverage of query (102 bits)

Build an alignment

Build an alignment for 3609639 and 21 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

3looB Crystal structure of anopheles gambiae adenosine kinase in complex with p1,p4-di(adenosine-5) tetraphosphate (see paper)
    28% identity, 92% coverage of query (95.9 bits)

STM4066 / Q8ZKR2 aminoimidazole riboside kinase (EC 2.7.1.223) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
AIRSK_SALTY / Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
Q8ZKR2 aminoimidazole riboside kinase (EC 2.7.1.223) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    28% identity, 75% coverage of query (89.7 bits)

6vwoA Crystal structure of e. Coli guanosine kinase
    28% identity, 72% coverage of query (80.1 bits)

gsk / AAC36932.1 guanosine kinase from Escherichia coli (see 2 papers)
    28% identity, 72% coverage of query (79.7 bits)

YdjH / b1772 L-glycero-L-galacto-octuluronate kinase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ydjH / P77493 L-glycero-L-galacto-octuluronate kinase from Escherichia coli (strain K12) (see 2 papers)
    28% identity, 98% coverage of query (79.7 bits)

Q5DKV0 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    26% identity, 92% coverage of query (79.7 bits)

Gsk / b0477 inosine/guanosine kinase (EC 2.7.1.73) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
gsk / P0AEW6 inosine/guanosine kinase (EC 2.7.1.73) from Escherichia coli (strain K12) (see 16 papers)
INGK_ECOLI / P0AEW6 Guanosine-inosine kinase; EC 2.7.1.73 from Escherichia coli (strain K12) (see 5 papers)
P0AEW6 inosine kinase (EC 2.7.1.73) from Escherichia coli (see paper)
    28% identity, 72% coverage of query (79.7 bits)

6vwpA / P0AEW6 Crystal structure of e. Coli guanosine kinase in complex with ppgpp (see paper)
    28% identity, 72% coverage of query (79.3 bits)

ADK_PHYPA / O49923 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens) (see paper)
    28% identity, 92% coverage of query (79.0 bits)

CCNA_01356 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Caulobacter crescentus NA1000
iolC-DUF2090 / A0A0H3C6B4 bifunctional 5-dehydro-2-deoxygluconokinase/5-dehydro-2-deoxyphosphogluconate aldolase (EC 2.7.1.92; EC 4.1.2.29) from Caulobacter vibrioides (strain NA1000 / CB15N) (see 3 papers)
    31% identity, 77% coverage of query (78.6 bits)

Q5DKU6 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    25% identity, 92% coverage of query (78.6 bits)

3in1A / P77493 Crystal structure of a putative ribokinase in complex with adp from e.Coli
    28% identity, 97% coverage of query (77.8 bits)

Q5DKU9 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    25% identity, 92% coverage of query (77.4 bits)

ADK1 / Q9SF85 adenosine kinase 1 (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
ADK1_ARATH / Q9SF85 Adenosine kinase 1; AK 1; Adenosine 5'-phosphotransferase 1; EC 2.7.1.20 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9SF85 adenosine kinase (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
    26% identity, 92% coverage of query (77.4 bits)

ADK2 / Q9LZG0 adenosine kinase 2 (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
ADK2_ARATH / Q9LZG0 Adenosine kinase 2; AK 2; Adenosine 5'-phosphotransferase 2; EC 2.7.1.20 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9LZG0 adenosine kinase (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
    26% identity, 92% coverage of query (76.6 bits)

1tz3A / Q8ZKR2 Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
    27% identity, 75% coverage of query (75.9 bits)

Q5DKU8 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    25% identity, 92% coverage of query (75.9 bits)

1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog
    27% identity, 75% coverage of query (75.9 bits)

Q2F635 adenosine kinase (EC 2.7.1.20) from Bombyx mori (see 2 papers)
    25% identity, 92% coverage of query (74.3 bits)

8cqxA / A0A0B0SD75 Ribokinase from t.Sp mutant a92g
    27% identity, 79% coverage of query (73.6 bits)

scrK / P26420 fructokinase (EC 2.7.1.4) from Klebsiella pneumoniae (see paper)
SCRK_KLEPN / P26420 Fructokinase; EC 2.7.1.4 from Klebsiella pneumoniae (see paper)
scrK / GB|CAA43322.1 fructokinase; EC 2.7.1.4 from Klebsiella pneumoniae (see paper)
scrK / CAA43322.1 fructokinase from Klebsiella pneumoniae (see paper)
    31% identity, 70% coverage of query (73.6 bits)

6znxC / A0A0B0SD75 Ribokinase from thermus species
    27% identity, 79% coverage of query (73.2 bits)

PS417_11850 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas simiae WCS417
    28% identity, 77% coverage of query (72.4 bits)

Q584S0 adenosine kinase (EC 2.7.1.20) from Trypanosoma brucei brucei (see paper)
4n09A / Q584S0 Structure of trypanosoma brucei brucei adenosine kinase in complex with adenosine and amppnp (see paper)
    27% identity, 94% coverage of query (71.2 bits)

3otxA Crystal structure of trypanosoma brucei rhodesiense adenosine kinase complexed with inhibitor ap5a
    26% identity, 94% coverage of query (71.2 bits)

AO353_21335 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2E3
    27% identity, 80% coverage of query (70.1 bits)

iolC / P42414 5-dehydro-2-deoxy-D-gluconate kinase (EC 2.7.1.92) from Bacillus subtilis (strain 168) (see 2 papers)
IOLC_BACSU / P42414 5-dehydro-2-deoxygluconokinase; 2-deoxy-5-keto-D-gluconate kinase; DKG kinase; EC 2.7.1.92 from Bacillus subtilis (strain 168) (see paper)
    29% identity, 75% coverage of query (70.1 bits)

Pf6N2E2_512 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2E2
    27% identity, 80% coverage of query (70.1 bits)

2xtbA Crystal structure of trypanosoma brucei rhodesiense adenosine kinase complexed with activator
    27% identity, 92% coverage of query (70.1 bits)

AO356_23160 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2C3
    26% identity, 80% coverage of query (69.7 bits)

TK2029 / Q5JDG9 α-D-ribose-1-phosphate 5-kinase (ADP) (EC 2.7.1.212) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
R1PK_THEKO / Q5JDG9 ADP-dependent ribose-1-phosphate kinase; ADP-R1P kinase; ADP:alpha-D-ribose-1-phosphate 5-phosphotransferase; Alpha-D-ribose-1-phosphate 5-kinase (ADP); EC 2.7.1.212 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    29% identity, 77% coverage of query (69.3 bits)

ADK / AAC80288.1 adenosine kinase from Leishmania donovani (see paper)
    26% identity, 91% coverage of query (66.6 bits)

scrK / GB|AAA08602.1 fructokinase; EC 2.7.1.4 from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
scrK / CAA43323.1 fructokinase from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    28% identity, 70% coverage of query (64.7 bits)

Sama_0561 Fructokinase (EC 2.7.1.4) from Shewanella amazonensis SB2B
    26% identity, 85% coverage of query (64.3 bits)

N515DRAFT_1919 Fructokinase (EC 2.7.1.4) from Dyella japonica UNC79MFTsu3.2
    26% identity, 97% coverage of query (64.3 bits)

HSERO_RS12125 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Herbaspirillum seropedicae SmR1
    24% identity, 77% coverage of query (63.9 bits)

5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
    27% identity, 71% coverage of query (62.8 bits)

A0A0H3AER7 fructokinase (EC 2.7.1.4) from Vibrio cholerae (see paper)
    27% identity, 71% coverage of query (62.4 bits)

3uq6A Adenosine kinase from schistosoma mansoni in complex with adenosine and amp (see paper)
    22% identity, 92% coverage of query (62.4 bits)

3uq9A Adenosine kinase from schistosoma mansoni in complex with tubercidin
    22% identity, 92% coverage of query (62.4 bits)

4dc3B Adenosine kinase from schistosoma mansoni in complex with 2- fluoroadenosine
    22% identity, 92% coverage of query (62.4 bits)

PGA1_c07240 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92) from Phaeobacter inhibens BS107
    28% identity, 79% coverage of query (62.0 bits)

5yggA / A0A0H3AER7 Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
    27% identity, 71% coverage of query (61.6 bits)

SMc01165 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Sinorhizobium meliloti 1021
    24% identity, 78% coverage of query (58.9 bits)

BPHYT_RS13910 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Burkholderia phytofirmans PsJN
    26% identity, 77% coverage of query (58.5 bits)

NK_METJA / Q57849 Nucleoside kinase; NK; ATP-dependent nucleoside monophosphokinase; Cytidine kinase; Guanosine-inosine kinase; EC 2.7.1.213; EC 2.7.1.73 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
    23% identity, 77% coverage of query (58.2 bits)

2c49A / Q57849 Crystal structure of methanocaldococcus jannaschii nucleoside kinase - an archaeal member of the ribokinase family (see paper)
    23% identity, 77% coverage of query (57.8 bits)

ADO1 putative uncharacterized protein from Candida albicans (see paper)
    24% identity, 92% coverage of query (57.4 bits)

ADK_CRIGR / P55262 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
    23% identity, 92% coverage of query (57.0 bits)

ADK_MOUSE / P55264 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Mus musculus (Mouse) (see paper)
P55264 adenosine kinase (EC 2.7.1.20) from Mus musculus (see 3 papers)
    24% identity, 92% coverage of query (56.2 bits)

5kb5A Crystal structure of the adenosine kinase from mus musculus in complex with adenosine and adenosine-diphosphate
    24% identity, 92% coverage of query (55.8 bits)

O82616 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see paper)
    25% identity, 72% coverage of query (55.5 bits)

G4N8F5 adenosine kinase (EC 2.7.1.20) from Pyricularia oryzae (see paper)
    25% identity, 89% coverage of query (55.1 bits)

4o1lA Human adenosine kinase in complex with inhibitor
    23% identity, 91% coverage of query (54.7 bits)

6ilsB / A1A6H3 Structure of arabidopsis thaliana ribokinase complexed with ribose and atp (see paper)
    26% identity, 77% coverage of query (54.3 bits)

RBSK / A1A6H3 ribokinase (EC 2.7.1.15) from Arabidopsis thaliana (see 2 papers)
RBSK_ARATH / A1A6H3 Ribokinase; AtRBSK; RK; EC 2.7.1.15 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
A1A6H3 ribokinase (EC 2.7.1.15) from Arabidopsis thaliana (see paper)
    26% identity, 77% coverage of query (54.3 bits)

2i6aA / P55263 Human adenosine kinase in complex with 5'-deoxy-5-iodotubercidin (see paper)
    23% identity, 92% coverage of query (54.3 bits)

1bx4A Structure of human adenosine kinase at 1.50 angstroms
    23% identity, 92% coverage of query (54.3 bits)

ADK / P55263 adenosine kinase (EC 2.7.1.20) from Homo sapiens (see 2 papers)
ADK_HUMAN / P55263 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Homo sapiens (Human) (see 4 papers)
    23% identity, 92% coverage of query (53.9 bits)

Q9LNE4 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see paper)
    24% identity, 72% coverage of query (53.5 bits)

Dshi_2797 Fructokinase (EC 2.7.1.4) from Dinoroseobacter shibae DFL-12
    30% identity, 77% coverage of query (53.1 bits)

O04897 fructokinase (EC 2.7.1.4) from Solanum lycopersicum (see paper)
    26% identity, 71% coverage of query (52.0 bits)

SCRK2_ORYSI / A2YQL4 Fructokinase-2; Fructokinase II; OsFKII; EC 2.7.1.4 from Oryza sativa subsp. indica (Rice) (see paper)
SCRK2_ORYSJ / Q0J8G4 Fructokinase-2; Fructokinase II; OsFKII; EC 2.7.1.4 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
A2YQL4 fructokinase (EC 2.7.1.4) from Oryza sativa (see paper)
    25% identity, 72% coverage of query (52.0 bits)

2i6bA Human adenosine kinase in complex with an acetylinic inhibitor
    23% identity, 90% coverage of query (51.6 bits)

Q42645 fructokinase (EC 2.7.1.4) from Beta vulgaris (see paper)
    25% identity, 72% coverage of query (51.2 bits)

Q9C524 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see 2 papers)
    26% identity, 71% coverage of query (51.2 bits)

ACBK_ACTS5 / Q8RMD4 Acarbose 7(IV)-phosphotransferase; Acarbose 7-kinase; EC 2.7.1.187 from Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) (see paper)
Q8RMD4 acarbose 7IV-phosphotransferase (EC 2.7.1.187) from Actinoplanes sp. (see 2 papers)
acbK / CAD29481.2 acarbose 7-kinase AcbK from Actinoplanes sp. SE50/110 (see 5 papers)
    28% identity, 73% coverage of query (49.3 bits)

6wb7A / Q8RMD4 Acarbose kinase acbk as a complex with acarbose and amp-pnp (see paper)
    28% identity, 73% coverage of query (49.3 bits)

6wb7C Acarbose kinase acbk as a complex with acarbose and amp-pnp
    28% identity, 77% coverage of query (49.3 bits)

SCRK1_ORYSJ / Q0JGZ6 Fructokinase-1; Fructokinase I; OsFKI; EC 2.7.1.4 from Oryza sativa subsp. japonica (Rice) (see paper)
    25% identity, 78% coverage of query (48.9 bits)

SCRK1_ORYSI / A2WXV8 Fructokinase-1; Fructokinase I; OsFKI; EC 2.7.1.4 from Oryza sativa subsp. indica (Rice) (see paper)
    25% identity, 78% coverage of query (48.1 bits)

ADK_YEAST / P47143 Adenosine kinase; EC 2.7.1.20 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    23% identity, 88% coverage of query (48.1 bits)

Q9SID0 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see paper)
    24% identity, 72% coverage of query (48.1 bits)

BT2803 ribokinase (EC 2.7.1.15) from Bacteroides thetaiotaomicron VPI-5482
    25% identity, 77% coverage of query (47.8 bits)

KDGK_THET8 / Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    29% identity, 78% coverage of query (47.0 bits)

1v1aA / Q53W83 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
    28% identity, 78% coverage of query (47.0 bits)

1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp
    29% identity, 78% coverage of query (47.0 bits)

SM_b21217 glucosamine kinase (EC 2.7.1.8) from Sinorhizobium meliloti 1021
    27% identity, 77% coverage of query (45.8 bits)

8omdA / P97328 Crystal structure of mkhk in complex with compound-4 (see paper)
    24% identity, 82% coverage of query (45.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory