Searching for up to 100 curated homologs for 5207514 FitnessBrowser__PV4:5207514 (235 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
53% identity, 98% coverage of query (239 bits)
Build an alignment for 5207514 and 1 homologs with ≥ 30% identity
Or download the sequences
gra-orf6 / BAD51477.1 ketoreductase from Streptomyces violaceoruber (see 3 papers)
29% identity, 97% coverage of query (88.2 bits)
FABG_SALTY / P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
28% identity, 97% coverage of query (78.2 bits)
fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
26% identity, 98% coverage of query (78.2 bits)
1e92A Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
27% identity, 97% coverage of query (76.6 bits)
5iz4A / Q13GL4 Crystal structure of a putative short-chain dehydrogenase/reductase from burkholderia xenovorans
26% identity, 96% coverage of query (75.9 bits)
CBR4 / Q8N4T8 carbonyl reductase family member 4 (EC 1.1.1.100) from Homo sapiens (see 2 papers)
CBR4_HUMAN / Q8N4T8 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; KAR beta subunit; Carbonyl reductase family member 4; CBR4; Quinone reductase CBR4; Short chain dehydrogenase/reductase family 45C member 1; EC 1.1.1.100; EC 1.6.5.10 from Homo sapiens (Human) (see 3 papers)
24% identity, 100% coverage of query (75.5 bits)
4cqmF / Q8N4T8 Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP (see paper)
24% identity, 100% coverage of query (75.1 bits)
5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
28% identity, 98% coverage of query (75.1 bits)
2bfpA Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin
27% identity, 97% coverage of query (75.1 bits)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH
27% identity, 97% coverage of query (75.1 bits)
FabG / b1093 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
fabG / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli (strain K12) (see 22 papers)
FABG_ECOLI / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 9 papers)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Escherichia coli (see 2 papers)
28% identity, 97% coverage of query (74.7 bits)
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+
28% identity, 97% coverage of query (74.7 bits)
7emgB / A0A0G8B235 Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
28% identity, 97% coverage of query (74.3 bits)
6t77A / W9B6I8 Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
27% identity, 97% coverage of query (73.9 bits)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii
26% identity, 98% coverage of query (73.9 bits)
6t62A / V5VHN7 Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
26% identity, 98% coverage of query (73.6 bits)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment
27% identity, 97% coverage of query (73.6 bits)
2bfmA Leishmania major pteridine reductase 1 in complex with NADP and trimethoprim
27% identity, 97% coverage of query (73.2 bits)
4qecA / I6ZQW6 Elxo with NADP bound (see paper)
26% identity, 98% coverage of query (72.4 bits)
3h4vA Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1
27% identity, 97% coverage of query (70.9 bits)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
26% identity, 97% coverage of query (70.5 bits)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
26% identity, 97% coverage of query (70.1 bits)
VC_1059 / Q9KT46 CAI-1 synthase from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
34% identity, 75% coverage of query (69.7 bits)
swb2 / D2KTX1 3-hydroxykynurenate reductase/dehydratase from Streptomyces sp. SNA15896 (see paper)
27% identity, 98% coverage of query (69.7 bits)
6t65C / V5VHN7 Crsytal structure of acinetobacter baumannii fabg inhibitor complex at 2.35 a resolution (see paper)
25% identity, 98% coverage of query (69.7 bits)
7pxxA The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
27% identity, 97% coverage of query (69.7 bits)
5l42A Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
26% identity, 97% coverage of query (69.7 bits)
2qhxA Structure of pteridine reductase from leishmania major complexed with a ligand
27% identity, 97% coverage of query (69.7 bits)
8bcjB / Q9HZ96 Crystal structure of short-chain dehydrogenase pa3128 from pseudomonas aeruginosa pao1 in complex with NADP+
26% identity, 99% coverage of query (69.3 bits)
2qhxC Structure of pteridine reductase from leishmania major complexed with a ligand
26% identity, 97% coverage of query (68.9 bits)
FOX2 / A0A1D8PJ13 D-specific enoyl-CoA hydratase (EC 4.2.1.119; EC 4.2.1.116) from Candida albicans (strain SC5314 / ATCC MYA-2876) (see 2 papers)
26% identity, 88% coverage of query (68.6 bits)
SDRA_ARATH / Q9S9W2 Short-chain dehydrogenase/reductase SDRA; Protein INDOLE-3-BUTYRIC ACID RESPONSE 1; Short-chain dehydrogenase/reductase A; EC 1.1.-.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
26% identity, 97% coverage of query (68.6 bits)
1w0cA / Q01782 Inhibition of leishmania major pteridine reductase (ptr1) by 2,4,6- triaminoquinazoline; structure of the NADP ternary complex. (see paper)
27% identity, 97% coverage of query (68.6 bits)
pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
27% identity, 100% coverage of query (68.6 bits)
7pxxC The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
26% identity, 97% coverage of query (68.6 bits)
5l4nA Leishmania major pteridine reductase 1 (ptr1) in complex with compound 1
26% identity, 97% coverage of query (68.6 bits)
5jdcC Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
26% identity, 97% coverage of query (68.6 bits)
6geyA Trypanosoma brucei ptr1 in complex with inhibitor 4g (f125)
26% identity, 97% coverage of query (68.2 bits)
6gdpA Trypanosoma brucei ptr1 in complex with inhibitor 4l (f162)
26% identity, 97% coverage of query (68.2 bits)
4cm7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (68.2 bits)
NR_NARAP / A0A1C9II22 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus aff. pseudonarcissus MK-2014 (Daffodil) (see paper)
NR_NARPS / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus pseudonarcissus (Daffodil) (see 2 papers)
5ff9B / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and tyramine (see paper)
24% identity, 99% coverage of query (67.8 bits)
6gcqA Trypanosoma brucei ptr1 in complex with inhibitor 2b (f192)
26% identity, 97% coverage of query (67.8 bits)
6gcpA Trypanosoma brucei ptr1 in complex with inhibitor 2d (f186)
26% identity, 97% coverage of query (67.8 bits)
6gckA Trypanosoma brucei ptr1 in complex with inhibitor 1e (f206)
26% identity, 97% coverage of query (67.8 bits)
4cm1A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.8 bits)
5fffA Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and piperonal
24% identity, 99% coverage of query (67.8 bits)
PTR1 / Q01782 pteridine reductase 1 monomer (EC 1.5.1.33; EC 1.5.1.3) from Leishmania major (see 4 papers)
PTR1_LEIMA / Q01782 Pteridine reductase 1; H region methotrexate resistance protein; EC 1.5.1.33 from Leishmania major (see 4 papers)
26% identity, 97% coverage of query (67.4 bits)
4cmjA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4cmcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4cmbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4cm4A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4cm3A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4clxA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4cloA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4cldA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
4cl8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.4 bits)
3mcvA Structure of ptr1 from trypanosoma brucei in ternary complex with 2,4- diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+
26% identity, 97% coverage of query (67.4 bits)
2yhuA Trypanosoma brucei ptr1 in complex with inhibitor whf30
26% identity, 97% coverage of query (67.4 bits)
2x9gA High resolution structure of tbptr1 in complex with pemetrexed
26% identity, 97% coverage of query (67.4 bits)
6rx6A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 4 (nmt- c0026)
25% identity, 97% coverage of query (67.4 bits)
6rx0A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 3 (nmt- c0013)
25% identity, 97% coverage of query (67.4 bits)
6howA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 2a (f219).
25% identity, 97% coverage of query (67.4 bits)
6gexA Trypanosoma brucei ptr1 in complex with inhibitor 2h (f246)
25% identity, 97% coverage of query (67.4 bits)
6gdoA Trypanosoma brucei ptr1 in complex with inhibitor 2g (f240)
25% identity, 97% coverage of query (67.4 bits)
5k6aA Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
25% identity, 97% coverage of query (67.4 bits)
2x9nA High resolution structure of tbptr1 in complex with cyromazine
25% identity, 97% coverage of query (67.4 bits)
6rxcA Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
26% identity, 97% coverage of query (67.0 bits)
4iinA Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from helicobacter pylori 26695 complexed with NAD+
26% identity, 97% coverage of query (67.0 bits)
4cmiA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.0 bits)
4cmgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.0 bits)
4cmaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.0 bits)
4cm6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.0 bits)
4cm5A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 97% coverage of query (67.0 bits)
A0A0G2SJM3 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) from Fimbriaphyllia ancora (see paper)
27% identity, 99% coverage of query (66.2 bits)
FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
24% identity, 98% coverage of query (66.2 bits)
5k6aC Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
25% identity, 97% coverage of query (66.2 bits)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
24% identity, 97% coverage of query (66.2 bits)
A0A2D0WG37 cyclohexanol dehydrogenase (EC 1.1.1.245) from Acidovorax sp. (see paper)
26% identity, 98% coverage of query (65.9 bits)
Q2FZ53 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Staphylococcus aureus (see paper)
24% identity, 98% coverage of query (65.9 bits)
1e7wA One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
27% identity, 97% coverage of query (65.9 bits)
6gd0A Trypanosoma brucei ptr1 in complex with inhibitor 4g (f133)
25% identity, 97% coverage of query (65.5 bits)
7opjA Trypanosoma brucei ptr1 (tbptr1) in complex with pyrimethamine
25% identity, 97% coverage of query (65.5 bits)
6gd4A Trypanosoma brucei ptr1 in complex with inhibitor 4c (f188)
25% identity, 97% coverage of query (65.5 bits)
6gclA Trypanosoma brucei ptr1 in complex with inhibitor 3a (f020)
25% identity, 97% coverage of query (65.5 bits)
4wcdA Trypanosoma brucei ptr1 in complex with inhibitor 10
25% identity, 97% coverage of query (65.5 bits)
4cmkA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (65.5 bits)
4cm8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (65.5 bits)
4clrA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (65.5 bits)
2x9vA High resolution structure of tbptr1 with trimetrexate
25% identity, 97% coverage of query (65.5 bits)
1w0cD Inhibition of leishmania major pteridine reductase (ptr1) by 2,4,6- triaminoquinazoline; structure of the NADP ternary complex.
26% identity, 97% coverage of query (65.5 bits)
1e92D Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
26% identity, 97% coverage of query (65.5 bits)
6rxcD Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
27% identity, 97% coverage of query (65.5 bits)
FABG_RICPR / P50941 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Rickettsia prowazekii (strain Madrid E)
P50941 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Rickettsia prowazekii (see paper)
28% identity, 97% coverage of query (65.1 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
25% identity, 97% coverage of query (65.1 bits)
FOX2_CANTR / P22414 Peroxisomal hydratase-dehydrogenase-epimerase; HDE; Multifunctional beta-oxidation protein; MFP; EC 4.2.1.119; EC 1.1.1.n12 from Candida tropicalis (Yeast) (see paper)
P22414 enoyl-CoA hydratase 2 (EC 4.2.1.119) from Candida tropicalis (see paper)
26% identity, 80% coverage of query (65.1 bits)
novJ / Q9L9F8 NovJ from Streptomyces niveus (see paper)
NOVJ_STRNV / Q9L9F8 Short-chain reductase protein NovJ; Novobiocin biosynthesis protein J; EC 1.1.1.- from Streptomyces niveus (Streptomyces spheroides) (see paper)
25% identity, 98% coverage of query (65.1 bits)
4nbtA / A9NFJ2 Crystal structure of fabg from acholeplasma laidlawii (see paper)
26% identity, 99% coverage of query (64.7 bits)
Q86RB1 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Plasmodium falciparum (see paper)
24% identity, 98% coverage of query (64.7 bits)
3bmoA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax4)
26% identity, 97% coverage of query (64.7 bits)
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Lawrence Berkeley National Laboratory