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Searching for up to 100 curated homologs for 5207560 FitnessBrowser__PV4:5207560 (369 a.a.)

Found high-coverage hits (≥70%) to 10 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
    34% identity, 95% coverage of query (181 bits)

TC 3.A.1.1.12 / Q9AI63 PalK, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    37% identity, 80% coverage of query (172 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    33% identity, 94% coverage of query (167 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    30% identity, 96% coverage of query (162 bits)

sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    34% identity, 82% coverage of query (152 bits)

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    33% identity, 71% coverage of query (100 bits)

Build an alignment

Build an alignment for 5207560 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

8bwoA Cryo-em structure of nanodisc-reconstituted human mrp4 with e1202q mutation (outward-facing occluded conformation)
    29% identity, 73% coverage of query (89.4 bits)

8j3wA Cryo-em structure of aspirin-bound abcc4
    29% identity, 73% coverage of query (82.8 bits)

8i4cA Cryo-em structure of u46619-bound abcc4
    29% identity, 73% coverage of query (82.8 bits)

8i4aA / O15439 Cryo-em structure of dipyridamole-bound abcc4
    29% identity, 73% coverage of query (82.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory