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Searching for up to 100 curated homologs for 5207773 FitnessBrowser__PV4:5207773 (380 a.a.)

Found high-coverage hits (≥70%) to 61 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1vjoA / Q8YY48 Crystal structure of alanine--glyoxylate aminotransferase (alr1004) from nostoc sp. At 1.70 a resolution (see paper)
    48% identity, 99% coverage of query (357 bits)

Agxt / P09139 serine-pyruvate aminotransferase, mitochondrial subunit (EC 2.6.1.51) from Rattus norvegicus (see 5 papers)
AGT1_RAT / P09139 Alanine--glyoxylate aminotransferase; AGT; Serine--pyruvate aminotransferase, mitochondrial; SPT; EC 2.6.1.44; EC 2.6.1.51 from Rattus norvegicus (Rat) (see 3 papers)
    42% identity, 98% coverage of query (284 bits)

AGT1_RABIT / P31030 Alanine--glyoxylate aminotransferase; AGT; Serine--pyruvate aminotransferase; SPT; EC 2.6.1.44; EC 2.6.1.51 from Oryctolagus cuniculus (Rabbit) (see paper)
    43% identity, 98% coverage of query (282 bits)

3kgwB / O35423 Crystal structure of putative aminotransferase (aah25799.1) from mus musculus at 1.65 a resolution
    40% identity, 98% coverage of query (275 bits)

AGXT1 / P21549 Serine--pyruvate aminotransferase (EC 2.6.1.44; EC 2.6.1.51) from Homo sapiens (see 6 papers)
AGT1_HUMAN / P21549 Alanine--glyoxylate aminotransferase; AGT; Serine--pyruvate aminotransferase; SPT; EC 2.6.1.44; EC 2.6.1.51 from Homo sapiens (Human) (see 26 papers)
    40% identity, 100% coverage of query (275 bits)

1j04A / P21549 Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro (see paper)
    40% identity, 100% coverage of query (275 bits)

6rv0A Human alanine:glyoxylate aminotransferase major allele (agt-ma); with pmp in the active site
    40% identity, 100% coverage of query (275 bits)

5hhyA Structure of human alanine:glyoxylate aminotransferase major allele (agt-ma) showing x-ray induced reduction of plp internal aldimine to 4'-deoxy-piridoxine-phosphate (plr)
    40% identity, 100% coverage of query (275 bits)

3islA / O32148 Crystal structure of ureidoglycine-glyoxylate aminotransferase (pucg) from bacillus subtilis
    38% identity, 97% coverage of query (274 bits)

3kgxA Crystal structure of putative aminotransferase (aah25799.1) from mus musculus at 1.80 a resolution
    40% identity, 98% coverage of query (274 bits)

1h0cA The crystal structure of human alanine:glyoxylate aminotransferase
    40% identity, 100% coverage of query (272 bits)

A2V838 alanine-glyoxylate transaminase (EC 2.6.1.44) from Homo sapiens (see 2 papers)
    40% identity, 100% coverage of query (270 bits)

2hufA / Q3LSM4 Crystal structure of aedes aegypti alanine glyoxylate aminotransferase (see paper)
    40% identity, 98% coverage of query (267 bits)

AGT_AEDAE / Q3LSM4 Alanine--glyoxylate aminotransferase; EC 2.6.1.44 from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see 3 papers)
    40% identity, 98% coverage of query (267 bits)

2huuA Crystal structure of aedes aegypti alanine glyoxylate aminotransferase in complex with alanine
    40% identity, 98% coverage of query (267 bits)

2huiA Crystal structure of aedes aegypti alanine glyoxylate aminotransferase in complex with glyoxylic acid
    40% identity, 98% coverage of query (267 bits)

D8V0F7 (S)-ureidoglycine-glyoxylate transaminase (EC 2.6.1.112) from Bacillus subtilis subsp. subtilis (see paper)
    37% identity, 97% coverage of query (265 bits)

PUCG_BACSU / O32148 (S)-ureidoglycine--glyoxylate transaminase; UGXT; (S)-ureidoglycine--glyoxylate aminotransferase; Purine catabolism protein PucG; EC 2.6.1.112 from Bacillus subtilis (strain 168) (see 2 papers)
    37% identity, 97% coverage of query (265 bits)

2ch1A / Q7PRG3 Structure of anopheles gambiae 3-hydroxykynurenine transaminase (see paper)
    37% identity, 98% coverage of query (263 bits)

HKT_ANOGA / Q7PRG3 3-hydroxykynurenine transaminase; AgHKT; Alanine--glyoxylate aminotransferase; EC 2.6.1.63; EC 2.6.1.44 from Anopheles gambiae (African malaria mosquito) (see 2 papers)
    37% identity, 98% coverage of query (263 bits)

2ch2A Structure of the anopheles gambiae 3-hydroxykynurenine transaminase in complex with inhibitor
    37% identity, 98% coverage of query (263 bits)

6mfbD / Q0IG34 Crystal structure of 3-hydroxykynurenine transaminase from aedes aegypti
    36% identity, 98% coverage of query (258 bits)

HKT_AEDAE / Q0IG34 3-hydroxykynurenine transaminase; 3-hydroxykynurenine transaminase and alanine--glyoxylate aminotransferase; Ae-HKT/AGT; Alanine--glyoxylate aminotransferase; EC 2.6.1.63; EC 2.6.1.44 from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see 2 papers)
    36% identity, 98% coverage of query (256 bits)

AGT_DROME / Q9W3Z3 Alanine--glyoxylate aminotransferase; AGT; EC 2.6.1.44 from Drosophila melanogaster (Fruit fly) (see 2 papers)
    38% identity, 98% coverage of query (253 bits)

hpxJ / A6T9C2 ureidoglycine aminotransferase subunit from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) (see paper)
    36% identity, 98% coverage of query (236 bits)

SAT_THEMA / Q9X1C0 Serine-pyruvate aminotransferase; SAT; EC 2.6.1.51 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    34% identity, 97% coverage of query (216 bits)

serC / Q58369 phosphoserine aminotransferase monomer (EC 2.6.1.1; EC 2.6.1.52) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
    36% identity, 94% coverage of query (214 bits)

BHCA_PARDP / A1B8Z3 L-aspartate--glyoxylate aminotransferase; EC 2.6.1.35 from Paracoccus denitrificans (strain Pd 1222) (see paper)
    33% identity, 90% coverage of query (191 bits)

2dr1A / O59033 Crystal structure of the ph1308 protein from pyrococcus horikoshii ot3
    31% identity, 97% coverage of query (185 bits)

2yriA / Q5SLX0 Crystal structure of alanine-pyruvate aminotransferase with 2- methylserine
    36% identity, 96% coverage of query (179 bits)

2yrrA Hypothetical alanine aminotransferase (tth0173) from thermus thermophilus hb8
    36% identity, 96% coverage of query (179 bits)

serC / P74281 serine—glyoxylate transaminase (EC 2.6.1.52) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
P74281 phosphoserine transaminase (EC 2.6.1.52) from Synechocystis sp. (see paper)
    33% identity, 96% coverage of query (176 bits)

G4T3S7 serine-glyoxylate transaminase (EC 2.6.1.45) from Methylotuvimicrobium alcaliphilum (see paper)
    34% identity, 91% coverage of query (169 bits)

rhiJ / D4HRI8 L-α-amino acid transaminase from Bacillus subtilis subsp. spizizenii ATCC 6633 (see paper)
    34% identity, 91% coverage of query (160 bits)

Build an alignment

Build an alignment for 5207773 and 34 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

6pk3B / Q56YA5 Alanine-glyoxylate aminotransferase 1 (agt1) from arabidopsis thaliana (see paper)
    28% identity, 98% coverage of query (154 bits)

AGT1 / Q56YA5 serine:glyoxylate aminotransferase (EC 2.6.1.45; EC 2.6.1.4) from Arabidopsis thaliana (see 2 papers)
SGAT_ARATH / Q56YA5 Serine--glyoxylate aminotransferase; Alanine--glyoxylate aminotransferase; AGT; Asparagine aminotransferase; Serine--pyruvate aminotransferase; EC 2.6.1.45; EC 2.6.1.44; EC 2.6.1.-; EC 2.6.1.51 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
Q56YA5 asparagine-oxo-acid transaminase (EC 2.6.1.14); alanine-glyoxylate transaminase (EC 2.6.1.44); serine-glyoxylate transaminase (EC 2.6.1.45) from Arabidopsis thaliana (see 5 papers)
    28% identity, 98% coverage of query (154 bits)

sgaA / O08374 serine-glyoxylate aminotransferase subunit (EC 2.6.1.45) from Hyphomicrobium methylovorum (see 2 papers)
SGAA_HYPME / O08374 Serine--glyoxylate aminotransferase; SGAT; EC 2.6.1.45 from Hyphomicrobium methylovorum (see paper)
    31% identity, 91% coverage of query (154 bits)

6pk1A Alanine-glyoxylate aminotransferase 1 (agt1) from arabidopsis thaliana in presence of serine
    28% identity, 98% coverage of query (154 bits)

CH_124276 putative alanine-glyoxylate aminotransferase 1 (C. neoformans) from Magnaporthe grisea 70-15 (see paper)
    29% identity, 97% coverage of query (150 bits)

SGAA_METEA / P55819 Serine--glyoxylate aminotransferase; SGAT; EC 2.6.1.45 from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (Methylobacterium extorquens) (see paper)
    30% identity, 92% coverage of query (148 bits)

Q608T3 serine-glyoxylate transaminase (EC 2.6.1.45) from Methylococcus capsulatus (see paper)
    34% identity, 92% coverage of query (144 bits)

D2Z0H9 glycine transaminase (EC 2.6.1.4) from Hydrogenobacter thermophilus (see paper)
    31% identity, 96% coverage of query (142 bits)

dhpH / D7PC20 1-amino-2-phosphorylethylphosphonate leucinyltransferase from Streptomyces luridus (see 2 papers)
    32% identity, 89% coverage of query (140 bits)

ppat / Q988B8 pyridoxamine-pyruvate aminotransferase subunit (EC 2.6.1.30) from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (see 9 papers)
PPAT_RHILO / Q988B8 Pyridoxamine--pyruvate transaminase; Pyridoxamine-pyruvate aminotransferase; EC 2.6.1.30 from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099)) (see 2 papers)
Q988B8 pyridoxamine-pyruvate transaminase (EC 2.6.1.30) from Mesorhizobium japonicum (see paper)
    28% identity, 95% coverage of query (135 bits)

2z9vA / Q988B8 Crystal structure of pyridoxamine-pyruvate aminotransferase complexed with pyridoxamine (see paper)
    28% identity, 95% coverage of query (135 bits)

2z9xA Crystal structure of pyridoxamine-pyruvate aminotransferase complexed with pyridoxyl-l-alanine
    28% identity, 95% coverage of query (135 bits)

2z9wA Crystal structure of pyridoxamine-pyruvate aminotransferase complexed with pyridoxal
    28% identity, 95% coverage of query (135 bits)

1iugA / P83786 The crystal structure of aspartate aminotransferase which belongs to subgroup iv from thermus thermophilus (see paper)
    34% identity, 96% coverage of query (133 bits)

3zrqA / Q97VM5 Crystal structure and substrate specificity of a thermophilic archaeal serine : pyruvate aminotransferase from sulfolobus solfataricus (see paper)
    29% identity, 96% coverage of query (131 bits)

Q97VM5 serine-pyruvate transaminase (EC 2.6.1.51) from Saccharolobus solfataricus (see paper)
    29% identity, 96% coverage of query (131 bits)

3zrrA Crystal structure and substrate specificity of a thermophilic archaeal serine : pyruvate aminotransferase from sulfolobus solfataricus
    29% identity, 96% coverage of query (130 bits)

3zrpA Crystal structure and substrate specificity of a thermophilic archaeal serine : pyruvate aminotransferase from sulfolobus solfataricus
    29% identity, 95% coverage of query (129 bits)

aepZ / Q5LE55 2-aminoethylphosphonate—pyruvate transaminase monomer (EC 2.6.1.37) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) (see 4 papers)
    26% identity, 78% coverage of query (112 bits)

AGX1 / P43567 alanine--glyoxylate aminotransferase subunit (EC 2.6.1.44) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
AGX1_YEAST / P43567 Alanine--glyoxylate aminotransferase 1; EC 2.6.1.44 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    28% identity, 93% coverage of query (108 bits)

2bkwA / P43567 Yeast alanine:glyoxylate aminotransferase yfl030w (see paper)
    28% identity, 93% coverage of query (108 bits)

1m32B / P96060 Crystal structure of 2-aminoethylphosphonate transaminase (see paper)
    28% identity, 81% coverage of query (103 bits)

PHNW_SALTY / P96060 2-aminoethylphosphonate--pyruvate transaminase; 2-aminoethylphosphonate aminotransferase; AEP transaminase; AEPT; EC 2.6.1.37 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
    28% identity, 81% coverage of query (103 bits)

1m32A Crystal structure of 2-aminoethylphosphonate transaminase
    28% identity, 81% coverage of query (103 bits)

PNTCW_TREDE / Q73MU2 Bifunctional 2-aminoethylphosphonate cytidylyltransferase/aminotransferase; EC 2.7.7.107; EC 2.6.1.37 from Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) (see paper)
6pd2C / Q73MU2 Pntc-aept: fusion protein of phosphonate-specific cytidylyltransferase and 2-aminoethylphosphonate (aep) transaminase from treponema denticola in complex with cytidine monophosphate-aep (see paper)
    27% identity, 82% coverage of query (100 bits)

rtxA / Q93HS5 dihydrorhizobitoxine synthase from Bradyrhizobium elkanii (see 5 papers)
    28% identity, 76% coverage of query (95.9 bits)

rtxA / AAA03070.1 aminotransferase and dihydrorhizobitoxine synthase from Bradyrhizobium japonicum (see 2 papers)
    29% identity, 76% coverage of query (94.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory