Searching for up to 100 curated homologs for 5208037 FitnessBrowser__PV4:5208037 (308 a.a.)
Found high-coverage hits (≥70%) to 63 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Sama_3039 Phosphoglycerate dehydrogenase (EC 1.1.1.95) from Shewanella amazonensis SB2B
74% identity, 100% coverage of query (474 bits)
ddh / Q2VEQ7 (D)-2-hydroxyacid dehydrogenase (NADP+) monomer (EC 1.1.1.272) from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (see paper)
DDH_HALMT / Q2VEQ7 D-2-hydroxyacid dehydrogenase; D2-HDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.- from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) (see paper)
Q2VEQ7 D-2-hydroxyacid dehydrogenase (NADP+) (EC 1.1.1.272) from Haloferax mediterranei (see 3 papers)
5mh5A / Q2VEQ7 D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-keto-hexanoic acid and NADP+ (1.4 a resolution)
31% identity, 79% coverage of query (125 bits)
5mhaB D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
31% identity, 79% coverage of query (125 bits)
5mhaA D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
31% identity, 79% coverage of query (125 bits)
5mh6A D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-ketohexanoic acid and NAD+ (1.35 a resolution)
31% identity, 79% coverage of query (125 bits)
5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
31% identity, 90% coverage of query (120 bits)
3kboA / Q8ZQ30 2.14 angstrom crystal structure of putative oxidoreductase (ycdw) from salmonella typhimurium in complex with NADP
32% identity, 71% coverage of query (117 bits)
7jqhA / A0A140NAE3 Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with phosphate and NADP+
33% identity, 71% coverage of query (116 bits)
GhrA / b1033 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ghrA / P75913 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli (strain K12) (see 4 papers)
GHRA_ECOLI / P75913 Glyoxylate/hydroxypyruvate reductase A; 2-ketoacid reductase; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli (strain K12) (see paper)
33% identity, 71% coverage of query (116 bits)
7jqiA Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with alpha-ketoglutarate and NADP+
33% identity, 71% coverage of query (116 bits)
6p35A 2.5 angstrom structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with 2-keto arginine and NADP
33% identity, 71% coverage of query (116 bits)
5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
32% identity, 75% coverage of query (101 bits)
Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
32% identity, 75% coverage of query (101 bits)
Q92T34 hydroxypyruvate reductase (EC 1.1.1.81) from Sinorhizobium meliloti (see paper)
30% identity, 87% coverage of query (99.8 bits)
4weqA / Q92T34 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADP and sulfate (see paper)
30% identity, 87% coverage of query (99.8 bits)
4z0pA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADPH and oxalate
30% identity, 87% coverage of query (99.8 bits)
Build an alignment for 5208037 and 16 homologs with ≥ 30% identity
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4zqbB / Q3IWN8 Crystal structure of NADP-dependent dehydrogenase from rhodobactersphaeroides in complex with NADP and sulfate
28% identity, 80% coverage of query (99.0 bits)
HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
29% identity, 84% coverage of query (97.8 bits)
GYAR_THELN / Q9C4M5 Glyoxylate reductase; EC 1.1.1.26 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
Q9C4M5 glyoxylate reductase (EC 1.1.1.26) from Thermococcus litoralis (see paper)
30% identity, 86% coverage of query (94.4 bits)
kguD / Q5TM04 2-dehydro-6-phosphogluconate reductase (EC 1.1.1.43) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see 2 papers)
30% identity, 74% coverage of query (92.8 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
25% identity, 81% coverage of query (91.3 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
25% identity, 81% coverage of query (90.9 bits)
5bqfA / Q2KDT2 Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADP, hepes and l(+)-tartaric acid
28% identity, 84% coverage of query (90.5 bits)
4xcvA Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH
28% identity, 84% coverage of query (90.5 bits)
5tsdA Crystal structure of NADPH-dependent 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH and oxalate
28% identity, 84% coverage of query (90.5 bits)
BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
29% identity, 81% coverage of query (87.4 bits)
HPR3 / Q9LE33 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 8 papers)
HPR3_ARATH / Q9LE33 Glyoxylate/hydroxypyruvate reductase HPR3; NAD(P)H-dependent hydroxypyruvate reductase 3; AtHPR3; HPR 3; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LE33 hydroxyphenylpyruvate reductase (EC 1.1.1.237); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 3 papers)
24% identity, 84% coverage of query (84.3 bits)
Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor (see paper)
25% identity, 88% coverage of query (83.6 bits)
Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
27% identity, 83% coverage of query (82.0 bits)
SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
27% identity, 83% coverage of query (81.6 bits)
PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
27% identity, 83% coverage of query (81.6 bits)
1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
26% identity, 84% coverage of query (81.3 bits)
A0A178WMD4 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 2 papers)
23% identity, 84% coverage of query (81.3 bits)
A0A0A7RFJ3 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Salvia miltiorrhiza (see paper)
23% identity, 81% coverage of query (80.9 bits)
hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
26% identity, 81% coverage of query (80.1 bits)
Q92LZ4 hydroxypyruvate reductase (EC 1.1.1.81) from Sinorhizobium meliloti (see paper)
29% identity, 76% coverage of query (79.3 bits)
5v6qB / Q92LZ4 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and malonate (see paper)
29% identity, 76% coverage of query (79.3 bits)
5j23A Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with 2'-phospho-adp-ribose
29% identity, 76% coverage of query (79.3 bits)
5v7nA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and 2-keto-d-gluconic acid
29% identity, 76% coverage of query (79.3 bits)
5v7gA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADPH and oxalate
29% identity, 76% coverage of query (79.3 bits)
Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
29% identity, 70% coverage of query (78.2 bits)
6plfA Crystal structure of human phgdh complexed with compound 1
26% identity, 80% coverage of query (77.0 bits)
6plfB Crystal structure of human phgdh complexed with compound 1
27% identity, 75% coverage of query (76.6 bits)
7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
26% identity, 75% coverage of query (75.1 bits)
6rj2A Crystal structure of phgdh in complex with compound 40
26% identity, 75% coverage of query (75.1 bits)
6plgA Crystal structure of human phgdh complexed with compound 15
26% identity, 75% coverage of query (75.1 bits)
6rj3A Crystal structure of phgdh in complex with compound 15
26% identity, 75% coverage of query (75.1 bits)
7ewhA Crystal structure of human phgdh in complex with homoharringtonine
26% identity, 75% coverage of query (75.1 bits)
6rihA Crystal structure of phgdh in complex with compound 9
26% identity, 75% coverage of query (75.1 bits)
6rj5A Crystal structure of phgdh in complex with compound 39
26% identity, 75% coverage of query (75.1 bits)
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
26% identity, 75% coverage of query (75.1 bits)
Q608T2 hydroxypyruvate reductase (EC 1.1.1.81) from Methylococcus capsulatus (see paper)
26% identity, 86% coverage of query (73.9 bits)
6p2iA Acyclic imino acid reductase (bsp5) in complex with NADPH and d-arg (see paper)
26% identity, 77% coverage of query (73.9 bits)
2w2lA / Q7LLW9 Crystal structure of the holo forms of rhodotorula graminis d- mandelate dehydrogenase at 2.5a.
27% identity, 81% coverage of query (63.5 bits)
6ttbA / A0A0H3JSR9 Crystal structure of NAD-dependent formate dehydrogenase from staphylococcus aureus in complex with NAD
25% identity, 71% coverage of query (60.5 bits)
5dt9A / Q9KQ92 Crystal structure of a putative d-erythronate-4-phosphate dehydrogenase from vibrio cholerae
25% identity, 87% coverage of query (55.1 bits)
FDH_PSESR / P33160 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Pseudomonas sp. (strain 101) (Achromobacter parvulus T1) (see 2 papers)
P33160 formate dehydrogenase (EC 1.17.1.9) from Pseudomonas sp. 101 (see paper)
22% identity, 81% coverage of query (54.7 bits)
2nadA High resolution structures of holo and apo formate dehydrogenase
22% identity, 81% coverage of query (54.7 bits)
3wr5A / Q76EB7 Structural basis on the efficient co2 reduction of acidophilic formate dehydrogenase
22% identity, 81% coverage of query (53.9 bits)
5z20F / Q9I530 The ternary structure of d-lactate dehydrogenase from pseudomonas aeruginosa with nadh and oxamate (see paper)
26% identity, 75% coverage of query (52.8 bits)
6jujA Crystal structure of formate dehydrogenase mutant v198i/c256i/p260s/e261p/s381n/s383f from pseudomonas sp. 101in complex with non-natural cofactor nicotinamide cytosine dinucleotide
22% identity, 81% coverage of query (51.2 bits)
6d4bA / A0A0A1EQY0 Crystal structure of candida boidinii formate dehydrogenase v123a mutant complexed with NAD+ and azide
22% identity, 90% coverage of query (48.1 bits)
FDH1_YEASC / N1P3Y5 Formate dehydrogenase 1; FDH 1; NAD-dependent formate dehydrogenase 1; EC 1.17.1.9 from Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) (see paper)
FDH1_YEAST / Q08911 Formate dehydrogenase 1; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
20% identity, 91% coverage of query (47.4 bits)
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