Searching for up to 100 curated homologs for 5208569 FitnessBrowser__PV4:5208569 (316 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ThrB / b0003 homoserine kinase (EC 2.7.1.39) from Escherichia coli K-12 substr. MG1655 (see paper)
thrB / P00547 homoserine kinase (EC 2.7.1.39) from Escherichia coli (strain K12) (see 9 papers)
KHSE_ECOLI / P00547 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Escherichia coli (strain K12) (see paper)
thrB / GB|BAB96580.2 homoserine kinase; EC 2.7.1.39 from Escherichia coli (see 2 papers)
    56% identity, 98% coverage of query (362 bits)

thrB / CAA43213.1 homoserine kinase from Serratia marcescens (see paper)
    56% identity, 97% coverage of query (362 bits)

Echvi_2001 homoserine kinase (EC 2.7.1.39) from Echinicola vietnamensis KMM 6221, DSM 17526
    36% identity, 89% coverage of query (130 bits)

CA265_RS23470 homoserine kinase (EC 2.7.1.39) from Pedobacter sp. GW460-11-11-14-LB5
    33% identity, 88% coverage of query (114 bits)

hsk / Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana (see paper)
KHSE_ARATH / Q8L7R2 Homoserine kinase; Protein DOWNY MILDEW RESISTANT 1; EC 2.7.1.39 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana (see 4 papers)
    35% identity, 99% coverage of query (105 bits)

N515DRAFT_0576 homoserine kinase (EC 2.7.1.39) from Dyella japonica UNC79MFTsu3.2
    37% identity, 85% coverage of query (104 bits)

KHSE_METMP / Q6M0H5 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Methanococcus maripaludis (strain S2 / LL) (see paper)
    31% identity, 85% coverage of query (92.0 bits)

thrB / Q58504 homoserine kinase monomer (EC 2.7.1.39) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
1fwkA / Q58504 Crystal structure of homoserine kinase complexed with adp (see paper)
    30% identity, 85% coverage of query (84.0 bits)

1h74B Crystal structure of homoserine kinase complexed with ile
    30% identity, 85% coverage of query (84.0 bits)

1h74A Crystal structure of homoserine kinase complexed with ile
    30% identity, 85% coverage of query (84.0 bits)

1h73A Crystal structure of homoserine kinase complexed with threonine
    30% identity, 85% coverage of query (84.0 bits)

1h72C Crystal structure of homoserine kinase complexed with hse
    30% identity, 85% coverage of query (84.0 bits)

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Build an alignment for 5208569 and 12 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

P07128 homoserine kinase (EC 2.7.1.39) from Corynebacterium glutamicum (see paper)
    28% identity, 84% coverage of query (68.2 bits)

6cyzA / B1MLU6 Mycobacterial homoserine kinase thrb in complex with amppnp
    29% identity, 86% coverage of query (63.2 bits)

KHSE_YEAST / P17423 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
THR1 / AAA35154.1 homoserine kinase from Saccharomyces cerevisiae (see paper)
    24% identity, 87% coverage of query (61.2 bits)

Q4Q6Y2 homoserine kinase (EC 2.7.1.39) from Leishmania major (see paper)
    25% identity, 84% coverage of query (55.5 bits)

2v2qB / O67060 Ispe in complex with ligand (see paper)
    23% identity, 71% coverage of query (48.9 bits)

O67060 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) from Aquifex aeolicus (see paper)
    23% identity, 71% coverage of query (48.9 bits)

2v8pA Ispe in complex with adp and cdp
    23% identity, 71% coverage of query (48.9 bits)

2v34B Ispe in complex with cytidine and ligand
    23% identity, 71% coverage of query (48.9 bits)

2v2vA Ispe in complex with ligand
    23% identity, 71% coverage of query (48.9 bits)

2vf3A Aquifex aeolicus ispe in complex with ligand
    23% identity, 71% coverage of query (48.5 bits)

2v34A Ispe in complex with cytidine and ligand
    23% identity, 71% coverage of query (48.5 bits)

2v2zA Ispe in complex with adp and cdpme
    23% identity, 71% coverage of query (48.5 bits)

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