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Searching for up to 100 curated homologs for 5208938 FitnessBrowser__PV4:5208938 (214 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SO1671 Maleylacetoacetate isomerase (EC 5.2.1.2) from Shewanella oneidensis MR-1
    67% identity, 100% coverage of query (304 bits)

Psest_3511 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas stutzeri RCH2
    56% identity, 100% coverage of query (237 bits)

Ac3H11_2306 Maleylacetoacetate isomerase (EC 5.2.1.2) from Acidovorax sp. GW101-3H11
    50% identity, 99% coverage of query (207 bits)

Q5K5T6 glutathione transferase subunit (EC 2.5.1.18) from Escherichia coli (see 8 papers)
    47% identity, 99% coverage of query (193 bits)

2v6kA / O86043 Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
    48% identity, 100% coverage of query (193 bits)

nagL / O86043 glutathion-dependent maleylpyruvate isomerase (EC 5.2.1.4) from Ralstonia sp. (see paper)
NAGL_RALSP / O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see 2 papers)
    48% identity, 100% coverage of query (192 bits)

2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class
    48% identity, 100% coverage of query (192 bits)

1fw1A / O43708 Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
    48% identity, 99% coverage of query (186 bits)

2cz2A / Q9WVL0 Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
    46% identity, 99% coverage of query (182 bits)

GSTZ1 / O43708 maleylacetoacetate isomerase/glutathione transferase ζ monomer (EC 2.5.1.18; EC 5.2.1.2) from Homo sapiens (see 11 papers)
MAAI_HUMAN / O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 3 papers)
O43708 glutathione transferase (EC 2.5.1.18); maleylacetoacetate isomerase (EC 5.2.1.2) from Homo sapiens (see 8 papers)
    47% identity, 99% coverage of query (182 bits)

Q9WVL0 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Mus musculus (Mouse)
    46% identity, 99% coverage of query (182 bits)

MAAI_RAT / P57113 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Rattus norvegicus (Rat) (see paper)
    46% identity, 99% coverage of query (180 bits)

MAAI2_DROME / Q9VHD2 Probable maleylacetoacetate isomerase 2; MAAI 2; Glutathione S-transferase zeta 2; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    45% identity, 99% coverage of query (176 bits)

GSTZ1_ARATH / Q9ZVQ3 Glutathione S-transferase Z1; AtGSTZ1; GST class-zeta member 1; Glutathione S-transferase 18; Maleylacetone isomerase; MAI; EC 2.5.1.18; EC 5.2.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    43% identity, 100% coverage of query (159 bits)

MAAI1_DROME / Q9VHD3 Probable maleylacetoacetate isomerase 1; MAAI 1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    39% identity, 99% coverage of query (156 bits)

Pf6N2E2_5292 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E2
    44% identity, 99% coverage of query (155 bits)

AO353_15560 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E3
    42% identity, 99% coverage of query (155 bits)

AO356_16835 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2C3
    44% identity, 99% coverage of query (154 bits)

4pxoA / C5ATQ9 Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
    40% identity, 100% coverage of query (148 bits)

3n5oA / D2YW48 Crystal structure of putative glutathione transferase from coccidioides immitis bound to glutathione (see paper)
    39% identity, 100% coverage of query (142 bits)

D2YW48 Probable glutathione S-transferase; EC 2.5.1.18 from Coccidioides immitis (strain RS) (Valley fever fungus)
    39% identity, 100% coverage of query (142 bits)

O04437 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    38% identity, 99% coverage of query (140 bits)

4kdyA / B8J605 Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound gsh in the active site
    38% identity, 100% coverage of query (134 bits)

MAIA_ASPFU / Q4WHT7 Maleylacetoacetate isomerase maiA; EC 5.2.1.2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    38% identity, 94% coverage of query (134 bits)

4kaeA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound dicarboxyethyl glutathione and citrate in the active site
    38% identity, 100% coverage of query (134 bits)

maiA / O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (see paper)
MAAI_EMENI / O43123 Maleylacetoacetate isomerase; MAAI; EC 5.2.1.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Aspergillus nidulans (see paper)
GI|2832725 maleylacetoacetate isomerase; EC 5.2.1.2 from Emericella nidulans (see paper)
maiA / CAA05041.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
maiA / CAA05044.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
    37% identity, 90% coverage of query (132 bits)

GSTD2_DROME / Q9VG98 Glutathione S-transferase D2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
Q9VG98 glutathione transferase (EC 2.5.1.18) from Drosophila melanogaster (see paper)
    33% identity, 83% coverage of query (77.8 bits)

Q8N0B3 glutathione transferase (EC 2.5.1.18) from Nilaparvata lugens (see paper)
    36% identity, 84% coverage of query (72.4 bits)

3wywB / Q8N0B3 Structural characterization of catalytic site of a nilaparvata lugens delta-class glutathione transferase (see paper)
    36% identity, 84% coverage of query (72.4 bits)

Build an alignment

Build an alignment for 5208938 and 29 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

GSTD3_DROME / Q9VG97 Inactive glutathione S-transferase D3 from Drosophila melanogaster (Fruit fly) (see paper)
    28% identity, 83% coverage of query (71.6 bits)

5zwpA / P28338 Crystal structure of the delta-class glutathione transferase from musca domestica (see paper)
    29% identity, 89% coverage of query (71.2 bits)

GSTD7_DROME / Q9VG93 Glutathione S-transferase D7; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    28% identity, 86% coverage of query (70.1 bits)

GSTD4_DROME / Q9VG96 Glutathione S-transferase D4; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    28% identity, 91% coverage of query (68.9 bits)

GSTD5_DROME / Q9VG95 Glutathione S-transferase D5; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    31% identity, 75% coverage of query (68.2 bits)

GSTD1_DROME / P20432 Glutathione S-transferase D1; DDT-dehydrochlorinase; EC 2.5.1.18; EC 4.5.1.1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
    29% identity, 86% coverage of query (67.8 bits)

3makA / P20432 Crystal structure of glutathione transferase dmgstd1 from drosophila melanogaster, in complex with glutathione (see paper)
    29% identity, 86% coverage of query (67.8 bits)

P42860 glutathione transferase (EC 2.5.1.18) from Lucilia cuprina (see paper)
    28% identity, 91% coverage of query (66.6 bits)

7rhpA / A0A7M7GUY7 Crystal structure of honeybee (apis mellifera) glutathione s- transferase amgstd1 (see paper)
    31% identity, 82% coverage of query (66.2 bits)

GST1 / AAA29287.1 glutathione transferase from Lucilia cuprina (see paper)
    29% identity, 86% coverage of query (66.2 bits)

Q60GK5 glutathione transferase (EC 2.5.1.18) from Bombyx mori (see paper)
    32% identity, 74% coverage of query (64.3 bits)

3m3mA / Q4K8I0 Crystal structure of glutathione s-transferase from pseudomonas fluorescens [pf-5]
    27% identity, 88% coverage of query (63.9 bits)

7dazA Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp015- and gsh-bound form
    29% identity, 91% coverage of query (63.9 bits)

7db4A Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp012- and glutathione-bound form
    29% identity, 91% coverage of query (63.9 bits)

6keoAA Glutathione S-transferase E14
    29% identity, 91% coverage of query (63.9 bits)

7db3A Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp011-bound form
    29% identity, 91% coverage of query (63.9 bits)

7db0A Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in dimedone-bound form
    29% identity, 91% coverage of query (63.9 bits)

7daxA Crystal structure of drosophila melanogaster noppera-bo, glutathione s-transferase epsilon 14 (dmgste14), in tdp013-bound form
    29% identity, 91% coverage of query (63.9 bits)

6t2tA / Q7JYX0 Crystal structure of drosophila melanogaster glutathione s-transferase epsilon 14 in complex with glutathione and 2-methyl-2,4-pentanediol (see paper)
    29% identity, 91% coverage of query (62.8 bits)

GSTEE_DROME / Q7JYX0 Glutathione S-transferase E14; Protein noppera-bo; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see 3 papers)
    29% identity, 91% coverage of query (62.8 bits)

GSTD6_DROME / Q9VG94 Glutathione S-transferase D6; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    24% identity, 86% coverage of query (62.8 bits)

GSTF3_MAIZE / P04907 Glutathione S-transferase 3; GST class-phi member 3; GST-III; EC 2.5.1.18 from Zea mays (Maize) (see 2 papers)
    31% identity, 94% coverage of query (62.4 bits)

4i97A / R4S8C5 The crystal structure of glutathione s-transferase sniggstd1a from scaptomyza nigrita in complex with glutathione
    27% identity, 83% coverage of query (58.9 bits)

3qawA / B9VX79 Crystal structure of a glutathione-s-transferase from antarctic clam laternula elliptica in a complex with glutathione (see paper)
    25% identity, 99% coverage of query (57.0 bits)

7rkaA / A0A1P8PEY0 Crystal structure analysis of colorado potato beetle glutathione-s transferase ldgstu1 (see paper)
    28% identity, 87% coverage of query (57.0 bits)

Pog / b3229 stringent starvation protein A from Escherichia coli K-12 substr. MG1655 (see 8 papers)
TC 1.A.12.3.1 / P0ACA3 The bacterial CLIC homologue, stringent starvation protein A, SspA (212 aas; 0 TMSs) [N-terminal Trx domain; C-terminal glutathione S-transferase (GST) domain] from Escherichia coli (strain K12) (see 5 papers)
sspA stringent starvation protein A from Escherichia coli K12 (see 5 papers)
    29% identity, 81% coverage of query (57.0 bits)

4ielB / Q0B681 Crystal structure of a glutathione s-transferase family protein from burkholderia ambifaria, target efi-507141, with bound glutathione
    31% identity, 75% coverage of query (57.0 bits)

gst3b / CAB38119.1 Glutathione transferase III(b) from Zea mays (see paper)
    34% identity, 78% coverage of query (55.8 bits)

3gh6A / Q9VGA1 Crystal structure of glutathione transferase dmgstd10 from drosophila melanogaster, in complex with glutathione (see paper)
    28% identity, 91% coverage of query (55.8 bits)

Q56AY1 glutathione transferase (EC 2.5.1.18) from Vitis vinifera (see paper)
    30% identity, 81% coverage of query (55.8 bits)

GST1C_ANOGA / Q93112 Glutathione S-transferase 1, isoform C; AgGst1-alpha; Aggst1-5; DDT-dehydrochlorinase; GST class-theta; EC 2.5.1.18; EC 4.5.1.1 from Anopheles gambiae (African malaria mosquito) (see paper)
    27% identity, 90% coverage of query (55.8 bits)

4qq7A / B4E6Q3 Crystal structure of putative stringent starvation protein a from burkholderia cenocepacia with bound glutathione
    29% identity, 80% coverage of query (55.5 bits)

GST1D_ANOGA / Q93113 Glutathione S-transferase 1, isoform D; AgGst1-alpha; Aggst1-1; Aggst1-6; Aggst2-1; DDT-dehydrochlorinase; GST class-theta; EC 2.5.1.18; EC 4.5.1.1 from Anopheles gambiae (African malaria mosquito) (see 3 papers)
1pn9A / Q93113 Crystal structure of an insect delta-class glutathione s-transferase from a ddt-resistant strain of the malaria vector anopheles gambiae (see paper)
GSTd1-6 / CAB03593.1 GSTD1-6 protein, partial from Anopheles gambiae (see 2 papers)
    28% identity, 89% coverage of query (55.1 bits)

GSTd1-5 / CAB03592.1 GSTD1-5 protein from Anopheles gambiae (see 2 papers)
    27% identity, 90% coverage of query (54.7 bits)

Q9FQE8 glutathione transferase (EC 2.5.1.18) from Glycine max (see paper)
    29% identity, 79% coverage of query (54.3 bits)

1jlvA / Q7KIF2 Anopheles dirus species b glutathione s-transferases 1-3 (see paper)
    27% identity, 86% coverage of query (54.3 bits)

4chsA Crystal structure of a tau class glutathione transferase 10 from glycine max
    29% identity, 79% coverage of query (54.3 bits)

gst3a / CAB38118.1 Glutathione transferase III(a) from Zea mays (see paper)
    34% identity, 78% coverage of query (53.9 bits)

4hojA / O33374 Crystal structure of glutathione transferase homolog from neisseria gonorrhoeae, target efi-501841, with bound glutathione
    26% identity, 91% coverage of query (53.9 bits)

GstB / b0838 glutathione S-transferase GstB from Escherichia coli K-12 substr. MG1655 (see 6 papers)
gstB / P0ACA7 glutathione S-transferase GstB from Escherichia coli (strain K12) (see 3 papers)
GSTB_ECOLI / P0ACA7 Glutathione S-transferase GstB; EC 2.5.1.18 from Escherichia coli (strain K12) (see paper)
yliJ / MB|P0ACA7 uncharacterized GST-like protein yliJ from Escherichia coli K12 (see paper)
    28% identity, 72% coverage of query (53.5 bits)

GSTO1_PIG / Q9N1F5 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Sus scrofa (Pig) (see paper)
    28% identity, 75% coverage of query (52.0 bits)

5a4uA / P46422 Atgstf2 from arabidopsis thaliana in complex with indole-3-aldehyde (see paper)
    30% identity, 81% coverage of query (52.0 bits)

GSTF2_ARATH / P46422 Glutathione S-transferase F2; AtGSTF2; 24 kDa auxin-binding protein; AtPM24; GST class-phi member 2; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 10 papers)
    30% identity, 81% coverage of query (52.0 bits)

5a4wA Atgstf2 from arabidopsis thaliana in complex with quercetrin
    30% identity, 81% coverage of query (52.0 bits)

5a4vA Atgstf2 from arabidopsis thaliana in complex with quercetin
    30% identity, 81% coverage of query (52.0 bits)

5a5kA Atgstf2 from arabidopsis thaliana in complex with camalexin
    30% identity, 81% coverage of query (52.0 bits)

1gnwA Structure of glutathione s-transferase
    30% identity, 81% coverage of query (52.0 bits)

1bx9A Glutathione s-transferase in complex with herbicide
    30% identity, 81% coverage of query (52.0 bits)

Q9GN60 glutathione transferase (EC 2.5.1.18) from Anopheles dirus (see 2 papers)
    26% identity, 91% coverage of query (51.6 bits)

GSTFA_ARATH / P42761 Glutathione S-transferase F10; AtGSTF10; AtGSTF4; GST class-phi member 10; Protein EARLY RESPONSE TO DEHYDRATION 13; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    30% identity, 76% coverage of query (51.6 bits)

3f63A / Q9GN60 Crystal structure of a delta class gst (adgstd4-4) from anopheles dirus, in complex with s-hexyl glutathione (see paper)
    26% identity, 91% coverage of query (51.6 bits)

4e8hB / O61996 Structural of bombyx mori glutathione transferase bmgstd1 complex with gtt
    23% identity, 82% coverage of query (49.7 bits)

7dw4A / A0A4Y5R032 Crystal structure of a glutathione s-transferase mutant sbgstu6(i55t) from salix babylonica in complex with glutathione
    29% identity, 79% coverage of query (49.3 bits)

1r5aA / Q9GQG7 Glutathione s-transferase (see paper)
    26% identity, 85% coverage of query (49.3 bits)

8agqA / B9MWW0 Crystal structure of anthocyanin-related gstf8 from populus trichocarpa in complex with (-)-catechin and glutathione (see paper)
    31% identity, 74% coverage of query (49.3 bits)

3g7iB Crystal structure of a delta class gst (adgstd4-4) from anopheles dirus, with glutathione complexed in one subunit
    26% identity, 91% coverage of query (48.9 bits)

5agyA / I1MJ34 Crystal structure of a tau class gst mutant from glycine (see paper)
    28% identity, 79% coverage of query (47.8 bits)

4topA Glycine max glutathione transferase
    28% identity, 79% coverage of query (47.4 bits)

4ecjA Crystal structure of glutathione s-transferase prk13972 (target efi- 501853) from pseudomonas aeruginosa pacs2 complexed with glutathione
    25% identity, 84% coverage of query (47.4 bits)

6tk8AAA f122t variant from alopecurus myosuroides
    29% identity, 84% coverage of query (47.4 bits)

6tahB 6tahB
    25% identity, 84% coverage of query (47.0 bits)

6f01B Arabidopsis thaliana gstf9, gso3 and gsoh bound
    30% identity, 74% coverage of query (47.0 bits)

6ezyB / O80852 Arabidopsis thaliana gstf9, gsh and gsoh bound (see paper)
    30% identity, 74% coverage of query (47.0 bits)

GSTF9_ARATH / O80852 Glutathione S-transferase F9; AtGSTF9; AtGSTF7; GST class-phi member 9; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    30% identity, 74% coverage of query (47.0 bits)

4kh7B / Q8Z859 Crystal structure of a glutathione transferase family member from salmonella enterica ty2, target efi-507262, with bound glutathione
    22% identity, 91% coverage of query (47.0 bits)

3pr8A / Q88RE7 Structure of glutathione s-transferase(pp0183) from pseudomonas putida in complex with gsh
    27% identity, 83% coverage of query (46.2 bits)

4pqiA Crystal structure of glutathione transferase lambda3 from populus trichocarpa (see paper)
    26% identity, 86% coverage of query (46.2 bits)

5f06A / U5GTL0 Crystal structure of glutathione transferase f7 from populus trichocarpa (see paper)
    25% identity, 94% coverage of query (45.4 bits)

3m0fA / Q4KDJ6 Crystal structure of glutathione s transferase in complex with glutathione from pseudomonas fluorescens
    27% identity, 97% coverage of query (45.4 bits)

3touA / Q8XVV6 Crystal structure of glutathione transferase (target efi-501058) from ralstonia solanacearum gmi1000 with gsh bound
    28% identity, 79% coverage of query (45.1 bits)

3zmkB / G0XSZ1 Anopheles funestus glutathione-s-transferase epsilon 2 (gste2) protein structure from different alelles: a single amino acid change confers high level of ddt resistance and cross resistance to permethrin in a major malaria vector in africa (see paper)
    25% identity, 86% coverage of query (43.9 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory