Searching for up to 100 curated homologs for 5209456 Shew_1927 dihydrolipoamide acetyltransferase (RefSeq) (520 a.a.)
Found high-coverage hits (≥70%) to 28 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
HP15_1631 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Marinobacter adhaerens HP15
53% identity, 72% coverage of query (379 bits)
ODB2_BOVIN / P11181 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Bos taurus (Bovine) (see 2 papers)
47% identity, 79% coverage of query (364 bits)
DBT / P11182 branched-chain α-keto acid dehydrogenase complex E2 component subunit (EC 2.3.1.168) from Homo sapiens (see 9 papers)
ODB2_HUMAN / P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; 52 kDa mitochondrial autoantigen of primary biliary cirrhosis; Branched chain 2-oxo-acid dehydrogenase complex component E2; BCOADC-E2; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; BCKDH-E2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Homo sapiens (Human) (see 9 papers)
P11182 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Homo sapiens (see 3 papers)
47% identity, 79% coverage of query (361 bits)
Q98UJ6 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Gallus gallus (see paper)
45% identity, 79% coverage of query (358 bits)
Q8QHL7 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Oncorhynchus mykiss (see paper)
42% identity, 78% coverage of query (324 bits)
ODB2_ARATH / Q9M7Z1 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCE2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; Protein DARK INDUCIBLE 3; EC 2.3.1.168 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
38% identity, 78% coverage of query (301 bits)
ODB2_CAEEL / Q23571 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; Dihydrolipoamide branched-chain transacylase E2; EC 2.3.1.168 from Caenorhabditis elegans (see paper)
40% identity, 78% coverage of query (295 bits)
pdhC / AAC24934.1 dihydrolipoamide acetyltransferase E2 from Bacillus subtilis (see 3 papers)
38% identity, 78% coverage of query (265 bits)
P21883 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; S complex, 48 kDa subunit; EC 2.3.1.12 from Bacillus subtilis (strain 168)
38% identity, 78% coverage of query (265 bits)
PfGW456L13_3542 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Pseudomonas fluorescens GW456-L13
37% identity, 78% coverage of query (261 bits)
Pf6N2E2_479 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Pseudomonas fluorescens FW300-N2E2
37% identity, 78% coverage of query (258 bits)
SMc03203 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Sinorhizobium meliloti 1021
39% identity, 77% coverage of query (249 bits)
P11961 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
37% identity, 78% coverage of query (248 bits)
AceF / b0115 pyruvate dehydrogenase, E2 subunit (EC 2.3.1.12) from Escherichia coli K-12 substr. MG1655 (see 48 papers)
aceF / P06959 pyruvate dehydrogenase E2 subunit (EC 2.3.1.12) from Escherichia coli (strain K12) (see 48 papers)
P06959 pyruvate dehydrogenase system (EC 1.2.1.104); prephenate dehydrogenase (EC 1.3.1.12); dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12) from Escherichia coli (see 6 papers)
AceF-lipoate / ECOCYC|ACEF-LIPOATE pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2 from Escherichia coli K12 (see 2 papers)
aceF / PDB|1QJO dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; EC 2.3.1.12 from Escherichia coli K12 (see 23 papers)
31% identity, 99% coverage of query (208 bits)
P06959 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Escherichia coli (strain K12)
31% identity, 99% coverage of query (208 bits)
ODP2_PSEAE / Q59638 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
31% identity, 98% coverage of query (188 bits)
acoC TPP-dependent acetoin dehydrogenase complex, E2 component, dihydrolipoyllysine-residue acetyltransferase; EC 2.3.1.12 from Clostridium magnum (see paper)
AAA21747.1 dihydrolipoamide acetyltransferase from Clostridium magnum (see paper)
30% identity, 78% coverage of query (186 bits)
P16263 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bacillus subtilis (see paper)
31% identity, 78% coverage of query (185 bits)
Build an alignment for 5209456 and 18 homologs with ≥ 30% identity
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ODP2_MYCTU / P9WIS7 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2; EC 2.3.1.12 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
29% identity, 97% coverage of query (176 bits)
Q6FYD4 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella quintana (see paper)
29% identity, 78% coverage of query (174 bits)
Q9RH46 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Coxiella burnetii (see paper)
28% identity, 78% coverage of query (171 bits)
BKDC_MYCTU / O06159 Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex; Branched-chain alpha-ketoacid dehydrogenase complex component E2; BCKADH E2; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
32% identity, 79% coverage of query (169 bits)
ODP23_ARATH / Q5M729 Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide S-acetyltransferase component 3 of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 3; PDC-E2 3; PDCE2 3; EC 2.3.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
29% identity, 78% coverage of query (166 bits)
Q8GCY1 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella vinsonii (see paper)
28% identity, 78% coverage of query (165 bits)
E2(o) subunit / b0727 dihydrolipoyltranssuccinylase (EC 2.3.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
sucB / P0AFG6 2-oxoglutarate dehydrogenase E2 subunit (EC 2.3.1.61) from Escherichia coli (strain K12) (see paper)
ODO2_ECOLI / P0AFG6 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli (strain K12) (see 3 papers)
P0AFG6 2-oxoglutarate dehydrogenase system (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Escherichia coli (see 6 papers)
SucB-lipoate / ECOCYC|SUCB-LIPOATE dihydrolipoyltranssuccinase from Escherichia coli K12 (see 3 papers)
sucB / PDB|1PMR dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli K12 (see 14 papers)
27% identity, 78% coverage of query (155 bits)
DLAT / P10515 pyruvate dehydrogenase E2 component from Homo sapiens (see 5 papers)
ODP2_HUMAN / P10515 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Homo sapiens (Human) (see 10 papers)
P10515 pyruvate dehydrogenase system (subunit 2/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
26% identity, 98% coverage of query (149 bits)
PDHX / O00330 pyruvate dehydrogenase complex E3-binding protein component from Homo sapiens (see 9 papers)
ODPX_HUMAN / O00330 Pyruvate dehydrogenase protein X component, mitochondrial; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; Lipoyl-containing pyruvate dehydrogenase complex component X; proX from Homo sapiens (Human) (see 8 papers)
O00330 pyruvate dehydrogenase system (subunit 3/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
27% identity, 77% coverage of query (148 bits)
ODP2_BOVIN / P11180 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Bos taurus (Bovine) (see 3 papers)
25% identity, 98% coverage of query (146 bits)
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Lawrence Berkeley National Laboratory