Searching for up to 100 curated homologs for 5209751 FitnessBrowser__PV4:5209751 (206 a.a.)

Found high-coverage hits (≥70%) to 10 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HisE / b2026 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase (EC 3.5.4.19; EC 3.6.1.31) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
hisI / P06989 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase (EC 3.5.4.19; EC 3.6.1.31) from Escherichia coli (strain K12) (see 5 papers)
    61% identity, 93% coverage of query (239 bits)

6j2lA / P37793 Crystal structure of bi-functional enzyme (see paper)
    60% identity, 82% coverage of query (212 bits)

6j2lB Crystal structure of bi-functional enzyme
    56% identity, 82% coverage of query (184 bits)

At-IE / O82768 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19; EC 3.6.1.31) from Arabidopsis thaliana (see paper)
HIS2_ARATH / O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic; Protein HISTIDINE BIOSYNTHESIS 2; EC 3.5.4.19; EC 3.6.1.31 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    36% identity, 95% coverage of query (127 bits)

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway
    37% identity, 94% coverage of query (120 bits)

7bgmA / A0A072U2X9 Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
    34% identity, 94% coverage of query (115 bits)

HIS2_YEAST / P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    33% identity, 98% coverage of query (89.7 bits)

HIS2_SCHPO / O59667 Histidine biosynthesis bifunctional protein his7; EC 3.5.4.19; EC 3.6.1.31 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
his7 / GI|3006138 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase His7; EC 3.5.4.19; EC 3.6.1.31 from Schizosaccharomyces pombe (see 2 papers)
    35% identity, 94% coverage of query (82.8 bits)

A1BPP9 histidinol dehydrogenase (EC 1.1.1.23) from Geotrichum candidum (see paper)
    30% identity, 92% coverage of query (69.3 bits)

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Build an alignment for 5209751 and 9 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

HIS4 multifunctional enzyme that catalyzes three steps of histidine biosynthesis from Candida albicans (see 4 papers)
    28% identity, 92% coverage of query (54.7 bits)

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