Searching for up to 100 curated homologs for 5210113 FitnessBrowser__PV4:5210113 (306 a.a.)
Found high-coverage hits (≥70%) to 60 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GI|164506977 D-bifunctional protein from Toxoplasma gondii (see paper)
42% identity, 80% coverage of query (170 bits)
Hsd17b4 / P97852 peroxisomal multifunctional enzyme type 2 subunit (EC 4.2.1.107) from Rattus norvegicus (see 4 papers)
DHB4_RAT / P97852 Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2; EC 1.1.1.n12; EC 4.2.1.107; EC 4.2.1.119 from Rattus norvegicus (Rat) (see 2 papers)
40% identity, 74% coverage of query (167 bits)
DHB4_MOUSE / P51660 Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2; EC 1.1.1.n12; EC 4.2.1.107; EC 4.2.1.119 from Mus musculus (Mouse) (see paper)
35% identity, 100% coverage of query (166 bits)
1zbqA / P51659 Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 4 in complex with NAD
41% identity, 74% coverage of query (166 bits)
1gz6A (3r)-hydroxyacyl-coa dehydrogenase fragment of rat peroxisomal multifunctional enzyme type 2
41% identity, 74% coverage of query (166 bits)
DHB4_DROME / Q9VXJ0 Peroxisomal multifunctional enzyme type 2; DmMFE-2; EC 1.1.1.n12; EC 4.2.1.119 from Drosophila melanogaster (Fruit fly) (see paper)
40% identity, 79% coverage of query (165 bits)
FOX2 / Q02207 peroxisomal multifunctional enzyme type 2 (EC 4.2.1.119) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
Q02207 enoyl-CoA hydratase 2 (EC 4.2.1.119) from Saccharomyces cerevisiae (see paper)
35% identity, 92% coverage of query (165 bits)
HSD17B4 / P51659 peroxisomal multifunctional enzyme type 2 (EC 4.2.1.119) from Homo sapiens (see 23 papers)
DHB4_HUMAN / P51659 Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2; Short chain dehydrogenase/reductase family 8C member 1; EC 1.1.1.n12; EC 4.2.1.107; EC 4.2.1.119 from Homo sapiens (Human) (see 10 papers)
P51659 enoyl-CoA hydratase 2 (EC 4.2.1.119) from Homo sapiens (see paper)
41% identity, 74% coverage of query (165 bits)
H0YSD6 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) from Taeniopygia guttata (see paper)
35% identity, 94% coverage of query (164 bits)
MFEA_DICDI / Q9NKW1 Peroxisomal multifunctional enzyme A; MFE-A; MFE-1; EC 1.1.1.35 from Dictyostelium discoideum (Social amoeba) (see paper)
32% identity, 95% coverage of query (155 bits)
FOX2 / A0A1D8PJ13 D-specific enoyl-CoA hydratase (EC 4.2.1.119; EC 4.2.1.116) from Candida albicans (strain SC5314 / ATCC MYA-2876) (see 2 papers)
32% identity, 94% coverage of query (148 bits)
FOX2_CANTR / P22414 Peroxisomal hydratase-dehydrogenase-epimerase; HDE; Multifunctional beta-oxidation protein; MFP; EC 4.2.1.119; EC 1.1.1.n12 from Candida tropicalis (Yeast) (see paper)
P22414 enoyl-CoA hydratase 2 (EC 4.2.1.119) from Candida tropicalis (see paper)
32% identity, 89% coverage of query (148 bits)
Y0148_MYCTU / P96825 Putative short-chain type dehydrogenase/reductase Rv0148; EC 1.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
37% identity, 75% coverage of query (148 bits)
MFP1 multifunctional beta-oxidation protein (Peroxisomal hydratase-dehydrogenase-epimerase); EC 4.2.1.-, 1.1.1.- from Magnaporthe grisea 70-15 (see paper)
34% identity, 74% coverage of query (140 bits)
foxA peroxisomal multifunctional beta-oxidation protein from Emericella nidulans (see paper)
32% identity, 92% coverage of query (129 bits)
zgc:113054 / Q5BLE6 gadusol synthase from Danio rerio (see 2 papers)
31% identity, 79% coverage of query (115 bits)
Build an alignment for 5210113 and 16 homologs with ≥ 30% identity
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phaB / BAC45231.1 3-keto-acyl-CoA reductase from Bacillus sp. INT005 (see paper)
29% identity, 77% coverage of query (111 bits)
Q9I1X3 3alpha-hydroxysteroid 3-dehydrogenase (EC 1.1.1.357); 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (EC 1.1.1.50) from Pseudomonas aeruginosa (see paper)
28% identity, 80% coverage of query (106 bits)
FABG_AQUAE / O67610 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Aquifex aeolicus (strain VF5)
31% identity, 81% coverage of query (105 bits)
Q5ZT49 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Legionella pneumophila subsp. pneumophila (see paper)
28% identity, 82% coverage of query (104 bits)
4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
30% identity, 81% coverage of query (104 bits)
fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
28% identity, 79% coverage of query (103 bits)
AT1G24360 / P33207 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic (EC 1.1.1.100) from Arabidopsis thaliana (see paper)
27% identity, 71% coverage of query (100 bits)
SQD_PSEPU / P0DOV5 Sulfoquinovose 1-dehydrogenase; SQ dehydrogenase; EC 1.1.1.390 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
P0DOV5 sulfoquinovose 1-dehydrogenase (EC 1.1.1.390) from Pseudomonas putida (see paper)
29% identity, 77% coverage of query (100 bits)
2ewmB / Q5P5I4 Crystal structure of the (s)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain ebn1 (see paper)
29% identity, 80% coverage of query (99.8 bits)
ped / Q5P5I4 1-phenylethanol dehydrogenase subunit (EC 1.1.1.311) from Aromatoleum aromaticum (strain EbN1) (see paper)
PED_AROAE / Q5P5I4 (S)-1-Phenylethanol dehydrogenase; EC 1.1.1.311 from Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) (see 2 papers)
Q5P5I4 (S)-1-phenylethanol dehydrogenase (EC 1.1.1.311) from Azoarcus sp. (see paper)
ped / CAI07428.1 (S)-1-Phenylethanol dehydrogenase from Aromatoleum aromaticum EbN1 (see 4 papers)
29% identity, 80% coverage of query (99.4 bits)
Q2FZ53 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Staphylococcus aureus (see paper)
28% identity, 79% coverage of query (98.6 bits)
FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
28% identity, 79% coverage of query (98.6 bits)
6d9yB / B2JLJ0 Crystal structure of a short chain dehydrogenase/reductase sdr from burkholderia phymatum with partially occupied NAD
32% identity, 76% coverage of query (98.6 bits)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
29% identity, 79% coverage of query (98.2 bits)
6oz7A / P33368 Putative oxidoreductase from escherichia coli str. K-12
28% identity, 77% coverage of query (95.9 bits)
HdhA / b1619 7-α-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
hdhA / P0AET8 7-α-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Escherichia coli (strain K12) (see 9 papers)
HDHA_ECOLI / P0AET8 7alpha-hydroxysteroid dehydrogenase; 7alpha-HSDH; NAD-dependent 7alpha-hydroxysteroid dehydrogenase; EC 1.1.1.159 from Escherichia coli (strain K12) (see 3 papers)
1ahiA / P0AET8 7 alpha-hydroxysteroid dehydrogenase complexed with nadh and 7-oxo glycochenodeoxycholic acid (see paper)
hdhA 7-alpha-hydroxysteroid dehydrogenase; EC 1.1.1.159 from Escherichia coli K12 (see 6 papers)
28% identity, 79% coverage of query (94.7 bits)
hdhA / Q9S3U5 7α-hydroxysteroid dehydrogenase subunit (EC 1.1.1.159) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) (see paper)
HDHA_BACFN / Q5LA59 7alpha-hydroxysteroid dehydrogenase; 7alpha-HSDH; Aromatic aldehyde reductase; NAD-dependent 7alpha-hydroxysteroid dehydrogenase; EC 1.1.1.159; EC 1.1.1.- from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) (see 2 papers)
Q9S3U5 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Bacteroides fragilis (see paper)
26% identity, 80% coverage of query (94.7 bits)
1ahhA 7 alpha-hydroxysteroid dehydrogenase complexed with NAD+
28% identity, 79% coverage of query (94.7 bits)
2d1yA Crystal structure of tt0321 from thermus thermophilus hb8
29% identity, 75% coverage of query (94.0 bits)
4k6fB / B4EAU4 X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
28% identity, 74% coverage of query (94.0 bits)
8g9vE / Q7Z5P4 Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 (see paper)
27% identity, 71% coverage of query (89.4 bits)
5ha5D Crystal structure of an NAD-bound oxidoreductase from brucella ovis
29% identity, 75% coverage of query (89.0 bits)
8dt1C / A0A1V2Y0M0 Crystal structure of a putative d-beta-hydroxybutyrate dehydrogenase from burkholderia cenocepacia j2315 in complex with NAD
28% identity, 81% coverage of query (88.6 bits)
6ixmC / X2D0L0 Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
27% identity, 78% coverage of query (88.6 bits)
7do7A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NAD and l-rhamnose bound-form)
28% identity, 81% coverage of query (88.2 bits)
7b81A / C1DMX5 Crystal structure of azotobacter vinelandii l-rhamnose 1-dehydrogenase (NAD bound-form) (see paper)
28% identity, 81% coverage of query (88.2 bits)
8g84A / A0A8I3RYU0 Crystal structures of hsd17b13 complexes (see paper)
27% identity, 71% coverage of query (87.4 bits)
8g89A Hsd17b13 in complex with cofactor and inhibitor
27% identity, 71% coverage of query (87.4 bits)
7do6A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NADP bound-form)
28% identity, 81% coverage of query (86.3 bits)
5vt6A / Q3JJT1 Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b complexed with NADP
29% identity, 74% coverage of query (85.5 bits)
5ts3A / C0RKU3 Crystal structure of a 3-oxoacyl-[acyl-carrier protein] reductase with bound NAD from brucella melitensis
30% identity, 77% coverage of query (84.7 bits)
DHB13_HUMAN / Q7Z5P4 17-beta-hydroxysteroid dehydrogenase 13; 17-beta-HSD 13; Hepatic retinol/retinal dehydrogenase; Short chain dehydrogenase/reductase family 16C member 3; Short-chain dehydrogenase/reductase 9; EC 1.1.1.-; EC 1.1.1.62; EC 1.1.1.105 from Homo sapiens (Human) (see 5 papers)
27% identity, 71% coverage of query (84.7 bits)
3tscA / Q73X99 Crystal structure of short chain dehydrogenase map_2410 from mycobacterium paratuberculosis bound to NAD (see paper)
26% identity, 72% coverage of query (83.6 bits)
4cqmF / Q8N4T8 Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP (see paper)
31% identity, 77% coverage of query (83.6 bits)
CBR4 / Q8N4T8 carbonyl reductase family member 4 (EC 1.1.1.100) from Homo sapiens (see 2 papers)
CBR4_HUMAN / Q8N4T8 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; KAR beta subunit; Carbonyl reductase family member 4; CBR4; Quinone reductase CBR4; Short chain dehydrogenase/reductase family 45C member 1; EC 1.1.1.100; EC 1.6.5.10 from Homo sapiens (Human) (see 3 papers)
31% identity, 77% coverage of query (83.2 bits)
7lgbA / O53547 Chsb1 in complex with NAD+ (see paper)
30% identity, 81% coverage of query (80.1 bits)
4fc7A Studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr
27% identity, 78% coverage of query (79.0 bits)
4fc6B / Q9NUI1 Studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr (see paper)
27% identity, 78% coverage of query (79.0 bits)
DECR2_HUMAN / Q9NUI1 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; pDCR; 2,4-dienoyl-CoA reductase 2; Short chain dehydrogenase/reductase family 17C member 1; EC 1.3.1.124 from Homo sapiens (Human) (see 2 papers)
Q9NUI1 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124) from Homo sapiens (see paper)
27% identity, 78% coverage of query (79.0 bits)
7caxD / A0A1K1L6W4 Crystal structure of bacterial reductase
25% identity, 73% coverage of query (74.3 bits)
6zyzA Structure of the borneol dehydrogenases of salvia rosmarinus with NAD+ (see paper)
28% identity, 78% coverage of query (73.6 bits)
7djsD / A0A554HE32 Crystal structure of isopiperitenol dehydrogenase from pseudomonas aeruginosa complexed with NAD
30% identity, 74% coverage of query (73.6 bits)
8hsaA / Q8YIN7 Brucella melitensis 7-alpha-hydroxysteroid dehydrogenase mutant: 1-53 truncation/m196i/i258m/k262t-NAD+
28% identity, 79% coverage of query (72.4 bits)
8u9aA / A0A0H3FXS4 Crystal structure of 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from klebsiella aerogenes (dbh bound)
27% identity, 75% coverage of query (72.0 bits)
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Lawrence Berkeley National Laboratory