Searching for up to 100 curated homologs for 5210455 Shew_2896 sodium:neurotransmitter symporter (RefSeq) (503 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.22.4.1 / O50649 High affinity tryptophan:Na+ symporter, TnaT, of 501 aas and 12 TMSs (Androutsellis-Theotokis et al., 2003). The Km for Tryptophan is 145 nM; tryptamine and serotonin weakly inhibited with Ki values of 200 and 440 μM, respectively. An evolutionarily conserved role of adjacent transmembrane segments 7 and 8 has been proposed from Symbiobacterium thermophilum (see 2 papers)
tnaT / BAD39427.1 sodium-and chloride-dependent transporter, TnaT from Symbiobacterium thermophilum IAM 14863 (see paper)
41% identity, 95% coverage of query (409 bits)
TC 2.A.22.5.1 / Q58715 Hypothetical Na+-dependent permease from Methanococcus jannaschii (see paper)
44% identity, 93% coverage of query (380 bits)
TC 2.A.22.4.3 / Q8NRL8 Transporter, component of The methionine/alanine uptake porter, MetPS (Trotschel et al., 2008) (MetP is the transporter; MetS is an essential auxiliary subunit) from Corynebacterium glutamicum
41% identity, 100% coverage of query (355 bits)
4xpgA X-ray structure of drosophila dopamine transporter with subsiteb mutations (d121g/s426m) bound to beta-cft or win35428
30% identity, 95% coverage of query (234 bits)
6m3zA X-ray structure of a drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in milnacipran bound form
31% identity, 95% coverage of query (234 bits)
6m0zA X-ray structure of drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in l-norepinephrine bound form
31% identity, 95% coverage of query (234 bits)
6m47A X-ray structure of a drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in tramadol bound form
31% identity, 95% coverage of query (234 bits)
4xpfA X-ray structure of drosophila dopamine transporter with subsiteb mutations (d121g/s426m) bound to rti-55
30% identity, 95% coverage of query (234 bits)
7wlwA X-ray structure of thermostabilized drosophila dopamine transporter with gaba transporter1-like substitutions in the binding site, in complex with skf89976a
30% identity, 95% coverage of query (234 bits)
7wgtA X-ray structure of thermostabilized drosophila dopamine transporter with gaba transporter1-like substitutions in the binding site, in complex with no711.
30% identity, 95% coverage of query (234 bits)
4xnuA X-ray structure of drosophila dopamine transporter in complex with nisoxetine
30% identity, 95% coverage of query (233 bits)
4m48A X-ray structure of dopamine transporter elucidates antidepressant mechanism
30% identity, 95% coverage of query (233 bits)
6m38A X-ray structure of a drosophila dopamine transporter with subsiteb mutations (d121g/s426m) in s-duloxetine bound form
30% identity, 95% coverage of query (233 bits)
Build an alignment for 5210455 and 13 homologs with ≥ 30% identity
Or download the sequences
S6A13_HUMAN / Q9NSD5 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13 from Homo sapiens (Human) (see 3 papers)
TC 2.A.22.3.10 / Q9NSD5 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) from Homo sapiens (see 5 papers)
29% identity, 88% coverage of query (232 bits)
4xp9C / Q7K4Y6 X-ray structure of drosophila dopamine transporter bound to psychostimulant d-amphetamine (see paper)
30% identity, 95% coverage of query (231 bits)
SC6A2_BOVIN / P51143 Sodium-dependent noradrenaline transporter; Norepinephrine transporter; NET; Solute carrier family 6 member 2 from Bos taurus (Bovine) (see paper)
30% identity, 95% coverage of query (231 bits)
4xpaA X-ray structure of drosophila dopamine transporter bound to 3, 4dichlorophenethylamine
30% identity, 95% coverage of query (231 bits)
4xp6A X-ray structure of drosophila dopamine transporter bound to psychostimulant methamphetamine
30% identity, 95% coverage of query (231 bits)
4xp5A X-ray structure of drosophila dopamine transporter bound to cocaine analogue-rti55
30% identity, 95% coverage of query (231 bits)
4xp4A X-ray structure of drosophila dopamine transporter in complex with cocaine
30% identity, 95% coverage of query (231 bits)
4xnxA X-ray structure of drosophila dopamine transporter in complex with reboxetine
31% identity, 95% coverage of query (231 bits)
4xp1A X-ray structure of drosophila dopamine transporter bound to neurotransmitter dopamine
30% identity, 95% coverage of query (231 bits)
SC6A2_MOUSE / O55192 Sodium-dependent noradrenaline transporter; Norepinephrine transporter; NET; Solute carrier family 6 member 2 from Mus musculus (Mouse) (see paper)
30% identity, 94% coverage of query (230 bits)
S6A13_MOUSE / P31649 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 13 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.22.3.8 / P31649 Mouse GABA, β-alanine, fluoro-β-alanine and taurine transporter-3 (GAT3) (Liu et al. 1999). Orthologous to rat and human GAT2; 72% identical to GAT4 (2.A.22.3.7) (takes up GABA with high affinity into presynaptic terminals). Also takes up the carnitine precursor, gamma-butyrobetaine from Mus musculus (see 3 papers)
29% identity, 89% coverage of query (228 bits)
SC6A2_HUMAN / P23975 Sodium-dependent noradrenaline transporter; Norepinephrine transporter; NET; Solute carrier family 6 member 2 from Homo sapiens (Human) (see 5 papers)
TC 2.A.22.1.2 / P23975 Noradrenaline (norepinephrine):Na+ symporter (NET1, NAT1, SLC6?A2) (also transports 1-methyl-4-tetrahydropyridinium and amphetamines; it is a target of cocaine and amphetamines as well as of therapetics for depression, obsessive-compulsive disorders, and post-traumatic stress disorder. This homooligomeric transporter binds one substrate molecule per transporter subunit (Schwartz et al., 2005; Schlessinger et al., 2011; Andersen et al., 2011). Extracellular loop 3 contributes to substrate and inhibitor selectivity (Lynagh et al. 2013). The highly conserved MELAL and GQXXRXG motifs, located in the second transmembrane domain and the first intracellular loop of hNET, respectively, are determinants of NET cell surface expression, and substrate and inhibitor binding (Sucic and Bryan-Lluka 2007). Based on modeling, the high affinity substrate binding site (S1) of the human norepinephrine transporter has been predicted and then verified by mutational studies from Homo sapiens (Human) (see 5 papers)
SLC6A2 / RF|NP_001034.1 sodium-dependent noradrenaline transporter from Homo sapiens
30% identity, 94% coverage of query (228 bits)
S6A13_RAT / P31646 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 89% coverage of query (227 bits)
SC6A1_RAT / P23978 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Rattus norvegicus (Rat) (see 4 papers)
SC6A1_MOUSE / P31648 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Mus musculus (Mouse) (see 4 papers)
31% identity, 88% coverage of query (226 bits)
SC6A1_HUMAN / P30531 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Homo sapiens (Human) (see 2 papers)
TC 2.A.22.3.2 / P30531 γ-aminobutyric acid (GABA):Na+:Cl- symporter, GAT-1 (Stoichiometry, GABA:Na+ = 1:2 where both Na+ binding sites, Na1 and Na2, have been identified. Na2 but not Na1 can accommodate Li+ (Zhou et al., 2006)). Cai et al. 2005 have reported that N-glycosylation increases the stability, trafficking and GABA-uptake of GABA transporter 1. Glutamine 291 is essential for Cl- binding (Ben-Yona et al., 2011). Four human isoforms have been identified, GAT-1, GAT-2, GAT-3, and GAT-4, all about 70% identical to each other (Borden et al., 1992). GAT-2 transports γ-aminobutyric acid and β-alanine (Christiansen et al, 2007) It also concentratively takes up β-alanine and α-fluoro-β-alanine (Liu et al., 1999). GAT1 is capable of intracellular Na+-, Cl-- and GABA-induced outward currents (reverse GABA transport; GABA efflux) from Homo sapiens (Human) (see 3 papers)
30% identity, 88% coverage of query (226 bits)
S6A11_HUMAN / P48066 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11 from Homo sapiens (Human) (see paper)
TC 2.A.22.3.9 / P48066 Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11). Expression of GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, and a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people as well. Thus, impaired GABA clearance within the amygdala contributes to alcohol addiction from Homo sapiens (see 2 papers)
30% identity, 88% coverage of query (225 bits)
SC6A1_MUSCO / P48057 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Mus cookii (Cook's mouse) (see paper)
31% identity, 88% coverage of query (225 bits)
SC6A4_HUMAN / P31645 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Homo sapiens (Human) (see 20 papers)
TC 2.A.22.1.1 / P31645 Serotonin (5-hydroxytryptamine; 5 HT):Na+:Cl- symporter, SERT-A from Homo sapiens (Human) (see 16 papers)
SLC6A4 / GB|AAW80933.1 sodium-dependent serotonin transporter from Homo sapiens
32% identity, 89% coverage of query (225 bits)
7txtS Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and nacl
32% identity, 89% coverage of query (225 bits)
7lwdA Cryo-em structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15b8 fab
32% identity, 89% coverage of query (225 bits)
6vrlA Cryo-em structure of the wild-type human serotonin transporter complexed with i-paroxetine and 8b6 fab
32% identity, 89% coverage of query (225 bits)
6vrkA Cryo-em structure of the wild-type human serotonin transporter complexed with br-paroxetine and 8b6 fab
32% identity, 89% coverage of query (225 bits)
S6A11_MOUSE / P31650 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Sodium- and chloride-dependent GABA transporter 4; GAT-4; Solute carrier family 6 member 11 from Mus musculus (Mouse) (see 2 papers)
TC 2.A.22.3.7 / Q8BWA7 The GABA transporter, GAT4 (single mutations render this transporter C1- independent) from Mus musculus (see 2 papers)
30% identity, 88% coverage of query (224 bits)
S6A11_RAT / P31647 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11 from Rattus norvegicus (Rat) (see 3 papers)
30% identity, 88% coverage of query (224 bits)
SC6A4_MACMU / Q9MYX0 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Macaca mulatta (Rhesus macaque) (see paper)
32% identity, 89% coverage of query (224 bits)
7li9A 5-ht bound serotonin transporter reconstituted in lipid nanodisc in kcl
32% identity, 89% coverage of query (224 bits)
6dzvA Wild type human serotonin transporter in complex with 15b8 fab bound to ibogaine in occluded conformation
32% identity, 89% coverage of query (224 bits)
TC 2.A.22.1.5 / Q95VZ4 High affinity octopamine transporter, OAT (also transports tyramine and dopamine in the 0.4-3.0 μM range (Donly et al., 2007)) from Trichoplusia ni (see paper)
29% identity, 88% coverage of query (223 bits)
6awnA / P31645 X-ray structure of the s439t human serotonin transporter complexed with paroxetine at the central site (see paper)
32% identity, 89% coverage of query (223 bits)
5i74A X-ray structure of the ts3 human serotonin transporter complexed with br-citalopram at the central site
32% identity, 89% coverage of query (223 bits)
5i71A X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site
32% identity, 89% coverage of query (223 bits)
6awpA X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site
32% identity, 89% coverage of query (223 bits)
6awoA X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site
32% identity, 89% coverage of query (223 bits)
5i6xA X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site
32% identity, 89% coverage of query (223 bits)
SC6A4_CAVPO / O35899 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Cavia porcellus (Guinea pig) (see paper)
32% identity, 89% coverage of query (222 bits)
7sk2A / P30531 Human wildtype gaba reuptake transporter 1 in complex with tiagabine, inward-open conformation (see paper)
30% identity, 88% coverage of query (222 bits)
SC6A4_MOUSE / Q60857 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Mus musculus (Mouse) (see 10 papers)
32% identity, 89% coverage of query (221 bits)
NTDO_CAEEL / Q03614 Sodium-dependent dopamine transporter; DA transporter; DAT from Caenorhabditis elegans (see 3 papers)
TC 2.A.22.1.4 / Q03614 Antidepressant- and cocaine-sensitive dopamine transporter, T23G5.5 (Km for dopamine, 1.2 µM; dependent on extracellular Na+ and Cl-; blocked by cocaine and D-amphetamine) (Jayanthi et al. 1998) from Caenorhabditis elegans (see 3 papers)
29% identity, 91% coverage of query (220 bits)
SC6A4_RAT / P31652 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Rattus norvegicus (Rat) (see 13 papers)
32% identity, 89% coverage of query (220 bits)
SC6A4_BOVIN / Q9XT49 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Bos taurus (Bovine) (see paper)
32% identity, 89% coverage of query (219 bits)
8de4A Native serotonin transporter in complex with 15b8 fab in the presence of methamphetamine
32% identity, 89% coverage of query (219 bits)
8de3A Native serotonin transporter in complex with 15b8 fab antibody in the presence of cocaine
32% identity, 89% coverage of query (219 bits)
7y7wA Cryo-em structure of human gaba transporter gat1 bound with gaba in nacl solution in an inward-occluded state at 2.4 angstrom
31% identity, 87% coverage of query (218 bits)
S6A12_HUMAN / P48065 Sodium- and chloride-dependent betaine transporter; BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12 from Homo sapiens (Human) (see paper)
TC 2.A.22.3.1 / P48065 Betaine/GABA:Na+ symporter, BGT1. (Substrates include: betaine, GABA, diaminobutyrate, β-alanine, proline, quinidine, dimethylglycine, glycine, and sarcosine with decreasing affinity in that order) from Homo sapiens (Human) (see 5 papers)
31% identity, 89% coverage of query (217 bits)
TC 2.A.22.3.6 / Q5J2D5 γ-aminobutyric acid (GABA):Na+:Cl- symporter GAT-1 (stoichiometry = 1:2:1) from Caenorhabditis elegans (see 3 papers)
28% identity, 98% coverage of query (217 bits)
8gnkA Cryoem structure of cytosol-facing, substrate-bound ratgat1
31% identity, 87% coverage of query (217 bits)
7y7yA Cryo-em structure of human gaba transporter gat1 bound with nipecotic acid in nacl solution in an inward-occluded state at 2.4 angstrom
31% identity, 86% coverage of query (216 bits)
DAT_DROME / Q7K4Y6 Sodium-dependent dopamine transporter; Protein fumin from Drosophila melanogaster (Fruit fly) (see 6 papers)
TC 2.A.22.1.7 / Q7K4Y6 Dopamine transporter from Drosophila melanogaster
29% identity, 95% coverage of query (214 bits)
S6A12_MOUSE / P31651 Sodium- and chloride-dependent betaine transporter; BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 12 from Mus musculus (Mouse) (see paper)
30% identity, 88% coverage of query (214 bits)
SC6A7_HUMAN / Q99884 Sodium-dependent proline transporter; Solute carrier family 6 member 7 from Homo sapiens (Human) (see paper)
TC 2.A.22.2.11 / Q99884 Sodium-dependent proline transporter (Solute carrier family 6 member 7) from Homo sapiens (see 3 papers)
30% identity, 95% coverage of query (213 bits)
SC6A7_RAT / P28573 Sodium-dependent proline transporter; Solute carrier family 6 member 7 from Rattus norvegicus (Rat) (see paper)
TC 2.A.22.2.1 / P28573 Proline:Na+ symporter from Rattus norvegicus (Rat) (see paper)
Slc6a7 / RF|NP_446448.2 sodium-dependent proline transporter from Rattus norvegicus
30% identity, 92% coverage of query (212 bits)
SC6A3_BOVIN / P27922 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Bos taurus (Bovine) (see paper)
28% identity, 95% coverage of query (211 bits)
SC6A3_HUMAN / Q01959 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Homo sapiens (Human) (see 10 papers)
TC 2.A.22.1.3 / Q01959 Dopamine:Na+ symporter, DAT (also takes up amphetamines in symport with Na+ which promotes intracellular Na+-dependent dopamine efflux (Khoshbouei et al., 2003)). It is inhibited by cocaine, amphetamines, neurotoxins, antidepressants and ethanol (Chen et al., 2004)]. Zn2+ potentiates uncoupled Cl- conductance from Homo sapiens (Human) (see 16 papers)
SLC6A3 / GB|ABO77644.1 sodium-dependent dopamine transporter from Homo sapiens (see paper)
28% identity, 94% coverage of query (210 bits)
SC6A3_RAT / P23977 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Rattus norvegicus (Rat) (see 6 papers)
28% identity, 94% coverage of query (209 bits)
SC6A3_MOUSE / Q61327 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Mus musculus (Mouse) (see 6 papers)
28% identity, 94% coverage of query (209 bits)
SC6A5_MOUSE / Q761V0 Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5 from Mus musculus (Mouse) (see paper)
TC 2.A.22.2.6 / Q761V0 Glycine:Na+ transporter, GlyT2b (glycine/3Na+/1Cl- symporter, SLC6A5) (see paper)
29% identity, 93% coverage of query (208 bits)
SC6A5_RAT / P58295 Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5 from Rattus norvegicus (Rat) (see 2 papers)
29% identity, 93% coverage of query (208 bits)
SC6A5_HUMAN / Q9Y345 Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5 from Homo sapiens (Human) (see 5 papers)
TC 2.A.22.2.10 / Q9Y345 Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) from Homo sapiens (see 7 papers)
29% identity, 93% coverage of query (208 bits)
SC6A4_DROME / P51905 Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; Cocaine-sensitive serotonin transporter; dSERT1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
TC 2.A.22.1.9 / P51905 The sodium-dependent serotonin transporter of 622 aas and 12 TMSs, SERT or SerT from Drosophila melanogaster
30% identity, 88% coverage of query (206 bits)
SC6A6_MOUSE / O35316 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Mus musculus (Mouse) (see 4 papers)
30% identity, 96% coverage of query (204 bits)
SC6A6_RAT / P31643 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Rattus norvegicus (Rat) (see 3 papers)
29% identity, 94% coverage of query (202 bits)
SC6A6_HUMAN / P31641 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Homo sapiens (Human) (see 5 papers)
TC 2.A.22.3.3 / P31641 The taurine:Na+ symporter, TauT or SLC6A6 (also transports β-alanine and γ-aminobutyric acid (GABA); Tomi et al., 2008; Anderson et al., 2009). Biallelic mutation of TauT is linked to early retinal degeneration (Preising et al. 2019). Oral taurine administration of retinal degeneration and cardiomyopathy reverses the phenotype from Homo sapiens (Human) (see 4 papers)
29% identity, 88% coverage of query (199 bits)
S6A12_CANLF / P27799 Sodium- and chloride-dependent betaine transporter; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12 from Canis lupus familiaris (Dog) (Canis familiaris) (see 3 papers)
30% identity, 89% coverage of query (199 bits)
TC 2.A.22.2.5 / O76188 Gut epithelium absorptive neutral amino acid, K+- and Na+-dependent transporter KAAT1 (electrogenic; Cl--dependent; activated by alkaline pH; all zwiterionic amino acids except methyl AIB are substrates). CAATCH1 is 95% identical to KAAT1. Leu > Thr and Pro from Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) (see paper)
28% identity, 92% coverage of query (197 bits)
SC6A6_CANLF / Q00589 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Canis lupus familiaris (Dog) (Canis familiaris) (see 2 papers)
29% identity, 88% coverage of query (197 bits)
TC 2.A.22.5.3 / Q9KDT3 Neurotransmitter:sodium symporter of 455 aas, MhsT from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
34% identity, 89% coverage of query (197 bits)
6yu6B / Q9KDT3 Crystal structure of mhst in complex with l-leucine (see paper)
34% identity, 89% coverage of query (197 bits)
6yu5A Crystal structure of mhst in complex with l-valine
34% identity, 87% coverage of query (197 bits)
6yu3A Crystal structure of mhst in complex with l-phenylalanine
34% identity, 87% coverage of query (197 bits)
6yu2A Crystal structure of mhst in complex with l-isoleucine
34% identity, 87% coverage of query (197 bits)
4us3A Crystal structure of the bacterial nss member mhst in an occluded inward-facing state
34% identity, 87% coverage of query (197 bits)
6yu7A Crystal structure of mhst in complex with l-tyrosine
34% identity, 89% coverage of query (197 bits)
6yu4A Crystal structure of mhst in complex with l-4f-phenylalanine
34% identity, 89% coverage of query (197 bits)
TC 2.A.22.2.4 / Q9U5A9 Gut epithelium absorptive neutral amino acid Na+- or K+-dependent transporter, CAATCH1 (electrogenic; Cl--independent. Substrates: L-proline-preferring + Na+; L-threonine-preferring + K+; also transports L-methionine) (CAATCH1 can also function as an amino acid-gated cation [Na+ and K+] channel.) from Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) (see paper)
28% identity, 92% coverage of query (196 bits)
SC6A8_MOUSE / Q8VBW1 Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8 from Mus musculus (Mouse) (see paper)
30% identity, 90% coverage of query (196 bits)
SC6A6_BOVIN / Q9MZ34 Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6 from Bos taurus (Bovine) (see paper)
30% identity, 87% coverage of query (196 bits)
SC6A8_RAT / P28570 Sodium- and chloride-dependent creatine transporter 1; CHOT1; CT1; Creatine transporter 1; Solute carrier family 6 member 8 from Rattus norvegicus (Rat) (see 4 papers)
TC 2.A.22.3.5 / P28570 Renal apical membrane creatine:Na2+:Cl- symporter (CRT) from Rattus norvegicus (Rat) (see paper)
30% identity, 90% coverage of query (196 bits)
SC6A8_HUMAN / P48029 Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.22.3.11 / P48029 Sodium- and chloride-dependent creatine transporter 1 (CT1 or CreaT) (Creatine transporter 1) (Solute carrier family 6 member 8, SLC6A8) from Homo sapiens (see 12 papers)
30% identity, 90% coverage of query (196 bits)
SC6A5_XENLA / A7Y2X0 Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; xGlyT2; Solute carrier family 6 member 5 from Xenopus laevis (African clawed frog) (see paper)
29% identity, 93% coverage of query (195 bits)
SC6A9_XENLA / A7Y2W8 Sodium- and chloride-dependent glycine transporter 1; GlyT-1; GlyT1; xGlyT1; Solute carrier family 6 member 9 from Xenopus laevis (African clawed frog) (see paper)
28% identity, 93% coverage of query (195 bits)
TC 2.A.22.1.10 / Q963F3 Serotonin transporter, Mod-5, of 671 aas and 12 TMSs from Caenorhabditis elegans
29% identity, 90% coverage of query (194 bits)
TC 2.A.22.2.8 / Q6VS78 Cation-dependent nutrient amino acid transporter, AAT1 (L-phe > cys > his > ala > ser > met > ile > tyr > D-phe > thr > gly) from Aedes aegypti (Yellowfever mosquito)
27% identity, 87% coverage of query (194 bits)
TC 2.A.22.2.9 / B2ZXL8 The densovirus type-2 (BmDNV-2) receptor; putative amino acid transporter, the densonucleosis refractoriness, Nsd-2 protein, of 625 aas and 11-12 TMSs (Abe et al. 2000). Deletion of the nsd2 gene, encoding this transporter in the midgut membrane, causes resistance to this parvo-like virus as well as bidensovirus from Bombyx mori (see paper)
27% identity, 90% coverage of query (192 bits)
S6A14_MOUSE / Q9JMA9 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); Amino acid transporter ATB0+; Colonic system B0+ amino acid transporter CATB0+; Solute carrier family 6 member 14 from Mus musculus (Mouse) (see 3 papers)
29% identity, 94% coverage of query (190 bits)
AAT07965.1 tryptophan transporter from Anopheles gambiae (see paper)
27% identity, 99% coverage of query (190 bits)
SC6A8_RABIT / P31661 Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8 from Oryctolagus cuniculus (Rabbit) (see paper)
TC 2.A.22.3.4 / P31661 Creatine:Na+ symporter from Oryctolagus cuniculus (Rabbit) (see paper)
29% identity, 90% coverage of query (189 bits)
S6A17_HUMAN / Q9H1V8 Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17 from Homo sapiens (Human) (see paper)
TC 2.A.22.6.6 / Q9H1V8 Sodium-dependent vesicular neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4/BOAT3) (Solute carrier family 6 member 17) from Homo sapiens (see 4 papers)
26% identity, 89% coverage of query (189 bits)
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Lawrence Berkeley National Laboratory