Searching for up to 100 curated homologs for 5210475 FitnessBrowser__PV4:5210475 (324 a.a.)
Found high-coverage hits (≥70%) to 57 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
DnaR / b1207 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
prs / P0A717 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Escherichia coli (strain K12) (see 27 papers)
KPRS_ECOLI / P0A717 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Escherichia coli (strain K12) (see 7 papers)
P0A719 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Escherichia coli (see paper)
83% identity, 97% coverage of query (546 bits)
KPRS_SALTY / P0A1V6 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
83% identity, 97% coverage of query (545 bits)
6asvC / P0A717 E. Coli prpp synthetase (see paper)
83% identity, 96% coverage of query (540 bits)
4s2uA Crystal structure of the phosphorybosylpyrophosphate synthetase from e. Coli
83% identity, 95% coverage of query (533 bits)
7xmvA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a(amp/adp) filament bound with adp, amp and r5p
82% identity, 97% coverage of query (526 bits)
7xmuA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a filament bound with adp, pi and r5p
82% identity, 97% coverage of query (526 bits)
Q63XL8 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Burkholderia pseudomallei (strain K96243)
63% identity, 96% coverage of query (403 bits)
6nfeB / Q5ZY30 Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
64% identity, 92% coverage of query (392 bits)
6nfeA Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
64% identity, 92% coverage of query (391 bits)
3dahC / Q63XL8 2.3 a crystal structure of ribose-phosphate pyrophosphokinase from burkholderia pseudomallei (see paper)
61% identity, 94% coverage of query (381 bits)
KPRS_BACSU / P14193 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PPRibP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Bacillus subtilis (strain 168) (see 5 papers)
51% identity, 96% coverage of query (321 bits)
prs1 / CAB43599.1 phosphoribosyl pyrophosphate synthase from Spinacia oleracea (see paper)
50% identity, 96% coverage of query (319 bits)
prs2 / CAB43600.1 phosphoribosyl pyrophosphate synthase isozyme 2 from Spinacia oleracea (see paper)
50% identity, 96% coverage of query (316 bits)
E7EAU9 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Bacillus amyloliquefaciens (see paper)
51% identity, 96% coverage of query (316 bits)
1ibsB / P14193 Phosphoribosyldiphosphate synthetase in complex with cadmium ions (see paper)
49% identity, 96% coverage of query (296 bits)
1ibsA Phosphoribosyldiphosphate synthetase in complex with cadmium ions
49% identity, 96% coverage of query (296 bits)
1dkuA Crystal structures of bacillus subtilis phosphoribosylpyrophosphate synthetase: molecular basis of allosteric inhibition and activation.
49% identity, 96% coverage of query (295 bits)
PRPS1 / P60891 Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) from Homo sapiens (see 5 papers)
PRPS1_HUMAN / P60891 Ribose-phosphate pyrophosphokinase 1; PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-I; EC 2.7.6.1 from Homo sapiens (Human) (see 7 papers)
PRPS1_MOUSE / Q9D7G0 Ribose-phosphate pyrophosphokinase 1; Phosphoribosyl pyrophosphate synthase I; PRS-I; EC 2.7.6.1 from Mus musculus (Mouse) (see paper)
P60891 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Homo sapiens (see 4 papers)
48% identity, 97% coverage of query (294 bits)
8dbeA / P60891 Human prps1 with adp; hexamer (see paper)
48% identity, 97% coverage of query (294 bits)
8dbkB Human prps1 with phosphate, atp, and r5p; hexamer with resolved catalytic loops
48% identity, 97% coverage of query (294 bits)
Q08CA5 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Danio rerio (see paper)
48% identity, 97% coverage of query (293 bits)
PRPS2 / P11908 Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) from Homo sapiens (see 2 papers)
47% identity, 97% coverage of query (290 bits)
Q4KME9 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Danio rerio (see paper)
47% identity, 97% coverage of query (290 bits)
PRPS1L1 / P21108 Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) from Homo sapiens (see 3 papers)
47% identity, 97% coverage of query (288 bits)
KPR2_SCHPO / O94413 Ribose-phosphate pyrophosphokinase 2; Phosphoribosyl pyrophosphate synthase 2; EC 2.7.6.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
49% identity, 96% coverage of query (285 bits)
8dbgA Human prps1 with phosphate and atp; hexamer
47% identity, 97% coverage of query (281 bits)
2hcrA Crystal structure of human phosphoribosyl pyrophosphate synthetase 1 in complex with amp(atp), cadmium and sulfate ion
47% identity, 96% coverage of query (279 bits)
7yk1A Structural basis of human prps2 filaments
46% identity, 97% coverage of query (279 bits)
KPR2_YEAST / P38620 Ribose-phosphate pyrophosphokinase 2; Phosphoribosyl pyrophosphate synthase 2; EC 2.7.6.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
46% identity, 96% coverage of query (271 bits)
H9D1K2 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Culex pipiens (see paper)
44% identity, 97% coverage of query (270 bits)
Q9VT33 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Drosophila melanogaster (see paper)
43% identity, 98% coverage of query (266 bits)
KPR4_YEAST / P38063 Ribose-phosphate pyrophosphokinase 4; Phosphoribosyl pyrophosphate synthase 4; EC 2.7.6.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
45% identity, 97% coverage of query (266 bits)
KPR3_YEAST / P38689 Ribose-phosphate pyrophosphokinase 3; Phosphoribosyl pyrophosphate synthase 3; EC 2.7.6.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
47% identity, 96% coverage of query (261 bits)
KPRS2_STRP6 / Q5XC85 Putative ribose-phosphate pyrophosphokinase 2; RPPK 2; 5-phospho-D-ribosyl alpha-1-diphosphate synthase 2; Phosphoribosyl diphosphate synthase 2; Phosphoribosyl pyrophosphate synthase 2; P-Rib-PP synthase 2; PRPP synthase 2; PRPPase 2; EC 2.7.6.1 from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
45% identity, 96% coverage of query (259 bits)
PRS1 ribose-phosphate pyrophosphokinase; EC 2.7.6.1 from Candida albicans (see 2 papers)
45% identity, 96% coverage of query (258 bits)
KPRS_MYCGE / P47304 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium) (see paper)
41% identity, 95% coverage of query (252 bits)
7pn0A / Q5SHU3 Crystal structure of the phosphorybosylpyrophosphate synthetase ii from thermus thermophilus at r32 space group
44% identity, 95% coverage of query (243 bits)
Q5SHU3 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Thermus thermophilus (see paper)
44% identity, 95% coverage of query (242 bits)
5t3oA Crystal structure of the phosphorybosylpyrophosphate synthetase ii from thermus thermophilus
44% identity, 95% coverage of query (242 bits)
A0R3C8 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Mycolicibacterium smegmatis (see paper)
43% identity, 96% coverage of query (241 bits)
KPRS_MYCTU / P9WKE3 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
44% identity, 96% coverage of query (239 bits)
O60256 Phosphoribosyl pyrophosphate synthase-associated protein 2; PRPP synthase-associated protein 2; 41 kDa phosphoribosypyrophosphate synthetase-associated protein; PAP41 from Homo sapiens (Human)
37% identity, 99% coverage of query (200 bits)
KPRS_METJA / Q58761 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58761 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Methanocaldococcus jannaschii (see paper)
34% identity, 84% coverage of query (149 bits)
1u9zA / Q58761 Crystal structure of phosphoribosyl diphosphate synthase complexed with amp and ribose 5-phosphate (see paper)
33% identity, 84% coverage of query (142 bits)
KPRS_THEKO / O52958 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
34% identity, 78% coverage of query (139 bits)
3mbiA / Q97CA5 Crystal structure of the phosphoribosylpyrophosphate (prpp) synthetase from thermoplasma volcanium in complex with adp-mg2+ and ribose 5- phosphate (see paper)
30% identity, 84% coverage of query (128 bits)
KPRS_THEVO / Q97CA5 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) (see paper)
Q97CA5 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Thermoplasma volcanium (see paper)
30% identity, 84% coverage of query (128 bits)
3lpnA Crystal structure of the phosphoribosylpyrophosphate (prpp) synthetase from thermoplasma volcanium in complex with an atp analog (ampcpp).
30% identity, 84% coverage of query (128 bits)
3mbiD Crystal structure of the phosphoribosylpyrophosphate (prpp) synthetase from thermoplasma volcanium in complex with adp-mg2+ and ribose 5- phosphate
30% identity, 84% coverage of query (128 bits)
Build an alignment for 5210475 and 49 homologs with ≥ 30% identity
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4twbA / Q97Z86 Sulfolobus solfataricus ribose-phosphate pyrophosphokinase (see paper)
28% identity, 85% coverage of query (126 bits)
Q97Z86 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Saccharolobus solfataricus (see paper)
27% identity, 85% coverage of query (126 bits)
Q97Z86 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
27% identity, 85% coverage of query (126 bits)
A3MV85 ribose-phosphate diphosphokinase (EC 2.7.6.1) from Pyrobaculum calidifontis (see paper)
35% identity, 77% coverage of query (114 bits)
prs3 / CAB43601.1 phosphoribosyl pyrophosphate synthase isozyme 3 from Spinacia oleracea (see paper)
28% identity, 85% coverage of query (82.0 bits)
prs3 / CAB43552.1 phosphoribosyl diphosphate synthase from Arabidopsis thaliana (see paper)
28% identity, 79% coverage of query (80.1 bits)
prs4 / CAB43602.1 phosphoribosyl pyrophosphate synthase isozyme 4 from Spinacia oleracea (see paper)
27% identity, 91% coverage of query (79.0 bits)
prs4 / CAB43553.1 phosphoribosyl diphosphate synthase from Arabidopsis thaliana (see paper)
29% identity, 75% coverage of query (76.6 bits)
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Lawrence Berkeley National Laboratory