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Searching for up to 100 curated homologs for 5210798 FitnessBrowser__PV4:5210798 (543 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

phoA / BAD90663.1 alkaline phosphatase from Shewanella sp. SIB1 (see paper)
    63% identity, 80% coverage of query (595 bits)

A0A218PHN9 alkaline phosphatase (EC 3.1.3.1) from Shewanella sp. T3-3 (see paper)
    68% identity, 80% coverage of query (590 bits)

3a52A / Q8RQU7 Crystal structure of cold-active alkailne phosphatase from psychrophile shewanella sp. (see paper)
    70% identity, 73% coverage of query (578 bits)

phoAIV / CAA74486.1 alkaline phosphatase from Bacillus subtilis (see 3 papers)
    39% identity, 73% coverage of query (276 bits)

P19406 alkaline phosphatase (EC 3.1.3.1) from Bacillus subtilis (see paper)
    39% identity, 73% coverage of query (276 bits)

Q9UZV2 alkaline phosphatase (EC 3.1.3.1) from Pyrococcus abyssi (see paper)
    33% identity, 80% coverage of query (219 bits)

A8WEG4 alkaline phosphatase (EC 3.1.3.1) from Geobacillus thermodenitrificans (see paper)
    32% identity, 80% coverage of query (184 bits)

Pho8 / P11491 farnesyl diphosphatase (EC 3.1.3.1; EC 3.1.7.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
PPB_YEAST / P11491 Repressible alkaline phosphatase; Fructose-2,6-bisphosphate 6-phosphatase; Membrane-bound repressible alkaline phosphatase; EC 3.1.3.1; EC 3.1.3.54; EC 3.1.7.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    31% identity, 79% coverage of query (181 bits)

A0A1E3P771 alkaline phosphatase (EC 3.1.3.1) from Wickerhamomyces anomalus (see paper)
    32% identity, 72% coverage of query (176 bits)

Build an alignment

Build an alignment for 5210798 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

CH_123991 alkaline phosphatase from Magnaporthe grisea 70-15 (see paper)
    28% identity, 74% coverage of query (162 bits)

B0R9W3 alkaline phosphatase (EC 3.1.3.1) from Halobacterium salinarum (see paper)
    34% identity, 72% coverage of query (159 bits)

2x98A / B0R9W3 H.Salinarum alkaline phosphatase (see paper)
    35% identity, 71% coverage of query (159 bits)

7kwdA / Q53W95 Crystal structure of thermus thermophilus alkaline phosphatase (see paper)
    29% identity, 73% coverage of query (144 bits)

PPBN_HUMAN / P10696 Alkaline phosphatase, germ cell type; ALP-1; Alkaline phosphatase Nagao isozyme; Alkaline phosphatase, placental-like; Germ cell alkaline phosphatase; GCAP; Placental alkaline phosphatase-like; PLAP-like; EC 3.1.3.1 from Homo sapiens (Human) (see paper)
    29% identity, 73% coverage of query (114 bits)

P19111 alkaline phosphatase (EC 3.1.3.1) from Bos taurus (see 3 papers)
    28% identity, 72% coverage of query (112 bits)

PPB1_HUMAN / P05187 Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1; EC 3.1.3.1 from Homo sapiens (Human) (see 9 papers)
    29% identity, 73% coverage of query (112 bits)

3mk0A / P05187 Refinement of placental alkaline phosphatase complexed with nitrophenyl (see paper)
    29% identity, 73% coverage of query (112 bits)

P19111 Intestinal-type alkaline phosphatase; IAP; Intestinal alkaline phosphatase; EC 3.1.3.1 from Bos taurus (Bovine)
    28% identity, 72% coverage of query (112 bits)

1zefA Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
    29% identity, 73% coverage of query (112 bits)

1zedA Alkaline phosphatase from human placenta in complex with p- nitrophenyl-phosphonate
    29% identity, 73% coverage of query (112 bits)

2glqA X-ray structure of human alkaline phosphatase in complex with strontium
    29% identity, 73% coverage of query (112 bits)

1ew2A Crystal structure of a human phosphatase
    29% identity, 73% coverage of query (112 bits)

PPBT_RAT / P08289 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Rattus norvegicus (Rat) (see paper)
P08289 alkaline phosphatase (EC 3.1.3.1) from Rattus norvegicus (see paper)
    29% identity, 72% coverage of query (110 bits)

PPBT_MOUSE / P09242 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNAP; TNSALP; Alkaline phosphatase 2; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Mus musculus (Mouse) (see 22 papers)
    28% identity, 72% coverage of query (109 bits)

A8TKU6 alkaline phosphatase (EC 3.1.3.1) from Schistosoma mansoni (see paper)
    29% identity, 72% coverage of query (109 bits)

D1.8 / CAJ14151.1 putative alkaline phosphatase from Anopheles gambiae (see paper)
    27% identity, 72% coverage of query (107 bits)

PPBN_MOUSE / P24823 Alkaline phosphatase, germ cell type; Alkaline phosphatase 5; Alkaline phosphatase, placental-like; Embryonic alkaline phosphatase; EAP; Embryonic-type alkaline phosphatase; EC 3.1.3.1 from Mus musculus (Mouse) (see 2 papers)
    28% identity, 72% coverage of query (106 bits)

PPBI1_RAT / P15693 Intestinal-type alkaline phosphatase 1; IAP-1; Intestinal alkaline phosphatase 1; Intestinal alkaline phosphatase I; IAP-I; EC 3.1.3.1 from Rattus norvegicus (Rat) (see 2 papers)
    27% identity, 77% coverage of query (106 bits)

4kjgA / P15693 Structure of rat intestinal alkaline phosphatase expressed in insect cell (see paper)
    27% identity, 72% coverage of query (105 bits)

PPB_GADMO / P83456 Alkaline phosphatase; AP; EC 3.1.3.1 from Gadus morhua (Atlantic cod) (see paper)
    27% identity, 73% coverage of query (105 bits)

PPBT_HUMAN / P05186 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNS-ALP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Homo sapiens (Human) (see 41 papers)
P05186 alkaline phosphatase (EC 3.1.3.1) from Homo sapiens (see 6 papers)
    27% identity, 72% coverage of query (102 bits)

7yivA / P05186 The crystal structure of human tissue nonspecific alkaline phosphatase (alpl) at basic ph (see paper)
    27% identity, 72% coverage of query (102 bits)

PPBT_FELCA / Q29486 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Felis catus (Cat) (Felis silvestris catus) (see paper)
    27% identity, 72% coverage of query (100 bits)

PPBT_CHICK / Q92058 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP; Phosphoamidase; EC 3.1.3.1 from Gallus gallus (Chicken) (see 2 papers)
    26% identity, 72% coverage of query (99.4 bits)

PPBT_BOVIN / P09487 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Bos taurus (Bovine) (see paper)
P09487 alkaline phosphatase (EC 3.1.3.1) from Bos taurus (see 2 papers)
    27% identity, 72% coverage of query (99.0 bits)

PPBI_MOUSE / P24822 Intestinal-type alkaline phosphatase; IAP; Intestinal alkaline phosphatase; Alkaline phosphatase 3; EC 3.1.3.1 from Mus musculus (Mouse) (see paper)
P24822 alkaline phosphatase (EC 3.1.3.1) from Mus musculus (see paper)
    27% identity, 73% coverage of query (97.4 bits)

C3U1V9 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
    25% identity, 75% coverage of query (92.4 bits)

C3U1W2 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
    25% identity, 75% coverage of query (92.0 bits)

PPBI2_RAT / P51740 Intestinal-type alkaline phosphatase 2; IAP-2; Intestinal alkaline phosphatase 2; Intestinal alkaline phosphatase II; IAP-II; EC 3.1.3.1 from Rattus norvegicus (Rat) (see paper)
    28% identity, 72% coverage of query (91.3 bits)

C3U1W1 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
    25% identity, 75% coverage of query (91.3 bits)

B4Z1D7 alkaline phosphatase (EC 3.1.3.1) from Helicoverpa armigera (see 2 papers)
    24% identity, 75% coverage of query (85.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory