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Searching for up to 100 curated homologs for 5210844 FitnessBrowser__PV4:5210844 (474 a.a.)

Found high-coverage hits (≥70%) to 61 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YidK / b3679 putative transporter YidK from Escherichia coli K-12 substr. MG1655 (see 5 papers)
    35% identity, 98% coverage of query (285 bits)

Echvi_1871 transporter for D-glucose/D-galactose/D-xylose/methyl-beta-D-galactopyranoside from Echinicola vietnamensis KMM 6221, DSM 17526
    32% identity, 94% coverage of query (208 bits)

SGLT_VIBPH / P96169 Sodium/glucose cotransporter; Na(+)/glucose symporter from Vibrio parahaemolyticus (see paper)
TC 2.A.21.3.2 / P96169 Glucose or galactose:Na+ symporter, SglS or SglT of 543 aas and 14 TMSs (Turk et al. 2006). The 3.0 Å structure is known (Faham et al., 2008). Sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required for substrate exit (Watanabe et al., 2010). The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined (see 3 papers)
AAF80602.1 Na+/galactose cotransporter SGLT from Vibrio parahaemolyticus (see paper)
    31% identity, 94% coverage of query (202 bits)

3dh4A / P96169 Crystal structure of sodium/sugar symporter with bound galactose from vibrio parahaemolyticus (see paper)
    30% identity, 87% coverage of query (173 bits)

CA265_RS06130 D-galactose transporter from Pedobacter sp. GW460-11-11-14-LB5
    31% identity, 86% coverage of query (169 bits)

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Build an alignment for 5210844 and 5 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Echvi_1880 L-arabinose symporter from Echinicola vietnamensis KMM 6221, DSM 17526
    28% identity, 97% coverage of query (164 bits)

SC5AB_RABIT / Q28728 Sodium/myo-inositol cotransporter 2; Na(+)/myo-inositol cotransporter 2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; rKST1; Sodium/myo-inositol transporter 2; SMIT2; Solute carrier family 5 member 11 from Oryctolagus cuniculus (Rabbit) (see 6 papers)
    30% identity, 82% coverage of query (156 bits)

SC5AB_MOUSE / Q8K0E3 Sodium/myo-inositol cotransporter 2; Na(+)/myo-inositol cotransporter 2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; Sodium/myo-inositol transporter 2; SMIT2; Solute carrier family 5 member 11 from Mus musculus (Mouse) (see paper)
    28% identity, 81% coverage of query (156 bits)

SC5AB_HUMAN / Q8WWX8 Sodium/myo-inositol cotransporter 2; Na(+)/myo-inositol cotransporter 2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; Sodium/myo-inositol transporter 2; SMIT2; Solute carrier family 5 member 11 from Homo sapiens (Human) (see 5 papers)
TC 2.A.21.3.6 / Q8WWX8 Myoinositol:Na+ symporter, SMIT2 (also transports D-chiro-inositol, D-glucose and D-xylose) (see 5 papers)
    29% identity, 82% coverage of query (153 bits)

SC5AB_RAT / Q9Z1F2 Sodium/myo-inositol cotransporter 2; Na(+)/myo-inositol cotransporter 2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; rkST1; Sodium/myo-inositol transporter 2; SMIT2; Solute carrier family 5 member 11 from Rattus norvegicus (Rat) (see paper)
    28% identity, 81% coverage of query (152 bits)

BT0355 L-arabinose/L-arabinobiose symporter from Bacteroides thetaiotaomicron VPI-5482
    27% identity, 90% coverage of query (152 bits)

SC5A1_RABIT / P11170 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Oryctolagus cuniculus (Rabbit) (see paper)
    29% identity, 82% coverage of query (149 bits)

TC 2.A.21.3.22 / Q2A687 Renal Na+:D-glucose symporter type 1 (Sglt1; Slc5a1) of 662 aas and 14 TMSs from Leucoraja erinacea
    27% identity, 90% coverage of query (145 bits)

SC5A3_CANLF / P31637 Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 from Canis lupus familiaris (Dog) (Canis familiaris) (see 2 papers)
TC 2.A.21.3.5 / P31637 Myoinositol:Na+ symporter, SMIT1 from Canis familiaris (Dog) (see paper)
    27% identity, 90% coverage of query (145 bits)

SC5A3_MOUSE / Q9JKZ2 Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 from Mus musculus (Mouse) (see 3 papers)
    27% identity, 82% coverage of query (144 bits)

SC5A3_HUMAN / P53794 Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 from Homo sapiens (Human) (see 4 papers)
    27% identity, 90% coverage of query (144 bits)

TC 2.A.21.3.14 / P53794 Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) from Homo sapiens (see 3 papers)
    27% identity, 90% coverage of query (144 bits)

SC5A4_HUMAN / Q9NY91 Probable glucose sensor protein SLC5A4; Solute carrier family 5 member 4 from Homo sapiens (Human) (see 4 papers)
TC 2.A.21.3.18 / Q9NY91 Low affinity sodium-glucose cotransporter (Sodium/glucose cotransporter 3) (Na+/glucose cotransporter 3) (Solute carrier family 5 member 4) from Homo sapiens (see paper)
    26% identity, 81% coverage of query (140 bits)

7slaA / P13866 Cryoem structure of sglt1 at 3.15 angstrom resolution (see paper)
    27% identity, 78% coverage of query (139 bits)

7sl8A Cryoem structure of sglt1 at 3.4 a resolution
    27% identity, 78% coverage of query (138 bits)

SC5A9_HUMAN / Q2M3M2 Sodium/glucose cotransporter 4; Na(+)/glucose cotransporter 4; hSGLT4; Solute carrier family 5 member 9 from Homo sapiens (Human) (see paper)
TC 2.A.21.3.17 / Q2M3M2 Sodium/glucose cotransporter 4 (Na+/glucose cotransporter 4) (hSGLT4) (Solute carrier family 5 member 9) from Homo sapiens (see 3 papers)
    27% identity, 81% coverage of query (136 bits)

SC5A2_MOUSE / Q923I7 Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2 from Mus musculus (Mouse) (see paper)
    26% identity, 80% coverage of query (136 bits)

7wmvA / P13866 Structure of human sglt1-map17 complex bound with lx2761 (see paper)
    27% identity, 80% coverage of query (132 bits)

SC5A1_HUMAN / P13866 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Homo sapiens (Human) (see 13 papers)
TC 2.A.21.3.1 / P13866 Glucose or galactose:Na+ symporter, SGLT1 (galactose > glucose > fucose). Cotransports water against an osmotic gradient (Naftalin, 2008). TMS IV of the high-affinity sodium-glucose cotransporter participates in sugar binding from Homo sapiens (Human) (see 9 papers)
SLC5A1 / GI|56202462 sodium/glucose cotransporter 1 from Homo sapiens (see paper)
    27% identity, 80% coverage of query (132 bits)

SC5A2_RAT / P53792 Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2 from Rattus norvegicus (Rat) (see paper)
    26% identity, 80% coverage of query (132 bits)

SC5A2_RABIT / P26430 Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2 from Oryctolagus cuniculus (Rabbit) (see paper)
TC 2.A.21.3.3 / P26430 Nucleoside or glucose(?):Na+ symporter from Oryctolagus cuniculus (Rabbit) (see paper)
    26% identity, 80% coverage of query (132 bits)

8hg7A / P31639 Structure of human sglt2-map17 complex with sotagliflozin (see paper)
    27% identity, 80% coverage of query (131 bits)

8hezA Structure of human sglt2-map17 complex with dapagliflozin
    27% identity, 80% coverage of query (131 bits)

7vsiA Structure of human sglt2-map17 complex bound with empagliflozin
    27% identity, 80% coverage of query (131 bits)

8hdhA Structure of human sglt2-map17 complex with canagliflozin
    27% identity, 80% coverage of query (131 bits)

8hb0A Structure of human sglt2-map17 complex with ta1887
    27% identity, 80% coverage of query (131 bits)

SC5A2_HUMAN / P31639 Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2 from Homo sapiens (Human) (see 4 papers)
TC 2.A.21.3.16 / P31639 Sodium/glucose cotransporter 2 (Na+/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2) of 672 aas and 14 TMSs from Homo sapiens (see 2 papers)
    27% identity, 80% coverage of query (130 bits)

SC5A1_MOUSE / Q8C3K6 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Mus musculus (Mouse) (see 2 papers)
    27% identity, 82% coverage of query (129 bits)

SC5A4_PIG / P31636 Solute carrier family 5 member 4; Low affinity sodium-glucose cotransporter from Sus scrofa (Pig) (see 3 papers)
TC 2.A.21.3.4 / P31636 Glucose:Na+ symporter 3 (low affinity) from Sus scrofa (Pig) (see 2 papers)
    26% identity, 90% coverage of query (127 bits)

S5A4B_MOUSE / Q91ZP4 Solute carrier family 5 member 4B; Low affinity sodium-glucose cotransporter; SGLT3-b from Mus musculus (Mouse) (see 4 papers)
    26% identity, 82% coverage of query (126 bits)

SC5AA_MOUSE / Q5SWY8 Sodium/mannose cotransporter SLC5A10; Sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; Solute carrier family 5 member 10 from Mus musculus (Mouse) (see paper)
    27% identity, 89% coverage of query (126 bits)

8hinA Structure of human sglt2-map17 complex with phlorizin
    26% identity, 79% coverage of query (123 bits)

SC5AA_BOVIN / Q6R4Q5 Sodium/mannose cotransporter SLC5A10; Sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; Solute carrier family 5 member 10 from Bos taurus (Bovine) (see paper)
    26% identity, 88% coverage of query (121 bits)

SC5A4_RAT / D3ZIS0 Solute carrier family 5 member 4 from Rattus norvegicus (Rat) (see paper)
    26% identity, 82% coverage of query (121 bits)

SC5AA_HUMAN / A0PJK1 Sodium/mannose cotransporter SLC5A10; Sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; Solute carrier family 5 member 10 from Homo sapiens (Human) (see 3 papers)
TC 2.A.21.3.15 / A0PJK1 Sodium/glucose cotransporter 5 (Na+/glucose cotransporter 5) (Solute carrier family 5 member 10) from Homo sapiens (see 4 papers)
    25% identity, 89% coverage of query (120 bits)

7ynjA Structure of human sglt2-map17 complex bound with substrate amg in the occluded conformation
    26% identity, 78% coverage of query (117 bits)

7yniA / P13866 Structure of human sglt1-map17 complex bound with substrate 4d4fdg in the occluded conformation (see paper)
    25% identity, 88% coverage of query (114 bits)

S5A4A_MOUSE / Q9ET37 Solute carrier family 5 member 4A; SGLT3-a from Mus musculus (Mouse) (see 2 papers)
    25% identity, 82% coverage of query (110 bits)

SC5AA_RABIT / Q28610 Sodium/mannose cotransporter SLC5A10; RK-D; Sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; Solute carrier family 5 member 10 from Oryctolagus cuniculus (Rabbit) (see paper)
    25% identity, 88% coverage of query (98.2 bits)

SC5A8_XENLA / Q7SYH5 Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; xSMCTe; Sodium solute transporter Vito; Solute carrier family 5 member 8 from Xenopus laevis (African clawed frog) (see paper)
    24% identity, 82% coverage of query (80.5 bits)

SC5AC_MOUSE / Q49B93 Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12 from Mus musculus (Mouse) (see 4 papers)
    22% identity, 92% coverage of query (75.5 bits)

SC5A6_HUMAN / Q9Y289 Sodium-dependent multivitamin transporter; Na(+)-dependent multivitamin transporter; hSMVT; Solute carrier family 5 member 6 from Homo sapiens (Human) (see 13 papers)
TC 2.A.21.5.7 / Q9Y289 Sodium-dependent multivitamin transporter (Na+-dependent multivitamin transporter) (Solute carrier family 5 member 6) from Homo sapiens (see 5 papers)
    24% identity, 85% coverage of query (74.7 bits)

SC5A6_RAT / O70247 Sodium-dependent multivitamin transporter; Na(+)-dependent multivitamin transporter; Solute carrier family 5 member 6 from Rattus norvegicus (Rat) (see 2 papers)
TC 2.A.21.5.2 / O70247 Na+-dependent multivitamin (pantothenate, biotin, lipoate) transporter (de Carvalho and Quick 2011). Broad specificity. May be useful for drug delivery using biotin-conjugated drugs such as Biotin-Acyclovir (B-ACV) from Rattus norvegicus (Rat) (see paper)
    25% identity, 85% coverage of query (73.9 bits)

SC5AC_HUMAN / Q1EHB4 Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12 from Homo sapiens (Human) (see paper)
TC 2.A.21.5.6 / Q1EHB4 Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) from Homo sapiens (see 3 papers)
    23% identity, 84% coverage of query (70.5 bits)

TC 2.A.21.5.8 / Q9VLR8 Sodium-coupled transporter, SLC5A11 or cupcake of 600 aas from Drosophila melanogaster
    25% identity, 85% coverage of query (67.0 bits)

SC5A8_DANRE / Q3ZMH1 Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; zSMCTe; Sodium solute symporter family 5 member 8 protein; Solute carrier family 5 member 8 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
TC 2.A.21.5.5 / Q3ZMH1 The high affinity (Km (lactate) = 0.2mM) electrogenic Na+ monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTe from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
slc5a8 / RF|NP_001030141.1 sodium-coupled monocarboxylate transporter 1 from Danio rerio (see paper)
    22% identity, 88% coverage of query (63.5 bits)

SC5AC_DANRE / Q7T384 Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; zSMCTn; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12; zSLC5A12 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
TC 2.A.21.5.4 / Q7T384 The low affinity (Km (lactate) = 2mM) electroneutral Na+:monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTn from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
slc5a12 / GB|AAW55812.1 sodium-coupled monocarboxylate transporter 2 from Danio rerio (see paper)
    21% identity, 94% coverage of query (60.8 bits)

PanF / b3258 pantothenate:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
panF / P16256 pantothenate:Na+ symporter from Escherichia coli (strain K12) (see 3 papers)
PANF_ECOLI / P16256 Sodium/pantothenate symporter; Pantothenate permease from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.21.1.1 / P16256 Pantothenate:Na+ symporter, PanF from Escherichia coli (see 5 papers)
panF / GB|AAC76290.2 sodium/pantothenate symporter from Escherichia coli K12 (see 5 papers)
    25% identity, 70% coverage of query (60.1 bits)

SC5A5_HUMAN / Q92911 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) (see 12 papers)
TC 2.A.21.5.1 / Q92911 Sodium iodide symporter (NIS; also transports other monovalent anions including: ClO3-, SCN-, SeCN-, NO3-, Br-, BF4-, IO4- and BrO3-). It mediates electroneutral active transport of the environmental pollutant perchlorate (Dohan et al., 2007). Five beta-OH group-containing residues (Thr-351, Ser-353, Thr-354, Ser-356, and Thr-357) and Asn-360, all of which putatively face the same side of the helix in TMS IX, plus Asp-369, located in the membrane/cytosol interface, play key roles in NIS function and seem to be involved in Na+ binding/translocation (De la Vieja et al. 2007). Thr-354 is essential for iodide uptake (Tatsumi et al., 2010). The stoichiometry is Na+:I-= 2:1. The G39R mutant (congenital) is inactive. G93 is a pivot for the inwardly to outwardly conformational change from Homo sapiens (Human) (see 8 papers)
    23% identity, 81% coverage of query (59.7 bits)

NANT_ALIF1 / Q5E733 N-acetylneuraminate transporter from Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri) (see paper)
    21% identity, 87% coverage of query (59.7 bits)

SC5A5_MOUSE / Q99PN0 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Mus musculus (Mouse) (see 3 papers)
    22% identity, 84% coverage of query (59.3 bits)

SC5A5_RAT / Q63008 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Rattus norvegicus (Rat) (see 3 papers)
    23% identity, 84% coverage of query (58.5 bits)

TC 2.A.21.3.11 / A3UWQ1 The alginate oligosaccharide uptake porter, ToaA from Vibrio splendidus 12B01
    21% identity, 70% coverage of query (55.8 bits)

TC 2.A.21.3.20 / Q38V35 NanT sialic acid transporter of 500 aas from Lactobacillus sakei subsp. sakei (strain 23K)
    23% identity, 91% coverage of query (55.5 bits)

TC 2.A.21.3.10 / Q8ZQ35 Na+-dependent, smf-driven, sialic acid transporter, STM1128 (NanP) (Severi et al., 2010). Also transports the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Salmonella typhimurium (see paper)
    23% identity, 96% coverage of query (48.1 bits)

7uuzA / Q63008 Structure of the sodium/iodide symporter (nis) in complex with perrhenate and sodium (see paper)
    23% identity, 78% coverage of query (44.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory