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Searching for up to 100 curated homologs for 6936385 FitnessBrowser__SB2B:6936385 (492 a.a.)

Found high-coverage hits (≥70%) to 30 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

phoA / BAD90663.1 alkaline phosphatase from Shewanella sp. SIB1 (see paper)
    67% identity, 84% coverage of query (573 bits)

A0A218PHN9 alkaline phosphatase (EC 3.1.3.1) from Shewanella sp. T3-3 (see paper)
    65% identity, 88% coverage of query (568 bits)

3a52A / Q8RQU7 Crystal structure of cold-active alkailne phosphatase from psychrophile shewanella sp. (see paper)
    68% identity, 80% coverage of query (556 bits)

P19406 alkaline phosphatase (EC 3.1.3.1) from Bacillus subtilis (see paper)
    39% identity, 87% coverage of query (278 bits)

phoAIV / CAA74486.1 alkaline phosphatase from Bacillus subtilis (see 3 papers)
    39% identity, 87% coverage of query (276 bits)

Q9UZV2 alkaline phosphatase (EC 3.1.3.1) from Pyrococcus abyssi (see paper)
    35% identity, 86% coverage of query (214 bits)

A0A1E3P771 alkaline phosphatase (EC 3.1.3.1) from Wickerhamomyces anomalus (see paper)
    30% identity, 80% coverage of query (172 bits)

Pho8 / P11491 farnesyl diphosphatase (EC 3.1.3.1; EC 3.1.7.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
PPB_YEAST / P11491 Repressible alkaline phosphatase; Fructose-2,6-bisphosphate 6-phosphatase; Membrane-bound repressible alkaline phosphatase; EC 3.1.3.1; EC 3.1.3.54; EC 3.1.7.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    32% identity, 86% coverage of query (172 bits)

A8WEG4 alkaline phosphatase (EC 3.1.3.1) from Geobacillus thermodenitrificans (see paper)
    32% identity, 86% coverage of query (165 bits)

B0R9W3 alkaline phosphatase (EC 3.1.3.1) from Halobacterium salinarum (see paper)
    34% identity, 79% coverage of query (146 bits)

2x98A / B0R9W3 H.Salinarum alkaline phosphatase (see paper)
    34% identity, 79% coverage of query (144 bits)

Build an alignment

Build an alignment for 6936385 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

7kwdA / Q53W95 Crystal structure of thermus thermophilus alkaline phosphatase (see paper)
    29% identity, 80% coverage of query (140 bits)

CH_123991 alkaline phosphatase from Magnaporthe grisea 70-15 (see paper)
    26% identity, 84% coverage of query (138 bits)

Q153J0 alkaline phosphatase (EC 3.1.3.1) from Thermus thermophilus (see paper)
    29% identity, 80% coverage of query (135 bits)

PPB_GADMO / P83456 Alkaline phosphatase; AP; EC 3.1.3.1 from Gadus morhua (Atlantic cod) (see paper)
    26% identity, 80% coverage of query (103 bits)

P19111 alkaline phosphatase (EC 3.1.3.1) from Bos taurus (see 3 papers)
    24% identity, 86% coverage of query (100 bits)

P19111 Intestinal-type alkaline phosphatase; IAP; Intestinal alkaline phosphatase; EC 3.1.3.1 from Bos taurus (Bovine)
    24% identity, 86% coverage of query (100 bits)

PPB1_HUMAN / P05187 Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1; EC 3.1.3.1 from Homo sapiens (Human) (see 9 papers)
    27% identity, 88% coverage of query (99.8 bits)

A8TKU6 alkaline phosphatase (EC 3.1.3.1) from Schistosoma mansoni (see paper)
    26% identity, 80% coverage of query (99.4 bits)

PPBN_HUMAN / P10696 Alkaline phosphatase, germ cell type; ALP-1; Alkaline phosphatase Nagao isozyme; Alkaline phosphatase, placental-like; Germ cell alkaline phosphatase; GCAP; Placental alkaline phosphatase-like; PLAP-like; EC 3.1.3.1 from Homo sapiens (Human) (see paper)
    27% identity, 88% coverage of query (98.6 bits)

2glqA X-ray structure of human alkaline phosphatase in complex with strontium
    27% identity, 85% coverage of query (97.8 bits)

1ew2A Crystal structure of a human phosphatase
    27% identity, 85% coverage of query (97.8 bits)

3mk0A / P05187 Refinement of placental alkaline phosphatase complexed with nitrophenyl (see paper)
    27% identity, 85% coverage of query (97.4 bits)

1zefA Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
    27% identity, 85% coverage of query (97.4 bits)

1zedA Alkaline phosphatase from human placenta in complex with p- nitrophenyl-phosphonate
    27% identity, 85% coverage of query (97.4 bits)

PPBN_MOUSE / P24823 Alkaline phosphatase, germ cell type; Alkaline phosphatase 5; Alkaline phosphatase, placental-like; Embryonic alkaline phosphatase; EAP; Embryonic-type alkaline phosphatase; EC 3.1.3.1 from Mus musculus (Mouse) (see 2 papers)
    24% identity, 86% coverage of query (96.3 bits)

PPBI1_RAT / P15693 Intestinal-type alkaline phosphatase 1; IAP-1; Intestinal alkaline phosphatase 1; Intestinal alkaline phosphatase I; IAP-I; EC 3.1.3.1 from Rattus norvegicus (Rat) (see 2 papers)
    25% identity, 86% coverage of query (95.1 bits)

PPBI_MOUSE / P24822 Intestinal-type alkaline phosphatase; IAP; Intestinal alkaline phosphatase; Alkaline phosphatase 3; EC 3.1.3.1 from Mus musculus (Mouse) (see paper)
P24822 alkaline phosphatase (EC 3.1.3.1) from Mus musculus (see paper)
    26% identity, 86% coverage of query (94.7 bits)

4kjgA / P15693 Structure of rat intestinal alkaline phosphatase expressed in insect cell (see paper)
    25% identity, 86% coverage of query (94.7 bits)

Q17TZ1 alkaline phosphatase (EC 3.1.3.1) from Pinctada fucata (see paper)
    25% identity, 83% coverage of query (73.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory