Searching for up to 100 curated homologs for 6936584 FitnessBrowser__SB2B:6936584 (319 a.a.)
Found high-coverage hits (≥70%) to 79 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YadG / b0127 putative ABC transporter ATP-binding protein YadG from Escherichia coli K-12 substr. MG1655 (see 7 papers)
YADG_ECOLI / P36879 Uncharacterized ABC transporter ATP-binding protein YadG from Escherichia coli (strain K12) (see paper)
yadG / MB|P36879 uncharacterized ABC transporter ATP-binding protein yadG from Escherichia coli K12 (see paper)
74% identity, 94% coverage of query (446 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
38% identity, 93% coverage of query (194 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
36% identity, 85% coverage of query (164 bits)
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
35% identity, 93% coverage of query (157 bits)
TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
30% identity, 93% coverage of query (149 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
32% identity, 96% coverage of query (149 bits)
TC 3.A.1.105.3 / Q70J75 CmrA, component of The 4A-4E-O-dideacetyl-chromomycin A3 (biosynthetic precursor of chromomycin) exporter (may also export chromomycin and mithramycin from Streptomyces griseus subsp. griseus
32% identity, 93% coverage of query (140 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
34% identity, 90% coverage of query (138 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
33% identity, 91% coverage of query (135 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
32% identity, 92% coverage of query (135 bits)
TC 3.A.1.211.1 / P41233 The cholesterol/phospholipid flippase, ABC1 (called ABCA1 in humans; Tangier disease proteins; 2261 aas; sp: O95477). An amphipathic helical region of the N-terminal barrel of the phospholipid transfer protein (PLTP) is critical for ABCA1-dependent cholesterol efflux (Oram et al., 2008). PLTP helix 144-163 removes lipid domains formed by ABCA1, stabilizing ABCA1, interacting with phospholipids, and promoting phospholipid transfer by direct interactions with ABCA1. May transport sphingosine-1-phosphate (Kobayashi et al., 2009). May protect from cardiovascular disease and diabetes from Mus musculus (Mouse) (see 7 papers)
Abca1 ATP-binding cassette sub-family A member 1 from Mus musculus (see paper)
37% identity, 75% coverage of query (134 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
37% identity, 75% coverage of query (134 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
37% identity, 72% coverage of query (134 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
37% identity, 75% coverage of query (133 bits)
ABCAH_MOUSE / E9PX95 ATP-binding cassette sub-family A member 17 from Mus musculus (Mouse) (see 2 papers)
31% identity, 94% coverage of query (133 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
32% identity, 92% coverage of query (133 bits)
ABCA4_MOUSE / O35600 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Mus musculus (Mouse) (see 4 papers)
36% identity, 72% coverage of query (132 bits)
7lkzA Structure of atp-bound human abca4
32% identity, 91% coverage of query (132 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
32% identity, 96% coverage of query (131 bits)
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
35% identity, 72% coverage of query (130 bits)
7roqA / O95477 Alternative structure of human abca1
35% identity, 87% coverage of query (130 bits)
ABCA3_RAT / A0A0G2K1Q8 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Rattus norvegicus (Rat) (see paper)
31% identity, 92% coverage of query (129 bits)
TC 3.A.1.131.1 / P42332 BcrA, component of The 2 or 3 component bacitracin-resistance efflex pump, BcrAB or BcrABC (Podlesek et al., 1995; Bernard et al., 2003) (BcrA is most similar to SpaF (3.A.1.124.2), but BcrB (5-6 TMSs) is only distantly related to other ABC2-type membrane proteins (Wang et al., 2009). BcrC is not sufficiently similar to detect similarity in BLAST searches. BcrC (5TMSs) belongs to the PAP2 phosphatase superfamily and may not be a contituent of the BcrAB transporter. Transcription is regulated by BcrR, a one-component transmembrane signal transduction system from Bacillus licheniformis (see paper)
bcrA / GB|AAA99504.1 bacitracin ABC transporter, ATP-binding protein BcrA from Bacillus licheniformis (see paper)
32% identity, 92% coverage of query (128 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
30% identity, 92% coverage of query (127 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
31% identity, 74% coverage of query (125 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
31% identity, 74% coverage of query (124 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
31% identity, 74% coverage of query (124 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
31% identity, 74% coverage of query (124 bits)
8eopA / Q8IZY2 Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
33% identity, 74% coverage of query (123 bits)
ABCA7_RAT / Q7TNJ2 ATP-binding cassette sub-family A member 7 from Rattus norvegicus (Rat) (see paper)
30% identity, 94% coverage of query (122 bits)
ABCA7_HUMAN / Q8IZY2 Phospholipid-transporting ATPase ABCA7; ABCA-SSN; ATP-binding cassette sub-family A member 7; Autoantigen SS-N; Macrophage ABC transporter; EC 7.6.2.1 from Homo sapiens (Human) (see 12 papers)
TC 3.A.1.211.10 / Q8IZY2 ABCA7. Regulates cellular efflux of phospholipids but not cholesterol, to apo A-1 from Homo sapiens (see 10 papers)
30% identity, 94% coverage of query (122 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
30% identity, 94% coverage of query (122 bits)
ABCA7_MOUSE / Q91V24 ATP-binding cassette sub-family A member 7 from Mus musculus (Mouse) (see 10 papers)
30% identity, 94% coverage of query (121 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
33% identity, 93% coverage of query (120 bits)
TC 3.A.1.105.4 / Q4VWC9 PltI, component of The pyoluteorin (a chlorinated polyketide) efflux pump, PltHIJKN (see 2 papers)
30% identity, 92% coverage of query (115 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
31% identity, 87% coverage of query (114 bits)
7lkpA Structure of atp-free human abca4
31% identity, 87% coverage of query (114 bits)
7ahhC Opua inhibited inward-facing, sbd docked
31% identity, 75% coverage of query (112 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
31% identity, 75% coverage of query (112 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
30% identity, 87% coverage of query (109 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
31% identity, 71% coverage of query (108 bits)
Build an alignment for 6936584 and 41 homologs with ≥ 30% identity
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2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
29% identity, 83% coverage of query (108 bits)
ABCA5_MOUSE / Q8K448 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Mus musculus (Mouse) (see 7 papers)
32% identity, 89% coverage of query (107 bits)
ABCA5_HUMAN / Q8WWZ7 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.9 / Q8WWZ7 ABCA5 of 1642 aas and 12 TMSs. It is related to lysosomal diseases and plays important roles, especially in cardiomyocytes and follicular cells (Kubo et al. 2005). It mediates cholesterol efflux to HDL3 (Voloshyna and Reiss, 2011) and functions in autolysosomes from Homo sapiens (see 3 papers)
31% identity, 92% coverage of query (107 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
32% identity, 71% coverage of query (102 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
32% identity, 76% coverage of query (97.8 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
30% identity, 72% coverage of query (95.1 bits)
8ipsA / P23886 Cryo-em structure of heme transporter cyddc from escherichia coli in the inward facing heme loading state (see paper)
33% identity, 72% coverage of query (92.8 bits)
ABC1_MYCTU / O65934 ABC transporter ATP-binding/permease protein Rv1747; EC 7.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
27% identity, 75% coverage of query (91.3 bits)
7zdaC If(apo/asym) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2)
33% identity, 72% coverage of query (91.3 bits)
7zdkC If(apo/asym) conformation of cyddc in amp-pnp(cydc)/amp-pnp(cydd) bound state (dataset-8)
33% identity, 72% coverage of query (90.9 bits)
7zdfC If(heme/confined) conformation of cyddc in amp-pnp(cydd) bound state (dataset-4)
33% identity, 72% coverage of query (90.9 bits)
7zdtC Occ(apo/return) conformation of cyddc mutant (e500q.C) in atp(cydc) bound state (dataset-18)
33% identity, 72% coverage of query (89.7 bits)
ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
31% identity, 71% coverage of query (80.1 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
29% identity, 72% coverage of query (79.7 bits)
Q00748 Multidrug resistance protein homolog 65; P-glycoprotein 65; EC 7.6.2.2 from Drosophila melanogaster (Fruit fly)
29% identity, 70% coverage of query (79.3 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
29% identity, 72% coverage of query (78.6 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
30% identity, 75% coverage of query (78.2 bits)
3nh9A Nucleotide binding domain of human abcb6 (atp bound structure)
28% identity, 73% coverage of query (77.4 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
31% identity, 75% coverage of query (76.6 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
32% identity, 71% coverage of query (76.3 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
32% identity, 71% coverage of query (76.3 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
32% identity, 71% coverage of query (76.3 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
32% identity, 71% coverage of query (76.3 bits)
6c0vA Molecular structure of human p-glycoprotein in the atp-bound, outward- facing conformation
30% identity, 75% coverage of query (76.3 bits)
AB25B_ARATH / Q9LVM1 ABC transporter B family member 25, mitochondrial; ABC transporter ABCB.25; AtABCB25; ABC transporter of the mitochondrion 3; AtATM3; Iron-sulfur clusters transporter ATM3; Protein STARIK 1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.210.8 / Q9LVM1 Mitochondrial ABC transporter, ATM3, involved in iron homeostasis (Chen et al. 2007) and heavy metal resistance (Kim et al. 2006). There are three isoforms: ATM1, ATM2 and ATM3 (Chen et al., 2007). ATM3 can replace the yeast iron/sulfur cluster exporter better than ATM1 or ATM2. Atm3 is most similar to the human and yeast homologues, TC# 3.A.1.210.4 and 3.A.1.210.1, 51% and 47% identical, respectively from Arabidopsis thaliana (Mouse-ear cress) (see 11 papers)
GB|AAN13224.1 putative ABC transporter protein from Arabidopsis thaliana (see paper)
29% identity, 71% coverage of query (76.3 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
32% identity, 71% coverage of query (75.9 bits)
7n59A / Q9LVM1 Structure of atatm3 in the inward-facing conformation with gssg bound (see paper)
29% identity, 71% coverage of query (75.9 bits)
7n5aA Structure of atatm3 in the closed conformation
29% identity, 71% coverage of query (75.9 bits)
6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
31% identity, 75% coverage of query (74.7 bits)
7dnyB Cryo-em structure of the human abcb6 (coproporphyrin iii-bound)
28% identity, 73% coverage of query (73.6 bits)
8k7bA Post-occluded structure of human abcb6 w546a mutant (adp/vo4-bound)
28% identity, 73% coverage of query (73.2 bits)
7dnzB Cryo-em structure of the human abcb6 (hemin and gsh-bound)
28% identity, 73% coverage of query (73.2 bits)
7dnzA / Q9NP58 Cryo-em structure of the human abcb6 (hemin and gsh-bound) (see paper)
28% identity, 73% coverage of query (73.2 bits)
ABCB6_HUMAN / Q9NP58 ATP-binding cassette sub-family B member 6; ABC-type heme transporter ABCB6; Mitochondrial ABC transporter 3; Mt-ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter; EC 7.6.2.5 from Homo sapiens (Human) (see 23 papers)
TC 3.A.1.210.6 / Q9NP58 Mitochondrial outer membrane/lysosome anionic porphyrin uptake half ABC transporter, ABCB6. Expressed in many mammalian tissues (including fetal liver) in response to intracellular porphyrin. Porphyrin uptake activates de novo porphyrin (haem) biosynthesis from Homo sapiens (Human) (see 7 papers)
ABCB6 / RF|NP_005680.1 ATP-binding cassette sub-family B member 6, mitochondrial from Homo sapiens (see paper)
28% identity, 73% coverage of query (72.4 bits)
7eklA Mitochondrial outer membrane protein
28% identity, 73% coverage of query (72.0 bits)
ABCB6_MOUSE / Q9DC29 ATP-binding cassette sub-family B member 6; ABC-type heme transporter ABCB6; EC 7.6.2.5 from Mus musculus (Mouse) (see 7 papers)
27% identity, 73% coverage of query (70.9 bits)
6ragB / Q72J04 Heterodimeric abc exporter tmrab in inward-facing wide conformation under turnover conditions (see paper)
29% identity, 73% coverage of query (68.2 bits)
ABCBB_RAT / O70127 Bile salt export pump; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein; EC 7.6.2.- from Rattus norvegicus (Rat) (see 12 papers)
29% identity, 70% coverage of query (50.1 bits)
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Lawrence Berkeley National Laboratory