Searching for up to 100 curated homologs for 6936881 FitnessBrowser__SB2B:6936881 (417 a.a.)
Found high-coverage hits (≥70%) to 53 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Psest_4075 symporter for L-glutamate, L-glutamine, and L-proline from Pseudomonas stutzeri RCH2
47% identity, 96% coverage of query (356 bits)
Sama_1319 symporter for L-glutamate, L-glutamine, and L-aspartate from Shewanella amazonensis SB2B
41% identity, 97% coverage of query (291 bits)
5e9sA / Q5JID0 Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
40% identity, 95% coverage of query (268 bits)
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis)
40% identity, 95% coverage of query (268 bits)
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound
40% identity, 95% coverage of query (268 bits)
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor
40% identity, 95% coverage of query (268 bits)
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate
40% identity, 95% coverage of query (267 bits)
GLT_PYRHO / O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 9 papers)
TC 2.A.23.1.5 / O59010 Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ from Pyrococcus horikoshii (see 2 papers)
39% identity, 94% coverage of query (266 bits)
6x15A / O59010 Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
39% identity, 94% coverage of query (257 bits)
2nwwA Crystal structure of gltph in complex with tboa
39% identity, 93% coverage of query (255 bits)
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine
39% identity, 94% coverage of query (255 bits)
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa
39% identity, 93% coverage of query (254 bits)
6bauA Crystal structure of gltph r397c in complex with l-cysteine
39% identity, 93% coverage of query (253 bits)
GLTT_BACSU / O07605 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus subtilis (strain 168) (see 2 papers)
36% identity, 94% coverage of query (248 bits)
GLTT_GEOSE / P24943 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 3 papers)
TC 2.A.23.1.2 / P24943 Glutamate/aspartate:Na+ + H+ symporter from Bacillus stearothermophilus (see 4 papers)
gltT / GI|143000 proton/sodium-glutamate symport protein GltT from Geobacillus stearothermophilus (see 4 papers)
37% identity, 89% coverage of query (248 bits)
GltP / b4077 glutamate/aspartate : H+ symporter GltP from Escherichia coli K-12 substr. MG1655 (see paper)
gltP / P21345 glutamate/aspartate : H+ symporter GltP from Escherichia coli (strain K12) (see 5 papers)
GLTP_ECOLI / P21345 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.23.1.1 / P21345 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) from Escherichia coli (see 6 papers)
36% identity, 96% coverage of query (245 bits)
GLTT_BACCA / P24944 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus caldotenax (see 2 papers)
gltT / GI|143002 proton/sodium-glutamate symport protein GltT from Bacillus caldotenax (see 4 papers)
37% identity, 89% coverage of query (245 bits)
6bmiA Crystal structure of gltph r397c in complex with l-serine
37% identity, 93% coverage of query (228 bits)
DctA / b3528 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
dctA / P0A830 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli (strain K12) (see 23 papers)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12) (see 6 papers)
dctA / GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli (see 5 papers)
33% identity, 94% coverage of query (216 bits)
DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
32% identity, 95% coverage of query (216 bits)
AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
32% identity, 96% coverage of query (214 bits)
TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
33% identity, 97% coverage of query (212 bits)
GLTP_BACSU / P39817 Proton/glutamate-aspartate symporter; Proton/glutamate symport protein from Bacillus subtilis (strain 168) (see paper)
GltP / AAA82878.1 proton/glutamate symport protein from Bacillus subtilis (see paper)
33% identity, 95% coverage of query (208 bits)
TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
32% identity, 96% coverage of query (198 bits)
Build an alignment for 6936881 and 24 homologs with ≥ 30% identity
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TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis (see 2 papers)
29% identity, 95% coverage of query (193 bits)
TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
31% identity, 96% coverage of query (184 bits)
7awmA / P43003,Q15758 Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
31% identity, 87% coverage of query (170 bits)
AO356_01905 L-aspartate transporter from Pseudomonas fluorescens FW300-N2C3
33% identity, 93% coverage of query (165 bits)
RR42_RS03990 aspartate:proton symporter Glt from Cupriavidus basilensis FW507-4G11
30% identity, 95% coverage of query (163 bits)
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101
31% identity, 87% coverage of query (161 bits)
TCYP_BACSU / P54596 L-cystine uptake protein TcyP; Symporter YhcL; Transporter of cystine TcyP from Bacillus subtilis (strain 168) (see 2 papers)
TC 2.A.23.1.4 / P54596 The L-cystine/L-selenocystine:H+ symporter, TcyP (YhcL) from Bacillus subtilis (see 4 papers)
29% identity, 97% coverage of query (160 bits)
7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613
32% identity, 87% coverage of query (160 bits)
7xr4A / P43004 Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
32% identity, 87% coverage of query (159 bits)
7vr7A Inward-facing structure of human eaat2 in the way213613-bound state
31% identity, 85% coverage of query (159 bits)
TC 2.A.23.2.10 / Q10901 Excitatory amino acid transporter (Sodium-dependent glutamate/aspartate transporter), Gkt-1 of 503 aas and 9 - 11 TMSs from Caenorhabditis elegans (see 5 papers)
29% identity, 90% coverage of query (158 bits)
Q10901 Excitatory amino acid transporter; Sodium-dependent glutamate/ aspartate transporter from Caenorhabditis elegans
29% identity, 90% coverage of query (158 bits)
TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
31% identity, 89% coverage of query (155 bits)
O35874 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Mus musculus (Mouse)
30% identity, 89% coverage of query (153 bits)
AAAT_RABIT / O19105 Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Oryctolagus cuniculus (Rabbit) (see paper)
32% identity, 89% coverage of query (152 bits)
EAA4_MOUSE / O35544 Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Mus musculus (Mouse) (see paper)
34% identity, 72% coverage of query (151 bits)
AAAT_BOVIN / Q95JC7 Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Bos taurus (Bovine) (see paper)
32% identity, 87% coverage of query (150 bits)
8cuaA Human excitatory amino acid transporter 3 (eaat3) with bound potassium in an intermediate outward facing state
30% identity, 93% coverage of query (150 bits)
6x2zA Heaat3-ofs-asp
29% identity, 93% coverage of query (150 bits)
8ctcA Human excitatory amino acid transporter 3 (eaat3) with bound glutamate in an intermediate outward facing state
30% identity, 92% coverage of query (149 bits)
AAAT_MOUSE / P51912 Neutral amino acid transporter B(0); ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Mus musculus (Mouse) (see 4 papers)
TC 2.A.23.3.2 / P51912 Insulin-activated, Na+-dependet amino acid (serine, alanine, glutamate, glutamine and other neutral amino acids):amino acid antiporter (Ndaru et al. 2019). Also transports homocysteine from Mus musculus (Mouse) (see 2 papers)
Slc1a5 neutral amino acid transporter B(0) from Mus musculus (see paper)
29% identity, 96% coverage of query (147 bits)
SATT_HUMAN / P43007 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Homo sapiens (Human) (see 7 papers)
TC 2.A.23.3.1 / P43007 Neutral amino acid (alanine, serine, cysteine, threonine):Na+ symporter. Also transports homocysteine (Jiang et al., 2007). AscT1 is the Syncytin-1 (Q9UQF0) receptor. Syncytin-1, of 538 aas with 4-7 TMSs, is a viral fusion protein and is involved in the development of multiple sclerosis (Antony et al. 2007). Mutation causes nuerological problems including global developmental delay, severe progressive microcephaly, seizures, spasticity and thin corpus callosum (CC) from Homo sapiens (Human) (see 9 papers)
SLC1A4 / RF|NP_003029.2 neutral amino acid transporter A from Homo sapiens (see paper)
29% identity, 89% coverage of query (145 bits)
Q21353 Putative sodium-dependent excitatory amino acid transporter glt-3 from Caenorhabditis elegans
27% identity, 90% coverage of query (143 bits)
8oudA / Q15758 Structure of the human neutral amino acid transporter asct2 in complex with nanobody 469
32% identity, 82% coverage of query (140 bits)
AAAT_HUMAN / Q15758 Neutral amino acid transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Homo sapiens (Human) (see 13 papers)
TC 2.A.23.3.3 / Q15758 Broad-specificity amino acid:Na+ symporter, LAT1, M7V1, RDR, RDRC or SLC1A5 (transports most neutral, zwitterionic and dibasic amino acids either uptake or bidirectional transport) (Scalise et al. 2018). Required for intracellular multiplication of Legionella pneumophila (Wieland et al., 2005). SLC7A5 with accessory protein SLC3A2 (the heavy chain; TC# 8.A.9.2.2) mediates bidirectional transport of amino acids and regulates mTOR and autophagy from Homo sapiens (Human) (see 13 papers)
SLC1A5 / RF|NP_005619.1 neutral amino acid transporter B(0) from Homo sapiens (see paper)
30% identity, 86% coverage of query (137 bits)
6mpbB / Q15758 Cryo-em structure of the human neutral amino acid transporter asct2 (see paper)
31% identity, 82% coverage of query (137 bits)
7bcsA Asct2 in the presence of the inhibitor lc-bpe (position "down") in the outward-open conformation.
31% identity, 82% coverage of query (136 bits)
7bcqA Asct2 in the presence of the inhibitor lc-bpe (position "up") in the outward-open conformation.
31% identity, 82% coverage of query (136 bits)
8ouhA Complex of human asct2 with syncytin-1
31% identity, 82% coverage of query (135 bits)
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Lawrence Berkeley National Laboratory