Sites on a Tree

 

Searching for up to 100 curated homologs for 6937231 FitnessBrowser__SB2B:6937231 (444 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

Removed hits that are identical to the query, leaving 24

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YicJ / b3657 putative xyloside transporter YicJ from Escherichia coli K-12 substr. MG1655 (see 5 papers)
TC 2.A.2.3.4 / P31435 Probable α-xyloside uptake permease, YicJ from Escherichia coli (see 4 papers)
    43% identity, 99% coverage of query (359 bits)

YagG / b0270 CP4-6 prophage; putative D-xylonate transporter YagG from Escherichia coli K-12 substr. MG1655 (see 5 papers)
YAGG_ECOLI / P75683 Putative glycoside/cation symporter YagG from Escherichia coli (strain K12) (see paper)
TC 2.A.2.3.5 / P75683 Probable β-xyloside uptake permease, YagG from Escherichia coli (see 2 papers)
    38% identity, 99% coverage of query (317 bits)

TC 2.A.2.3.2 / P94488 Pentoside permease from Bacillus subtilis (see 2 papers)
    37% identity, 99% coverage of query (282 bits)

XYLP_LACPE / P96792 Isoprimeverose transporter; Isoprimeverose cation symporter from Lactiplantibacillus pentosus (Lactobacillus pentosus) (see 2 papers)
TC 2.A.2.3.3 / P96792 Isoprimeverose (α-D xylopyranosyl-(1,6)-D-glucopyranose) permease [xylose is not a substrate] from Lactobacillus pentosus (see paper)
xylP xylose transporter from Lactobacillus pentosus (see paper)
    35% identity, 100% coverage of query (242 bits)

SquO / b3876 putative sulfoquinovose transporter from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yihO / P32136 putative sulfoquinovose transporter from Escherichia coli (strain K12) (see 3 papers)
YIHO_ECOLI / P32136 Putative sulfoquinovose importer from Escherichia coli (strain K12) (see paper)
    32% identity, 99% coverage of query (199 bits)

UIDB2_ECOLI / P0CE45 Glucuronide carrier protein; Glucuronide permease from Escherichia coli (strain K12) (see paper)
TC 2.A.2.3.1 / P0CE45 Glucuronide permease, UidB, GusB, UidP from Escherichia coli (strain K12) (see 2 papers)
    31% identity, 99% coverage of query (187 bits)

UidP / b1616 glucuronide:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
uidB / P0CE44 glucuronide:H+ symporter from Escherichia coli (strain K12) (see 3 papers)
    31% identity, 99% coverage of query (184 bits)

Build an alignment

Build an alignment for 6937231 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

TC 2.A.2.1.1 / A7ZUZ0 Melibiose permease. Catalyzes the coupled stoichiometric symport of a galactoside with a cation (either Na+, Li+, or H+). Based on LacY, a 3-d model has been derived (Yousef and Guan, 2009). Asp55 and Asp59 are essential for Na+ from Escherichia coli O139:H28 (strain E24377A / ETEC) (see paper)
    27% identity, 99% coverage of query (181 bits)

MELB_SALTY / P30878 Melibiose permease; Melibiose carrier; Melibiose transporter; Melibiose/cation symporter; Na+ (Li+)/melibiose symporter; Thiomethylgalactoside permease II from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
    28% identity, 100% coverage of query (180 bits)

MelB / b4120 melibiose:H+/Na+/Li+ symporter from Escherichia coli K-12 substr. MG1655 (see 25 papers)
melB / P02921 melibiose:H+/Na+/Li+ symporter from Escherichia coli (strain K12) (see 28 papers)
MELB_ECOLI / P02921 Melibiose permease; Melibiose carrier; Melibiose transporter; Melibiose/cation symporter; Na+ (Li+)/melibiose symporter; Thiomethylgalactoside permease II from Escherichia coli (strain K12) (see 10 papers)
    27% identity, 99% coverage of query (179 bits)

YihP / b3877 putative 2,3-dihydroxypropane-1-sulfonate export protein from Escherichia coli K-12 substr. MG1655 (see 3 papers)
YIHP_ECOLI / P32137 Putative 2,3-dihydroxypropane-1-sulfonate exporter from Escherichia coli (strain K12) (see paper)
    29% identity, 99% coverage of query (179 bits)

7l16A / P30878 Crystal structure of sugar-bound melibiose permease melb (see paper)
    28% identity, 100% coverage of query (177 bits)

7l17A Crystal structure of sugar-bound melibiose permease melb
    28% identity, 100% coverage of query (177 bits)

MELB_KLEPN / Q02581 Melibiose permease; Melibiose carrier; Melibiose transporter from Klebsiella pneumoniae (see paper)
melB / AAA25067.1 melibiose carrier from Klebsiella pneumoniae (see paper)
    27% identity, 99% coverage of query (173 bits)

MELB_KLEAE / O07366 Melibiose permease; Melibiose carrier; Melibiose transporter from Klebsiella aerogenes (Enterobacter aerogenes) (see paper)
    27% identity, 99% coverage of query (170 bits)

lacP / CAA74936.1 lactose permease from Staphylococcus xylosus (see paper)
    27% identity, 99% coverage of query (143 bits)

TC 2.A.2.2.1 / P23936 Lactose permease, LacS. Mediates uptake of β-galactooligosaccharides, lactitol, and a broad range of prebiotic β-galactosides that selectively stimulate beneficial gut microbiota from Streptococcus thermophilus (see 2 papers)
    24% identity, 99% coverage of query (100 bits)

galP / CAB44214.1 galactose permease from Lactococcus lactis (see paper)
    23% identity, 99% coverage of query (86.7 bits)

LACY_LACHE / Q7WTB2 Lactose permease; Lactose transport protein; Lactose transporter; Lactose-proton symporter; EC 2.7.1.- from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
    24% identity, 89% coverage of query (83.2 bits)

MFS2B_HUMAN / A6NFX1 Sphingosine-1-phosphate transporter MFSD2B; Major facilitator superfamily domain-containing protein 2B; hMfsd2b from Homo sapiens (Human) (see 2 papers)
    25% identity, 89% coverage of query (80.5 bits)

NLS1A_DANRE / Q5U3U7 Sodium-dependent lysophosphatidylcholine symporter 1-A; NLS1-A; Sodium-dependent LPC symporter 1-A; Major facilitator superfamily domain-containing protein 2A-A from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
    22% identity, 96% coverage of query (78.2 bits)

MFS2B_MOUSE / Q3T9M1 Sphingosine-1-phosphate transporter MFSD2B; Major facilitator superfamily domain-containing protein 2B; mMfsd2b from Mus musculus (Mouse) (see 6 papers)
    23% identity, 85% coverage of query (77.0 bits)

TC 2.A.2.5.1 / Q93KC2 Saturated and unsaturated oligogalacturonide transporter, TogT (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5- hexosulose uronate at the reducing position) from Erwinia chrysanthemi (see paper)
    24% identity, 93% coverage of query (74.7 bits)

TC 2.A.2.1.2 / B3W8U5 Probable fucosyl-α-1,6-N-acetylglucosamine uptake porter, AlfD (next to and in an operon with a fucosidase (AlfA) specific for this disaccharide which is present in mammalian glycoproteins, glycolipids and milk from Lactobacillus casei (strain BL23)
    23% identity, 97% coverage of query (71.6 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory