Searching for up to 100 curated homologs for 6937849 FitnessBrowser__SB2B:6937849 (518 a.a.)
Found high-coverage hits (≥70%) to 59 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.53.3.13 / Q1J2S8 Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs from Deinococcus geothermalis (strain DSM 11300)
45% identity, 95% coverage of query (378 bits)
5da0A / Q1J2S8 Structure of the the slc26 transporter slc26dg in complex with a nanobody (see paper)
45% identity, 95% coverage of query (373 bits)
TC 2.A.53.3.1 / O07488 Sulfate permease from Yersinia enterocolitica (see paper)
42% identity, 94% coverage of query (363 bits)
BICA_SYNY3 / Q55415 Bicarbonate transporter BicA from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
31% identity, 93% coverage of query (191 bits)
BICA_SYNP2 / Q14SY0 Bicarbonate transporter BicA from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) (see 2 papers)
TC 2.A.53.3.3 / Q14SY0 12 TMS Na+:bicarbonate symporter, BicA (Price et al., 2004; Shelden et al., 2010) (low affinity but high efficiency) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see paper)
30% identity, 93% coverage of query (183 bits)
Build an alignment for 6937849 and 5 homologs with ≥ 30% identity
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DauA / b1206 aerobic C4-dicarboxylate transporter DauA from Escherichia coli K-12 substr. MG1655 (see 9 papers)
DauA / P0AFR2 aerobic C4-dicarboxylate transporter DauA from Escherichia coli (strain K12) (see 9 papers)
DAUA_ECOLI / P0AFR2 C4-dicarboxylic acid transporter DauA; Dicarboxylic acid uptake system A from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.53.3.11 / P0AFR2 Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7) from Escherichia coli (strain K12)
29% identity, 95% coverage of query (176 bits)
6ki1B / Q55415 The transmembrane domain of a cyanobacterium bicarbonate transporter bica (see paper)
35% identity, 73% coverage of query (172 bits)
TC 2.A.53.3.2 / Q7U617 Bicarbonate:Na+ symporter, BicA (see paper)
29% identity, 93% coverage of query (166 bits)
TC 2.A.53.3.9 / A1JRS3 SulP homologue. The low resolution structure is available from Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) (see paper)
29% identity, 88% coverage of query (164 bits)
7lhvA / Q9FY46 Structure of arabidopsis thaliana sulfate transporter atsultr4;1 (see paper)
24% identity, 96% coverage of query (119 bits)
SUT41_ARATH / Q9FY46 Sulfate transporter 4.1, chloroplastic; AST82 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 96% coverage of query (119 bits)
TC 2.A.53.3.8 / Q8F8H7 SulP homologue with fused C-terminal carbonic anhydrase domain, probable bicarbonate uptake transporter from Leptospira interrogans (see paper)
26% identity, 96% coverage of query (108 bits)
Y1739_MYCTU / P9WGF7 Probable sulfate transporter Rv1739c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 2.A.53.4.2 / P71997 Sulfate transporter, Rv1739c from Mycobacterium tuberculosis
24% identity, 96% coverage of query (103 bits)
7v74A Thermostabilized human prestin in complex with sulfate
25% identity, 93% coverage of query (103 bits)
7v75A Thermostabilized human prestin in complex with salicylate (see paper)
25% identity, 90% coverage of query (101 bits)
bst3.1 / CAE46442.1 sulphate transporter from Brassica napus (see paper)
23% identity, 88% coverage of query (96.7 bits)
SUT33_ARATH / Q9SXS2 Probable sulfate transporter 3.3; AST91 from Arabidopsis thaliana (Mouse-ear cress)
24% identity, 73% coverage of query (89.0 bits)
TC 2.A.53.1.12 / Q0P7I2 Symbiotic sulfate transporter-1, SST1 of 645 aas from Lotus japonicus
22% identity, 88% coverage of query (88.6 bits)
TC 2.A.53.3.5 / F5R8F2 SulP homologue with fused C-terminal STAS/CAP-ED domains (function unknown COG0659) from Methyloversatilis universalis FAM5
26% identity, 97% coverage of query (85.9 bits)
S2611_MOUSE / Q80ZD3 Sodium-independent sulfate anion transporter; Kidney brain anion transporter; KBAT; Solute carrier family 26 member 11 from Mus musculus (Mouse) (see 5 papers)
22% identity, 92% coverage of query (84.3 bits)
S2611_HUMAN / Q86WA9 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Homo sapiens (Human) (see 3 papers)
22% identity, 92% coverage of query (82.8 bits)
S26A1_HUMAN / Q9H2B4 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Homo sapiens (Human) (see 3 papers)
TC 2.A.53.2.16 / Q9H2B4 Sulfate anion transporter 1 (SAT-1 or SAT1) (Solute carrier family 26 member 1); anion exchanger. Transports chloride, sulfate, bicarbonate and oxalate (Regeer et al. 2003; Lee et al. 2003). The mouse and rat orthologues have the same specificities and functions. Loss in mice is associated with hyperoxalurea and calcium oxalate kidney stones, and specific mutations when heterozygous in humans cause urolithiasis (Dawson et al. 2013). When homozygous, they can cause severe nephrocalcinosis from Homo sapiens (see 5 papers)
22% identity, 82% coverage of query (82.8 bits)
ST1 / CAA65291.1 high affinity sulphate transporter from Hordeum vulgare (see paper)
24% identity, 74% coverage of query (77.8 bits)
TC 2.A.53.1.4 / P53393 Low-affinity sulfate:H+ symporter, Sut3 from Stylosanthes hamata (see paper)
23% identity, 70% coverage of query (76.6 bits)
TC 2.A.53.4.1 / P72770 Sulfate transporter (see paper)
23% identity, 92% coverage of query (76.3 bits)
SUT21_ARATH / O04722 Sulfate transporter 2.1; AST68 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
23% identity, 75% coverage of query (76.3 bits)
P96878 carbonic anhydrase (EC 4.2.1.1) from Mycobacterium tuberculosis (see paper)
TC 2.A.53.3.12 / P96878 A bicarbonate transporter fused to a carbonic anhydrase, Rv3273 from Mycobacterium tuberculosis
27% identity, 75% coverage of query (75.9 bits)
TC 2.A.53.2.5 / Q99NH7 Prestin, the outer hair cell voltage-sensitive motor protein (voltage sensitivity depends on intracellular Cl- and HCO3- which may bind to prestin). Prestin transports anions including formate and oxalate; transport and voltage-sensing capabilities are independent functions of the same protein (Bai et al., 2009). Prestin-mediated electromotility is a dual-step process: transport of anions by an alternate access cycle, followed by an anion-dependent transition generating electromotility from Mus musculus (Mouse) (see paper)
Slc26a5 / GB|AAG59999.2 prestin from Mus musculus
21% identity, 81% coverage of query (73.6 bits)
S26A5_HUMAN / P58743 Prestin; Solute carrier family 26 member 5 from Homo sapiens (Human) (see 2 papers)
TC 2.A.53.2.19 / P58743 Prestin (Solute carrier family 26 member 5) from Homo sapiens (see 3 papers)
21% identity, 81% coverage of query (73.6 bits)
S26A5_MERUN / Q9JKQ2 Prestin; Solute carrier family 26 member 5 from Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) (see 4 papers)
21% identity, 81% coverage of query (73.2 bits)
S26A5_MOUSE / Q99NH7 Prestin; Solute carrier family 26 member 5 from Mus musculus (Mouse) (see 5 papers)
21% identity, 81% coverage of query (72.8 bits)
S26A5_RAT / Q9EPH0 Prestin; Solute carrier family 26 member 5 from Rattus norvegicus (Rat) (see 11 papers)
21% identity, 81% coverage of query (72.8 bits)
7lguA / P58743 Structure of human prestin in the presence of nacl (see paper)
21% identity, 81% coverage of query (72.8 bits)
SUT22_ARATH / P92946 Sulfate transporter 2.2; AST56; AtH14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
22% identity, 87% coverage of query (72.0 bits)
SHST2 / CAA57711.1 high affinity sulphate transporter from Stylosanthes hamata (see paper)
24% identity, 75% coverage of query (72.0 bits)
S26A5_TURTR / D7PC76 Prestin; Solute carrier family 26 member 5 from Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) (see paper)
20% identity, 81% coverage of query (71.2 bits)
S26A1_RAT / P45380 Sulfate anion transporter 1; SAT-1; Canalicular sulfate transporter; Solute carrier family 26 member 1; Sulfate/carbonate antiporter from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.53.2.2 / P45380 Canicular sulfate:HCO3- antiporter (Slc26a1) from Rattus norvegicus (Rat) (see paper)
20% identity, 82% coverage of query (71.2 bits)
7xulA Human slc26a3 in complex with tenidap
23% identity, 83% coverage of query (70.5 bits)
TC 2.A.53.1.3 / P53391 The molybdate (high affinity)/Sulfate (lower affinity) transporter, ShsT1 from Stylosanthes hamata (see paper)
SHST1 / CAA57710.1 high affinity sulphate transporter from Stylosanthes hamata (see paper)
23% identity, 75% coverage of query (69.7 bits)
S26A6_MOUSE / Q8CIW6 Solute carrier family 26 member 6; Anion exchange transporter; Chloride-formate exchanger; Pendrin-L1; Pendrin-like protein 1; Putative anion transporter-1; Pat-1 from Mus musculus (Mouse) (see 22 papers)
22% identity, 73% coverage of query (69.7 bits)
TC 2.A.53.2.8 / Q8K142 The mouse Slc26a6 anion exchanger (same substrate specificity as its human orthologue (2.A.53.2.7)), but Cl- and HSO4- are transported rapidly. Moreover, although Cl-/HCO3- and Cl-/OH- exchange reactions are electroneutral, Cl-:oxalate exchange is electrogenic (Chernova et al., 2005). Also catalyzes Cl-:formate exchange (see paper)
Slc26a6 / RF|NP_599252.2 solute carrier family 26, member 6 from Mus musculus
22% identity, 73% coverage of query (69.7 bits)
S26A6_HUMAN / Q9BXS9 Solute carrier family 26 member 6; Anion exchange transporter; Pendrin-like protein 1; Pendrin-L1 from Homo sapiens (Human) (see 7 papers)
TC 2.A.53.2.7 / Q9BXS9 The human Slc26a6 anion exchanger (transports sulfate, formate, oxalate, chloride and bicarbonate in antiport with any one of these anions) (Jiang et al., 2002). However, Cl- and HSO4- are transported slowly; Cl-/HCO3-, Cl-/OH- and Cl-:oxalate exchange reactions are electroneutral (Chernova et al., 2005). (The oxalate nephrolithiasis gene; Clark et al., 2008). Catalyzes 1Cl-/2HCO3- antiport from Homo sapiens (Human) (see 4 papers)
20% identity, 73% coverage of query (69.7 bits)
7xujA Human slc26a3 in complex with uk5099
23% identity, 83% coverage of query (69.7 bits)
S26A1_MOUSE / P58735 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Mus musculus (Mouse) (see 4 papers)
21% identity, 82% coverage of query (67.8 bits)
7xuhA / P40879 Down-regulated in adenoma in complex with tqr1122
23% identity, 83% coverage of query (67.4 bits)
S26A5_DANRE / Q7T2C4 Prestin; Solute carrier family 26 member 5 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
19% identity, 84% coverage of query (66.2 bits)
Q9URY8 Probable sulfate permease C869.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
23% identity, 73% coverage of query (65.9 bits)
sB sulfate permease from Emericella nidulans (see 3 papers)
25% identity, 78% coverage of query (64.7 bits)
S26A3_HUMAN / P40879 Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 from Homo sapiens (Human) (see 16 papers)
TC 2.A.53.2.18 / P40879 Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) from Homo sapiens (see 12 papers)
22% identity, 83% coverage of query (63.9 bits)
S26A2_BOVIN / Q9BEG8 Sulfate transporter; Solute carrier family 26 member 2 from Bos taurus (Bovine) (see paper)
22% identity, 86% coverage of query (61.2 bits)
8sgwC / A0A8D0Z6H8 Pendrin in complex with chloride
20% identity, 81% coverage of query (60.8 bits)
8sieC Pendrin in complex with bicarbonate
20% identity, 81% coverage of query (60.8 bits)
8shcC Pendrin in complex with niflumic acid
20% identity, 81% coverage of query (60.8 bits)
S26A4_HUMAN / O43511 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Homo sapiens (Human) (see 34 papers)
TC 2.A.53.2.17 / O43511 Pendrin (Sodium-independent chloride/iodide/bicarbonate transporter) (Solute carrier family 26 member 4, Slc26a4) from Homo sapiens (see 30 papers)
21% identity, 81% coverage of query (60.1 bits)
sutA / AAF14540.1 SutA from Penicillium chrysogenum (see paper)
22% identity, 75% coverage of query (59.7 bits)
TC 2.A.53.2.11 / G3C7W5 Guinea pig Slc26a3 electroneutral Cl-/HCO3- exchanger (does not transport oxalate or sulfate). from Cavia porcellus (see paper)
19% identity, 82% coverage of query (53.1 bits)
SULX_YEAST / P53394 Putative sulfate transporter YPR003C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
20% identity, 93% coverage of query (52.8 bits)
S26A4_MOUSE / Q9R155 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.53.2.4 / Q9R155 Pendrin (Pendred) syndrome (hereditary deafness) anion transporter (Na+-independent). Anions transported: iodide (thyroid gland; apical membrane of follicular epithelium); bicarbonate (kidney; apical membrane of intercalated cells of the cortical collecting duct), chloride, formate, etc. Pendrin probably catalyzes uniport and anion/anion antiport (SLC26A4). It also regulates Na+ absorption by the epithelial Na+ channel (Wall and Pech, 2008). CFTR controls the rate of liquid secretion while pendrin mediates transcellular HCO3- from Mus musculus (Mouse) (see paper)
19% identity, 83% coverage of query (52.4 bits)
S26A8_HUMAN / Q96RN1 Testis anion transporter 1; Anion exchange transporter; Solute carrier family 26 member 8 from Homo sapiens (Human) (see 8 papers)
20% identity, 73% coverage of query (52.0 bits)
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Lawrence Berkeley National Laboratory