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Searching for up to 100 curated homologs for 6938067 FitnessBrowser__SB2B:6938067 (405 a.a.)

Found high-coverage hits (≥70%) to 35 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YgjU / b3089 serine/threonine:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
sstT / P0AGE4 serine/threonine:Na+ symporter from Escherichia coli (strain K12) (see 7 papers)
SSTT_ECOLI / P0AGE4 Serine/threonine transporter SstT; Na(+)/serine-threonine symporter from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.23.4.1 / P0AGE4 Serine/threonine:Na+ symporter, SstT from Escherichia coli (see 5 papers)
    67% identity, 100% coverage of query (516 bits)

Build an alignment

Build an alignment for 6938067 and 1 homologs with ≥ 30% identity

Select sequences

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Additional hits (identity < 30%)

GLT_PYRHO / O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 9 papers)
TC 2.A.23.1.5 / O59010 Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ from Pyrococcus horikoshii (see 2 papers)
    26% identity, 96% coverage of query (101 bits)

6bauA Crystal structure of gltph r397c in complex with l-cysteine
    26% identity, 94% coverage of query (99.4 bits)

6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine
    26% identity, 94% coverage of query (99.4 bits)

2nwwA Crystal structure of gltph in complex with tboa
    26% identity, 94% coverage of query (99.0 bits)

TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
    26% identity, 95% coverage of query (98.2 bits)

6x15A / O59010 Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
    25% identity, 94% coverage of query (94.7 bits)

6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa
    25% identity, 94% coverage of query (94.7 bits)

CH_124149 excitatory amino acid transporter 2 from Magnaporthe grisea 70-15 (see paper)
    27% identity, 86% coverage of query (91.3 bits)

6bmiA Crystal structure of gltph r397c in complex with l-serine
    27% identity, 75% coverage of query (90.5 bits)

TC 2.A.23.2.12 / B0W0K5 Dicarboxylic acid over dicarboxylic amino acid from Culex quinquefasciatus
    27% identity, 86% coverage of query (89.0 bits)

6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate
    25% identity, 93% coverage of query (88.6 bits)

Psest_4075 symporter for L-glutamate, L-glutamine, and L-proline from Pseudomonas stutzeri RCH2
    27% identity, 93% coverage of query (87.0 bits)

5e9sA / Q5JID0 Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
    25% identity, 93% coverage of query (83.2 bits)

6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis)
    25% identity, 93% coverage of query (83.2 bits)

6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound
    25% identity, 93% coverage of query (82.8 bits)

6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor
    25% identity, 93% coverage of query (82.8 bits)

TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
    27% identity, 84% coverage of query (80.9 bits)

7awmA / P43003,Q15758 Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
    25% identity, 94% coverage of query (79.0 bits)

AAAT_RAT / D3ZJ25 Neutral amino acid transporter B(0); ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2 from Rattus norvegicus (Rat) (see paper)
    30% identity, 71% coverage of query (78.2 bits)

GLTT_BACSU / O07605 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus subtilis (strain 168) (see 2 papers)
    25% identity, 93% coverage of query (77.8 bits)

EAA4_MOUSE / O35544 Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Mus musculus (Mouse) (see paper)
    25% identity, 74% coverage of query (77.0 bits)

DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    26% identity, 83% coverage of query (76.3 bits)

DctA / b3528 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
dctA / P0A830 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli (strain K12) (see 23 papers)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12) (see 6 papers)
dctA / GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli (see 5 papers)
    26% identity, 85% coverage of query (75.9 bits)

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
    24% identity, 88% coverage of query (75.9 bits)

TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis (see 2 papers)
    22% identity, 83% coverage of query (75.5 bits)

AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
    23% identity, 88% coverage of query (73.2 bits)

7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613
    25% identity, 95% coverage of query (71.2 bits)

7vr7A Inward-facing structure of human eaat2 in the way213613-bound state
    25% identity, 93% coverage of query (71.2 bits)

7xr4A / P43004 Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
    25% identity, 95% coverage of query (70.5 bits)

GLTP_BACSU / P39817 Proton/glutamate-aspartate symporter; Proton/glutamate symport protein from Bacillus subtilis (strain 168) (see paper)
GltP / AAA82878.1 proton/glutamate symport protein from Bacillus subtilis (see paper)
    23% identity, 91% coverage of query (70.5 bits)

5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101
    25% identity, 94% coverage of query (70.1 bits)

RR42_RS03990 aspartate:proton symporter Glt from Cupriavidus basilensis FW507-4G11
    23% identity, 84% coverage of query (67.8 bits)

TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
    25% identity, 84% coverage of query (64.7 bits)

GltP / b4077 glutamate/aspartate : H+ symporter GltP from Escherichia coli K-12 substr. MG1655 (see paper)
gltP / P21345 glutamate/aspartate : H+ symporter GltP from Escherichia coli (strain K12) (see 5 papers)
GLTP_ECOLI / P21345 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.23.1.1 / P21345 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) from Escherichia coli (see 6 papers)
    22% identity, 96% coverage of query (63.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory