Searching for up to 100 curated homologs for 6938073 FitnessBrowser__SB2B:6938073 (612 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
34% identity, 79% coverage of query (276 bits)
2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp
34% identity, 79% coverage of query (276 bits)
YWJA_BACSU / P45861 Uncharacterized ABC transporter ATP-binding protein YwjA from Bacillus subtilis (strain 168) (see 2 papers)
35% identity, 80% coverage of query (266 bits)
TC 3.A.1.106.14 / P73239 Lipid A exporter homologue of 593 aas and 6 TMSs (N-terminal with a C-terminal ATPase domain from Synechocystis sp. (strain PCC 6803 / Kazusa)
32% identity, 96% coverage of query (261 bits)
TC 3.A.1.106.9 / Q9KZE5 SoxR regulon single protein ABC exporter, Sco7008, containing an N-terminal membrane domain and a C-terminal ATPase domain (Shin et al. 2011). SoxR responds to extracellular redox-active compounds from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
32% identity, 94% coverage of query (252 bits)
7metA / A0A0B9X4I2 A. Baumannii msba in complex with tbt1 decoupler (see paper)
34% identity, 83% coverage of query (251 bits)
TC 3.A.1.210.2 / Q02592 The vacuolar heavy metal tolerance protein precursor, HMT1 (transports phytochelins and Cd2+·phytochelin complexes) from Schizosaccharomyces pombe (Fission yeast) (see 2 papers)
hmt1 / RF|NP_588371.3 heavy metal tolerance protein from Schizosaccharomyces pombe (see 2 papers)
34% identity, 80% coverage of query (248 bits)
Q9HUG8 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Pseudomonas aeruginosa (see paper)
32% identity, 96% coverage of query (244 bits)
AB19B_ARATH / Q9LJX0 ABC transporter B family member 19; ABC transporter ABCB.19; AtABCB19; Multidrug resistance protein 11; P-glycoprotein 19 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 3.A.1.201.6 / Q9LJX0 Auxin efflux pump Pgp19 (MDR11; ABCB19; ABCB21) (regulated by Twd1, an FK506-binding protein immunophilin prolyl/peptidyl isomerase (TC# 8.A.11.1.1) from Arabidopsis thaliana (Mouse-ear cress) (see 9 papers)
MDR11 / RF|NP_189528.1 multidrug resistance protein 11 from Arabidopsis thaliana (see paper)
35% identity, 79% coverage of query (239 bits)
msbA / Q2YJN8 lipid A-core oligosaccharide flippase (EC 7.5.2.6) from Brucella abortus (strain 2308) (see 2 papers)
33% identity, 78% coverage of query (239 bits)
At3g28860 / AAN28720.2 MDR-like p-glycoprotein from Arabidopsis thaliana (see paper)
35% identity, 79% coverage of query (239 bits)
TC 3.A.1.106.3 / Q8G7R7 Probable permease protein of ABC transporter system, component of The dimeric multidrug resistance exporter, ABC1/2 (exports the peptide antimicrobials, nisin and polymyxin; (Margolles et al., 2006) (both ABC1 and ABC2 also show striking similarity to family 3.A.1.117) from Bifidobacterium longum (see paper)
33% identity, 77% coverage of query (238 bits)
MSBA_FRANO / Q47908 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; EC 7.5.2.6 from Francisella novicida (see paper)
31% identity, 77% coverage of query (237 bits)
TC 3.A.1.201.23 / Q8T9W4 The cyclic AMP efflux pump of 1432 aas, ABCB3 from Dictyostelium discoideum
33% identity, 78% coverage of query (236 bits)
MSBA_VIBCH / Q9KQW9 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; EC 7.5.2.6 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
Q9KQW9 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Vibrio cholerae (see paper)
33% identity, 81% coverage of query (235 bits)
TC 3.A.1.201.12 / B2WTH9 California mussel ABCB/MDR multixenobiotic resistance efflux pump from Mytilus californianus (see paper)
33% identity, 79% coverage of query (234 bits)
MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
31% identity, 84% coverage of query (233 bits)
AB1B_ARATH / Q9ZR72 ABC transporter B family member 1; ABC transporter ABCB.1; AtABCB1; Multidrug resistance protein 1; P-glycoprotein 1; AtPgp1 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
TC 3.A.1.201.5 / Q9ZR72 Auxin efflux pump Pgp1 (MDR1; ABCB1) (Carraro et al. 2012). Regulated by Twd1, an FK506-binding protein immunophilin prolyl/peptidyl isomerase; 8.A.11.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see 14 papers)
MDR1 / RF|NP_181228.1 multidrug resistance protein 1 from Arabidopsis thaliana (see paper)
33% identity, 80% coverage of query (232 bits)
ACLQ_ASPOR / Q2UPC0 ABC transporter aclQ; Aspirochlorine biosynthesis protein Q from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
33% identity, 73% coverage of query (232 bits)
7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
31% identity, 84% coverage of query (232 bits)
7mewA E. Coli msba in complex with g247
31% identity, 84% coverage of query (232 bits)
8dmmA Structure of the vanadate-trapped msba bound to kdl
31% identity, 84% coverage of query (232 bits)
7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
31% identity, 84% coverage of query (231 bits)
6bppA E. Coli msba in complex with lps and inhibitor g092
31% identity, 84% coverage of query (231 bits)
6bplA E. Coli msba in complex with lps and inhibitor g907
31% identity, 84% coverage of query (231 bits)
7bcwA Structure of msba in salipro with adp vanadate
31% identity, 84% coverage of query (231 bits)
CYAB_BORP1 / P0DKX6 Cyclolysin secretion/processing ATP-binding protein CyaB; EC 3.4.22.-; EC 7.6.2.- from Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323) (see paper)
34% identity, 82% coverage of query (230 bits)
TC 3.A.1.109.2 / P18770 Cyclolysin exporter, CyaB (Glaser et al., 1988) from Bordetella pertussis (see 2 papers)
34% identity, 82% coverage of query (230 bits)
7selA E. Coli msba in complex with lps and inhibitor g7090 (compound 3)
31% identity, 84% coverage of query (224 bits)
7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
32% identity, 78% coverage of query (224 bits)
3wmgA Crystal structure of an inward-facing eukaryotic abc multidrug transporter g277v/a278v/a279v mutant in complex with an cyclic peptide inhibitor, acap
35% identity, 79% coverage of query (223 bits)
8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
32% identity, 78% coverage of query (222 bits)
ABCB9_HUMAN / Q9NP78 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Homo sapiens (Human) (see 16 papers)
Q9NP78 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
TC 3.A.1.209.2 / Q9NP78 Homodimeric transporter ABCB9 or TAPL. Transports a broad spectrum of peptides (low affinity) from the cytosol to the lysosomal lumen. It exists in two forms (812 aas and 1257 aas). The latter full length protein confers resistance to taxanes and anthracyclines (Kawanobe et al., 2012). Resistance and transport were demonstrated for paclitaxel and docetaxel. TapL transports a broad range of peptides of 6-60aas (23aas optimal). It has also been detected in the ER. It is stabilized by interaction with LAMP-1 and LAMP-2 (see 9.A.16) from Homo sapiens (see 18 papers)
30% identity, 80% coverage of query (220 bits)
7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
30% identity, 79% coverage of query (218 bits)
8fhkC / O07550 Heterodimeric abc transporter bmrcd in the occluded conformation bound to atp: bmrcd_oc-atp (see paper)
31% identity, 78% coverage of query (218 bits)
8t1pC Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
31% identity, 78% coverage of query (218 bits)
7m33C The structure of bacillus subtilis bmrcd in the inward-facing conformation bound to hoechst-33342 and atp
31% identity, 78% coverage of query (218 bits)
4s0fA Crystal structure of the peptidase-containing abc transporter pcat1 e648q mutant complexed with atpgs in an occluded conformation
30% identity, 79% coverage of query (218 bits)
7vfiA Cryo-em structure of the mouse tapl (9mer-peptide bound)
30% identity, 79% coverage of query (217 bits)
7v5cA / Q9JJ59 Cryo-em structure of the mouse abcb9 (adp.Bef3-bound) (see paper)
30% identity, 79% coverage of query (217 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
31% identity, 78% coverage of query (216 bits)
BMRA_BACSU / O06967 Multidrug resistance ABC transporter ATP-binding/permease protein BmrA; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 7 papers)
TC 3.A.1.117.3 / O06967 Multidrug resistance homodimeric efflux pump, BmrA (YvcC) of 589 aas from Bacillus subtilis (strain 168)
31% identity, 83% coverage of query (215 bits)
8t1pD Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
30% identity, 78% coverage of query (214 bits)
8fpfD / O07549 Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to atp: bmrcd_if-atp (see paper)
30% identity, 78% coverage of query (214 bits)
7ow8A / O06967 Cryoem structure of the abc transporter bmra e504a mutant in complex with atp-mg (see paper)
31% identity, 83% coverage of query (212 bits)
7zoaB / Q2YQ73 Cryo-em structure of cgt abc transporter in presence of cbg substrate (see paper)
32% identity, 70% coverage of query (212 bits)
8fmvD Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to substrate and atp: bmrcd_if-2ht/atp
30% identity, 78% coverage of query (212 bits)
Build an alignment for 6938073 and 47 homologs with ≥ 30% identity
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7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
29% identity, 94% coverage of query (209 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
29% identity, 94% coverage of query (209 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
29% identity, 94% coverage of query (209 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
29% identity, 94% coverage of query (209 bits)
7bg4A Multidrug resistance transporter bmra mutant e504a bound with atp, mg, and rhodamine 6g solved by cryo-em
30% identity, 83% coverage of query (209 bits)
Q00748 Multidrug resistance protein homolog 65; P-glycoprotein 65; EC 7.6.2.2 from Drosophila melanogaster (Fruit fly)
30% identity, 97% coverage of query (208 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
28% identity, 95% coverage of query (207 bits)
MITOS_HUMAN / Q9NUT2 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR from Homo sapiens (Human) (see 5 papers)
Q9NUT2 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
TC 3.A.1.201.22 / Q9NUT2 Mitochondrial ATP-binding cassette 1, ABCB8 from Homo sapiens
28% identity, 89% coverage of query (207 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
28% identity, 96% coverage of query (206 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
28% identity, 96% coverage of query (206 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
28% identity, 96% coverage of query (206 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
28% identity, 97% coverage of query (206 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
29% identity, 93% coverage of query (206 bits)
5koyA Mouse pgp 34 linker deleted bound with atp
28% identity, 96% coverage of query (206 bits)
AB27B_ARATH / Q0WML0 ABC transporter B family member 27; ABC transporter ABCB.27; AtABCB27; Aluminum tolerance-related ATP-binding cassette transporter; Antigen peptide transporter-like 2; Transporter associated with antigen processing-like protein 2; AtTAP2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 3.A.1.201.8 / Q0WML0 The aluminum chelate (aluminum sensitivity (ALS1)) protein; expressed in root vacuoles half-type ABC transporter from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
TAP2 / RF|NP_198720.2 antigen peptide transporter-like 2 from Arabidopsis thaliana (see paper)
30% identity, 78% coverage of query (206 bits)
5ochE / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
29% identity, 84% coverage of query (206 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
28% identity, 96% coverage of query (205 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
29% identity, 87% coverage of query (201 bits)
ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
31% identity, 78% coverage of query (200 bits)
7wixB / P9WQJ7 Cryo-em structure of mycobacterium tuberculosis irtab in complex with adp
31% identity, 74% coverage of query (199 bits)
8hf7B Cryo-em structure of coma bound to its mature substrate csp peptide
27% identity, 90% coverage of query (197 bits)
MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
30% identity, 80% coverage of query (196 bits)
7wiwB Cryo-em structure of mycobacterium tuberculosis irtab complexed with atp in an occluded conformation
31% identity, 73% coverage of query (196 bits)
8hf4A / A0A0H2ZPI8 Cryo-em structure of nucleotide-bound coma at outward-facing state with ec gate closed conformation (see paper)
27% identity, 90% coverage of query (196 bits)
8k7aA Cryo-em structure of nucleotide-bound coma e647q mutant with mg2+
27% identity, 90% coverage of query (194 bits)
8hf6A Cryo-em structure of nucleotide-bound coma e647q mutant
27% identity, 90% coverage of query (194 bits)
6p6jA / Q1RAG2 Structure of ybtpq importer with substrate ybt-fe bound (see paper)
31% identity, 70% coverage of query (192 bits)
4q4aA / Q9WYC3 Improved model of amp-pnp bound tm287/288 (see paper)
28% identity, 80% coverage of query (192 bits)
6quzA Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35
28% identity, 80% coverage of query (191 bits)
6qv0A Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
28% identity, 80% coverage of query (191 bits)
YCF1 / P39109 ATP-dependent vacuolar transporter YCF1 (EC 7.6.2.3; EC 7.2.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 16 papers)
YCFI_YEAST / P39109 Metal resistance protein YCF1; ABC-type Cd(2+) transporter; ABC-type glutathione-S-conjugate transporter; Yeast cadmium factor 1; EC 7.2.2.2; EC 7.6.2.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P39109 ABC-type Cd2+ transporter (EC 7.2.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Saccharomyces cerevisiae (see 2 papers)
TC 3.A.1.208.11 / P39109 Vacuolar metal resistance and drug detoxification protein, yeast cadmium factor (YCF1); transports cadmium-glutathione conjugates, glutathione S-conjugated leukotriene C4, organic glutathione S-conjugates, selenodigluthatione, unconjugated bilirubin, reduced glutathione, and diazaborine (Lazard et al., 2011). Mediates arsenite expulsion, possibly as a glutathione conjugate. Activity is dependent on Tus1p, a guanine nucleotide exchange factor (GEF) for the small GTPase Rho1p and a Rho1p-dependent-positive regulator of Ycf1p from Saccharomyces cerevisiae (Baker's yeast) (see 12 papers)
YCF1 / RF|NP_010419.1 metal resistance protein YCF1 from Saccharomyces cerevisiae
27% identity, 76% coverage of query (189 bits)
7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
30% identity, 75% coverage of query (180 bits)
6s7pA Nucleotide bound abcb4
30% identity, 75% coverage of query (180 bits)
P59852 Lactococcin-G-processing and transport ATP-binding protein LagD; EC 3.4.22.-; EC 7.-.-.- from Lactococcus lactis subsp. lactis (Streptococcus lactis)
30% identity, 79% coverage of query (177 bits)
8rq4A / Q63120 Cryo-em structure of the rat multidrug resistance-associated protein 2 (rmrp2) in complex with probenecid
27% identity, 80% coverage of query (175 bits)
ABC2_SCHPO / Q10185 ATP-binding cassette transporter abc2; ABC transporter abc2; ATP-energized glutathione S-conjugate pump abc2; Glutathione S-conjugate-transporting ATPase abc2; EC 7.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
TC 3.A.1.208.16 / Q10185 The vacuolar Abc2p (SPAC3F10.11c) transporter for xenobiotics, glutathione S-conjugates and monochlorobimane from Schizosaccharomyces pombe (Fission yeast) (see 3 papers)
abc2 / RF|NP_593943.2 ATP-binding cassette transporter abc2 from Schizosaccharomyces pombe (see 3 papers)
27% identity, 83% coverage of query (174 bits)
8jxqA Cryo-em structure of bilirubin ditaurate (bdt) bound human abc transporter abcc2
27% identity, 77% coverage of query (172 bits)
8jxuA / Q92887 Cryo-em structure of human abc transporter abcc2 under active turnover condition
27% identity, 77% coverage of query (172 bits)
MRP2_HUMAN / Q92887 ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2; EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3 from Homo sapiens (Human) (see 14 papers)
Q92887 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 12 papers)
27% identity, 77% coverage of query (172 bits)
TAP1_HUMAN / Q03518 Antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; Peptide supply factor 1; Peptide transporter PSF1; PSF-1; Peptide transporter TAP1; Peptide transporter involved in antigen processing 1; Really interesting new gene 4 protein; RING4; EC 7.4.2.14 from Homo sapiens (Human) (see 30 papers)
Q03518 ABC-type antigen peptide transporter (EC 7.4.2.14); bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
26% identity, 89% coverage of query (171 bits)
6rafB Heterodimeric abc exporter tmrab in inward-facing narrow conformation under turnover conditions
28% identity, 76% coverage of query (171 bits)
8t3kC / O07550 Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to atp: bmrcd_if-atp2 (see paper)
28% identity, 77% coverage of query (171 bits)
6rajB Heterodimeric abc exporter tmrab in vanadate trapped outward-facing open conformation
28% identity, 76% coverage of query (170 bits)
6ragB / Q72J04 Heterodimeric abc exporter tmrab in inward-facing wide conformation under turnover conditions (see paper)
28% identity, 76% coverage of query (170 bits)
TAP2_RAT / P36372 Antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; EC 7.4.2.14 from Rattus norvegicus (Rat) (see paper)
P36372 ABC-type antigen peptide transporter (subunit 1/2) (EC 7.4.2.14) from Rattus norvegicus (see 6 papers)
27% identity, 77% coverage of query (170 bits)
8hw2A / O15438 Cryo-em structure of beta-estradiol 17-(beta-d-glucuronide)-bound human abc transporter abcc3 in nanodiscs (see paper)
27% identity, 77% coverage of query (169 bits)
8hw4A Cryo-em structure of dehydroepiandrosterone sulfate-bound human abc transporter abcc3 in nanodiscs
27% identity, 77% coverage of query (169 bits)
ABC3_SCHPO / Q9P5N0 Vacuolar heme ABC transmembrane exporter abc3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 4 papers)
TC 3.A.1.208.28 / Q9P5N0 Vacuolar iron transporter, Abc3(+) of 1465 aas from Schizosaccharomyces pombe (strain 972 / ATCC 24843)
abc3 ABC transporter Abc3, unknown specificity from Schizosaccharomyces pombe (see paper)
26% identity, 76% coverage of query (169 bits)
ABCC1 / P33527 multidrug resistance-associated protein 1 (EC 7.6.2.3) from Homo sapiens (see 32 papers)
MRP1_HUMAN / P33527 Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter; EC 7.6.2.2; EC 7.6.2.3 from Homo sapiens (Human) (see 9 papers)
P33527 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 16 papers)
TC 3.A.1.208.8 / P33527 Drug resistance pump; ABCC1 (MRP1), exports chemotherapeutic agents, organic anions such as leukotriene C4 (LTC4), 17-β-estradiol 17-β-D-glucuronide, glucuronide-X (E217βG, etoposide-glucuronide), estrone-3-sulfate, folic acid and methotrexate, arsenic triglutathione, arsenic and antimonial oxyanions, glutathione (GSH), GSSG, glutathione conjugates (GSH-X; LTC4, DNP-SG, EA-SG, NEH-SG), sulfate-X (E1S, DHEAS), HIV protease inhibitors, anthracyclines, epipodophyllotoxins, and Vinca alkaloids. Changing charged residues in TMS6 (K332, H335 and D336) gave rise to specific changes in specificity from Homo sapiens (Human) (see 27 papers)
27% identity, 77% coverage of query (169 bits)
TAP2_HUMAN / Q03519 Antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; Peptide supply factor 2; Peptide transporter PSF2; PSF-2; Peptide transporter TAP2; Peptide transporter involved in antigen processing 2; Really interesting new gene 11 protein; RING11; EC 7.4.2.14 from Homo sapiens (Human) (see 28 papers)
Q03519 ABC-type antigen peptide transporter (subunit 1/2) (EC 7.4.2.14); bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 19 papers)
TC 3.A.1.209.1 / Q03519 TAP2 aka ABCB3 aka PSF2 aka RING11 aka Y1, component of MHC heterodimeric peptide exporter (TAP) (from cytoplasm to the endoplasmic reticulum) (TAP1=ABCB2; TAP2=ABCB3) (defects in TAP1 or TAP2 cause immunodeficiency) (TAP1/TAP2 is stabilized by tapasin isoforms 1, 2 and 3) (Raghuraman et al., 2002). TAP1 has 10 TMSs, 4 unique N-terminal TMSs and 6 TMSs that form the translocation pore with N- and C-termini in the cytosol (Schrodt et al., 2006). The TAP2 nucleotide binding site appears to be the main catalytic active site driving transport suggesting asymmetry in the transporter (Perria et al., 2006). The TAP complex shows strict coupling between peptide binding and ATP hydrolysis, revealing no basal ATPase activity in the absence of peptides from Homo sapiens (Human) (see 21 papers)
TAP2 antigen peptide transporter 2 from Homo sapiens (see paper)
29% identity, 74% coverage of query (168 bits)
MRP1_RAT / Q8CG09 Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter; EC 7.6.2.2; EC 7.6.2.3 from Rattus norvegicus (Rat) (see 3 papers)
27% identity, 77% coverage of query (165 bits)
TAP1_RAT / P36370 Antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; Peptide transporter TAP1; EC 7.4.2.14 from Rattus norvegicus (Rat) (see 2 papers)
P36370 ABC-type antigen peptide transporter (subunit 2/2) (EC 7.4.2.14) from Rattus norvegicus (see 6 papers)
26% identity, 89% coverage of query (164 bits)
6uy0A Cryo-em structure of wild-type bovine multidrug resistance protein 1 (mrp1) under active turnover conditions
27% identity, 77% coverage of query (163 bits)
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Lawrence Berkeley National Laboratory