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Searching for up to 100 curated homologs for 6938128 FitnessBrowser__SB2B:6938128 (307 a.a.)

Found high-coverage hits (≥70%) to 45 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

wreQ / Q6TP29 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see 2 papers)
Q6TP29 UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see paper)
    32% identity, 99% coverage of query (178 bits)

ORF35x7 / CAA69124.1 ORF35x7 from Vibrio cholerae (see paper)
    33% identity, 97% coverage of query (173 bits)

wbpV / Q9RHC9 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Pseudomonas aeruginosa (see paper)
    31% identity, 96% coverage of query (157 bits)

Build an alignment

Build an alignment for 6938128 and 3 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

wbiG / GI|3135686 putative epimerase/dehydratase WbiG from Burkholderia pseudomallei (see paper)
    28% identity, 99% coverage of query (137 bits)

wbpK / P72144 UDP-N-acetyl-α-D-fucosamine dehydrogenase from Pseudomonas aeruginosa (see 2 papers)
    27% identity, 97% coverage of query (125 bits)

tylA2 / Q54144 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces fradiae (see 2 papers)
    25% identity, 82% coverage of query (78.6 bits)

agl12 / D4GU72 dTDP-glucose-4,6-dehydratase (EC 4.2.1.46) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
AGL12_HALVD / D4GU72 Low-salt glycan biosynthesis protein Agl12; EC 4.2.1.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
    27% identity, 82% coverage of query (68.2 bits)

RMLB_BACSU / P39630 dTDP-glucose 4,6-dehydratase; Spore coat polysaccharide biosynthesis protein SpsJ; EC 4.2.1.46 from Bacillus subtilis (strain 168) (see paper)
    25% identity, 78% coverage of query (66.2 bits)

desIV / Q9ZGH3 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces venezuelae (see paper)
    26% identity, 79% coverage of query (65.9 bits)

1r66A / Q9ZGH3 Crystal structure of desiv (dtdp-glucose 4,6-dehydratase) from streptomyces venezuelae with NAD and tyd bound (see paper)
    26% identity, 79% coverage of query (65.9 bits)

1r6dA Crystal structure of desiv double mutant (dtdp-glucose 4,6- dehydratase) from streptomyces venezuelae with NAD and dau bound
    26% identity, 79% coverage of query (65.9 bits)

gnu / Q8X7P7 N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase (EC 5.1.3.26) from Escherichia coli O157:H7 (see 2 papers)
GNU_ECO57 / Q8X7P7 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase; GlcNAc-P-P-Und 4-epimerase; EC 5.1.3.26 from Escherichia coli O157:H7 (see paper)
gne UDP-N-acetylglucosamine 4-epimerase; EC 5.1.3.7 from Escherichia coli O157:H7 (see paper)
    26% identity, 83% coverage of query (65.5 bits)

graE / AAA99939.1 dTDP-glucose dehydratase from Streptomyces violaceoruber (see paper)
    25% identity, 78% coverage of query (64.7 bits)

Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
    24% identity, 97% coverage of query (64.3 bits)

5u9cA / Q56905 1.9 angstrom resolution crystal structure of dtdp-4-dehydrorhamnose reductase from yersinia enterocolitica
    27% identity, 86% coverage of query (62.4 bits)

Q20697 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Caenorhabditis elegans (see paper)
    26% identity, 79% coverage of query (62.0 bits)

2hunA / O58151 Crystal structure of hypothetical protein ph0414 from pyrococcus horikoshii ot3
    28% identity, 75% coverage of query (60.8 bits)

gdh / Q54116 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Saccharopolyspora erythraea (see 2 papers)
    24% identity, 83% coverage of query (60.5 bits)

6bwlA / Q3ESA4 X-ray structure of pal from bacillus thuringiensis (see paper)
    25% identity, 79% coverage of query (59.7 bits)

auaH / H1ZZB0 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide 3-reductase (EC 1.1.1.394) from Stigmatella aurantiaca (see 2 papers)
AUAH_STIAU / H1ZZB0 Aurachin B dehydrogenase; EC 1.1.1.394 from Stigmatella aurantiaca (see 2 papers)
H1ZZB0 aurachin B dehydrogenase (EC 1.1.1.394) from Stigmatella aurantiaca (see paper)
    22% identity, 84% coverage of query (59.3 bits)

ravE / D1H0J1 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces ravidus (see 2 papers)
    25% identity, 80% coverage of query (58.9 bits)

rmd / AAK53475.1 putative NDP-hexose epimerase/oxydoreductase from Xanthomonas campestris pv. campestris (see 4 papers)
    26% identity, 97% coverage of query (58.5 bits)

6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
    23% identity, 84% coverage of query (57.4 bits)

oleE / Q9RR28 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces antibioticus (see paper)
OLEE_STRAT / Q9RR28 dTDP-glucose 4,6-dehydratase; EC 4.2.1.46 from Streptomyces antibioticus (see paper)
    25% identity, 79% coverage of query (57.4 bits)

6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD
    23% identity, 84% coverage of query (57.4 bits)

6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD
    23% identity, 84% coverage of query (57.4 bits)

6kvcA Moee5 in complex with udp-glucose and NAD
    25% identity, 78% coverage of query (57.0 bits)

6kv9A / A0A003 Moee5 in complex with udp-glucuronic acid and NAD (see paper)
    25% identity, 78% coverage of query (56.6 bits)

hygJ / Q2MFR9 NDP-heptose C-6''-dehydrogenase from Streptomyces hygroscopicus subsp. hygroscopicus (see paper)
    25% identity, 78% coverage of query (56.6 bits)

6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD
    22% identity, 84% coverage of query (56.2 bits)

gdh / Q93EK0 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Saccharopolyspora spinosa (see 2 papers)
    25% identity, 83% coverage of query (55.5 bits)

mtmE / Q194R3 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces argillaceus (see paper)
    24% identity, 79% coverage of query (53.9 bits)

RMLB_STRGR / P29782 dTDP-glucose 4,6-dehydratase; EC 4.2.1.46 from Streptomyces griseus (see paper)
    24% identity, 80% coverage of query (53.1 bits)

Q9SZB3 farnesol dehydrogenase (NAD+) (EC 1.1.1.354) from Arabidopsis thaliana (see paper)
    25% identity, 87% coverage of query (53.1 bits)

GAL102 putative uncharacterized protein TGD99 from Candida albicans (see paper)
    25% identity, 79% coverage of query (51.6 bits)

cpsJ polysaccharide capsule synthesis protein CpsJ from Streptococcus iniae (see paper)
    21% identity, 76% coverage of query (51.6 bits)

TGDS_HUMAN / O95455 dTDP-D-glucose 4,6-dehydratase; EC 4.2.1.46 from Homo sapiens (Human) (see paper)
    24% identity, 81% coverage of query (51.6 bits)

A0A0H3JP37 UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase (EC 1.1.1.367) from Staphylococcus aureus (see 2 papers)
3st7A / A0A0H3JP37 Crystal structure of capsular polysaccharide assembling protein capf from staphylococcus aureus (see paper)
    25% identity, 81% coverage of query (51.2 bits)

P95700 UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase (EC 1.1.1.367) from Staphylococcus aureus (see paper)
    25% identity, 81% coverage of query (50.1 bits)

6dntA / D3E402 Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
    25% identity, 79% coverage of query (49.3 bits)

3e8xA / Q9KCP9 Putative NAD-dependent epimerase/dehydratase from bacillus halodurans.
    24% identity, 74% coverage of query (47.4 bits)

UXS1_DANRE / Q6GMI9 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UXS-1; EC 4.1.1.35 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
    24% identity, 84% coverage of query (43.9 bits)

6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac
    22% identity, 80% coverage of query (43.1 bits)

2b69A / Q8NBZ7 Crystal structure of human udp-glucoronic acid decarboxylase
    23% identity, 82% coverage of query (43.1 bits)

6wj9B / Q4KCF6 Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
    22% identity, 80% coverage of query (43.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory