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Searching for up to 100 curated homologs for 6938805 FitnessBrowser__SB2B:6938805 (593 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hcuC / BAC81752.1 hydrophobic compound transport factor from Pseudomonas aeruginosa (see paper)
    51% identity, 96% coverage of query (529 bits)

ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
    35% identity, 98% coverage of query (314 bits)

MITOS_RAT / Q5RKI8 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Rattus norvegicus (Rat) (see paper)
    36% identity, 95% coverage of query (312 bits)

MDL1_SCHPO / Q9Y7M7 ATP-dependent permease MDL1, mitochondrial; ABC transporter mdl1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
mdl1 mitochondrial peptide-transporting ATPase from Schizosaccharomyces pombe (see 2 papers)
    36% identity, 86% coverage of query (306 bits)

7metA / A0A0B9X4I2 A. Baumannii msba in complex with tbt1 decoupler (see paper)
    34% identity, 94% coverage of query (306 bits)

4ayxA / Q9NRK6 Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
    38% identity, 85% coverage of query (306 bits)

ABCBA_HUMAN / Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 7 papers)
Q9NRK6 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
    37% identity, 88% coverage of query (306 bits)

MITOS_MOUSE / Q9CXJ4 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Mus musculus (Mouse) (see paper)
    35% identity, 95% coverage of query (305 bits)

Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
    33% identity, 95% coverage of query (305 bits)

2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp
    33% identity, 95% coverage of query (305 bits)

AB25B_ORYSJ / Q9FNU2 ABC transporter B family member 25; ABC transporter ABCB.25; OsABCB25; Protein ALS1 homolog; Protein ALUMINUM SENSITIVE 1; OsALS1 from Oryza sativa subsp. japonica (Rice) (see paper)
    34% identity, 95% coverage of query (303 bits)

5ochE / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
    35% identity, 92% coverage of query (302 bits)

MITOS_HUMAN / Q9NUT2 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR from Homo sapiens (Human) (see 5 papers)
Q9NUT2 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
TC 3.A.1.201.22 / Q9NUT2 Mitochondrial ATP-binding cassette 1, ABCB8 from Homo sapiens
    35% identity, 91% coverage of query (300 bits)

Q9HUG8 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Pseudomonas aeruginosa (see paper)
    33% identity, 96% coverage of query (298 bits)

MSBA_VIBCH / Q9KQW9 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; EC 7.5.2.6 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
Q9KQW9 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Vibrio cholerae (see paper)
    32% identity, 96% coverage of query (295 bits)

AB27B_ARATH / Q0WML0 ABC transporter B family member 27; ABC transporter ABCB.27; AtABCB27; Aluminum tolerance-related ATP-binding cassette transporter; Antigen peptide transporter-like 2; Transporter associated with antigen processing-like protein 2; AtTAP2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 3.A.1.201.8 / Q0WML0 The aluminum chelate (aluminum sensitivity (ALS1)) protein; expressed in root vacuoles half-type ABC transporter from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
TAP2 / RF|NP_198720.2 antigen peptide transporter-like 2 from Arabidopsis thaliana (see paper)
    34% identity, 95% coverage of query (295 bits)

7y48B Cryo-em structure of biliverdin-bound mitochondrial abc transporter abcb10 from biortus
    37% identity, 85% coverage of query (294 bits)

TC 3.A.1.201.12 / B2WTH9 California mussel ABCB/MDR multixenobiotic resistance efflux pump from Mytilus californianus (see paper)
    31% identity, 97% coverage of query (293 bits)

BMRA_BACSU / O06967 Multidrug resistance ABC transporter ATP-binding/permease protein BmrA; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 7 papers)
TC 3.A.1.117.3 / O06967 Multidrug resistance homodimeric efflux pump, BmrA (YvcC) of 589 aas from Bacillus subtilis (strain 168)
    35% identity, 95% coverage of query (290 bits)

TAGA_DICDI / Q9GTN7 Serine protease/ABC transporter B family protein tagA; EC 3.4.21.- from Dictyostelium discoideum (Social amoeba) (see 3 papers)
    33% identity, 91% coverage of query (288 bits)

4aywA Structure of the human mitochondrial abc transporter, abcb10 (plate form)
    36% identity, 85% coverage of query (288 bits)

7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
    33% identity, 94% coverage of query (287 bits)

7ow8A / O06967 Cryoem structure of the abc transporter bmra e504a mutant in complex with atp-mg (see paper)
    35% identity, 95% coverage of query (287 bits)

TC 3.A.1.112.9 / A3DCU1 ABC bacteriocin exporter with two peptidase domains, Pcat1. The 3-D structure is known (4S0F). The pathway for peptide export consists of an large α-helical barrel for small folded peptides from Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)
    33% identity, 94% coverage of query (287 bits)

TC 3.A.1.201.23 / Q8T9W4 The cyclic AMP efflux pump of 1432 aas, ABCB3 from Dictyostelium discoideum
    33% identity, 84% coverage of query (285 bits)

7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
    30% identity, 94% coverage of query (285 bits)

MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
    30% identity, 95% coverage of query (285 bits)

7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
    30% identity, 95% coverage of query (285 bits)

8dmmA Structure of the vanadate-trapped msba bound to kdl
    30% identity, 95% coverage of query (285 bits)

7bcwA Structure of msba in salipro with adp vanadate
    30% identity, 94% coverage of query (285 bits)

4s0fA Crystal structure of the peptidase-containing abc transporter pcat1 e648q mutant complexed with atpgs in an occluded conformation
    33% identity, 93% coverage of query (285 bits)

6bppA E. Coli msba in complex with lps and inhibitor g092
    30% identity, 94% coverage of query (285 bits)

6bplA E. Coli msba in complex with lps and inhibitor g907
    30% identity, 94% coverage of query (285 bits)

7mewA E. Coli msba in complex with g247
    30% identity, 94% coverage of query (285 bits)

P63359 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
    30% identity, 95% coverage of query (284 bits)

TC 3.A.1.117.1 / P97046 The multidrug exporter, LmrA from Lactococcus lactis (see 2 papers)
    32% identity, 95% coverage of query (281 bits)

MDR2_ASPFU / Q4WPP6 ABC multidrug transporter mdr2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 4 papers)
    34% identity, 84% coverage of query (281 bits)

7selA E. Coli msba in complex with lps and inhibitor g7090 (compound 3)
    30% identity, 94% coverage of query (281 bits)

7ehlA Cryo-em structure of human abcb8 transporter in nucleotide binding state
    35% identity, 91% coverage of query (280 bits)

TC 3.A.1.201.16 / I0DHH7 MDR efflux pump, ABCB4a from Strongylocentrotus purpuratus
    34% identity, 84% coverage of query (279 bits)

TC 3.A.1.106.3 / Q8G7R7 Probable permease protein of ABC transporter system, component of The dimeric multidrug resistance exporter, ABC1/2 (exports the peptide antimicrobials, nisin and polymyxin; (Margolles et al., 2006) (both ABC1 and ABC2 also show striking similarity to family 3.A.1.117) from Bifidobacterium longum (see paper)
    31% identity, 94% coverage of query (278 bits)

TC 3.A.1.123.2 / Q93GF4 Aureocin A70 multipeptide bacteriocin (AurA, AurB, AurC, AurD) exporter, AurT from Staphylococcus aureus (see 2 papers)
    31% identity, 88% coverage of query (278 bits)

CH_090868 putative lipid A export ATP-binding/permease protein MsbA from Haemophilus influenzae (see paper)
    32% identity, 96% coverage of query (277 bits)

5ochC / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
    35% identity, 90% coverage of query (277 bits)

7bg4A Multidrug resistance transporter bmra mutant e504a bound with atp, mg, and rhodamine 6g solved by cryo-em
    34% identity, 95% coverage of query (276 bits)

msbA / Q2YJN8 lipid A-core oligosaccharide flippase (EC 7.5.2.6) from Brucella abortus (strain 2308) (see 2 papers)
    32% identity, 95% coverage of query (274 bits)

Build an alignment

Build an alignment for 6938805 and 46 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

4q4aA / Q9WYC3 Improved model of amp-pnp bound tm287/288 (see paper)
    29% identity, 96% coverage of query (273 bits)

TC 3.A.1.135.5 / Q9WYC3 ABC transporter, ATP-binding protein, component of The hetrodimeric ABC transporter, TM287/TM288 from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    29% identity, 96% coverage of query (273 bits)

TC 3.A.1.123.1 / Q54121 Pep5 lantibiotic exporter, PepT from Staphylococcus epidermidis (see paper)
    32% identity, 83% coverage of query (273 bits)

ABCB9_HUMAN / Q9NP78 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Homo sapiens (Human) (see 16 papers)
Q9NP78 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
TC 3.A.1.209.2 / Q9NP78 Homodimeric transporter ABCB9 or TAPL. Transports a broad spectrum of peptides (low affinity) from the cytosol to the lysosomal lumen. It exists in two forms (812 aas and 1257 aas). The latter full length protein confers resistance to taxanes and anthracyclines (Kawanobe et al., 2012). Resistance and transport were demonstrated for paclitaxel and docetaxel. TapL transports a broad range of peptides of 6-60aas (23aas optimal). It has also been detected in the ER. It is stabilized by interaction with LAMP-1 and LAMP-2 (see 9.A.16) from Homo sapiens (see 18 papers)
    32% identity, 87% coverage of query (273 bits)

6quzA Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35
    29% identity, 96% coverage of query (273 bits)

ABCB9_MOUSE / Q9JJ59 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; mABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Mus musculus (Mouse) (see paper)
    33% identity, 82% coverage of query (272 bits)

7v5cA / Q9JJ59 Cryo-em structure of the mouse abcb9 (adp.Bef3-bound) (see paper)
    31% identity, 95% coverage of query (271 bits)

ABCB9_RAT / Q9QYJ4 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; TAP-like protein; TAPL; EC 7.4.2.6 from Rattus norvegicus (Rat) (see 3 papers)
    33% identity, 82% coverage of query (270 bits)

6qv0A Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
    29% identity, 96% coverage of query (270 bits)

7vfiA Cryo-em structure of the mouse tapl (9mer-peptide bound)
    31% identity, 95% coverage of query (270 bits)

TC 3.A.1.117.2 / O32748 Hop resistance protein, HorA. Reconstitution in phosphatidyl ethanolamine bilayers resulted in normal activity, but reconstitution in phosphatidyl choline resulted in uncoupling of ATP hydrolysis from transport and a change in the orientations of the TMSs from Lactobacillus brevis
    32% identity, 83% coverage of query (268 bits)

TC 3.A.1.201.24 / Q00449 Multidrug exporter, MDR49 or Pgp of 1302 aas and 12 TMSs from Drosophila melanogaster
    33% identity, 86% coverage of query (266 bits)

AB4B_ARATH / O80725 ABC transporter B family member 4; ABC transporter ABCB.4; AtABCB4; Multidrug resistance protein 4; P-glycoprotein 4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 3.A.1.201.7 / O80725 Auxin efflux pump Pgp4; AbcB4; MDR4; PGP4 (Lefèvre and Boutry 2018) of 1286 aas and 12 TMSs in a MCMC domain arrangement from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
MDR4 / RF|NP_182223.1 multidrug resistance protein 4; EC 3.6.3.44 from Arabidopsis thaliana (see paper)
    34% identity, 87% coverage of query (266 bits)

3wmgA Crystal structure of an inward-facing eukaryotic abc multidrug transporter g277v/a278v/a279v mutant in complex with an cyclic peptide inhibitor, acap
    35% identity, 84% coverage of query (264 bits)

6rafA / Q72J05 Heterodimeric abc exporter tmrab in inward-facing narrow conformation under turnover conditions (see paper)
    33% identity, 88% coverage of query (263 bits)

TC 3.A.1.135.2 / Q9A1K4 RscB, component of The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)] from Streptococcus pyogenes serotype M1 (see 2 papers)
    31% identity, 89% coverage of query (263 bits)

TC 3.A.1.135.3 / G9CHY9 SatB, component of Narrow spectrum fluoroquinolone (ciprofloxacin and norfloxacin) efflux pump, SatAB from Streptococcus suis
    32% identity, 82% coverage of query (263 bits)

6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
    32% identity, 90% coverage of query (263 bits)

6rajA Heterodimeric abc exporter tmrab in vanadate trapped outward-facing open conformation
    33% identity, 88% coverage of query (263 bits)

6ragA Heterodimeric abc exporter tmrab in inward-facing wide conformation under turnover conditions
    33% identity, 88% coverage of query (263 bits)

6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
    31% identity, 90% coverage of query (262 bits)

6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
    32% identity, 90% coverage of query (261 bits)

6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
    33% identity, 83% coverage of query (261 bits)

3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    33% identity, 83% coverage of query (261 bits)

3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    33% identity, 83% coverage of query (261 bits)

7fc9A Crystal structure of cmabcb1 in lipidic mesophase revealed by lcp-sfx
    36% identity, 84% coverage of query (261 bits)

6a6mA / M1VAN7 Crystal structure of an outward-open nucleotide-bound state of the eukaryotic abc multidrug transporter cmabcb1 (see paper)
    36% identity, 84% coverage of query (260 bits)

7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
    33% identity, 84% coverage of query (259 bits)

6c0vA Molecular structure of human p-glycoprotein in the atp-bound, outward- facing conformation
    31% identity, 93% coverage of query (259 bits)

7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
    33% identity, 82% coverage of query (259 bits)

7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
    33% identity, 82% coverage of query (258 bits)

7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
    33% identity, 82% coverage of query (258 bits)

7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
    33% identity, 82% coverage of query (258 bits)

7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
    33% identity, 82% coverage of query (258 bits)

4xwkA P-glycoprotein co-crystallized with bde-100
    33% identity, 82% coverage of query (258 bits)

7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
    33% identity, 82% coverage of query (258 bits)

4q9iA P-glycoprotein cocrystallised with qz-ala
    33% identity, 82% coverage of query (258 bits)

7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
    33% identity, 82% coverage of query (258 bits)

4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
    33% identity, 82% coverage of query (258 bits)

8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
    32% identity, 82% coverage of query (258 bits)

6quzD / Q9WYC4 Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35 (see paper)
    29% identity, 95% coverage of query (258 bits)

5koyA Mouse pgp 34 linker deleted bound with atp
    33% identity, 82% coverage of query (257 bits)

7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
    33% identity, 82% coverage of query (256 bits)

7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
    33% identity, 82% coverage of query (256 bits)

7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
    33% identity, 82% coverage of query (256 bits)

6qv0B Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
    29% identity, 95% coverage of query (256 bits)

8fhkC / O07550 Heterodimeric abc transporter bmrcd in the occluded conformation bound to atp: bmrcd_oc-atp (see paper)
    30% identity, 95% coverage of query (255 bits)

8t1pC Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
    30% identity, 95% coverage of query (255 bits)

7m33C The structure of bacillus subtilis bmrcd in the inward-facing conformation bound to hoechst-33342 and atp
    30% identity, 95% coverage of query (255 bits)

7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
    33% identity, 93% coverage of query (254 bits)

MDL1_YEAST / P33310 ATP-dependent permease MDL1, mitochondrial; ABC transporter MDL1; Multidrug resistance-like protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
TC 3.A.1.212.1 / P33310 The mitochondrial peptide exporter, Mdl1p (exports peptides of 6-21 amino acyl residues from the mitochondrial matrix as well as degradation products of misassembled respiratory chain complexes) (Janas et al., 2003; van der Does et al., 2006; Gompf et al., 2007). A leaderless Mdl1p targets to the ER membrane instead of to the mitochondria from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
MDL1 / RF|NP_013289.1 ATP-dependent permease MDL1, mitochondrial; EC 3.6.3.43 from Saccharomyces cerevisiae (see paper)
    32% identity, 85% coverage of query (253 bits)

MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
    33% identity, 81% coverage of query (252 bits)

6s7pA Nucleotide bound abcb4
    33% identity, 80% coverage of query (248 bits)

7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
    33% identity, 80% coverage of query (248 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory