Searching for up to 100 curated homologs for 6938941 FitnessBrowser__SB2B:6938941 (308 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
Removed hits that are identical to the query, leaving 49
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ddh / Q2VEQ7 (D)-2-hydroxyacid dehydrogenase (NADP+) monomer (EC 1.1.1.272) from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (see paper)
DDH_HALMT / Q2VEQ7 D-2-hydroxyacid dehydrogenase; D2-HDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.- from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) (see paper)
Q2VEQ7 D-2-hydroxyacid dehydrogenase (NADP+) (EC 1.1.1.272) from Haloferax mediterranei (see 3 papers)
5mh5A / Q2VEQ7 D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-keto-hexanoic acid and NADP+ (1.4 a resolution)
31% identity, 83% coverage of query (125 bits)
5mh6A D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-ketohexanoic acid and NAD+ (1.35 a resolution)
31% identity, 83% coverage of query (125 bits)
5mhaB D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
31% identity, 83% coverage of query (125 bits)
5mhaA D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
31% identity, 83% coverage of query (125 bits)
5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
31% identity, 91% coverage of query (124 bits)
7jqhA / A0A140NAE3 Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with phosphate and NADP+
30% identity, 78% coverage of query (112 bits)
GhrA / b1033 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ghrA / P75913 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli (strain K12) (see 4 papers)
GHRA_ECOLI / P75913 Glyoxylate/hydroxypyruvate reductase A; 2-ketoacid reductase; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli (strain K12) (see paper)
30% identity, 78% coverage of query (112 bits)
4zqbB / Q3IWN8 Crystal structure of NADP-dependent dehydrogenase from rhodobactersphaeroides in complex with NADP and sulfate
31% identity, 81% coverage of query (112 bits)
7jqiA Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with alpha-ketoglutarate and NADP+
30% identity, 78% coverage of query (112 bits)
6p35A 2.5 angstrom structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with 2-keto arginine and NADP
30% identity, 78% coverage of query (112 bits)
Build an alignment for 6938941 and 10 homologs with ≥ 30% identity
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3kboA / Q8ZQ30 2.14 angstrom crystal structure of putative oxidoreductase (ycdw) from salmonella typhimurium in complex with NADP
28% identity, 94% coverage of query (110 bits)
kguD / Q5TM04 2-dehydro-6-phosphogluconate reductase (EC 1.1.1.43) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see 2 papers)
32% identity, 83% coverage of query (102 bits)
5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
30% identity, 81% coverage of query (97.4 bits)
Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
29% identity, 82% coverage of query (97.1 bits)
4weqA / Q92T34 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADP and sulfate (see paper)
30% identity, 89% coverage of query (93.2 bits)
4z0pA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADPH and oxalate
30% identity, 89% coverage of query (93.2 bits)
Q92T34 hydroxypyruvate reductase (EC 1.1.1.81) from Sinorhizobium meliloti (see paper)
30% identity, 89% coverage of query (92.8 bits)
HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
29% identity, 85% coverage of query (90.1 bits)
BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
30% identity, 82% coverage of query (86.3 bits)
6p2iA Acyclic imino acid reductase (bsp5) in complex with NADPH and d-arg (see paper)
29% identity, 77% coverage of query (86.3 bits)
1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
26% identity, 78% coverage of query (83.2 bits)
hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
31% identity, 82% coverage of query (82.4 bits)
TkrA / b3553 glyoxylate reductase (EC 1.1.1.79; EC 1.1.1.215) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ghrB / P37666 glyoxylate reductase (EC 1.1.1.79; EC 1.1.1.215) from Escherichia coli (strain K12) (see 4 papers)
GHRB_ECOLI / P37666 Glyoxylate/hydroxypyruvate reductase B; 2-ketoaldonate reductase; 2-ketogluconate reductase; 2KR; EC 1.1.1.79; EC 1.1.1.81; EC 1.1.1.215 from Escherichia coli (strain K12) (see 2 papers)
ghrB / GB|AAC76577.2 glyoxylate/hydroxypyruvate reductase B; EC 1.1.1.215; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli K12 (see 6 papers)
30% identity, 73% coverage of query (82.0 bits)
5bqfA / Q2KDT2 Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADP, hepes and l(+)-tartaric acid
27% identity, 84% coverage of query (81.6 bits)
4xcvA Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH
27% identity, 84% coverage of query (81.6 bits)
A0A178WMD4 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 2 papers)
25% identity, 78% coverage of query (81.3 bits)
PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
27% identity, 83% coverage of query (81.3 bits)
5tsdA Crystal structure of NADPH-dependent 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH and oxalate
27% identity, 84% coverage of query (81.3 bits)
Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
27% identity, 83% coverage of query (79.7 bits)
SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
26% identity, 83% coverage of query (79.3 bits)
HPR3 / Q9LE33 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 8 papers)
HPR3_ARATH / Q9LE33 Glyoxylate/hydroxypyruvate reductase HPR3; NAD(P)H-dependent hydroxypyruvate reductase 3; AtHPR3; HPR 3; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LE33 hydroxyphenylpyruvate reductase (EC 1.1.1.237); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 3 papers)
25% identity, 78% coverage of query (79.0 bits)
6plfB Crystal structure of human phgdh complexed with compound 1
28% identity, 75% coverage of query (79.0 bits)
7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
28% identity, 75% coverage of query (77.8 bits)
6rj3A Crystal structure of phgdh in complex with compound 15
28% identity, 75% coverage of query (77.8 bits)
7ewhA Crystal structure of human phgdh in complex with homoharringtonine
28% identity, 75% coverage of query (77.8 bits)
6rihA Crystal structure of phgdh in complex with compound 9
28% identity, 75% coverage of query (77.8 bits)
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
28% identity, 75% coverage of query (77.8 bits)
6rj5A Crystal structure of phgdh in complex with compound 39
28% identity, 75% coverage of query (77.8 bits)
6plgA Crystal structure of human phgdh complexed with compound 15
28% identity, 75% coverage of query (77.8 bits)
6plfA Crystal structure of human phgdh complexed with compound 1
28% identity, 75% coverage of query (77.8 bits)
6rj2A Crystal structure of phgdh in complex with compound 40
28% identity, 75% coverage of query (77.4 bits)
Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
27% identity, 72% coverage of query (76.3 bits)
hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
27% identity, 77% coverage of query (72.4 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
25% identity, 81% coverage of query (70.1 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
25% identity, 81% coverage of query (70.1 bits)
5dt9A / Q9KQ92 Crystal structure of a putative d-erythronate-4-phosphate dehydrogenase from vibrio cholerae
30% identity, 78% coverage of query (64.3 bits)
4xkjA / A0A0M3KL04 A novel d-lactate dehydrogenase from sporolactobacillus sp
26% identity, 80% coverage of query (55.1 bits)
1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
25% identity, 71% coverage of query (53.9 bits)
DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lacticaseibacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
25% identity, 71% coverage of query (53.9 bits)
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Lawrence Berkeley National Laboratory