Searching for up to 100 curated homologs for 7023349 FitnessBrowser__ANA3:7023349 (310 a.a.)
Found high-coverage hits (≥70%) to 68 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Sama_3039 Phosphoglycerate dehydrogenase (EC 1.1.1.95) from Shewanella amazonensis SB2B
59% identity, 100% coverage of query (382 bits)
5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
33% identity, 81% coverage of query (125 bits)
ddh / Q2VEQ7 (D)-2-hydroxyacid dehydrogenase (NADP+) monomer (EC 1.1.1.272) from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (see paper)
DDH_HALMT / Q2VEQ7 D-2-hydroxyacid dehydrogenase; D2-HDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.- from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) (see paper)
Q2VEQ7 D-2-hydroxyacid dehydrogenase (NADP+) (EC 1.1.1.272) from Haloferax mediterranei (see 3 papers)
5mh5A / Q2VEQ7 D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-keto-hexanoic acid and NADP+ (1.4 a resolution)
30% identity, 79% coverage of query (122 bits)
5mh6A D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with 2-ketohexanoic acid and NAD+ (1.35 a resolution)
30% identity, 79% coverage of query (122 bits)
5mhaB D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
30% identity, 79% coverage of query (122 bits)
5mhaA D-2-hydroxyacid dehydrogenases (d2-hdh) from haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 a resolution)
30% identity, 79% coverage of query (122 bits)
4zqbB / Q3IWN8 Crystal structure of NADP-dependent dehydrogenase from rhodobactersphaeroides in complex with NADP and sulfate
33% identity, 94% coverage of query (118 bits)
Build an alignment for 7023349 and 7 homologs with ≥ 30% identity
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4weqA / Q92T34 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADP and sulfate (see paper)
28% identity, 94% coverage of query (110 bits)
Q92T34 hydroxypyruvate reductase (EC 1.1.1.81) from Sinorhizobium meliloti (see paper)
28% identity, 94% coverage of query (110 bits)
4z0pA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADPH and oxalate
28% identity, 94% coverage of query (110 bits)
5bqfA / Q2KDT2 Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADP, hepes and l(+)-tartaric acid
27% identity, 84% coverage of query (108 bits)
4xcvA Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH
27% identity, 84% coverage of query (108 bits)
5tsdA Crystal structure of NADPH-dependent 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH and oxalate
27% identity, 84% coverage of query (107 bits)
7jqhA / A0A140NAE3 Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with phosphate and NADP+
31% identity, 71% coverage of query (105 bits)
7jqiA Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with alpha-ketoglutarate and NADP+
31% identity, 71% coverage of query (105 bits)
6p35A 2.5 angstrom structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with 2-keto arginine and NADP
31% identity, 71% coverage of query (105 bits)
3kboA / Q8ZQ30 2.14 angstrom crystal structure of putative oxidoreductase (ycdw) from salmonella typhimurium in complex with NADP
28% identity, 90% coverage of query (104 bits)
GhrA / b1033 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ghrA / P75913 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli (strain K12) (see 4 papers)
GHRA_ECOLI / P75913 Glyoxylate/hydroxypyruvate reductase A; 2-ketoacid reductase; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli (strain K12) (see paper)
31% identity, 71% coverage of query (104 bits)
1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
31% identity, 81% coverage of query (97.1 bits)
HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
29% identity, 76% coverage of query (95.5 bits)
hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
28% identity, 76% coverage of query (90.1 bits)
Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
29% identity, 72% coverage of query (87.4 bits)
5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
29% identity, 72% coverage of query (87.0 bits)
BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
30% identity, 75% coverage of query (85.9 bits)
kguD / Q5TM04 2-dehydro-6-phosphogluconate reductase (EC 1.1.1.43) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see 2 papers)
28% identity, 84% coverage of query (82.8 bits)
A0A1Z4EAX4 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
28% identity, 72% coverage of query (80.9 bits)
A0A178WMD4 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 2 papers)
24% identity, 81% coverage of query (80.1 bits)
hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
28% identity, 79% coverage of query (79.0 bits)
HPR3 / Q9LE33 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 8 papers)
HPR3_ARATH / Q9LE33 Glyoxylate/hydroxypyruvate reductase HPR3; NAD(P)H-dependent hydroxypyruvate reductase 3; AtHPR3; HPR 3; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LE33 hydroxyphenylpyruvate reductase (EC 1.1.1.237); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 3 papers)
25% identity, 81% coverage of query (77.8 bits)
SSO3187 / Q97U35 glycolate dehydrogenase (EC 1.1.1.26) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
Q97U35 glyoxylate reductase (EC 1.1.1.26) from Saccharolobus solfataricus (see paper)
25% identity, 93% coverage of query (75.9 bits)
7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
27% identity, 86% coverage of query (75.1 bits)
6rj5A Crystal structure of phgdh in complex with compound 39
27% identity, 86% coverage of query (75.1 bits)
7ewhA Crystal structure of human phgdh in complex with homoharringtonine
27% identity, 86% coverage of query (75.1 bits)
6rihA Crystal structure of phgdh in complex with compound 9
27% identity, 86% coverage of query (75.1 bits)
6plgA Crystal structure of human phgdh complexed with compound 15
27% identity, 86% coverage of query (75.1 bits)
6plfA Crystal structure of human phgdh complexed with compound 1
27% identity, 86% coverage of query (75.1 bits)
6rj3A Crystal structure of phgdh in complex with compound 15
27% identity, 86% coverage of query (75.1 bits)
6rj2A Crystal structure of phgdh in complex with compound 40
27% identity, 86% coverage of query (75.1 bits)
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
27% identity, 86% coverage of query (75.1 bits)
PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
27% identity, 86% coverage of query (74.3 bits)
Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
27% identity, 86% coverage of query (73.9 bits)
Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor (see paper)
27% identity, 76% coverage of query (73.6 bits)
SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
27% identity, 86% coverage of query (73.6 bits)
D6CJK0 formate dehydrogenase (EC 1.17.1.9) from Bacillus sp. (in: Bacteria) (see paper)
26% identity, 88% coverage of query (73.2 bits)
6plfB Crystal structure of human phgdh complexed with compound 1
27% identity, 75% coverage of query (70.9 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
24% identity, 82% coverage of query (70.5 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
24% identity, 82% coverage of query (70.5 bits)
SERA_YEAST / P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
24% identity, 90% coverage of query (70.1 bits)
Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
24% identity, 72% coverage of query (70.1 bits)
SER33_YEAST / P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
24% identity, 77% coverage of query (70.1 bits)
O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pyrococcus horikoshii (see paper)
22% identity, 74% coverage of query (69.7 bits)
A0A0A7RFJ3 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Salvia miltiorrhiza (see paper)
24% identity, 90% coverage of query (68.6 bits)
O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus (see paper)
3kb6B / O66939 Crystal structure of d-lactate dehydrogenase from aquifex aeolicus complexed with NAD and lactic acid (see paper)
25% identity, 79% coverage of query (67.4 bits)
5dt9A / Q9KQ92 Crystal structure of a putative d-erythronate-4-phosphate dehydrogenase from vibrio cholerae
27% identity, 79% coverage of query (63.9 bits)
7arzA / A9SQZ2 Ternary complex of NAD-dependent formate dehydrogenase from physcomitrium patens
27% identity, 78% coverage of query (63.5 bits)
2nadA High resolution structures of holo and apo formate dehydrogenase
24% identity, 78% coverage of query (57.8 bits)
FDH_PSESR / P33160 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Pseudomonas sp. (strain 101) (Achromobacter parvulus T1) (see 2 papers)
P33160 formate dehydrogenase (EC 1.17.1.9) from Pseudomonas sp. 101 (see paper)
24% identity, 78% coverage of query (57.8 bits)
6t9wB / G8NTI5 Crystal structure of formate dehydrogenase fdh2 d222a/q223r enzyme from granulicella mallensis mp5actx8 in complex with NADP and azide.
25% identity, 90% coverage of query (56.2 bits)
8bxxAA Formate dehydrogenase
25% identity, 78% coverage of query (56.2 bits)
FDH1_YEASC / N1P3Y5 Formate dehydrogenase 1; FDH 1; NAD-dependent formate dehydrogenase 1; EC 1.17.1.9 from Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) (see paper)
FDH1_YEAST / Q08911 Formate dehydrogenase 1; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
23% identity, 89% coverage of query (55.1 bits)
3wr5A / Q76EB7 Structural basis on the efficient co2 reduction of acidophilic formate dehydrogenase
23% identity, 88% coverage of query (54.3 bits)
6jujA Crystal structure of formate dehydrogenase mutant v198i/c256i/p260s/e261p/s381n/s383f from pseudomonas sp. 101in complex with non-natural cofactor nicotinamide cytosine dinucleotide
23% identity, 78% coverage of query (53.5 bits)
DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lacticaseibacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
23% identity, 80% coverage of query (53.5 bits)
1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
23% identity, 80% coverage of query (53.1 bits)
2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
23% identity, 77% coverage of query (48.5 bits)
8j3pA / B9WHT3 Formate dehydrogenase mutant from from candida dubliniensis m4 complexed with NADP+ (see paper)
22% identity, 83% coverage of query (48.5 bits)
8j3oA Formate dehydrogenase wild-type enzyme from candida dubliniensis complexed with nadh
22% identity, 83% coverage of query (47.4 bits)
8j3oB Formate dehydrogenase wild-type enzyme from candida dubliniensis complexed with nadh
22% identity, 83% coverage of query (47.4 bits)
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