Searching for up to 100 curated homologs for 7024442 FitnessBrowser__ANA3:7024442 (302 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
33% identity, 99% coverage of query (154 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
30% identity, 98% coverage of query (149 bits)
TC 3.A.1.124.5 / Q09II0 SboF, component of The salivaricin exporter, SboEFG from Streptococcus salivarius (see paper)
33% identity, 79% coverage of query (127 bits)
TC 3.A.1.148.1 / W2ET84 ABC transporter ATP binding domain, component of ABC lantibiotic NAI-107 immunity exporter, MlbYZ from Microbispora sp. ATCC PTA-5024
35% identity, 74% coverage of query (126 bits)
ABCAC_HUMAN / Q86UK0 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; ATP-binding cassette transporter 12; ATP-binding cassette 12; EC 7.6.2.1 from Homo sapiens (Human) (see 16 papers)
TC 3.A.1.211.13 / Q86UK0 ABCA12 keratinocyte lipid transporter of 2595 aas from Homo sapiens
33% identity, 75% coverage of query (126 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
30% identity, 88% coverage of query (125 bits)
ABCA7_MOUSE / Q91V24 ATP-binding cassette sub-family A member 7 from Mus musculus (Mouse) (see 10 papers)
34% identity, 75% coverage of query (125 bits)
ABCA7_RAT / Q7TNJ2 ATP-binding cassette sub-family A member 7 from Rattus norvegicus (Rat) (see paper)
34% identity, 75% coverage of query (125 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
32% identity, 90% coverage of query (124 bits)
Build an alignment for 7024442 and 9 homologs with ≥ 30% identity
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7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
29% identity, 88% coverage of query (124 bits)
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
31% identity, 82% coverage of query (124 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
31% identity, 77% coverage of query (124 bits)
TC 3.A.1.142.1 / Q8DNB9 Putative uncharacterized protein ABC-NBD, component of Glycolipid translocase (flippase) Spr1816/Spr1817 (R.Hakenbeck, personal communication) from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
34% identity, 75% coverage of query (123 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
32% identity, 75% coverage of query (122 bits)
TC 3.A.1.124.2 / Q45404 SpaF, component of The 3-component subtilin immunity exporter, SpaEFG from Bacillus subtilis (see paper)
33% identity, 76% coverage of query (122 bits)
ABCA3_RAT / A0A0G2K1Q8 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Rattus norvegicus (Rat) (see paper)
31% identity, 79% coverage of query (121 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
30% identity, 93% coverage of query (121 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
33% identity, 74% coverage of query (120 bits)
ABCA7_HUMAN / Q8IZY2 Phospholipid-transporting ATPase ABCA7; ABCA-SSN; ATP-binding cassette sub-family A member 7; Autoantigen SS-N; Macrophage ABC transporter; EC 7.6.2.1 from Homo sapiens (Human) (see 12 papers)
TC 3.A.1.211.10 / Q8IZY2 ABCA7. Regulates cellular efflux of phospholipids but not cholesterol, to apo A-1 from Homo sapiens (see 10 papers)
34% identity, 77% coverage of query (120 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
31% identity, 79% coverage of query (120 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
33% identity, 75% coverage of query (120 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
29% identity, 75% coverage of query (117 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
29% identity, 75% coverage of query (116 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
31% identity, 77% coverage of query (115 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
29% identity, 75% coverage of query (115 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
30% identity, 75% coverage of query (114 bits)
6xjiC / X5EJW5 Pmtcd abc exporter at c1 symmetry (see paper)
26% identity, 99% coverage of query (114 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
31% identity, 70% coverage of query (114 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
31% identity, 71% coverage of query (114 bits)
7lkpA Structure of atp-free human abca4
29% identity, 75% coverage of query (113 bits)
7lkzA Structure of atp-bound human abca4
30% identity, 70% coverage of query (113 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
30% identity, 71% coverage of query (112 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
32% identity, 72% coverage of query (111 bits)
7mdyC Lolcde nucleotide-bound
34% identity, 71% coverage of query (105 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
27% identity, 87% coverage of query (103 bits)
LolD / b1117 lipoprotein release complex - ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 2 papers)
LolD / P75957 lipoprotein release complex - ATP binding subunit from Escherichia coli (strain K12) (see paper)
LOLD_ECOLI / P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
TC 3.A.1.125.1 / P75957 LolD aka B1117, component of Lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope) (see 1.B.46; Narita et al., 2003; Ito et al., 2006; Watanabe et al., 2007). The structure of ligand-bound LolCDE has been solved (Ito et al., 2006). LolC and LolE each have 4 TMSs (1+3). Unlike most ATP binding cassette transporters mediating the transmembrane flux of substrates, the LolCDE complex catalyzes the extrusion of lipoproteins anchored to the outer leaflet of the inner membrane. The LolCDE complex is unusual in that it can be purified as a liganded form, which is an intermediate of the lipoprotein release reaction (Taniguchi and Tokuda, 2008). LolCDE has been reconstituted from separated subunits from Escherichia coli (see 5 papers)
lolD / GB|BAA35937.2 lipoprotein releasing system, ATP-binding protein; EC 3.6.3.- from Escherichia coli K12 (see 5 papers)
34% identity, 71% coverage of query (103 bits)
6xjhC Pmtcd abc exporter without the basket domain at c2 symmetry
30% identity, 70% coverage of query (103 bits)
7v8iD / P75957 Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
33% identity, 71% coverage of query (102 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
29% identity, 71% coverage of query (98.6 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
29% identity, 71% coverage of query (97.1 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
27% identity, 78% coverage of query (93.6 bits)
7ahhC Opua inhibited inward-facing, sbd docked
26% identity, 76% coverage of query (86.3 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
26% identity, 76% coverage of query (86.3 bits)
7ahdC Opua (e190q) occluded
26% identity, 71% coverage of query (82.8 bits)
7p7q0 7p7q0 (see paper)
25% identity, 77% coverage of query (77.8 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
25% identity, 70% coverage of query (76.6 bits)
8dncA Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen and adp
23% identity, 76% coverage of query (76.6 bits)
8dkuA / O67181 Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen (see paper)
23% identity, 76% coverage of query (76.6 bits)
2pclA / O66646 Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
26% identity, 70% coverage of query (76.6 bits)
7r89B / Q9H221 The structure of human abcg5/abcg8 purified from yeast (see paper)
29% identity, 70% coverage of query (76.3 bits)
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