Searching for up to 100 curated homologs for 7024960 FitnessBrowser__ANA3:7024960 (392 a.a.)
Found high-coverage hits (≥70%) to 65 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ODBA_CAEEL / O45924 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; EC 1.2.4.4 from Caenorhabditis elegans (see paper)
51% identity, 93% coverage of query (384 bits)
ODBA1_ARATH / Q9LPL5 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
50% identity, 94% coverage of query (379 bits)
BCKDHA / P12694 branched-chain α-keto acid dehydrogenase E1 component α subunit (EC 1.2.4.4) from Homo sapiens (see 15 papers)
ODBA_HUMAN / P12694 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Homo sapiens (Human) (see 13 papers)
P12694 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Homo sapiens (see 5 papers)
50% identity, 93% coverage of query (369 bits)
ODBA2_ARATH / Q84JL2 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
47% identity, 93% coverage of query (365 bits)
2bffA / P12694 Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch (see paper)
49% identity, 93% coverage of query (362 bits)
ODBA_RAT / P11960 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Rattus norvegicus (Rat) (see paper)
49% identity, 93% coverage of query (361 bits)
P50136 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Mus musculus (see paper)
48% identity, 93% coverage of query (361 bits)
2bewA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
49% identity, 93% coverage of query (361 bits)
2bevA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
49% identity, 93% coverage of query (361 bits)
2beuA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
49% identity, 93% coverage of query (361 bits)
1wciA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
49% identity, 93% coverage of query (361 bits)
ODBA_BOVIN / P11178 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Bos taurus (Bovine) (see paper)
49% identity, 93% coverage of query (360 bits)
1dtwA Human branched-chain alpha-keto acid dehydrogenase
49% identity, 93% coverage of query (357 bits)
1v1mA / P12694 Crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine (see paper)
47% identity, 93% coverage of query (338 bits)
1oluA Roles of his291-alpha and his146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase
46% identity, 95% coverage of query (332 bits)
2bfcA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
46% identity, 93% coverage of query (331 bits)
Q9HIA3 branched-chain-2-oxoacid decarboxylase (subunit 1/2) (EC 4.1.1.72) from Thermoplasma acidophilum (see paper)
36% identity, 86% coverage of query (229 bits)
3dufA / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
36% identity, 93% coverage of query (228 bits)
ODPA_BACCE / Q4MTG0 Pyruvate dehydrogenase E1 component subunit alpha; EC 1.2.4.1 from Bacillus cereus (see paper)
36% identity, 90% coverage of query (227 bits)
pdhA / AAC24932.1 pyruvate decarboxylase E-1 alpha subunit from Bacillus subtilis (see 3 papers)
38% identity, 91% coverage of query (226 bits)
SMc03201 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Sinorhizobium meliloti 1021
39% identity, 88% coverage of query (221 bits)
1qs0A / P09060 Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
37% identity, 91% coverage of query (218 bits)
bkdA1 / GI|790514 2-oxoisovalerate dehydrogenase subunit alpha; EC 1.2.4.4 from Pseudomonas putida (see 4 papers)
37% identity, 91% coverage of query (218 bits)
Pf6N2E2_481 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E2
37% identity, 91% coverage of query (217 bits)
AO356_22990 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2C3
38% identity, 91% coverage of query (215 bits)
1w85A The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2
36% identity, 92% coverage of query (215 bits)
bfmBAA / P37940 2-keto-isovalerate dehydrogenase component α subunit (EC 1.2.4.4) from Bacillus subtilis (strain 168) (see 2 papers)
40% identity, 80% coverage of query (214 bits)
BKDA_MYCTU / P9WIS3 3-methyl-2-oxobutanoate dehydrogenase subunit alpha; Branched-chain alpha-ketoacid dehydrogenase E1 component subunit alpha; BCKADH E1-alpha; EC 1.2.4.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
35% identity, 92% coverage of query (207 bits)
Q72GU1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Thermus thermophilus (see paper)
38% identity, 83% coverage of query (206 bits)
1umbA / Q5SLR4 Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
38% identity, 83% coverage of query (206 bits)
ODBA_THET8 / Q5SLR4 2-oxoisovalerate dehydrogenase subunit alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
38% identity, 83% coverage of query (206 bits)
PfGW456L13_3540 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens GW456-L13
38% identity, 91% coverage of query (206 bits)
1umdA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate
38% identity, 83% coverage of query (206 bits)
1umcA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate
38% identity, 83% coverage of query (206 bits)
AO353_26635 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E3
37% identity, 91% coverage of query (204 bits)
3dv0A Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
34% identity, 92% coverage of query (204 bits)
pdhA / P75390 α subunit from Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (see 3 papers)
36% identity, 82% coverage of query (197 bits)
Q53592 branched-chain alpha-keto acid dehydrogenase system (EC 1.2.1.25) from Streptomyces avermitilis (see paper)
34% identity, 88% coverage of query (196 bits)
3dv0E / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
33% identity, 92% coverage of query (196 bits)
1w88A The crystal structure of pyruvate dehydrogenase e1(d180n,e183q) bound to the peripheral subunit binding domain of e2
33% identity, 92% coverage of query (188 bits)
Q46142 acetoin dehydrogenase system (EC 2.3.1.190) from Clostridium magnum (see paper)
acoA TPP-dependent acetoin dehydrogenase complex, E1 component, alpha subunit; EC 1.1.1.- from Clostridium magnum (see paper)
AAA21744.1 TPP-dependent acetoin dehydrogenase alpha-subunit from Clostridium magnum (see paper)
34% identity, 79% coverage of query (186 bits)
Q7NAZ8 pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Mycoplasma gallisepticum (see paper)
32% identity, 91% coverage of query (186 bits)
ACOA_BACSU / O31404 Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 3 papers)
31% identity, 81% coverage of query (150 bits)
pdhB pyruvate dehydrogenase (lipoamide) from Emericella nidulans (see 2 papers)
30% identity, 82% coverage of query (143 bits)
Q10489 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; PDHE1-A; EC 1.2.4.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
31% identity, 77% coverage of query (140 bits)
G3H5K6 pyruvate dehydrogenase system (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Cricetulus griseus (see paper)
31% identity, 73% coverage of query (139 bits)
ODPA_MOUSE / P35486 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Mus musculus (Mouse) (see 6 papers)
P35486 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Mus musculus (see 2 papers)
31% identity, 73% coverage of query (139 bits)
P74490 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Synechocystis sp. PCC 6803 (see 2 papers)
30% identity, 78% coverage of query (139 bits)
ODPA_RAT / P26284 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Rattus norvegicus (Rat) (see 2 papers)
31% identity, 73% coverage of query (138 bits)
3exeA / P08559 Crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex (see paper)
31% identity, 73% coverage of query (135 bits)
6cfoA Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate
31% identity, 73% coverage of query (135 bits)
1ni4A Human pyruvate dehydrogenase
31% identity, 73% coverage of query (135 bits)
PDHA1 / P08559 pyruvate dehydrogenase E1 component α subunit (somatic) from Homo sapiens (see 6 papers)
ODPA_HUMAN / P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Homo sapiens (Human) (see 24 papers)
P08559 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Homo sapiens (see 2 papers)
31% identity, 73% coverage of query (134 bits)
Build an alignment for 7024960 and 53 homologs with ≥ 30% identity
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A2XPT6 pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Oryza sativa Indica Group (see paper)
26% identity, 80% coverage of query (134 bits)
ODPA_PIG / P29804 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Sus scrofa (Pig) (see paper)
31% identity, 73% coverage of query (133 bits)
PDHA1 / P26267 pyruvate dehydrogenase α1 subunit from Ascaris suum (see paper)
30% identity, 72% coverage of query (133 bits)
P26267 Pyruvate dehydrogenase E1 component subunit alpha type I, mitochondrial; PDHA1; PDHE1-A; EC 1.2.4.1 from Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
30% identity, 72% coverage of query (133 bits)
ODPAT_HUMAN / P29803 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; PDHE1-A type II; EC 1.2.4.1 from Homo sapiens (Human) (see 5 papers)
28% identity, 82% coverage of query (131 bits)
ODPA1_ARATH / P52901 Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial; PDHE1-A; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
28% identity, 71% coverage of query (130 bits)
P52903 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104) from Solanum tuberosum (see paper)
CAA81558.1 E1 alpha subunit of pyruvate dehydrogenase precursor from Solanum tuberosum (see paper)
30% identity, 71% coverage of query (129 bits)
ODPA2_ARATH / Q8H1Y0 Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial; PDHE1-A; Protein IAA-CONJUGATE-RESISTANT 4; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8H1Y0 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Arabidopsis thaliana (see paper)
30% identity, 71% coverage of query (128 bits)
ODPA_YEAST / P16387 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; Pyruvate dehydrogenase complex component E1 alpha; PDHE1-A; EC 1.2.4.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P16387 pyruvate dehydrogenase system (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Saccharomyces cerevisiae (see 2 papers)
26% identity, 90% coverage of query (124 bits)
6cerA / P08559 Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
29% identity, 73% coverage of query (111 bits)
6cerE Human pyruvate dehydrogenase complex e1 component v138m mutation
28% identity, 73% coverage of query (108 bits)
3exhE Crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex
27% identity, 73% coverage of query (102 bits)
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Lawrence Berkeley National Laboratory