Searching for up to 100 curated homologs for 7025581 FitnessBrowser__ANA3:7025581 (272 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
pstB / OMNI|NTL02SP1895 phosphate ABC transporter, ATP-binding protein; EC 3.6.3.27 from Streptococcus pneumoniae R6 (see 2 papers)
62% identity, 91% coverage of query (343 bits)
PstB / b3725 phosphate ABC transporter ATP binding subunit (EC 7.3.2.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
PstB / P0AAH0 phosphate ABC transporter ATP binding subunit (EC 7.3.2.1) from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.7.1 / P0AAH0 Phosphate import ATP-binding protein PstB aka PhoT aka B3725, component of Phosphate porter, PhoSPstABC. Serves as both a transporter and a sensor for transcriptional activation of the pho regulon in the presence of low external phosphate. The unphosphorylated EIIANtr protein of the PTS (TC# 4.A) activates PhoR, the senor kinase that phosphorylates the response regulator, PhoB, that activates the pho regulon from Escherichia coli (see 6 papers)
pstB phosphate import ATP-binding protein pstB; EC 3.6.3.27 from Escherichia coli K12 (see 6 papers)
62% identity, 92% coverage of query (324 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
62% identity, 92% coverage of query (324 bits)
TC 3.A.1.7.5 / O51236 Phosphate import ATP-binding protein PstB, component of The phosphate transporter, PstABCS from Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
57% identity, 93% coverage of query (312 bits)
TC 3.A.1.7.2 / P0C560 PstB, component of Phosphate transporter, PstSCAB from Mycobacterium smegmatis (see paper)
58% identity, 91% coverage of query (295 bits)
PSTB1_MYCTU / P9WQL1 Phosphate import ATP-binding protein PstB 1; ABC phosphate transporter 1; Phosphate-transporting ATPase 1; EC 7.3.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
59% identity, 91% coverage of query (293 bits)
TC 3.A.1.7.3 / C3KCB5 Putative ABC transporter ATP-binding protein, component of High-affinity phosphate-specific permease, PstAB/PhoS. The 3-d structure of PhoS = (PBP) = PfluDING) has been solved at high resolution by x-ray crystallography (Ahn et al. 2007) with phosphate bound (4F1U and 4F1V; 0.95Å resolution) and with arsenate bound (4F18 and 4F19; 0.88Å resolution) (Elias et al. 2012). Phosphate binds with 500-fold higher affinity than arsenate due to a dense and rigid network of ion-dipole interactions (Elias et al. 2012). The PBP from Halomonas sp from Pseudomonas fluorescens (strain SBW25)
50% identity, 93% coverage of query (268 bits)
PSTB2_MYCTU / P9WQK9 Phosphate import ATP-binding protein PstB 2; ABC phosphate transporter 2; Phosphate-transporting ATPase 2; EC 7.3.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
50% identity, 89% coverage of query (249 bits)
ARTM_BACSU / P54537 Arginine transport ATP-binding protein ArtM from Bacillus subtilis (strain 168) (see paper)
37% identity, 89% coverage of query (156 bits)
GlnQ / b0809 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnQ / P10346 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
GLNQ_ECOLI / P10346 Glutamine transport ATP-binding protein GlnQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.2 / P10346 GlnQ aka B0809, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
glnQ / GB|ABB65374.1 glutamine ABC transporter, ATP-binding protein GlnQ from Escherichia coli K12 (see 5 papers)
36% identity, 89% coverage of query (155 bits)
TC 3.A.1.3.14 / P39456 TcyC (YckI), component of Uptake system for L-cystine from Bacillus subtilis (see 7 papers)
38% identity, 89% coverage of query (154 bits)
GLNQ_BACSU / O34677 Glutamine transport ATP-binding protein GlnQ; EC 7.4.2.- from Bacillus subtilis (strain 168) (see paper)
36% identity, 89% coverage of query (152 bits)
TCYN_BACSU / O34900 L-cystine import ATP-binding protein TcyN; EC 7.4.2.- from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.3.13 / O34900 TcyN (YtmN), component of Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine from Bacillus subtilis (see 4 papers)
38% identity, 89% coverage of query (151 bits)
TC 3.A.1.139.1 / Q5Z8H2 Sensitive to aluminum rhizotoxicity 1, component of UDP-glucose exporter, STAR1/STAR2 (sensitive to aluminum rhizotoxicity) (Probable Type I topology) from Oryza sativa subsp. japonica
45% identity, 78% coverage of query (150 bits)
STAR1_ORYSJ / Q0D9V6 Protein STAR1; ABC transporter ABCI.12; OsABCI12; ABC transporter I family member 12; Protein ALUMINUM SENSITIVE 1; Protein SENSITIVE TO ALUMINUM RHIZOTOXICITY 1 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
45% identity, 78% coverage of query (150 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
38% identity, 89% coverage of query (150 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
39% identity, 86% coverage of query (150 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
36% identity, 89% coverage of query (148 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
36% identity, 89% coverage of query (148 bits)
2olkA Abc protein artp in complex with adp-beta-s
36% identity, 89% coverage of query (148 bits)
2oljA Abc protein artp in complex with adp/mg2+
36% identity, 89% coverage of query (148 bits)
ANTRA_HALVD / D4GSY7 Probable anion import ATP-binding protein HVO_1886; EC 7.3.2.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
35% identity, 92% coverage of query (145 bits)
TC 3.A.1.3.23 / Q9HU32 Probable ATP-binding component of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
37% identity, 92% coverage of query (145 bits)
ARGV_CORGL / Q8NQU4 Arginine transport ATP-binding protein ArgV; EC 7.4.2.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
35% identity, 86% coverage of query (145 bits)
TC 3.A.1.3.22 / Q9I405 Amino acid ABC transporter ATP binding protein, component of Amino acid transporter, AatJMQP. Probably transports L-glutamic acid, D-glutamine acid, L-glutamine and N-acetyl L-glutamic acid (Johnson et al. 2008). Very similar to 3.A.1.3.19 of P. putida from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
37% identity, 85% coverage of query (144 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
35% identity, 84% coverage of query (133 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
35% identity, 84% coverage of query (131 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
35% identity, 84% coverage of query (131 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
35% identity, 84% coverage of query (131 bits)
7ahhC Opua inhibited inward-facing, sbd docked
34% identity, 86% coverage of query (122 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
34% identity, 86% coverage of query (122 bits)
7ahdC Opua (e190q) occluded
33% identity, 86% coverage of query (121 bits)
7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
32% identity, 85% coverage of query (119 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
35% identity, 91% coverage of query (117 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
33% identity, 81% coverage of query (117 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
36% identity, 90% coverage of query (116 bits)
Build an alignment for 7025581 and 36 homologs with ≥ 30% identity
Or download the sequences
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
29% identity, 98% coverage of query (114 bits)
7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
34% identity, 70% coverage of query (110 bits)
7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
34% identity, 70% coverage of query (110 bits)
7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
34% identity, 70% coverage of query (110 bits)
7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
34% identity, 70% coverage of query (110 bits)
7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
34% identity, 70% coverage of query (110 bits)
6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
34% identity, 70% coverage of query (110 bits)
6c0vA Molecular structure of human p-glycoprotein in the atp-bound, outward- facing conformation
33% identity, 70% coverage of query (109 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
33% identity, 90% coverage of query (108 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
33% identity, 90% coverage of query (108 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 90% coverage of query (108 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 90% coverage of query (108 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
33% identity, 90% coverage of query (108 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
33% identity, 90% coverage of query (108 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
32% identity, 86% coverage of query (108 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
33% identity, 90% coverage of query (108 bits)
4ayxA / Q9NRK6 Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
33% identity, 86% coverage of query (108 bits)
3nhaA Nucleotide binding domain of human abcb6 (adp mg bound structure)
32% identity, 82% coverage of query (108 bits)
5koyA Mouse pgp 34 linker deleted bound with atp
33% identity, 90% coverage of query (107 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
34% identity, 81% coverage of query (107 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
29% identity, 90% coverage of query (107 bits)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
36% identity, 75% coverage of query (107 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
36% identity, 75% coverage of query (107 bits)
7y48B Cryo-em structure of biliverdin-bound mitochondrial abc transporter abcb10 from biortus
32% identity, 86% coverage of query (107 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
33% identity, 78% coverage of query (107 bits)
ABCBA_HUMAN / Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 7 papers)
Q9NRK6 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
33% identity, 86% coverage of query (107 bits)
6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
33% identity, 90% coverage of query (106 bits)
7dv5U / O95342 Human bile salt exporter abcb11 in complex with taurocholate (see paper)
33% identity, 78% coverage of query (106 bits)
7chaI / Q9HVW1 Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
29% identity, 87% coverage of query (106 bits)
8pmjA / O95342 Vanadate-trapped bsep in nanodiscs (see paper)
33% identity, 78% coverage of query (106 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
32% identity, 81% coverage of query (105 bits)
8pm6A / O95342 Human bile salt export pump (bsep) in complex with inhibitor gbm in nanodiscs (see paper)
33% identity, 78% coverage of query (105 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
31% identity, 91% coverage of query (105 bits)
ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
33% identity, 86% coverage of query (105 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
33% identity, 77% coverage of query (104 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
33% identity, 77% coverage of query (104 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
33% identity, 77% coverage of query (104 bits)
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
33% identity, 90% coverage of query (103 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
33% identity, 90% coverage of query (103 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
33% identity, 90% coverage of query (103 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
33% identity, 90% coverage of query (103 bits)
3nh9A Nucleotide binding domain of human abcb6 (atp bound structure)
32% identity, 82% coverage of query (103 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
30% identity, 84% coverage of query (103 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
30% identity, 90% coverage of query (103 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
30% identity, 90% coverage of query (103 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
30% identity, 90% coverage of query (103 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
30% identity, 90% coverage of query (103 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
30% identity, 90% coverage of query (103 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
30% identity, 90% coverage of query (103 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
33% identity, 90% coverage of query (102 bits)
7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
32% identity, 85% coverage of query (102 bits)
6bppA E. Coli msba in complex with lps and inhibitor g092
32% identity, 85% coverage of query (102 bits)
6bplA E. Coli msba in complex with lps and inhibitor g907
32% identity, 85% coverage of query (102 bits)
ABCBB_RAT / O70127 Bile salt export pump; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein; EC 7.6.2.- from Rattus norvegicus (Rat) (see 12 papers)
32% identity, 78% coverage of query (102 bits)
6a6mA / M1VAN7 Crystal structure of an outward-open nucleotide-bound state of the eukaryotic abc multidrug transporter cmabcb1 (see paper)
33% identity, 80% coverage of query (102 bits)
MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
33% identity, 83% coverage of query (102 bits)
8dmmA Structure of the vanadate-trapped msba bound to kdl
33% identity, 83% coverage of query (102 bits)
3wmgA Crystal structure of an inward-facing eukaryotic abc multidrug transporter g277v/a278v/a279v mutant in complex with an cyclic peptide inhibitor, acap
33% identity, 80% coverage of query (102 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
30% identity, 89% coverage of query (102 bits)
7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
33% identity, 83% coverage of query (102 bits)
7mewA E. Coli msba in complex with g247
33% identity, 83% coverage of query (102 bits)
7bcwA Structure of msba in salipro with adp vanadate
33% identity, 83% coverage of query (102 bits)
7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
33% identity, 82% coverage of query (102 bits)
7fc9A Crystal structure of cmabcb1 in lipidic mesophase revealed by lcp-sfx
33% identity, 80% coverage of query (102 bits)
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Lawrence Berkeley National Laboratory