Searching for up to 100 curated homologs for 7026006 FitnessBrowser__ANA3:7026006 (590 a.a.)
Found high-coverage hits (≥70%) to 58 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.53.3.9 / A1JRS3 SulP homologue. The low resolution structure is available from Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) (see paper)
59% identity, 94% coverage of query (613 bits)
DauA / b1206 aerobic C4-dicarboxylate transporter DauA from Escherichia coli K-12 substr. MG1655 (see 9 papers)
DauA / P0AFR2 aerobic C4-dicarboxylate transporter DauA from Escherichia coli (strain K12) (see 9 papers)
DAUA_ECOLI / P0AFR2 C4-dicarboxylic acid transporter DauA; Dicarboxylic acid uptake system A from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.53.3.11 / P0AFR2 Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7) from Escherichia coli (strain K12)
56% identity, 96% coverage of query (589 bits)
Build an alignment for 7026006 and 2 homologs with ≥ 30% identity
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TC 2.A.53.3.13 / Q1J2S8 Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs from Deinococcus geothermalis (strain DSM 11300)
27% identity, 85% coverage of query (175 bits)
5da0A / Q1J2S8 Structure of the the slc26 transporter slc26dg in complex with a nanobody (see paper)
27% identity, 85% coverage of query (171 bits)
BICA_SYNY3 / Q55415 Bicarbonate transporter BicA from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
28% identity, 93% coverage of query (161 bits)
BICA_PICP2 / Q14SY0 Bicarbonate transporter BicA from Picosynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) (see 2 papers)
TC 2.A.53.3.3 / Q14SY0 12 TMS Na+:bicarbonate symporter, BicA (Price et al., 2004; Shelden et al., 2010) (low affinity but high efficiency) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see paper)
25% identity, 90% coverage of query (157 bits)
TC 2.A.53.3.1 / O07488 Sulfate permease from Yersinia enterocolitica (see paper)
26% identity, 84% coverage of query (154 bits)
TC 2.A.53.3.8 / Q8F8H7 SulP homologue with fused C-terminal carbonic anhydrase domain, probable bicarbonate uptake transporter from Leptospira interrogans (see paper)
27% identity, 72% coverage of query (146 bits)
SUT41_ARATH / Q9FY46 Sulfate transporter 4.1, chloroplastic; AST82 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 94% coverage of query (142 bits)
7lhvA / Q9FY46 Structure of arabidopsis thaliana sulfate transporter atsultr4;1 (see paper)
25% identity, 92% coverage of query (141 bits)
P96878 carbonic anhydrase (EC 4.2.1.1) from Mycobacterium tuberculosis (see paper)
TC 2.A.53.3.12 / P96878 A bicarbonate transporter fused to a carbonic anhydrase, Rv3273 from Mycobacterium tuberculosis
26% identity, 83% coverage of query (130 bits)
S2611_CAVPO / G3C7W6 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Cavia porcellus (Guinea pig) (see paper)
TC 2.A.53.1.9 / G3C7W6 Slc26a11 Cl-/oxalate or sulfate (but not bicarbonate) exchanger from Cavia porcellus (see paper)
25% identity, 92% coverage of query (129 bits)
SUT22_ARATH / P92946 Sulfate transporter 2.2; AST56; AtH14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
25% identity, 92% coverage of query (125 bits)
TC 2.A.53.3.2 / Q7U617 Bicarbonate:Na+ symporter, BicA (see paper)
25% identity, 86% coverage of query (125 bits)
S2611_HUMAN / Q86WA9 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Homo sapiens (Human) (see 3 papers)
26% identity, 95% coverage of query (125 bits)
SUT21_ARATH / O04722 Sulfate transporter 2.1; AST68 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
24% identity, 92% coverage of query (123 bits)
7v75A Thermostabilized human prestin in complex with salicylate (see paper)
25% identity, 89% coverage of query (121 bits)
7v74A Thermostabilized human prestin in complex with sulfate
25% identity, 89% coverage of query (121 bits)
7xulA Human slc26a3 in complex with tenidap
26% identity, 76% coverage of query (115 bits)
7xujA Human slc26a3 in complex with uk5099
26% identity, 76% coverage of query (114 bits)
7xuhA / P40879 Down-regulated in adenoma in complex with tqr1122
25% identity, 76% coverage of query (112 bits)
S26A3_HUMAN / P40879 Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 from Homo sapiens (Human) (see 16 papers)
TC 2.A.53.2.18 / P40879 Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) from Homo sapiens (see 12 papers)
25% identity, 76% coverage of query (108 bits)
TC 2.A.53.4.1 / P72770 Sulfate transporter (see paper)
25% identity, 81% coverage of query (106 bits)
TC 2.A.53.1.12 / Q0P7I2 Symbiotic sulfate transporter-1, SST1 of 645 aas from Lotus japonicus
22% identity, 92% coverage of query (105 bits)
SUT11_ARATH / Q9SAY1 Sulfate transporter 1.1; AST101; High-affinity sulfate transporter 1; Hst1At from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.7 / Q9SAY1 High affinity sulfate transporter, Sultr1.1 regulated differently from Sultr1.2 (2.A.53.1.6) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
22% identity, 87% coverage of query (103 bits)
SULT2_CHLRE / A8J6J0 Proton/sulfate cotransporter 2 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see 2 papers)
TC 2.A.53.1.8 / A8J6J0 The proton:sulfate symporter, SulP from Chlamydomonas reinhardtii (see paper)
21% identity, 93% coverage of query (102 bits)
ST1 / CAA65291.1 high affinity sulphate transporter from Hordeum vulgare (see paper)
21% identity, 93% coverage of query (101 bits)
Y1739_MYCTU / P9WGF7 Probable sulfate transporter Rv1739c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 2.A.53.4.2 / P71997 Sulfate transporter, Rv1739c from Mycobacterium tuberculosis
25% identity, 78% coverage of query (99.0 bits)
bst3.1 / CAE46442.1 sulphate transporter from Brassica napus (see paper)
22% identity, 89% coverage of query (98.6 bits)
sB sulfate permease from Emericella nidulans (see 3 papers)
25% identity, 71% coverage of query (98.6 bits)
TC 2.A.53.1.3 / P53391 The molybdate (high affinity)/Sulfate (lower affinity) transporter, ShsT1 from Stylosanthes hamata (see paper)
SHST1 / CAA57710.1 high affinity sulphate transporter from Stylosanthes hamata (see paper)
21% identity, 92% coverage of query (98.2 bits)
SUT33_ARATH / Q9SXS2 Probable sulfate transporter 3.3; AST91 from Arabidopsis thaliana (Mouse-ear cress)
22% identity, 90% coverage of query (98.2 bits)
SULX_YEAST / P53394 Putative sulfate transporter YPR003C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
23% identity, 72% coverage of query (97.4 bits)
sutA / AAF14540.1 SutA from Penicillium chrysogenum (see paper)
25% identity, 71% coverage of query (95.1 bits)
SUT12_ARATH / Q9MAX3 Sulfate transporter 1.2 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.6 / Q9MAX3 The sulfate transporter, Sultr1.2 with C-terminal STAS domain that is required both for activity and biogenesis/stability (Shibagaki and Grossman, 2006). It physically interacts with 0-acetylserine (thiol)lyase (cysteine synthetase) via its STAS domain. This interaction stimulates the activity of from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
SULTR1;2 / RF|NP_849899.1 sulfate transporter 1.2 from Arabidopsis thaliana (see paper)
23% identity, 87% coverage of query (94.7 bits)
S26A7_HUMAN / Q8TE54 Anion exchange transporter; Solute carrier family 26 member 7 from Homo sapiens (Human) (see 11 papers)
TC 2.A.53.2.6 / Q8TE54 Basolateral kidney cortical collecting duct and parietal cell chloride/sulfate/oxalate permease or channel, SLC26A7 [substrate preference: NO3- >> Cl- = Br- = I- > SO42- = Glucarate-] (minimal OH- and HCO3- transport; regulated by cytoplasmic pH) (see 7 papers)
SLC26A7 / RF|NP_439897.1 anion exchange transporter from Homo sapiens (see paper)
23% identity, 83% coverage of query (92.4 bits)
SUT13_ARATH / Q9FEP7 Sulfate transporter 1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 87% coverage of query (92.0 bits)
S26A5_RAT / Q9EPH0 Prestin; Solute carrier family 26 member 5 from Rattus norvegicus (Rat) (see 11 papers)
23% identity, 77% coverage of query (90.5 bits)
TC 2.A.53.2.5 / Q99NH7 Prestin, the outer hair cell voltage-sensitive motor protein (voltage sensitivity depends on intracellular Cl- and HCO3- which may bind to prestin). Prestin transports anions including formate and oxalate; transport and voltage-sensing capabilities are independent functions of the same protein (Bai et al., 2009). Prestin-mediated electromotility is a dual-step process: transport of anions by an alternate access cycle, followed by an anion-dependent transition generating electromotility from Mus musculus (Mouse) (see paper)
Slc26a5 / GB|AAG59999.2 prestin from Mus musculus
23% identity, 77% coverage of query (90.5 bits)
S26A5_MERUN / Q9JKQ2 Prestin; Solute carrier family 26 member 5 from Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) (see 4 papers)
23% identity, 77% coverage of query (88.6 bits)
S26A5_MOUSE / Q99NH7 Prestin; Solute carrier family 26 member 5 from Mus musculus (Mouse) (see 5 papers)
23% identity, 77% coverage of query (88.6 bits)
S26A7_MOUSE / Q8R2Z3 Anion exchange transporter; Solute carrier family 26 member 7 from Mus musculus (Mouse) (see 9 papers)
22% identity, 82% coverage of query (87.4 bits)
S26A1_RAT / P45380 Sulfate anion transporter 1; SAT-1; Canalicular sulfate transporter; Solute carrier family 26 member 1; Sulfate/carbonate antiporter from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.53.2.2 / P45380 Canicular sulfate:HCO3- antiporter (Slc26a1) from Rattus norvegicus (Rat) (see paper)
24% identity, 80% coverage of query (84.3 bits)
7lguA / P58743 Structure of human prestin in the presence of nacl (see paper)
21% identity, 77% coverage of query (84.0 bits)
S26A5_HUMAN / P58743 Prestin; Solute carrier family 26 member 5 from Homo sapiens (Human) (see 2 papers)
TC 2.A.53.2.19 / P58743 Prestin (Solute carrier family 26 member 5) from Homo sapiens (see 3 papers)
21% identity, 77% coverage of query (83.2 bits)
S26A5_TURTR / D7PC76 Prestin; Solute carrier family 26 member 5 from Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) (see paper)
22% identity, 77% coverage of query (81.3 bits)
TC 2.A.53.2.11 / G3C7W5 Guinea pig Slc26a3 electroneutral Cl-/HCO3- exchanger (does not transport oxalate or sulfate). from Cavia porcellus (see paper)
22% identity, 76% coverage of query (79.3 bits)
S26A1_MOUSE / P58735 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Mus musculus (Mouse) (see 4 papers)
23% identity, 80% coverage of query (79.0 bits)
7ch1A / Q7LBE3 The overall structure of slc26a9 (see paper)
22% identity, 85% coverage of query (77.4 bits)
8sgwC / I3L8V6 Pendrin in complex with chloride (see paper)
23% identity, 89% coverage of query (77.0 bits)
S26A4_MOUSE / Q9R155 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.53.2.4 / Q9R155 Pendrin (Pendred) syndrome (hereditary deafness) anion transporter (Na+-independent). Anions transported: iodide (thyroid gland; apical membrane of follicular epithelium); bicarbonate (kidney; apical membrane of intercalated cells of the cortical collecting duct), chloride, formate, etc. Pendrin probably catalyzes uniport and anion/anion antiport (SLC26A4). It also regulates Na+ absorption by the epithelial Na+ channel (Wall and Pech, 2008). CFTR controls the rate of liquid secretion while pendrin mediates transcellular HCO3- from Mus musculus (Mouse) (see paper)
23% identity, 87% coverage of query (77.0 bits)
8sieC Pendrin in complex with bicarbonate
23% identity, 89% coverage of query (77.0 bits)
8shcC Pendrin in complex with niflumic acid
23% identity, 89% coverage of query (77.0 bits)
8sh3C Pendrin in complex with iodide
23% identity, 89% coverage of query (77.0 bits)
S26A5_DANRE / Q7T2C4 Prestin; Solute carrier family 26 member 5 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
21% identity, 77% coverage of query (73.9 bits)
S26A3_MOUSE / Q9WVC8 Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.53.2.3 / Q9WVC8 Intestinal down-regulated in adenoma (DRA) protein; HCO3-/Cl- antiporter, SLC26a3 (responsible for congenital chloride-losing diarrhea in humans) (Schweinfest et al., 2006). DRA has 12 putative TMSs and a C-terminal STAS domain required for function and activation of CFTR by DRA (Dorwart et al., 2008). Catalyzes 2Cl-/1HCO3- antiport, Cl-/OH- exchange and sulfate transport (Shcheynikov et al., 2006; Moseley et al., 1999). Loss in mice impairs mucosal HCO3- from Mus musculus (Mouse) (see 2 papers)
Slc26a3 / RF|NP_067328.1 chloride anion exchanger from Mus musculus (see paper)
22% identity, 76% coverage of query (72.0 bits)
S26A9_MOUSE / Q8BU91 Solute carrier family 26 member 9; Anion transporter/exchanger protein 9 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.53.2.10 / Q8BU91 The anion exchanger, channel and Na+-transporter, SLC26a9 from Mus musculus (see 3 papers)
22% identity, 81% coverage of query (72.0 bits)
S26A9_HUMAN / Q7LBE3 Solute carrier family 26 member 9; Anion transporter/exchanger protein 9 from Homo sapiens (Human) (see 5 papers)
TC 2.A.53.2.15 / Q7LBE3 Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) from Homo sapiens (see 4 papers)
21% identity, 81% coverage of query (71.6 bits)
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Lawrence Berkeley National Laboratory