Searching for up to 100 curated homologs for 7026365 FitnessBrowser__ANA3:7026365 (239 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
54% identity, 99% coverage of query (246 bits)
Build an alignment for 7026365 and 1 homologs with ≥ 30% identity
Or download the sequences
5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
29% identity, 99% coverage of query (75.1 bits)
gra-orf6 / BAD51477.1 ketoreductase from Streptomyces violaceoruber (see 3 papers)
24% identity, 99% coverage of query (73.6 bits)
6rxcA Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
27% identity, 99% coverage of query (73.6 bits)
FABG_SALTY / P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
28% identity, 97% coverage of query (72.8 bits)
fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
27% identity, 96% coverage of query (71.2 bits)
6j7uA / D6NKF4 Crystal structure of blue fluorescent protein from metagenomic library in complex with NADPH (see paper)
31% identity, 96% coverage of query (71.2 bits)
O09352 pteridine reductase (EC 1.5.1.33) from Leishmania amazonensis (see paper)
26% identity, 100% coverage of query (70.5 bits)
FabG / b1093 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
fabG / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli (strain K12) (see 22 papers)
FABG_ECOLI / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 9 papers)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Escherichia coli (see 2 papers)
27% identity, 97% coverage of query (68.9 bits)
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+
27% identity, 97% coverage of query (68.9 bits)
pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
27% identity, 98% coverage of query (68.6 bits)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment
27% identity, 97% coverage of query (67.8 bits)
5iz4A / Q13GL4 Crystal structure of a putative short-chain dehydrogenase/reductase from burkholderia xenovorans
29% identity, 92% coverage of query (67.4 bits)
4iqgD / Q12GY8 Crystal structure of bpro0239 oxidoreductase from polaromonas sp. Js666 in NADP bound form
27% identity, 99% coverage of query (67.4 bits)
1p33B / P42556 Pteridine reductase from leishmania tarentolae complex with NADPH and mtx (see paper)
26% identity, 99% coverage of query (67.0 bits)
ptmO8 / D8L2W5 ent-kauranol 7β-dehydrogenase from Streptomyces platensis (see paper)
31% identity, 96% coverage of query (67.0 bits)
Q5SLC4 aldose 1-dehydrogenase (NAD+) (EC 1.1.1.121) from Thermus thermophilus (see paper)
26% identity, 97% coverage of query (67.0 bits)
4b79A / Q9HWT0 The aeropath project and pseudomonas aeruginosa high-throughput crystallographic studies for assessment of potential targets in early stage drug discovery. (see paper)
29% identity, 97% coverage of query (67.0 bits)
7pxxA The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
26% identity, 99% coverage of query (67.0 bits)
2qhxA Structure of pteridine reductase from leishmania major complexed with a ligand
26% identity, 99% coverage of query (67.0 bits)
2d1yA Crystal structure of tt0321 from thermus thermophilus hb8
27% identity, 97% coverage of query (66.6 bits)
6rxcD Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
27% identity, 99% coverage of query (66.2 bits)
PTR1 / Q01782 pteridine reductase 1 monomer (EC 1.5.1.33; EC 1.5.1.3) from Leishmania major (see 4 papers)
PTR1_LEIMA / Q01782 Pteridine reductase 1; H region methotrexate resistance protein; EC 1.5.1.33 from Leishmania major (see 4 papers)
25% identity, 100% coverage of query (65.9 bits)
5l42A Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
26% identity, 99% coverage of query (65.9 bits)
2qhxC Structure of pteridine reductase from leishmania major complexed with a ligand
27% identity, 97% coverage of query (65.9 bits)
1e7wA One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
26% identity, 99% coverage of query (65.9 bits)
S5U393 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Comamonas testosteroni (see paper)
29% identity, 96% coverage of query (65.1 bits)
6rx5A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 1 (nmt- c0003)
26% identity, 97% coverage of query (65.1 bits)
2bfpA Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin
26% identity, 97% coverage of query (65.1 bits)
5l4nA Leishmania major pteridine reductase 1 (ptr1) in complex with compound 1
27% identity, 99% coverage of query (64.7 bits)
novJ / Q9L9F8 NovJ from Streptomyces niveus (see paper)
NOVJ_STRNV / Q9L9F8 Short-chain reductase protein NovJ; Novobiocin biosynthesis protein J; EC 1.1.1.- from Streptomyces niveus (Streptomyces spheroides) (see paper)
27% identity, 97% coverage of query (64.3 bits)
6t77A / W9B6I8 Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
26% identity, 97% coverage of query (64.3 bits)
3bmoA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax4)
25% identity, 97% coverage of query (64.3 bits)
3h4vA Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1
25% identity, 99% coverage of query (64.3 bits)
2bfmA Leishmania major pteridine reductase 1 in complex with NADP and trimethoprim
26% identity, 97% coverage of query (64.3 bits)
2c7vC / O76290 Structure of trypanosoma brucei pteridine reductase (ptr1) in ternary complex with cofactor and the antifolate methotrexate (see paper)
26% identity, 97% coverage of query (63.9 bits)
3bmqA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax5)
26% identity, 97% coverage of query (63.9 bits)
A4I067 pteridine reductase (EC 1.5.1.33) from Leishmania infantum (see paper)
25% identity, 99% coverage of query (63.5 bits)
7pxxC The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
26% identity, 97% coverage of query (63.5 bits)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH
26% identity, 97% coverage of query (63.5 bits)
1e92A Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
25% identity, 97% coverage of query (63.5 bits)
6geyA Trypanosoma brucei ptr1 in complex with inhibitor 4g (f125)
26% identity, 100% coverage of query (63.5 bits)
6gdpA Trypanosoma brucei ptr1 in complex with inhibitor 4l (f162)
26% identity, 100% coverage of query (63.5 bits)
NR_NARAP / A0A1C9II22 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus aff. pseudonarcissus MK-2014 (Daffodil) (see paper)
NR_NARPS / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus pseudonarcissus (Daffodil) (see 2 papers)
5ff9B / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and tyramine (see paper)
23% identity, 98% coverage of query (63.2 bits)
TPRL3_ERYCB / H9BFQ2 Tropinone reductase-like 3; EC 1.1.1.- from Erythroxylum coca (Coca plant) (see paper)
25% identity, 96% coverage of query (63.2 bits)
5fffA Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and piperonal
23% identity, 98% coverage of query (63.2 bits)
4clhA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.8 bits)
4cleA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.8 bits)
6gd0A Trypanosoma brucei ptr1 in complex with inhibitor 4g (f133)
25% identity, 97% coverage of query (62.8 bits)
6gcqA Trypanosoma brucei ptr1 in complex with inhibitor 2b (f192)
25% identity, 97% coverage of query (62.8 bits)
6gcpA Trypanosoma brucei ptr1 in complex with inhibitor 2d (f186)
25% identity, 97% coverage of query (62.8 bits)
6gckA Trypanosoma brucei ptr1 in complex with inhibitor 1e (f206)
25% identity, 97% coverage of query (62.8 bits)
4cm1A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.8 bits)
2bfaC Leishmania major pteridine reductase 1 in complex with NADP and cb3717
26% identity, 97% coverage of query (62.4 bits)
4cmiA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.4 bits)
4cmgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.4 bits)
4cmaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.4 bits)
4cm6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.4 bits)
4cm5A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (62.4 bits)
1w0cD Inhibition of leishmania major pteridine reductase (ptr1) by 2,4,6- triaminoquinazoline; structure of the NADP ternary complex.
26% identity, 99% coverage of query (62.4 bits)
1e92D Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
26% identity, 99% coverage of query (62.4 bits)
2bfpD / Q01782 Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin (see paper)
26% identity, 99% coverage of query (62.0 bits)
6t62A / V5VHN7 Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
23% identity, 97% coverage of query (62.0 bits)
3gn1C Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00067116)
25% identity, 97% coverage of query (62.0 bits)
5l42C Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
26% identity, 99% coverage of query (62.0 bits)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii
23% identity, 97% coverage of query (62.0 bits)
Q4UN54 acetoacetyl-CoA reductase (EC 1.1.1.36) from Rickettsia felis (see paper)
25% identity, 100% coverage of query (61.6 bits)
3jq8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7- trimethyl-7,8-dihydropteridine-2,4-diamine (dx3)
25% identity, 97% coverage of query (61.6 bits)
4cmjA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4cmcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4cmbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4cm4A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4cm3A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4clxA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4cloA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4cldA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
4cl8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.6 bits)
3mcvA Structure of ptr1 from trypanosoma brucei in ternary complex with 2,4- diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+
25% identity, 97% coverage of query (61.6 bits)
2yhuA Trypanosoma brucei ptr1 in complex with inhibitor whf30
25% identity, 97% coverage of query (61.6 bits)
2x9gA High resolution structure of tbptr1 in complex with pemetrexed
25% identity, 97% coverage of query (61.6 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
26% identity, 100% coverage of query (61.2 bits)
1w0cA / Q01782 Inhibition of leishmania major pteridine reductase (ptr1) by 2,4,6- triaminoquinazoline; structure of the NADP ternary complex. (see paper)
24% identity, 97% coverage of query (61.2 bits)
5jdcA Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
25% identity, 97% coverage of query (61.2 bits)
5jcxA Trypanosoma brucei ptr1 in complex with inhibitor np-29
25% identity, 97% coverage of query (61.2 bits)
5jcjA Trypanosoma brucei ptr1 in complex with inhibitor nmt-h037 (compound 7)
25% identity, 97% coverage of query (61.2 bits)
5izcA Trypanosoma brucei ptr1 in complex with inhibitor f032
25% identity, 97% coverage of query (61.2 bits)
4wcfA Trypanosoma brucei ptr1 in complex with inhibitor 9
25% identity, 97% coverage of query (61.2 bits)
4cmeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.2 bits)
4cm9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
25% identity, 97% coverage of query (61.2 bits)
3jqgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4- methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (ax6)
25% identity, 97% coverage of query (61.2 bits)
3jqfA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5- triazine-2,4,6-triamine (ax2)
25% identity, 97% coverage of query (61.2 bits)
3jqeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (dx8)
25% identity, 97% coverage of query (61.2 bits)
3jqdA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-4-oxo-6-phenyl-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (dx7)
25% identity, 97% coverage of query (61.2 bits)
3jqcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-bromo-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (ju2)
25% identity, 97% coverage of query (61.2 bits)
3jqbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-5-(2-phenylethyl)-3,7-dihydro-4h-pyrrolo[2,3-d]pyrimidin-4-one (dx6)
25% identity, 97% coverage of query (61.2 bits)
3jqaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-1,9-dihydro-6h-purine-6-thione (dx4)
25% identity, 97% coverage of query (61.2 bits)
3jq9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (ax1)
25% identity, 97% coverage of query (61.2 bits)
3jq7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
25% identity, 97% coverage of query (61.2 bits)
3jq6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7- bis(1-methylethyl)pteridine-2,4-diamine (dx1)
25% identity, 97% coverage of query (61.2 bits)
3gn2A Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00066730)
25% identity, 97% coverage of query (61.2 bits)
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Lawrence Berkeley National Laboratory