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Searching for up to 100 curated homologs for 73 a.a. (SDKPKRPLSA...) (73 a.a.)

Found high-coverage hits (≥70%) to 43 curated proteins.

Removed hits that are identical to the query, leaving 41

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q06943 High mobility group protein Z; HMG-Z from Drosophila melanogaster (Fruit fly)
    71% identity, 100% coverage of query (115 bits)

SSRP1_DROME / Q05344 FACT complex subunit Ssrp1; Chorion-factor 5; Facilitates chromatin transcription complex subunit Ssrp1; Recombination signal sequence recognition protein; Single-strand recognition protein; dSSRP1 from Drosophila melanogaster (Fruit fly) (see 3 papers)
    60% identity, 93% coverage of query (87.4 bits)

SSRP1_XENLA / Q9W602 FACT complex subunit SSRP1; DNA unwinding factor 87 kDa subunit; DUF87; Facilitates chromatin transcription complex subunit ssrp1; Structure-specific recognition protein 1 from Xenopus laevis (African clawed frog) (see 2 papers)
    54% identity, 95% coverage of query (86.7 bits)

SSRP1_HUMAN / Q08945 FACT complex subunit SSRP1; Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; FACTp80; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; hSSRP1; T160 from Homo sapiens (Human) (see 19 papers)
    53% identity, 93% coverage of query (85.9 bits)

SSRP1_MOUSE / Q08943 FACT complex subunit SSRP1; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; T160 from Mus musculus (Mouse) (see 2 papers)
    51% identity, 93% coverage of query (84.0 bits)

SSRP1_RAT / Q04931 FACT complex subunit SSRP1; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; T160 from Rattus norvegicus (Rat) (see paper)
    51% identity, 93% coverage of query (84.0 bits)

HMGB2_HUMAN / P26583 High mobility group protein B2; High mobility group protein 2; HMG-2 from Homo sapiens (Human) (see 8 papers)
HMGB2_BOVIN / P40673 High mobility group protein B2; High mobility group protein 2; HMG-2 from Bos taurus (Bovine) (see paper)
    42% identity, 96% coverage of query (62.8 bits)

HMGB2_MOUSE / P30681 High mobility group protein B2; High mobility group protein 2; HMG-2 from Mus musculus (Mouse) (see 8 papers)
    42% identity, 96% coverage of query (61.6 bits)

HMGB2_PIG / P17741 High mobility group protein B2; High mobility group protein 2; HMG-2 from Sus scrofa (Pig) (see paper)
    43% identity, 86% coverage of query (60.1 bits)

HMGB3_MOUSE / O54879 High mobility group protein B3; High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4 from Mus musculus (Mouse) (see 4 papers)
    40% identity, 96% coverage of query (60.1 bits)

HMGB3_CHICK / P40618 High mobility group protein B3; High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4 from Gallus gallus (Chicken) (see paper)
    40% identity, 96% coverage of query (60.1 bits)

HMGB3_HUMAN / O15347 High mobility group protein B3; High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4 from Homo sapiens (Human) (see paper)
    40% identity, 96% coverage of query (59.7 bits)

HMGB2_CHICK / P26584 High mobility group protein B2; High mobility group protein 2; HMG-2 from Gallus gallus (Chicken) (see paper)
    40% identity, 93% coverage of query (58.2 bits)

MNH6 nonhistone protein 6 (MNH6) from Magnaporthe grisea 70-15 (see paper)
    42% identity, 96% coverage of query (57.8 bits)

HMGB1 / AAY44045.1 high mobility group B1 from Schistosoma mansoni (see paper)
    40% identity, 96% coverage of query (57.0 bits)

HMGB1 / AAY44044.1 high mobility group B1 from Schistosoma japonicum (see paper)
    41% identity, 96% coverage of query (57.0 bits)

SSP1B_CAEEL / O01683 FACT complex subunit ssrp1-B; Facilitates chromatin transcription complex subunit ssrp1-B; HMG box-containing protein 3; Structure-specific recognition protein 1-B from Caenorhabditis elegans (see paper)
    41% identity, 99% coverage of query (55.8 bits)

NHP6A / GB|AAF06350.1 non-histone chromosomal protein 6 from Candida albicans (see paper)
    43% identity, 93% coverage of query (54.7 bits)

HMGB1_ARATH / O49595 High mobility group B protein 1; High mobility group protein A; AtHMGalpha; HMG alpha; Nucleosome/chromatin assembly factor group D 01; Nucleosome/chromatin assembly factor group D 1 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    39% identity, 97% coverage of query (53.1 bits)

HMGB2_ARATH / O49596 High mobility group B protein 2; High mobility group protein B 1; AtHMGbeta1; HMG beta 1; Nucleosome/chromatin assembly factor group D 02; Nucleosome/chromatin assembly factor group D 2 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    39% identity, 93% coverage of query (52.0 bits)

NHP6A_YEAST / P11632 Non-histone chromosomal protein 6A from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 14 papers)
1j5nA / P11632 Solution structure of the non-sequence-specific hmgb protein nhp6a in complex with sry DNA (see paper)
NHP6A / AAA34754.1 high mobility group non-histone protein from Saccharomyces cerevisiae (see 3 papers)
    44% identity, 82% coverage of query (51.6 bits)

HMGB1_CHICK / Q9YH06 High mobility group protein B1; High mobility group protein 1; HMG-1 from Gallus gallus (Chicken) (see paper)
    43% identity, 96% coverage of query (50.8 bits)

HMGB1_PIG / P12682 High mobility group protein B1; High mobility group protein 1; HMG-1 from Sus scrofa (Pig) (see 3 papers)
    43% identity, 96% coverage of query (50.8 bits)

HMGB1_BOVIN / P10103 High mobility group protein B1; High mobility group protein 1; HMG-1 from Bos taurus (Bovine) (see 7 papers)
    43% identity, 96% coverage of query (50.8 bits)

HMGB1_HUMAN / P09429 High mobility group protein B1; High mobility group protein 1; HMG-1 from Homo sapiens (Human) (see 45 papers)
    43% identity, 96% coverage of query (50.8 bits)

HMGB1_MOUSE / P63158 High mobility group protein B1; High mobility group protein 1; HMG-1 from Mus musculus (Mouse) (see 34 papers)
HMGB1_RAT / P63159 High mobility group protein B1; Amphoterin; Heparin-binding protein p30; High mobility group protein 1; HMG-1 from Rattus norvegicus (Rat) (see 22 papers)
    43% identity, 96% coverage of query (50.8 bits)

ABF2_YEAST / Q02486 ARS-binding factor 2, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    36% identity, 92% coverage of query (50.1 bits)

5jh0D / Q02486 Crystal structure of the mitochondrial DNA packaging protein abf2p in complex with DNA at 2.18 angstrom resolution (see paper)
    36% identity, 92% coverage of query (50.1 bits)

HMG_TETPY / P40625 High mobility group protein; Non-histone chromosomal protein from Tetrahymena pyriformis (see paper)
    35% identity, 92% coverage of query (48.9 bits)

HMGB7_ARATH / Q8LDF9 High mobility group B protein 7; Nucleosome/chromatin assembly factor group D 07; Nucleosome/chromatin assembly factor group D 7; Protein NUCLEAR FUSION DEFECTIVE 7 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    35% identity, 90% coverage of query (48.9 bits)

SSRP1_ARATH / Q05153 FACT complex subunit SSRP1; Facilitates chromatin transcription complex subunit SSRP1; High mobility group B protein 8; Nucleosome/chromatin assembly factor group D 08; Nucleosome/chromatin assembly factor group D 8; Protein NUCLEAR FUSION DEFECTIVE 8; Recombination signal sequence recognition protein 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    37% identity, 89% coverage of query (47.4 bits)

HMGB3_ARATH / P93047 High mobility group B protein 3; High mobility group protein B 2; AtHMGbeta2; HMG beta 2; Nucleosome/chromatin assembly factor group D 03; Nucleosome/chromatin assembly factor group D 3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    39% identity, 93% coverage of query (47.4 bits)

2gzkA / P63159,Q05066 Structure of a complex of tandem hmg boxes and DNA (see paper)
    43% identity, 93% coverage of query (47.4 bits)

NHP6B_YEAST / P11633 Non-histone chromosomal protein 6B from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 11 papers)
    39% identity, 82% coverage of query (47.0 bits)

Build an alignment

Build an alignment for 73 and 34 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

TOX4_MOUSE / Q8BU11 TOX high mobility group box family member 4; Epidermal Langerhans cell protein LCP1 from Mus musculus (Mouse) (see 2 papers)
    29% identity, 97% coverage of query (45.4 bits)

TOX4_HUMAN / O94842 TOX high mobility group box family member 4; Epidermal Langerhans cell protein LCP1 from Homo sapiens (Human) (see 2 papers)
    29% identity, 97% coverage of query (45.1 bits)

TOX3_RAT / B7SBD2 TOX high mobility group box family member 3; Trinucleotide repeat-containing gene 9 protein from Rattus norvegicus (Rat) (see paper)
    29% identity, 97% coverage of query (44.7 bits)

TOX3_HUMAN / O15405 TOX high mobility group box family member 3; CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein from Homo sapiens (Human) (see paper)
    29% identity, 97% coverage of query (44.3 bits)

6cikN / P09429 Pre-reaction complex, rag1(e962q)/2-intact/nicked 12/23rss complex in mn2+ (see paper)
    42% identity, 85% coverage of query (43.9 bits)

HMGB4_ARATH / Q42344 High mobility group B protein 4; High mobility group protein G; AtHMGgamma; HMG gamma; Nucleosome/chromatin assembly factor group D 04; Nucleosome/chromatin assembly factor group D 4 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    37% identity, 93% coverage of query (43.1 bits)

TOX2_RAT / Q76IQ7 TOX high mobility group box family member 2; Granulosa cell HMG box protein 1; GCX-1 from Rattus norvegicus (Rat) (see paper)
    27% identity, 97% coverage of query (42.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory