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Searching for up to 100 curated homologs for 8499281 FitnessBrowser__Miya:8499281 (450 a.a.)

Found high-coverage hits (≥70%) to 67 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q5X1A3 phosphoglucosamine mutase (EC 5.4.2.10) from Legionella pneumophila (see paper)
    47% identity, 99% coverage of query (407 bits)

YhbF / b3176 phosphoglucosamine mutase (EC 5.4.2.10) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
glmM / P31120 phosphoglucosamine mutase (EC 5.4.2.10) from Escherichia coli (strain K12) (see 9 papers)
GLMM_ECOLI / P31120 Phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli (strain K12) (see 2 papers)
glmM phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli K12 (see 6 papers)
    49% identity, 99% coverage of query (397 bits)

GLMM_HELPY / P25177 Phosphoglucosamine mutase; EC 5.4.2.10 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see 2 papers)
    46% identity, 99% coverage of query (395 bits)

GLMM_STAA8 / P0C0V7 Phosphoglucosamine mutase; EC 5.4.2.10 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
GLMM_STAAC / Q5HE43 Phosphoglucosamine mutase; EC 5.4.2.10 from Staphylococcus aureus (strain COL) (see 3 papers)
    45% identity, 100% coverage of query (385 bits)

GLMM_BACSU / O34824 Phosphoglucosamine mutase; EC 5.4.2.10 from Bacillus subtilis (strain 168) (see 2 papers)
    44% identity, 100% coverage of query (384 bits)

7ojrA / O34824 Bacillus subtilis phosphoglucomutase glmm (phosphate bound) (see paper)
    44% identity, 99% coverage of query (383 bits)

7omlA Bacillus subtilis phosphoglucomutase glmm (metal bound)
    44% identity, 99% coverage of query (383 bits)

Q81VN7 phosphoglucosamine mutase (EC 5.4.2.10) from Bacillus anthracis (see paper)
    44% identity, 100% coverage of query (370 bits)

GLMM_STRR6 / Q8DP16 Phosphoglucosamine mutase; EC 5.4.2.10 from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
    43% identity, 100% coverage of query (349 bits)

A9CQM6 phosphoglucosamine mutase (EC 5.4.2.10) from Streptococcus gordonii (see paper)
    42% identity, 100% coverage of query (346 bits)

Q8DTC6 phosphoglucosamine mutase (EC 5.4.2.10) from Streptococcus mutans (see paper)
    43% identity, 100% coverage of query (343 bits)

B3WD16 phosphoglucosamine mutase (EC 5.4.2.10) from Lacticaseibacillus casei (see paper)
    40% identity, 99% coverage of query (338 bits)

3i3wA / Q5NII8 Structure of a phosphoglucosamine mutase from francisella tularensis
    42% identity, 99% coverage of query (334 bits)

PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
    34% identity, 100% coverage of query (217 bits)

PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    35% identity, 100% coverage of query (215 bits)

GLMM_METMP / Q6LYB4 Phosphoglucosamine mutase; EC 5.4.2.10 from Methanococcus maripaludis (strain S2 / LL) (see paper)
Q6LYB4 phosphoglucosamine mutase (EC 5.4.2.10) from Methanococcus maripaludis (see paper)
    32% identity, 96% coverage of query (212 bits)

GLMM_METJA / Q58500 Phosphoglucosamine mutase; EC 5.4.2.10 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
    30% identity, 96% coverage of query (172 bits)

PPM_THEKO / Q6I7B6 Phosphopentomutase; PPM; EC 5.4.2.7 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
Q6I7B6 phosphopentomutase (EC 5.4.2.7) from Thermococcus kodakarensis (see paper)
    30% identity, 99% coverage of query (169 bits)

Build an alignment

Build an alignment for 8499281 and 18 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q980S1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Saccharolobus solfataricus (see paper)
    29% identity, 99% coverage of query (163 bits)

ST0242 / Q976E4 hexose-6-phosphate mutase/isomerase (EC 5.3.1.8; EC 5.3.1.9; EC 5.4.2.10; EC 5.4.2.13) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see paper)
PGMUT_SULTO / Q976E4 Phosphoglucosamine/phosphogalactosamine mutase; PGlcNM; EC 5.4.2.10; EC 5.4.2.13 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q976E4 phosphogalactosamine mutase (EC 5.4.2.13) from Sulfurisphaera tokodaii (see paper)
    29% identity, 99% coverage of query (161 bits)

MANB_METJA / Q57842 Phosphomannomutase; PMM; Phosphoglucomutase; EC 5.4.2.8 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
    27% identity, 94% coverage of query (129 bits)

Q8PGN7 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Xanthomonas citri pv. citri (see paper)
    29% identity, 91% coverage of query (123 bits)

5bmpA Crystal structure of phosphoglucomutase from xanthomonas citri complexed with glucose-1-phosphate (see paper)
    29% identity, 91% coverage of query (123 bits)

6nqhA Xanthomonas citri dephospho-pgm in complex with xylose-1-phosphate
    29% identity, 91% coverage of query (123 bits)

6np8A Xanthomonas citri phospho-pgm in complex with mannose-6-phosphate
    29% identity, 91% coverage of query (123 bits)

6nolA Xanthomonas citri dephospho-pgm in complex with mannose-1-phosphate
    29% identity, 91% coverage of query (123 bits)

6nnpA Xanthomonas citri dephospho-pgm in complex with glucose-6-phosphate
    29% identity, 91% coverage of query (123 bits)

6nn2A Xanthomonas citri pgm apo-phospho
    29% identity, 91% coverage of query (123 bits)

6n1eA Crystal structure of x. Citri phosphoglucomutase in complex with 1- methyl-glucose 6-phosphate
    29% identity, 91% coverage of query (123 bits)

6mnvA Crystal structure of x. Citri phosphoglucomutase in complex with ch2fg1p
    29% identity, 91% coverage of query (123 bits)

6mlhA Crystal structure of x. Citri phosphoglucomutase in complex with glucopyranosyl-1-methyl-phosphonic acid
    29% identity, 91% coverage of query (123 bits)

6mlfA Crystal structure of x. Citri phosphoglucomutase in complex with 6- fluoro glucose 1-phosphate
    29% identity, 91% coverage of query (123 bits)

5kl0A Crystal structure of phosphoglucomutase from xanthomonas citri citri complexed with glucose-1,6-biphosphate
    29% identity, 91% coverage of query (123 bits)

6mlwA Crystal structure of x. Citri phosphoglucomutase in complex with 2- fluoro mannosyl-1-methyl-phosphonic acid
    29% identity, 91% coverage of query (123 bits)

M1T754 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Sphingomonas sanxanigenens (see paper)
    30% identity, 95% coverage of query (122 bits)

algC / P26276 phosphomannomutase (EC 5.4.2.2; EC 5.4.2.8) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
ALGC_PSEAE / P26276 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 12 papers)
    27% identity, 94% coverage of query (122 bits)

1pcjX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    27% identity, 94% coverage of query (122 bits)

2h5aX Complex of the enzyme pmm/pgm with xylose 1-phosphate
    27% identity, 94% coverage of query (122 bits)

2h4lX Complex of pmm/pgm with ribose 1-phosphate
    27% identity, 94% coverage of query (122 bits)

2fkfA Phosphomannomutase/phosphoglucomutase from pseudomonas aeruginosa with alpha-d-glucose 1,6-bisphosphate bound
    27% identity, 94% coverage of query (122 bits)

1pcmX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    27% identity, 94% coverage of query (122 bits)

1p5gX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    27% identity, 94% coverage of query (122 bits)

1p5dX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    27% identity, 94% coverage of query (122 bits)

Q02E40 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain UCBPP-PA14)
    27% identity, 94% coverage of query (122 bits)

1k2yX Crystal structure of phosphomannomutase/phosphoglucomutase s108a mutant from p. Aeruginosa
    27% identity, 94% coverage of query (120 bits)

pgm / AAA20589.1 phosphoglucomutase from Neisseria meningitidis (see paper)
    26% identity, 90% coverage of query (119 bits)

RfbK / b2048 phosphomannomutase (EC 5.4.2.8) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
cpsG / P24175 phosphomannomutase (EC 5.4.2.8) from Escherichia coli (strain K12) (see 6 papers)
manB / GB|AAC75109.1 phosphomannomutase; EC 5.4.2.8 from Escherichia coli K12 (see paper)
    28% identity, 94% coverage of query (118 bits)

4il8A / P26276 Crystal structure of an h329a mutant of p. Aeruginosa pmm/pgm (see paper)
    27% identity, 94% coverage of query (118 bits)

xanA / AAA27610.1 phosphomannomutase/phosphoglucomutase from Xanthomonas campestris pv. campestris (see 4 papers)
    28% identity, 91% coverage of query (115 bits)

pgm / AAA20399.1 phosphoglucomutase from Neisseria gonorrhoeae (see paper)
pgm / AAA20588.1 phosphoglucomutase from Neisseria gonorrhoeae (see paper)
    26% identity, 90% coverage of query (113 bits)

B6Z254 phosphomannomutase (EC 5.4.2.8) from Streptomyces nodosus (see paper)
    30% identity, 72% coverage of query (111 bits)

manB / AAC27539.1 ManB from Escherichia coli (see 6 papers)
    28% identity, 94% coverage of query (109 bits)

3rsmA Crystal structure of s108c mutant of pmm/pgm
    26% identity, 94% coverage of query (108 bits)

rfbK / BAA07746.1 phosphomannomutase from Escherichia coli (see 2 papers)
    26% identity, 97% coverage of query (107 bits)

3uw2A / Q2SYG4 X-ray crystal structure of phosphoglucomutase/phosphomannomutase family protein (bth_i1489)from burkholderia thailandensis (see paper)
    28% identity, 82% coverage of query (105 bits)

4hjhA Iodide sad phased crystal structure of a phosphoglucomutase from brucella melitensis complexed with glucose-6-phosphate
    28% identity, 99% coverage of query (97.4 bits)

pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
    27% identity, 77% coverage of query (80.5 bits)

5jn5A Crystal structure of the d263y missense variant of human pgm1
    24% identity, 93% coverage of query (73.6 bits)

PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
    24% identity, 93% coverage of query (70.9 bits)

7s0wB / P36871 Crystal structure of the t337m variant of human pgm-1 (see paper)
    25% identity, 80% coverage of query (67.8 bits)

3pmgA Structure of rabbit muscle phosphoglucomutase at 2.4 angstroms resolution. Use of freezing point depressant and reduced temperature to enhance diffractivity
    24% identity, 93% coverage of query (67.8 bits)

1c4gA Phosphoglucomutase vanadate based transition state analog complex
    24% identity, 93% coverage of query (67.8 bits)

1c47A Binding driven structural changes in crystaline phosphoglucomutase associated with chemical reaction
    24% identity, 93% coverage of query (67.8 bits)

PGM1_RABIT / P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
    24% identity, 93% coverage of query (67.8 bits)

PGM_DROME / Q9VUY9 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Drosophila melanogaster (Fruit fly) (see paper)
    25% identity, 81% coverage of query (65.9 bits)

6y8yA / A0A6P3VN15 Structure of baltic herring (clupea harengus) phosphoglucomutase 5 (pgm5) with bound glucose-1-phosphate (see paper)
    23% identity, 80% coverage of query (52.8 bits)

7pjcB / A0A1D8PSA9 The structure of candida albicans phosphoglucomutase with isothiazolone modification on cys359
    23% identity, 78% coverage of query (50.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory