Sites on a Tree

 

Searching for up to 100 curated homologs for 8500076 FitnessBrowser__Miya:8500076 (329 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q5JHT1 asparaginase (EC 3.5.1.1) from Thermococcus kodakarensis (see paper)
    42% identity, 95% coverage of query (202 bits)

ASGL1_MOUSE / Q8C0M9 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Mus musculus (Mouse) (see paper)
    39% identity, 98% coverage of query (194 bits)

ASGL1_RAT / Q8VI04 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Asparaginase-like sperm autoantigen; Beta-aspartyl-peptidase; Glial asparaginase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Rattus norvegicus (Rat) (see 2 papers)
    39% identity, 98% coverage of query (193 bits)

4o48A Crystal structure of cleaved guinea pig l-asparaginase type iii in complex with l-aspartate (see paper)
    40% identity, 99% coverage of query (181 bits)

ASRGL1 / Q7L266 isoaspartyl peptidase/L-asparaginase precursor from Homo sapiens (see paper)
ASGL1_HUMAN / Q7L266 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Homo sapiens (Human) (see 6 papers)
Q7L266 beta-aspartyl-peptidase (EC 3.4.19.5); asparaginase (EC 3.5.1.1) from Homo sapiens (see 3 papers)
    39% identity, 91% coverage of query (179 bits)

4osxA / Q7L266 Structure of uncleaved glycine-bound human l-asparaginase protein (see paper)
    39% identity, 91% coverage of query (175 bits)

4pvrA Crystal structure of partially-cleaved human l-asparaginase protein in complex with l-aspartate
    39% identity, 91% coverage of query (174 bits)

4o0hA Crystal structure of human l-asparaginase protein with covalently linked substrate l-asparagine
    40% identity, 91% coverage of query (172 bits)

ASPG_LUPLU / Q9ZSD6 Isoaspartyl peptidase/L-asparaginase; LlA; L-asparagine amidohydrolase; Potassium-independent L-asparaginase; EC 3.4.19.5 from Lupinus luteus (European yellow lupine) (see paper)
Q9ZSD6 beta-aspartyl-peptidase (EC 3.4.19.5) from Lupinus luteus (see paper)
    37% identity, 95% coverage of query (171 bits)

ASGL1_DANRE / Q5BKW9 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
    37% identity, 98% coverage of query (171 bits)

IAAA_SALTY / Q7CQV5 Isoaspartyl peptidase; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; EC 3.4.19.5 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    38% identity, 97% coverage of query (163 bits)

IAAA_ECOLI / P37595 Isoaspartyl peptidase; Beta-aspartyl-peptidase; EcAIII; Isoaspartyl dipeptidase; EC 3.4.19.5 from Escherichia coli (strain K12) (see 5 papers)
P37595 beta-aspartyl-peptidase (EC 3.4.19.5); asparaginase (EC 3.5.1.1) from Escherichia coli (see 2 papers)
IaaA / ECOCYC|MONOMER0-3 L-asparaginase from Escherichia coli K12 (see paper)
    38% identity, 97% coverage of query (162 bits)

Q8GXG1 asparaginase (EC 3.5.1.1) from Arabidopsis thaliana (see paper)
    36% identity, 90% coverage of query (153 bits)

ASPGA_ARATH / P50287 Isoaspartyl peptidase/L-asparaginase 1; L-asparagine amidohydrolase 1; EC 3.4.19.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    36% identity, 94% coverage of query (150 bits)

A0A141NXG8 N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) from Leptopilina heterotoma (see paper)
    33% identity, 88% coverage of query (149 bits)

CCNA_00096 asparaginase (EC 3.5.1.1) from Caulobacter crescentus NA1000
    37% identity, 96% coverage of query (139 bits)

ASPG_ELIMR / Q47898 N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; AGA; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Elizabethkingia miricola (Chryseobacterium miricola) (see 4 papers)
Q47898 N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) from Elizabethkingia miricola (see paper)
    33% identity, 85% coverage of query (138 bits)

1p4vA / Q47898 Crystal structure of the glycosylasparaginase precursor d151n mutant with glycine (see paper)
    34% identity, 85% coverage of query (137 bits)

4r4yA Structural basis of a point mutation that causes the genetic disease aspartylglucosaminuria
    33% identity, 85% coverage of query (135 bits)

TASP1_HUMAN / Q9H6P5 Threonine aspartase 1; Taspase-1; EC 3.4.25.- from Homo sapiens (Human) (see 2 papers)
    32% identity, 79% coverage of query (123 bits)

ASGX_SYNY3 / P74383 Isoaspartyl peptidase/L-asparaginase; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; EC 3.4.19.5 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    33% identity, 92% coverage of query (119 bits)

TASP1_MOUSE / Q8R1G1 Threonine aspartase 1; Taspase-1; EC 3.4.25.- from Mus musculus (Mouse) (see paper)
    32% identity, 79% coverage of query (117 bits)

ASGX_NOSS1 / Q8YQB1 Isoaspartyl peptidase/L-asparaginase; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; EC 3.4.19.5 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
    32% identity, 85% coverage of query (108 bits)

2a8jB / Q9H6P5 Crystal structure of human taspase1 (acivated form) (see paper)
    31% identity, 85% coverage of query (106 bits)

AGA / P20933 glycosylasparaginase α chain (EC 3.5.1.26) from Homo sapiens (see 6 papers)
ASPG_HUMAN / P20933 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Homo sapiens (Human) (see 9 papers)
P20933 N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) from Homo sapiens (see 5 papers)
    33% identity, 85% coverage of query (99.4 bits)

ASPG_MOUSE / Q64191 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; AGA; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Mus musculus (Mouse) (see paper)
    31% identity, 85% coverage of query (98.6 bits)

ASPG_RAT / P30919 N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; AGA; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Rattus norvegicus (Rat) (see 2 papers)
    33% identity, 85% coverage of query (96.7 bits)

Build an alignment

Build an alignment for 8500076 and 27 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

TASP1_SCHPO / Q9P6N7 Putative threonine aspartase; Taspase-1; EC 3.4.25.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    28% identity, 76% coverage of query (87.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory