Searching for up to 100 curated homologs for 8500664 FitnessBrowser__Miya:8500664 (436 a.a.)

Found high-coverage hits (≥70%) to 27 curated proteins.

Removed hits that are identical to the query, leaving 26

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

DHOM_NEIG1 / Q5F8J4 NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; NgHSD; EC 1.1.1.3 from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) (see paper)
    42% identity, 93% coverage of query (311 bits)

hom / AAF21129.1 homoserine dehydrogenase from Methylobacillus flagellatus (see paper)
    42% identity, 94% coverage of query (309 bits)

DHOM_LACLC / P52985 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Lactococcus lactis subsp. cremoris (Streptococcus cremoris) (see paper)
    37% identity, 94% coverage of query (272 bits)

D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    37% identity, 96% coverage of query (271 bits)

A0A0H2WVX4 homoserine dehydrogenase (EC 1.1.1.3) from Staphylococcus aureus (see 2 papers)
    45% identity, 73% coverage of query (256 bits)

DHOM_CORGL / P08499 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
P08499 homoserine dehydrogenase (EC 1.1.1.3) from Corynebacterium glutamicum (see 2 papers)
    39% identity, 98% coverage of query (252 bits)

6dzsA / K5BJC9 Mycobacterial homoserine dehydrogenase thra in complex with NADP
    40% identity, 92% coverage of query (250 bits)

DHOM_BACSU / P19582 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Bacillus subtilis (strain 168) (see paper)
P19582 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus subtilis (see paper)
    34% identity, 97% coverage of query (246 bits)

Ga0059261_2711 homoserine dehydrogenase (EC 1.1.1.3) from Sphingomonas koreensis DSMZ 15582
    39% identity, 97% coverage of query (242 bits)

4pg7A / A0A0M3KKV6 Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
    41% identity, 80% coverage of query (239 bits)

Q56R01 homoserine dehydrogenase (EC 1.1.1.3) from Streptomyces clavuligerus (see paper)
    38% identity, 94% coverage of query (236 bits)

P46806 homoserine dehydrogenase (EC 1.1.1.3) from Mycobacterium leprae (see paper)
    38% identity, 92% coverage of query (229 bits)

D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    37% identity, 71% coverage of query (205 bits)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima (see paper)
    34% identity, 93% coverage of query (189 bits)

6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH
    43% identity, 74% coverage of query (174 bits)

2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
    43% identity, 74% coverage of query (174 bits)

Q5SL04 homoserine dehydrogenase (EC 1.1.1.3) from Thermus thermophilus (see paper)
6a0tB / Q5SL04 Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
    43% identity, 74% coverage of query (173 bits)

7f4cA The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon sulfurisphaera tokodaii.
    30% identity, 72% coverage of query (107 bits)

F9VNG5 homoserine dehydrogenase (EC 1.1.1.3) from Sulfurisphaera tokodaii (see paper)
    30% identity, 72% coverage of query (106 bits)

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Build an alignment for 8500664 and 19 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH
    29% identity, 72% coverage of query (105 bits)

O58802 homoserine dehydrogenase (EC 1.1.1.3) from Pyrococcus horikoshii (see paper)
4xb1A / O58802 Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
    29% identity, 72% coverage of query (104 bits)

5x9dA / F9VNG5 Crystal structure of homoserine dehydrogenase in complex with l- cysteine and NAD (see paper)
    30% identity, 72% coverage of query (103 bits)

3ingA / Q9HIZ7 Crystal structure of homoserine dehydrogenase (np_394635.1) from thermoplasma acidophilum at 1.95 a resolution
    26% identity, 73% coverage of query (95.9 bits)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    26% identity, 72% coverage of query (94.7 bits)

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
    28% identity, 73% coverage of query (73.9 bits)

MetM / b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
metL / P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 9 papers)
    25% identity, 73% coverage of query (73.2 bits)

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