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Searching for up to 100 curated homologs for 8500719 FitnessBrowser__Miya:8500719 (249 a.a.)

Found high-coverage hits (≥70%) to 50 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q54NE6 2,3-bisphosphoglycerate 3-phosphatase (EC 3.1.3.80) from Dictyostelium discoideum (see paper)
    56% identity, 100% coverage of query (305 bits)

PGAM1_CHICK / Q5ZLN1 Phosphoglycerate mutase 1; BPG-dependent PGAM 1; EC 5.4.2.11; EC 5.4.2.4 from Gallus gallus (Chicken) (see paper)
    57% identity, 100% coverage of query (295 bits)

GPMA_BURP1 / Q3JWH7 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM; EC 5.4.2.11 from Burkholderia pseudomallei (strain 1710b) (see paper)
Q3JWH7 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Burkholderia pseudomallei (see paper)
    61% identity, 92% coverage of query (295 bits)

3gp5A / Q3JWH7 Crystal structure of phosphoglyceromutase from burkholderia pseudomallei with 3-phosphoglyceric acid and vanadate (see paper)
    61% identity, 92% coverage of query (294 bits)

B5KJG2 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Sus scrofa (see paper)
    56% identity, 99% coverage of query (294 bits)

3fdzA Crystal structure of phosphoglyceromutase from burkholderia pseudomallei 1710b with bound 2,3-diphosphoglyceric acid and 3- phosphoglyceric acid
    61% identity, 92% coverage of query (293 bits)

PGAM2_MOUSE / O70250 Phosphoglycerate mutase 2; BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; Phosphoglycerate mutase isozyme M; PGAM-M; EC 5.4.2.11; EC 5.4.2.4 from Mus musculus (Mouse) (see 2 papers)
O70250 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Mus musculus (see paper)
    56% identity, 99% coverage of query (292 bits)

3gp3A Crystal structure of phosphoglyceromutase from burkholderia pseudomallei with 2-phosphoserine
    61% identity, 92% coverage of query (291 bits)

PGAM2 / P15259 phosphoglycerate mutase 2 (EC 5.4.2.4; EC 5.4.2.11) from Homo sapiens (see 3 papers)
PGAM2_HUMAN / P15259 Phosphoglycerate mutase 2; BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; Phosphoglycerate mutase isozyme M; PGAM-M; EC 5.4.2.11; EC 5.4.2.4 from Homo sapiens (Human) (see 3 papers)
P15259 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Homo sapiens (see paper)
    54% identity, 99% coverage of query (289 bits)

Gpm / b0755 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (EC 5.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
gpmA / P62707 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (EC 5.4.2.11) from Escherichia coli (strain K12) (see 20 papers)
GPMA_ECOLI / P62707 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM; EC 5.4.2.11 from Escherichia coli (strain K12) (see 4 papers)
gpmA / PDB|1E58_A 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; EC 5.4.2.1 from Shigella flexneri (see 12 papers)
    57% identity, 98% coverage of query (283 bits)

1e59A / P62707 E.Coli cofactor-dependent phosphoglycerate mutase complexed with vanadate (see paper)
    57% identity, 94% coverage of query (283 bits)

PGAM1 / P18669 phosphoglycerate mutase 1 (EC 5.4.2.4; EC 5.4.2.11) from Homo sapiens (see 6 papers)
PGAM1_HUMAN / P18669 Phosphoglycerate mutase 1; BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B; EC 5.4.2.11; EC 5.4.2.4 from Homo sapiens (Human) (see 4 papers)
P18669 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Homo sapiens (see 5 papers)
    57% identity, 100% coverage of query (279 bits)

Q9DBJ1 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Mus musculus (see paper)
    56% identity, 100% coverage of query (278 bits)

7xb8B / P18669 Phosphoglycerate mutase 1 complexed with a covalent inhibitor
    57% identity, 98% coverage of query (275 bits)

7xb7B Phosphoglycerate mutase 1 complexed with a covalent inhibitor
    56% identity, 97% coverage of query (270 bits)

PGM / AAA26800.1 phosphoglycerate mutase from Streptomyces coelicolor (see paper)
    56% identity, 99% coverage of query (269 bits)

1yfkA Crystal structure of human b type phosphoglycerate mutase
    58% identity, 92% coverage of query (266 bits)

5zs8C Acetylation of lysine 100 of phosphoglycerate mutase 1 complexed with kh_ol
    58% identity, 92% coverage of query (265 bits)

5y65C Phosphoglycerate mutase 1 complexed with a small molecule inhibitor kh2
    58% identity, 92% coverage of query (265 bits)

5y35C Phosphoglycerate mutase 1 complexed with a small molecule inhibitor kh1
    58% identity, 92% coverage of query (265 bits)

5y2uB X-ray structure of phosphoglycerate mutase 1(pgam1) complexed with a small molecule
    58% identity, 92% coverage of query (265 bits)

5y2iB Phosphoglycerate mutase 1 (pgam1) complexed with its inhibitor pgmi- 004a
    58% identity, 92% coverage of query (265 bits)

6isnC Phosphoglycerate mutase 1 complexed with a small molecule inhibitor
    58% identity, 92% coverage of query (265 bits)

5zrmC Phosphoglycerate mutase 1 complexed with a small molecule inhibitor in-ac
    58% identity, 92% coverage of query (265 bits)

7xb9B Phosphoglycerate mutase 1 complexed with a covalent inhibitor
    58% identity, 89% coverage of query (263 bits)

GPM1 / P00950 phosphoglycerate mutase (EC 5.4.2.11) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
PMG1_YEAST / P00950 Phosphoglycerate mutase 1; PGAM 1; BPG-dependent PGAM 1; MPGM 1; Phosphoglyceromutase 1; EC 5.4.2.11 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 12 papers)
    54% identity, 98% coverage of query (261 bits)

5pgmE Saccharomyces cerevisiae phosphoglycerate mutase
    54% identity, 93% coverage of query (260 bits)

1bq4A Saccharomyces cerevisiae phosphoglycerate mutase in complex with benzene hexacarboxylate
    54% identity, 93% coverage of query (260 bits)

1bq3A Saccharomyces cerevisiae phosphoglycerate mutase in complex with inositol hexakisphosphate
    54% identity, 93% coverage of query (260 bits)

1qhfA / P00950 Yeast phosphoglycerate mutase-3pg complex structure to 1.7 a (see paper)
    54% identity, 92% coverage of query (259 bits)

PMGY_CANAL / P82612 Phosphoglycerate mutase; PGAM; BPG-dependent PGAM; MPGM; Phosphoglyceromutase; EC 5.4.2.11 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
GPM1 phosphoglycerate mutase; EC 5.4.2.1 from Candida albicans (see 6 papers)
    54% identity, 100% coverage of query (252 bits)

GPMA_STRP6 / Q5XB88 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM; EC 5.4.2.11 from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
    51% identity, 92% coverage of query (243 bits)

BPGM / P07738 Bisphosphoglycerate mutase (EC 5.4.2.11; EC 5.4.2.4) from Homo sapiens (see 5 papers)
PMGE_HUMAN / P07738 Bisphosphoglycerate mutase; BPGM; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM; EC 5.4.2.4; EC 5.4.2.11 from Homo sapiens (Human) (see 10 papers)
P07738 Bisphosphoglycerate mutase (EC 5.4.2.4) from Homo sapiens (see 3 papers)
    45% identity, 100% coverage of query (238 bits)

2h4zA / P07738 Human bisphosphoglycerate mutase complexed with 2,3- bisphosphoglycerate (see paper)
    45% identity, 100% coverage of query (238 bits)

PMGE_RABIT / P07952 Bisphosphoglycerate mutase; BPGM; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM; EC 5.4.2.4; EC 5.4.2.11 from Oryctolagus cuniculus (Rabbit) (see paper)
    45% identity, 100% coverage of query (238 bits)

2f90A Crystal structure of bisphosphoglycerate mutase in complex with 3-phosphoglycerate and alf4-
    45% identity, 100% coverage of query (238 bits)

PMGE_MOUSE / P15327 Bisphosphoglycerate mutase; BPGM; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM; EC 5.4.2.4; EC 5.4.2.11 from Mus musculus (Mouse) (see 2 papers)
    44% identity, 100% coverage of query (234 bits)

GPMA_MYCTU / P9WIC9 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM; EC 5.4.2.11 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    53% identity, 89% coverage of query (233 bits)

7n3rB The ternary complex of human bisphosphoglycerate mutase with 3- phosphoglycerate and 2-phosphoglycolate
    47% identity, 92% coverage of query (228 bits)

Q2YJN6 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Brucella abortus (see paper)
    47% identity, 86% coverage of query (186 bits)

PMGY_SCHPO / P36623 Phosphoglycerate mutase; PGAM; BPG-dependent PGAM; MPGM; Phosphoglyceromutase; EC 5.4.2.11 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
gpm1 / RF|NP_594889.1 monomeric 2,3-bisphosphoglycerate (BPG)-dependent phosphoglycerate mutase (PGAM), Gpm1; EC 5.4.2.1 from Schizosaccharomyces pombe (see paper)
    44% identity, 87% coverage of query (180 bits)

GPM2 phosphoglycerate mutase from Candida albicans (see paper)
    36% identity, 100% coverage of query (166 bits)

GPMA2_ARATH / F4I8M8 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2; BPG-dependent PGAM 2; PGAM 2; Phosphoglyceromutase 2; dPGM 2; EC 5.4.2.11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    38% identity, 86% coverage of query (158 bits)

Build an alignment

Build an alignment for 8500719 and 43 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

PMG3_YEAST / Q12326 Phosphoglycerate mutase 3; PGAM 3; BPG-dependent PGAM 3; MPGM 3; Phosphoglyceromutase 3; EC 5.4.2.11 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    29% identity, 98% coverage of query (141 bits)

PMG2_YEAST / Q12008 Phosphoglycerate mutase 2; PGAM 2; BPG-dependent PGAM 2; MPGM 2; Phosphoglyceromutase 2; EC 5.4.2.11 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    31% identity, 99% coverage of query (134 bits)

PHOE_BACSU / O07617 Uncharacterized phosphatase PhoE; EC 3.1.3.- from Bacillus subtilis (strain 168) (see 2 papers)
    27% identity, 80% coverage of query (71.2 bits)

CA1P_ARATH / Q9FNJ9 Probable 2-carboxy-D-arabinitol-1-phosphatase; EC 3.1.3.63 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 81% coverage of query (64.3 bits)

CA1P_WHEAT / W5EP13 2-carboxy-D-arabinitol-1-phosphatase; EC 3.1.3.63 from Triticum aestivum (Wheat) (see paper)
    28% identity, 79% coverage of query (59.3 bits)

YtjC / b4395 putative phosphatase from Escherichia coli K-12 substr. MG1655 (see 7 papers)
gpmB / RF|NP_418812 PGAM from Escherichia coli K12 (see paper)
    28% identity, 83% coverage of query (49.7 bits)

SERCL_ARATH / F4KI56 Metal-independent phosphoserine phosphatase; iPSP; Phosphoglycerate mutase-like protein 3; EC 3.1.3.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    27% identity, 76% coverage of query (49.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory