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Searching for up to 100 curated homologs for 8502142 FitnessBrowser__Miya:8502142 (210 a.a.)

Found high-coverage hits (≥70%) to 44 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2zwrB / Q5SHV7 Crystal structure of ttha1623 from thermus thermophilus hb8 (see paper)
    40% identity, 97% coverage of query (130 bits)

7ev5A / A0A060M4R1 Crystal structure of bleg-1 b3 metallo-beta-lactamase (see paper)
    36% identity, 95% coverage of query (127 bits)

2zziA Crystal structure of ttha1623 in a di-iron-bound form
    40% identity, 93% coverage of query (127 bits)

7l0bA Crystal structure of hydroxyacyl glutathione hydrolase (glob) from staphylococcus aureus, apoenzyme (see paper)
    35% identity, 94% coverage of query (125 bits)

GloC / b0927 hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gloC / P75849 hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) from Escherichia coli (strain K12) (see 5 papers)
GLO22_ECOLI / P75849 Hydroxyacylglutathione hydrolase GloC; Accessory type II glyoxalase; Glyoxalase II 2; GlxII-2; EC 3.1.2.6 from Escherichia coli (strain K12) (see paper)
    35% identity, 99% coverage of query (125 bits)

A0A0D1GCF8 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Staphylococcus aureus (see paper)
    35% identity, 94% coverage of query (124 bits)

2xf4A Crystal structure of salmonella enterica serovar typhimurium ycbl (see paper)
    33% identity, 99% coverage of query (119 bits)

sdo / B7J413 sulfur dioxygenase α subunit (EC 1.13.11.18) from Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) (see 4 papers)
B7J413 persulfide dioxygenase (EC 1.13.11.18) from Acidithiobacillus ferrooxidans (see paper)
    39% identity, 84% coverage of query (100 bits)

Y554_STRP6 / Q5XD24 Probable metallo-hydrolase M6_Spy0554; EC 3.-.-.- from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
    33% identity, 91% coverage of query (99.4 bits)

4ysbA / Q1D4C9 Crystal structure of ethe1 from myxococcus xanthus (see paper)
    36% identity, 85% coverage of query (92.8 bits)

ETHE1_ARATH / Q9C8L4 Persulfide dioxygenase ETHE1 homolog, mitochondrial; Glyoxalase II; Glx II; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9C8L4 persulfide dioxygenase (EC 1.13.11.18) from Arabidopsis thaliana (see paper)
    32% identity, 89% coverage of query (83.2 bits)

2gcuA / Q9C8L4 X-ray structure of gene product from arabidopsis thaliana at1g53580 (see paper)
    32% identity, 89% coverage of query (83.2 bits)

GLO2M_ARATH / O24495 Hydroxyacylglutathione hydrolase 1, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    35% identity, 87% coverage of query (80.5 bits)

Q940L0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Oryza sativa (see 3 papers)
    34% identity, 88% coverage of query (78.2 bits)

BLH_XYLFA / Q9PFB0 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Xylella fastidiosa (strain 9a5c) (see paper)
    32% identity, 80% coverage of query (77.8 bits)

Build an alignment

Build an alignment for 8502142 and 15 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

6sg9FL 6sg9FL (see paper)
    29% identity, 77% coverage of query (77.4 bits)

blhA / CBY83975.1 metallo-beta-lactamase family from Serratia sp. ATCC 39006 (see paper)
    31% identity, 79% coverage of query (77.0 bits)

ETHE1_MOUSE / Q9DCM0 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1 homolog; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Mus musculus (Mouse) (see paper)
    33% identity, 86% coverage of query (77.0 bits)

A0A1E7YQH3 persulfide dioxygenase (EC 1.13.11.18) from Acidithiobacillus caldus (see paper)
    31% identity, 88% coverage of query (77.0 bits)

5ve5A / B2TEQ2 Crystal structure of persulfide dioxygenase rhodanese fusion protein with rhodanese domain inactivating mutation (c314s) from burkholderia phytofirmans in complex with glutathione (see paper)
    34% identity, 77% coverage of query (77.0 bits)

GLO2N_ARATH / Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    33% identity, 88% coverage of query (76.3 bits)

BLH_AGRFC / Q8UAA9 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    34% identity, 80% coverage of query (76.3 bits)

2q42A / Q9SID3 Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
    33% identity, 88% coverage of query (76.3 bits)

ETHE1 / O95571 mitochondrial persulfide dioxygenase monomer (EC 1.13.11.18) from Homo sapiens (see 6 papers)
ETHE1_HUMAN / O95571 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Homo sapiens (Human) (see 6 papers)
    32% identity, 86% coverage of query (76.3 bits)

4chlB / O95571 Human ethylmalonic encephalopathy protein 1 (hethe1) (see paper)
    32% identity, 86% coverage of query (75.9 bits)

4yskA / A5VWI3 Crystal structure of apo-form sdoa from pseudomonas putida (see paper)
    35% identity, 74% coverage of query (74.7 bits)

4yslA Crystal structure of sdoa from pseudomonas putida in complex with glutathione
    35% identity, 74% coverage of query (74.7 bits)

G5ELA4 persulfide dioxygenase (EC 1.13.11.18) from Staphylococcus aureus (see paper)
    29% identity, 93% coverage of query (72.4 bits)

PNKD_HUMAN / Q8N490 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2; EC 3.-.-.- from Homo sapiens (Human) (see 8 papers)
    35% identity, 88% coverage of query (70.1 bits)

3r2uB 2.1 angstrom resolution crystal structure of metallo-beta-lactamase from staphylococcus aureus subsp. Aureus col
    28% identity, 88% coverage of query (69.7 bits)

PNKD_MOUSE / Q69ZP3 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; EC 3.-.-.- from Mus musculus (Mouse) (see 3 papers)
    36% identity, 79% coverage of query (68.6 bits)

GLO2_HUMAN / Q16775 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Homo sapiens (Human) (see 3 papers)
Q16775 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Homo sapiens (see 8 papers)
    31% identity, 83% coverage of query (67.4 bits)

1qh3A / Q16775 Human glyoxalase ii with cacodylate and acetate ions present in the active site (see paper)
    31% identity, 83% coverage of query (67.4 bits)

1qh5B Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    31% identity, 83% coverage of query (67.4 bits)

1qh5A Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    31% identity, 83% coverage of query (67.4 bits)

3tp9A / C8WS08 Crystal structure of alicyclobacillus acidocaldarius protein with beta-lactamase and rhodanese domains
    29% identity, 88% coverage of query (66.6 bits)

GLO21_SCHPO / Q9UT36 Probable hydroxyacylglutathione hydrolase C824.07; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    30% identity, 78% coverage of query (65.5 bits)

3r2uA / A0A0H2X0Y8 2.1 angstrom resolution crystal structure of metallo-beta-lactamase from staphylococcus aureus subsp. Aureus col
    26% identity, 88% coverage of query (62.4 bits)

GLO2_RAT / O35952 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; Round spermatid protein RSP29; EC 3.1.2.6 from Rattus norvegicus (Rat) (see 2 papers)
O35952 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Rattus norvegicus (see paper)
    29% identity, 83% coverage of query (61.6 bits)

4efzA / Q3JRV4 Crystal structure of a hypothetical metallo-beta-lactamase from burkholderia pseudomallei
    31% identity, 77% coverage of query (60.5 bits)

GLO22_SCHPO / O94250 Probable hydroxyacylglutathione hydrolase C13B11.03c; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    30% identity, 78% coverage of query (52.8 bits)

BAEB_BACVZ / A7Z4X7 Probable polyketide biosynthesis zinc-dependent hydrolase BaeB; EC 3.-.-.- from Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum) (see paper)
    25% identity, 86% coverage of query (51.2 bits)

6ao1A / B2JKI6 Crystal structure of a beta-lactamase from burkholderia phymatum
    28% identity, 70% coverage of query (47.8 bits)

5i0pB / B1YNR3 Crystal structure of a beta-lactamase domain protein from burkholderia ambifaria
    28% identity, 70% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory