Searching for up to 100 curated homologs for AO353_01980 FitnessBrowser__pseudo3_N2E3:AO353_01980 (323 a.a.)
Found high-coverage hits (≥70%) to 68 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
wbpV / Q9RHC9 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Pseudomonas aeruginosa (see paper)
56% identity, 99% coverage of query (360 bits)
ORF35x7 / CAA69124.1 ORF35x7 from Vibrio cholerae (see paper)
52% identity, 98% coverage of query (321 bits)
wreQ / Q6TP29 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see 2 papers)
Q6TP29 UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see paper)
47% identity, 96% coverage of query (293 bits)
wbiG / GI|3135686 putative epimerase/dehydratase WbiG from Burkholderia pseudomallei (see paper)
42% identity, 97% coverage of query (237 bits)
wbpK / P72144 UDP-N-acetyl-α-D-fucosamine dehydrogenase from Pseudomonas aeruginosa (see 2 papers)
36% identity, 98% coverage of query (205 bits)
Build an alignment for AO353_01980 and 5 homologs with ≥ 30% identity
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gnu / Q8X7P7 N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase (EC 5.1.3.26) from Escherichia coli O157:H7 (see 2 papers)
GNU_ECO57 / Q8X7P7 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase; GlcNAc-P-P-Und 4-epimerase; EC 5.1.3.26 from Escherichia coli O157:H7 (see paper)
gne UDP-N-acetylglucosamine 4-epimerase; EC 5.1.3.7 from Escherichia coli O157:H7 (see paper)
26% identity, 99% coverage of query (96.3 bits)
Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
25% identity, 97% coverage of query (79.3 bits)
oleD / Q8PDW5 2-alkyl-3-oxo-fatty acid reductase monomer (EC 1.1.1.412) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
OLED_XANCP / Q8PDW5 2-alkyl-3-oxoalkanoate reductase; EC 1.1.1.412 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
30% identity, 78% coverage of query (78.6 bits)
hsdD / P9WQP7 3 β-hydroxysteroid dehydrogenase (EC 5.3.3.1; EC 1.1.1.145) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
3BHS_MYCTU / P9WQP7 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Cholesterol dehydrogenase; EC 1.1.1.145; EC 5.3.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WQP7 3beta-hydroxy-DELTA5-steroid dehydrogenase (EC 1.1.1.145) from Mycobacterium tuberculosis (see paper)
27% identity, 97% coverage of query (78.2 bits)
3BHD_MYCNE / P0DX24 3-beta-hydroxysteroid dehydrogenase; 3beta-HSD; EC 1.1.1.51 from Mycolicibacterium neoaurum (Mycobacterium neoaurum) (see paper)
25% identity, 97% coverage of query (78.2 bits)
OLED_STRMK / B2FI29 2-alkyl-3-oxoalkanoate reductase; EC 1.1.1.412 from Stenotrophomonas maltophilia (strain K279a) (see paper)
B2FI29 2-alkyl-3-oxoalkanoate reductase (EC 1.1.1.412) from Stenotrophomonas maltophilia (see 2 papers)
31% identity, 78% coverage of query (78.2 bits)
tylA2 / Q54144 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces fradiae (see 2 papers)
25% identity, 98% coverage of query (72.0 bits)
JF740056 / F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Magnaporthe oryzae (see paper)
F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Pyricularia grisea (see paper)
27% identity, 76% coverage of query (71.2 bits)
NSDHL_MOUSE / Q9R1J0 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; EC 1.1.1.170 from Mus musculus (Mouse) (see 4 papers)
Q9R1J0 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) from Mus musculus (see paper)
25% identity, 98% coverage of query (70.1 bits)
6bwlA / Q3ESA4 X-ray structure of pal from bacillus thuringiensis (see paper)
25% identity, 98% coverage of query (67.8 bits)
F8U971 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Botrytis cinerea (see paper)
26% identity, 97% coverage of query (67.8 bits)
RMD_PSEAE / Q9HTB6 GDP-6-deoxy-D-mannose reductase; EC 1.1.1.281 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HTB6 GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) from Pseudomonas aeruginosa (see paper)
25% identity, 77% coverage of query (67.4 bits)
ERG26_SCHPO / O43050 Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating; C-3 sterol dehydrogenase erg26; C-4 decarboxylase erg26; Ergosterol biosynthetic protein 26; EC 1.1.1.170 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
24% identity, 97% coverage of query (67.4 bits)
6x3bA / Q9HTB6 Structure of rmd from pseudomonas aeruginosa complexed with NADPH
25% identity, 77% coverage of query (67.4 bits)
6x3bB Structure of rmd from pseudomonas aeruginosa complexed with NADPH
25% identity, 77% coverage of query (67.4 bits)
A7K9F4 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Acanthocystis turfacea chlorella virus 1 (see paper)
25% identity, 98% coverage of query (65.5 bits)
RMLB_BACSU / P39630 dTDP-glucose 4,6-dehydratase; Spore coat polysaccharide biosynthesis protein SpsJ; EC 4.2.1.46 from Bacillus subtilis (strain 168) (see paper)
22% identity, 99% coverage of query (65.5 bits)
GALE_MYCS2 / A0R5C5 UDP-glucose 4-epimerase; UDP-galactose 4-epimerase; Uridine diphosphate galactose 4-epimerase; EC 5.1.3.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
27% identity, 98% coverage of query (65.1 bits)
8vr2B / Q1QD53 Crystal structure of the pcryo_0617 oxidoreductase/decarboxylase from psychrobacter cryohalolentis k5 in the presence of NAD and udp
23% identity, 97% coverage of query (65.1 bits)
1r66A / Q9ZGH3 Crystal structure of desiv (dtdp-glucose 4,6-dehydratase) from streptomyces venezuelae with NAD and tyd bound (see paper)
26% identity, 98% coverage of query (63.9 bits)
agl12 / D4GU72 dTDP-glucose-4,6-dehydratase (EC 4.2.1.46) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
AGL12_HALVD / D4GU72 Low-salt glycan biosynthesis protein Agl12; EC 4.2.1.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
24% identity, 97% coverage of query (63.9 bits)
1r6dA Crystal structure of desiv double mutant (dtdp-glucose 4,6- dehydratase) from streptomyces venezuelae with NAD and dau bound
26% identity, 98% coverage of query (63.9 bits)
3eheA / O29886 Crystal structure of udp-glucose 4 epimerase (gale-1) from archaeoglobus fulgidus
23% identity, 97% coverage of query (63.5 bits)
Rff / b3788 dTDP-glucose 4,6-dehydratase 2 (EC 4.2.1.46) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
rffG / P27830 dTDP-glucose 4,6-dehydratase 2 (EC 4.2.1.46) from Escherichia coli (strain K12) (see 5 papers)
RMLB2_ECOLI / P27830 dTDP-glucose 4,6-dehydratase 2; EC 4.2.1.46 from Escherichia coli (strain K12) (see 3 papers)
25% identity, 97% coverage of query (63.2 bits)
desIV / Q9ZGH3 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces venezuelae (see paper)
26% identity, 98% coverage of query (62.8 bits)
NSDHL / Q15738 NAD(P)-dependent 3β-hydroxy-4α-carboxy-sterol 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) from Homo sapiens (see 5 papers)
NSDHL_HUMAN / Q15738 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Protein H105e3; EC 1.1.1.170 from Homo sapiens (Human) (see 4 papers)
Q15738 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) from Homo sapiens (see paper)
24% identity, 98% coverage of query (61.6 bits)
gdh / Q54116 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Saccharopolyspora erythraea (see 2 papers)
24% identity, 98% coverage of query (60.5 bits)
rhsB / AAC44074.1 dTDP-D-glucose-4,6-dehydratase from Sphingomonas sp. S88 (see paper)
25% identity, 98% coverage of query (59.7 bits)
3β-HSD/D1 / Q9FX01 plant 3β-hydroxysteroid dehydrogenase/C4-decarboxylase 1 (EC 1.1.1.418) from Arabidopsis thaliana (see 3 papers)
HSDD1_ARATH / Q9FX01 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1; At3BETAHSD/D1; 4alpha-carboxysterol-C3-dehydrogenase/C4-decarboxylase isoform 1-1; Reticulon-like protein B24; AtRTNLB24; Sterol-4-alpha-carboxylate 3-dehydrogenase 1, decarboxylating; EC 1.1.1.418 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
24% identity, 96% coverage of query (59.7 bits)
6kvcA Moee5 in complex with udp-glucose and NAD
23% identity, 96% coverage of query (59.3 bits)
P51110 dihydroflavonol 4-reductase (EC 1.1.1.219) from Vitis vinifera (see paper)
26% identity, 72% coverage of query (58.9 bits)
DFR1 / B9GRL5 dihydroflavonol-4-reductase (EC 1.1.1.219) from Populus trichocarpa (see paper)
B9GRL5 dihydroflavonol 4-reductase (EC 1.1.1.219) from Populus trichocarpa (see paper)
26% identity, 79% coverage of query (58.9 bits)
P51110 Dihydroflavonol 4-reductase; DFR; Dihydrokaempferol 4-reductase; Flavanone 4-reductase; FNR; EC 1.1.1.219; EC 1.1.1.234 from Vitis vinifera (Grape)
26% identity, 72% coverage of query (58.9 bits)
3bxxA Binding of two substrate analogue molecules to dihydroflavonol 4-reductase alters the functional geometry of the catalytic site
27% identity, 72% coverage of query (58.5 bits)
2nnlD Binding of two substrate analogue molecules to dihydroflavonol-4- reductase alters the functional geometry of the catalytic site
27% identity, 72% coverage of query (58.5 bits)
2c29D Structure of dihydroflavonol reductase from vitis vinifera at 1.8 a.
27% identity, 72% coverage of query (58.5 bits)
rfbB / AAA63157.1 TDP-glucose-dehydratase from Neisseria meningitidis (see paper)
24% identity, 99% coverage of query (58.2 bits)
TGDS_HUMAN / O95455 dTDP-D-glucose 4,6-dehydratase; EC 4.2.1.46 from Homo sapiens (Human) (see paper)
22% identity, 98% coverage of query (58.2 bits)
RHM3 / Q9LH76 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM3 (EC 4.2.1.76) from Arabidopsis thaliana (see 2 papers)
RHM3_ARATH / Q9LH76 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM3; Probable rhamnose biosynthetic enzyme 3; AtRHM3; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
23% identity, 98% coverage of query (57.8 bits)
1bxkB / P27830 Dtdp-glucose 4,6-dehydratase from e. Coli
25% identity, 97% coverage of query (57.8 bits)
6kv9A / A0A003 Moee5 in complex with udp-glucuronic acid and NAD (see paper)
23% identity, 96% coverage of query (57.8 bits)
rmd / AAK53475.1 putative NDP-hexose epimerase/oxydoreductase from Xanthomonas campestris pv. campestris (see 4 papers)
26% identity, 96% coverage of query (57.8 bits)
3c1tB / P51110 Binding of two substrate analogue molecules to dihydroflavonol 4- reductase alters the functional geometry of the catalytic site (see paper)
26% identity, 72% coverage of query (57.8 bits)
DFR / Q8GV52 dihydroflavonol-4-reductase (EC 1.1.1.219) from Populus tremuloides (see 2 papers)
25% identity, 76% coverage of query (57.8 bits)
H9TZS8 dihydroflavonol 4-reductase (EC 1.1.1.219) from Vitis bellula (see paper)
27% identity, 72% coverage of query (57.4 bits)
6pnlA / O26475 Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
22% identity, 98% coverage of query (57.0 bits)
3β-HSD/D2 / Q67ZE1 plant 3β-hydroxysteroid dehydrogenase/C4-decarboxylase 2 (EC 1.1.1.418) from Arabidopsis thaliana (see 3 papers)
HSDD2_ARATH / Q67ZE1 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2; At3BETAHSD/D2; 4alpha-carboxysterol-C3-dehydrogenase/C4-decarboxylase isoform 1-2; Reticulon-like protein B19; AtRTNLB19; Sterol-4-alpha-carboxylate 3-dehydrogenase 2, decarboxylating; EC 1.1.1.418 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
23% identity, 96% coverage of query (56.6 bits)
6pmhA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
22% identity, 98% coverage of query (56.6 bits)
6dntA / D3E402 Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
25% identity, 79% coverage of query (56.2 bits)
3vpsA / E5KJ94 Structure of a novel NAD dependent-ndp-hexosamine 5,6-dehydratase, tuna, involved in tunicamycin biosynthesis
27% identity, 75% coverage of query (54.3 bits)
7qskP / P34943 Bovine complex i in lipid nanodisc, active-q10 (see paper)
24% identity, 82% coverage of query (53.9 bits)
8fipA / A0A1B6PND3 Hypothetical anthocyanidin reducatase from sorghum bicolor- NADP+ complex (see paper)
26% identity, 72% coverage of query (50.1 bits)
8fioA Hypothetical anthocyanidin reductase from sorghum bicolor-NADP(h) and naringenin complex
26% identity, 72% coverage of query (50.1 bits)
8fevA Flavanone 4-reductase from sorghum bicolor-NADP(h) and dihydroquercetin complex
27% identity, 72% coverage of query (50.1 bits)
8feuA Flavanone 4-reductase from sorghum bicolor-NADP(h) and naringenin complex
27% identity, 72% coverage of query (50.1 bits)
8fetA / C5YGL7 Flavanone 4-reductase from sorghum bicolor-NADP(h) complex (see paper)
27% identity, 72% coverage of query (50.1 bits)
wbgU / Q7BJX9 UDP-N-acetylglucosamine C4-epimerase subunit (EC 5.1.3.7) from Plesiomonas shigelloides (see paper)
GNE_PLESH / Q7BJX9 UDP-N-acetylglucosamine 4-epimerase; UDP-GalNAc 4-epimerase; EC 5.1.3.7 from Plesiomonas shigelloides (Aeromonas shigelloides) (see 3 papers)
Q7BJX9 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Plesiomonas shigelloides (see 2 papers)
22% identity, 96% coverage of query (49.7 bits)
3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
23% identity, 96% coverage of query (48.5 bits)
8sk0B / A0A1C5ADV9 Crystal structure of evds6 decarboxylase in ligand bound state (see paper)
26% identity, 78% coverage of query (48.1 bits)
8sk0A Crystal structure of evds6 decarboxylase in ligand bound state
26% identity, 78% coverage of query (48.1 bits)
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
23% identity, 79% coverage of query (47.8 bits)
3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
23% identity, 79% coverage of query (47.8 bits)
3lu1A / Q7BJX9 Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
23% identity, 79% coverage of query (47.8 bits)
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Lawrence Berkeley National Laboratory