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Searching for up to 100 curated homologs for AO353_04455 FitnessBrowser__pseudo3_N2E3:AO353_04455 (336 a.a.)

Found high-coverage hits (≥70%) to 54 curated proteins.

Removed hits that are identical to the query, leaving 53

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PfGW456L13_4831 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Pseudomonas fluorescens GW456-L13
    91% identity, 100% coverage of query (613 bits)

BPHYT_RS02735 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Burkholderia phytofirmans PsJN
    66% identity, 100% coverage of query (404 bits)

Ga0059261_1644 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Sphingomonas koreensis DSMZ 15582
    50% identity, 92% coverage of query (266 bits)

CCNA_00453 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Caulobacter crescentus NA1000
    47% identity, 100% coverage of query (266 bits)

PGA1_c27890 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Phaeobacter inhibens BS107
    43% identity, 90% coverage of query (219 bits)

8fdbB / Q12KP2 Crystal structure of nagb-ii phosphosugar isomerase from shewanella denitrificans os217 in complex with glucitolamine-6-phosphate at 3.06 a resolution. (see paper)
    37% identity, 100% coverage of query (212 bits)

8fdbA Crystal structure of nagb-ii phosphosugar isomerase from shewanella denitrificans os217 in complex with glucitolamine-6-phosphate at 3.06 a resolution.
    37% identity, 100% coverage of query (212 bits)

SO3506 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Shewanella oneidensis MR-1
    37% identity, 100% coverage of query (211 bits)

Shewana3_3113 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Shewanella sp. ANA-3
    37% identity, 100% coverage of query (207 bits)

Sama_0945 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) from Shewanella amazonensis SB2B
    37% identity, 100% coverage of query (203 bits)

8eymA Crystal structure of nagb-ii phosphosugar isomerase from shewanella denitrificans os217 in complex with glucitolamine-6-phosphate and n- acetylglucosamine-6-phosphate at 2.31 a resolution
    36% identity, 96% coverage of query (200 bits)

glmS / F9VPA4 glutamine—fructose-6-phosphate transaminase (EC 2.6.1.16) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see paper)
GLMS_SULTO / F9VPA4 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Glutamine:fructose-6-phosphate amidotransferase; Hexosephosphate aminotransferase; L-glutamine--D-fructose-6-phosphate amidotransferase; EC 2.6.1.16 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
    31% identity, 88% coverage of query (135 bits)

4amvA / P17169 E.Coli glucosamine-6p synthase in complex with fructose-6p (see paper)
    34% identity, 73% coverage of query (124 bits)

glmS / AAA86988.1 L-glutamine:D-fructose-6-P amidotransferase precursor from Thermus thermophilus (see paper)
    33% identity, 87% coverage of query (124 bits)

GlmS / b3729 L-glutamine—D-fructose-6-phosphate aminotransferase (EC 2.6.1.16) from Escherichia coli K-12 substr. MG1655 (see 24 papers)
glmS / P17169 L-glutamine—D-fructose-6-phosphate aminotransferase (EC 2.6.1.16) from Escherichia coli (strain K12) (see 22 papers)
GLMS_ECOLI / P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine--D-fructose-6-phosphate amidotransferase; EC 2.6.1.16 from Escherichia coli (strain K12) (see 4 papers)
P17169 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Escherichia coli (see 8 papers)
glmS / PDB|2BPJ_A glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; EC 2.6.1.16 from Escherichia coli K12 (see 12 papers)
    34% identity, 73% coverage of query (124 bits)

1morA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucose 6-phosphate
    34% identity, 73% coverage of query (124 bits)

1moqA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucosamine 6-phosphate
    34% identity, 73% coverage of query (124 bits)

1mosA Isomerase domain of glucosamine 6-phosphate synthase complexed with 2- amino-2-deoxyglucitol 6-phosphate
    34% identity, 73% coverage of query (124 bits)

1jxaA Glucosamine 6-phosphate synthase with glucose 6-phosphate
    34% identity, 73% coverage of query (124 bits)

2j6hA E. Coli glucosamine-6-p synthase in complex with glucose-6p and 5-oxo- l-norleucine
    34% identity, 73% coverage of query (123 bits)

B4F0F0 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Proteus mirabilis (see 2 papers)
    32% identity, 87% coverage of query (122 bits)

Build an alignment

Build an alignment for AO353_04455 and 21 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

GFAT1_ARATH / Q9LIP9 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; AtGFAT; AtGFAT1; Glutamine:fructose-6-phosphate amidotransferase 1; D-fructose-6-phosphate amidotransferase GFAT1; Hexosephosphate aminotransferase GFAT1; EC 2.6.1.16 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 95% coverage of query (120 bits)

7dnrA Crystal structure of zn-bound sis domain of glucosamine-6-p synthase from e. Coli
    34% identity, 72% coverage of query (120 bits)

GFA1_ENCCU / Q8SRI2 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; GFAT; D-fructose-6-phosphate amidotransferase; Hexosephosphate aminotransferase; EC 2.6.1.16 from Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) (see paper)
    30% identity, 89% coverage of query (117 bits)

Q8G545 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Bifidobacterium longum (see paper)
    28% identity, 87% coverage of query (115 bits)

Q32KF3 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Drosophila melanogaster (see paper)
    28% identity, 87% coverage of query (114 bits)

GFA1 / P53704 glucosamine-6-phosphate synthase subunit (EC 2.6.1.16) from Candida albicans (strain SC5314 / ATCC MYA-2876) (see paper)
GFA1_CANAL / P53704 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; GFAT; D-fructose-6-phosphate amidotransferase; Hexosephosphate aminotransferase; EC 2.6.1.16 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
    30% identity, 86% coverage of query (113 bits)

GFA1 / GI|1429267 glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (GFAT); EC 2.6.1.16 from Candida albicans (see 5 papers)
    30% identity, 86% coverage of query (113 bits)

Gfat1 / Q9Y093 glucosamine-fructose-6-phosphate aminotransferase (EC 2.6.1.16) from Drosophila melanogaster (see 3 papers)
Q9Y093 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Drosophila melanogaster (see paper)
    28% identity, 87% coverage of query (112 bits)

nodM / CAA41485.1 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) from Sinorhizobium meliloti (see paper)
    30% identity, 82% coverage of query (110 bits)

Q9HT25 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Pseudomonas aeruginosa (see paper)
    32% identity, 87% coverage of query (107 bits)

GFA1_YEAST / P14742 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; GFAT; D-fructose-6-phosphate amidotransferase; Hexosephosphate aminotransferase; EC 2.6.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P14742 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Saccharomyces cerevisiae (see paper)
    27% identity, 87% coverage of query (106 bits)

2pocB / P53704 The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans (see paper)
    29% identity, 84% coverage of query (104 bits)

D3YIG6 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Sporothrix schenckii (see paper)
    29% identity, 80% coverage of query (103 bits)

GLMS_BACSU / P0CI73 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine--D-fructose-6-phosphate amidotransferase; EC 2.6.1.16 from Bacillus subtilis (strain 168) (see paper)
P0CI73 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Bacillus subtilis (see 3 papers)
    31% identity, 74% coverage of query (103 bits)

Q6DLZ8 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Volvariella volvacea (see paper)
    29% identity, 88% coverage of query (103 bits)

Q6GES3 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Staphylococcus aureus (see paper)
    29% identity, 87% coverage of query (102 bits)

A2QH83 glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) from Aspergillus niger (see paper)
    31% identity, 86% coverage of query (102 bits)

2zj4A Isomerase domain of human glucose:fructose-6-phosphate amidotransferase
    27% identity, 73% coverage of query (102 bits)

2zj3A Isomerase domain of human glucose:fructose-6-phosphate amidotransferase
    27% identity, 73% coverage of query (102 bits)

6r4eA / Q06210 Crystal structure of human gfat-1 in complex with glucose-6-phosphate and l-glu (see paper)
    27% identity, 73% coverage of query (101 bits)

6svmA Crystal structure of human gfat-1 in complex with glucose-6-phosphate, l-glu, and udp-galnac
    27% identity, 73% coverage of query (101 bits)

Gfpt1 / P82808 glutamine:fructose 6-phosphate amidotransferase subunit (EC 2.6.1.16) from Rattus norvegicus (see paper)
GFPT1_RAT / P82808 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1; EC 2.6.1.16 from Rattus norvegicus (Rat) (see paper)
    27% identity, 73% coverage of query (100 bits)

GFPT1 / Q06210 glutamine:fructose-6-phosphate amidotransferase I (EC 2.6.1.16) from Homo sapiens (see 3 papers)
GFPT1_HUMAN / Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1; EC 2.6.1.16 from Homo sapiens (Human) (see 4 papers)
    27% identity, 73% coverage of query (100 bits)

GFPT1_MOUSE / P47856 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1; EC 2.6.1.16 from Mus musculus (Mouse) (see 2 papers)
    26% identity, 87% coverage of query (100 bits)

6r4gA Crystal structure of human gfat-1 in complex with udp-glcnac
    27% identity, 72% coverage of query (99.4 bits)

2v4mA The isomerase domain of human glutamine-fructose-6-phosphate transaminase 1 (gfpt1) in complex with fructose 6-phosphate
    26% identity, 71% coverage of query (94.4 bits)

2df8A / O58246 Crystal structure of the ph0510 protein from pyrococcus horikoshii ot3 in complex with beta-d-fructopyranose-1-phosphate
    28% identity, 89% coverage of query (90.9 bits)

glmS / AAC21670.1 glucosamine synthase from Acidithiobacillus ferridurans (see paper)
    30% identity, 74% coverage of query (87.0 bits)

GLMS_METMP / Q6LWM9 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine--D-fructose-6-phosphate amidotransferase; EC 2.6.1.16 from Methanococcus maripaludis (strain S2 / LL) (see paper)
    25% identity, 93% coverage of query (84.7 bits)

2putA The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans
    28% identity, 84% coverage of query (81.3 bits)

2puvA The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans
    27% identity, 84% coverage of query (78.6 bits)

2puwB / P53704 The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans (see paper)
    27% identity, 84% coverage of query (76.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory